2. Gene
  3. Trpm2 - transient receptor potential cation channel, subfamily M, member 2 Gene

Trpm2 - transient receptor potential cation channel, subfamily M, member 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Trp7; TRPC7; Trrp7; LTRPC2; 9830168K16Rik

Gene ID: 28240 | Gene type: protein coding

About Trpm2

Summary

Enables ligand-gated Calcium Channel activity and manganese ion transmembrane transporter activity. Involved in several processes, including calcium ion transmembrane import into cytosol; calcium-mediated signaling using intracellular calcium source; and cellular response to temperature stimulus. Acts upstream of or within manganese ion transport and response to hydroperoxide. Located in cytoplasmic vesicle membrane; lysosomal membrane; and plasma membrane. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human TRPM2 (transient receptor potential cation channel subfamily M member 2). [provided by Alliance of Genome Resources, Apr 2022]

Trpm2 Products(2)

mRNA Protein Name
NM_001411900.1 NP_001398829.1 transient receptor potential cation channel subfamily M member 2
NM_138301.2 NP_612174.2 transient receptor potential cation channel subfamily M member 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables ligand-gated calcium channel activity IMP
IMP: Inferred from mutant phenotype
21753080 MGI
enables manganese ion transmembrane transporter activity IDA
IDA: Inferred from direct assay
11804595 MGI
Biological Process GO Annotation Evidence Reference Source
involved in calcium ion import across plasma membrane IMP
IMP: Inferred from mutant phenotype
21753080 MGI
involved in cellular response to temperature stimulus IMP
IMP: Inferred from mutant phenotype
27562954 MGI
involved in dendritic cell chemotaxis IMP
IMP: Inferred from mutant phenotype
21753080 MGI
involved in dendritic cell differentiation IMP
IMP: Inferred from mutant phenotype
21753080 MGI
acts upstream of or within manganese ion transport IDA
IDA: Inferred from direct assay
11804595 MGI
involved in release of sequestered calcium ion into cytosol IMP
IMP: Inferred from mutant phenotype
21753080 MGI
involved in response to heat IMP
IMP: Inferred from mutant phenotype
27562954 MGI
acts upstream of or within response to hydroperoxide IDA
IDA: Inferred from direct assay
11804595 MGI
involved in temperature homeostasis IMP
IMP: Inferred from mutant phenotype
27562954 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasmic vesicle membrane IDA
IDA: Inferred from direct assay
21753080 MGI
located in lysosomal membrane IDA
IDA: Inferred from direct assay
21753080 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
11804595 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transient receptor potential cation channel subfamily M member 2

LTrpC-2

long transient receptor potential channel 2

transient receptor potential channel 7

transient receptor protein 7

Related Agents

Approval
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-14600 Rosiglitazone maleate 99.73% Yes
HY-14600R Rosiglitazone (maleate) (Standard) / Unkown
HY-B0700 Rosiglitazone sodium / Unkown
Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-100973A Adenosine 5′-diphosphoribose sodium 99.47% Phase 1
Pre-clinical Phase
Bioactive Molecules (17)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-110220 CIM0216 Agonist 99.94% Unkown
HY-149143 JNJ-28583113 Inhibitor 98.82% Unkown
HY-101507 Zerencotrep Inhibitor 99.47% Unkown
HY-113037C Farnesyl pyrophosphate ammonium Agonist ≥95.0% Unkown
HY-18662 RQ-00203078 Antagonist 99.84% Unkown
HY-N7395 Cyclic ADP-​ribose Activator ≥96.0% Unkown
HY-N7395A Cyclic ADP-​ribose ammonium Activator 99.38% Unkown
HY-113037 (E/Z)-Farnesyl pyrophosphate Agonist / Unkown
HY-134261 8-Br-ADPR / Unkown
HY-173449 TRPM2-IN-1 Inhibitor / Unkown
HY-P5883 TAT-M2NX Inhibitor / Unkown
HY-RS15112 TRPM2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-117804 8-Br-cADPR Antagonist / Unkown
HY-134268 8-Br-7-CH-ADPR Antagonist / Unkown
HY-137704 2′-Deoxy-ADPR Agonist / Unkown
HY-RS16755 Trpm2 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23194 Trpm2 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Trpm2 NCBI NCBI:7226