Farnesyl pyrophosphate  (Synonyms: Farnesyl diphosphate)

Farnesyl pyrophosphate is a metabolic intermediate in the mevalonate (MVA) pathway. It is a TRP channel (TRPM2) agonist that triggers Ca2+ influx and cell death. Farnesyl pyrophosphate is a key branch substrate for cholesterol synthesis, ubiquinone synthesis, protein farnesylation, and geranylgeranyl pyrophosphate (GGPP) synthesis. Farnesyl pyrophosphate is used in research on cerebral ischemia, neurodegenerative diseases, pancreatic cancer, inflammation, and autoimmune diseases.

Farnesyl pyrophosphate (0-120 μg/mL, 0-60 min) induces cell death in P815 cell, A20 cells, Jurkat T cells, spleen cells, thymocytes and neure^[1].
Farnesyl pyrophosphate (0-60 μM, 0-60 min) activates TRPM2 opening for Ca²⁺ influx in P815 cells^[1].
Farnesyl pyrophosphate (10 μM, 14-26 h) significantly reverses the cytotoxicity, ROS elevation and AKT phosphorylation caused by Simvastatin (HY-17502) in CT26 cells^[2].
Farnesyl pyrophosphate (10 μM, 48 h) significantly reverses the inhibitory effect of Simvastatin on the production of cytokines in mouse intestinal intraepithelial lymphocytes (IELs)^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Farnesyl pyrophosphate (30 mg/mL (3 μL), injected into the left striatum, single dose) accumulates in the ischemic hemisphere and induces acute neuronal death in mouse brain ischemia and reperfusion^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

382.33

C₁₅H₂₈O₇P₂

372-97-4

O=P(O)(O)OP(OC/C=C(C)/CC/C=C(C)/CC/C=C(C)/C)(O)=O

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• [1]. Jing Chen, et al. Farnesyl pyrophosphate is a new danger signal inducing acute cell death. PLoS Biol. 2021 Apr 26;19(4):e3001134.  [Content Brief]

  [2]. Qi XF, et al. Involvement of oxidative stress in simvastatin-induced apoptosis of murine CT26 colon carcinoma cells. Toxicol Lett. 2010 Dec 15;199(3):277-87.  [Content Brief]

  [3]. Zhang J, et al. Statins directly suppress cytokine production in murine intraepithelial lymphocytes. Cytokine. 2013 Feb;61(2):540-5.  [Content Brief]