2. Membrane Transporter/Ion Channel Metabolic Enzyme/Protease Neuronal Signaling
  3. TRP Channel Endogenous Metabolite Calcium Channel
  4. Farnesyl pyrophosphate ammonium

Farnesyl pyrophosphate ammonium  (Synonyms: Farnesyl diphosphate ammonium)

Cat. No.: HY-113037C Purity: 95.0%
COA
SDS
Handling Instructions Technical Support

Farnesyl pyrophosphate (Farnesyl diphosphate) ammonium is a metabolic intermediate in the mevalonate (MVA) pathway. It is a TRP channel (TRPM2) agonist that triggers Ca2+ influx and cell death. Farnesyl pyrophosphate ammonium is a key branch substrate for cholesterol synthesis, ubiquinone synthesis, protein farnesylation, and geranylgeranyl pyrophosphate (GGPP) synthesis. Farnesyl pyrophosphate ammonium is used in research on cerebral ischemia, neurodegenerative diseases, pancreatic cancer, inflammation, and autoimmune diseases.

For research use only. We do not sell to patients.

Farnesyl pyrophosphate ammonium

Farnesyl pyrophosphate ammonium Chemical Structure

CAS No. : 116057-57-9

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Based on 1 publication(s) in Google Scholar

Other Forms of Farnesyl pyrophosphate ammonium:

Farnesyl pyrophosphate ammonium Related Antibodies

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

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Description

Farnesyl pyrophosphate (Farnesyl diphosphate) ammonium is a metabolic intermediate in the mevalonate (MVA) pathway. It is a TRP channel (TRPM2) agonist that triggers Ca2+ influx and cell death. Farnesyl pyrophosphate ammonium is a key branch substrate for cholesterol synthesis, ubiquinone synthesis, protein farnesylation, and geranylgeranyl pyrophosphate (GGPP) synthesis. Farnesyl pyrophosphate ammonium is used in research on cerebral ischemia, neurodegenerative diseases, pancreatic cancer, inflammation, and autoimmune diseases[1][2][3].

In Vitro

Farnesyl pyrophosphate ammonium (0-120 μg/mL, 0-60 min) induces cell death in P815 cell, A20 cells, Jurkat T cells, spleen cells, thymocytes and neure[1].
Farnesyl pyrophosphate ammonium (0-60 μM, 0-60 min) activates TRPM2 opening for Ca2+ influx in P815 cells[1].
Farnesyl pyrophosphate ammonium (10 μM, 14-26 h) significantly reverses the cytotoxicity, ROS elevation and AKT phosphorylation caused by Simvastatin (HY-17502) in CT26 cells[2].
Farnesyl pyrophosphate ammonium (10 μM, 48 h) significantly reverses the inhibitory effect of Simvastatin on the production of cytokines in mouse intestinal intraepithelial lymphocytes (IELs)[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Farnesyl pyrophosphate ammonium Related Antibodies

Cell Viability Assay[1]

Cell Line: CT26 cells
Concentration: 10 μM
Incubation Time: Pretreat for 2 h and with Simvastatin for 24 h
Result: Had no effect on cell viability alone, but restored the decreased cell viability caused by simvastatin.

Western Blot Analysis[1]

Cell Line: CT26 cells
Concentration: 10 μM
Incubation Time: Pretreat for 2 h and with Simvastatin for 12 h
Result: Completely inhibited the Akt phosphorylation induced by simvastatin.
Had no effect on the Akt phosphorylation level when treated alone.

ELISA Assay[3]

Cell Line: IELs
Concentration: 10 μM
Incubation Time: Pretreat for 15 min and with Simvastatin for 48 h
Result: Restored the inhibition rates of IFN-γ, TNF-a and IL-2.
In Vivo

Farnesyl pyrophosphate ammonium (30 mg/mL (3 μL), injected into the left striatum, single dose) accumulates in the ischemic hemisphere and induces acute neuronal death in mouse brain ischemia and reperfusion[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Middle cerebral artery occlusion (MCAO) model established in adult C57BL/6J mice (male, 10 to 12 weeks old, weight: 22 to 26 g)[1]
Dosage: 30 mg/mL, 3 μL
Administration: Injected into the left striatum, single dose
Result: Induced acute neuron death.
Induced TRPM2-mediated cell death axis.
Molecular Weight

433.42

Formula

C15H37N3O7P2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=P(O)(O)OP(OC/C=C(C)/CC/C=C(C)/CC/C=C(C)/C)(O)=O.N.N.N
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (230.72 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3072 mL 11.5362 mL 23.0723 mL
5 mM 0.4614 mL 2.3072 mL 4.6145 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 95.0%

SDS (393 KB)

COA (245 KB) HNMR (256 KB) CNMR (277 KB) MS (73 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.3072 mL 11.5362 mL 23.0723 mL 57.6808 mL
5 mM 0.4614 mL 2.3072 mL 4.6145 mL 11.5362 mL
10 mM 0.2307 mL 1.1536 mL 2.3072 mL 5.7681 mL
15 mM 0.1538 mL 0.7691 mL 1.5382 mL 3.8454 mL
20 mM 0.1154 mL 0.5768 mL 1.1536 mL 2.8840 mL
25 mM 0.0923 mL 0.4614 mL 0.9229 mL 2.3072 mL
30 mM 0.0769 mL 0.3845 mL 0.7691 mL 1.9227 mL
40 mM 0.0577 mL 0.2884 mL 0.5768 mL 1.4420 mL
50 mM 0.0461 mL 0.2307 mL 0.4614 mL 1.1536 mL
60 mM 0.0385 mL 0.1923 mL 0.3845 mL 0.9613 mL
80 mM 0.0288 mL 0.1442 mL 0.2884 mL 0.7210 mL
100 mM 0.0231 mL 0.1154 mL 0.2307 mL 0.5768 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Farnesyl pyrophosphate ammonium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Farnesyl pyrophosphate116057-57-9Farnesyl diphosphateTRP ChannelEndogenous MetaboliteCalcium ChannelTransient receptor potential channelsCa2+ channelsCa channelsGGPP synthesision influxMVA pathwayInhibitorinhibitorinhibit

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