Trpv1 - transient receptor potential cation channel, subfamily V, member 1 Gene

Mus musculus

Also known as Vr1; VR-1; OTRPC1; TRPV1beta; TRPV1alpha

Gene ID: 193034 | Gene type: protein coding

About Trpv1

Summary

Enables Calcium Channel activity; identical protein binding activity; and temperature-gated ion channel activity. Involved in detection of temperature stimulus involved in sensory perception of pain; ion transmembrane transport; and negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including detection of stimulus involved in sensory perception; diet induced thermogenesis; and fever generation. Located in neuron projection and plasma membrane. Is expressed in central nervous system; cochlea; and dorsal root ganglion. Human ortholog(s) of this gene implicated in migraine. Orthologous to human TRPV1 (transient receptor potential cation channel subfamily V member 1). [provided by Alliance of Genome Resources, Apr 2022]

Trpv1 Products(1)

mRNA	Protein	Name
NM_001001445.2	NP_001001445.1	transient receptor potential cation channel subfamily V member 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium channel activity	IDA IDA: Inferred from direct assay	15489017	MGI
enables calcium channel activity	IMP IMP: Inferred from mutant phenotype	10764638	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	20351268	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	18455988	MGI
enables temperature-gated ion channel activity	IDA IDA: Inferred from direct assay	18455988	MGI
enables temperature-gated ion channel activity	IMP IMP: Inferred from mutant phenotype	22634729	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within behavioral response to pain	IDA IDA: Inferred from direct assay	18455988	MGI
acts upstream of or within behavioral response to pain	IMP IMP: Inferred from mutant phenotype	17767493	MGI
acts upstream of or within calcium ion transport	IDA IDA: Inferred from direct assay	17194758	MGI
acts upstream of or within calcium ion transport	IMP IMP: Inferred from mutant phenotype	17767493	MGI
acts upstream of or within catagen	IMP IMP: Inferred from mutant phenotype	16645591	MGI
acts upstream of or within detection of chemical stimulus involved in sensory perception of pain	IDA IDA: Inferred from direct assay	18272293	MGI
acts upstream of or within detection of chemical stimulus involved in sensory perception of pain	IMP IMP: Inferred from mutant phenotype	18297068	MGI
involved in detection of temperature stimulus involved in sensory perception of pain	IGI IGI: Inferred from genetic interaction	22634729	MGI
involved in detection of temperature stimulus involved in sensory perception of pain	IMP IMP: Inferred from mutant phenotype	22634729	MGI
acts upstream of or within detection of temperature stimulus involved in thermoception	IDA IDA: Inferred from direct assay	18455988	MGI
acts upstream of or within diet induced thermogenesis	IMP IMP: Inferred from mutant phenotype	12161756	MGI
acts upstream of or within fever generation	IMP IMP: Inferred from mutant phenotype	15763167	MGI
acts upstream of or within lipid metabolic process	IMP IMP: Inferred from mutant phenotype	12161756	MGI
involved in monoatomic ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	22634729	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	23021218	MGI
acts upstream of or within peptide secretion	IMP IMP: Inferred from mutant phenotype	18172555	MGI
acts upstream of or within response to heat	IMP IMP: Inferred from mutant phenotype	10764638	MGI
acts upstream of or within response to pH	IMP IMP: Inferred from mutant phenotype	10764638	MGI
acts upstream of or within response to pain	IDA IDA: Inferred from direct assay	18272293	MGI
acts upstream of or within response to pain	IMP IMP: Inferred from mutant phenotype	18297068	MGI
acts upstream of or within sensory perception of mechanical stimulus	IMP IMP: Inferred from mutant phenotype	12161756	MGI
acts upstream of or within sensory perception of pain	IMP IMP: Inferred from mutant phenotype	10764638	MGI
acts upstream of or within sensory perception of taste	IMP IMP: Inferred from mutant phenotype	17767493	MGI
acts upstream of or within smooth muscle contraction involved in micturition	IMP IMP: Inferred from mutant phenotype	12161756	MGI
acts upstream of or within temperature homeostasis	IMP IMP: Inferred from mutant phenotype	10764638	MGI
acts upstream of or within urinary bladder smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	12161756	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	25775089	MGI
is active in GABA-ergic synapse	IMP IMP: Inferred from mutant phenotype	25775089	MGI
located in neuron projection	IDA IDA: Inferred from direct assay	11466438	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	18455988	MGI
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	25775089	MGI
is active in postsynaptic membrane	IMP IMP: Inferred from mutant phenotype	25775089	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

transient receptor potential cation channel subfamily V member 1

capsaicin receptor	cation channel
deltaN-TRPv1	osm-9-like TRP channel 1
transient receptor potential cation channel V1	vanilloid receptor 1
vanilloid receptor subtype 1

Related Agents

Approval

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10448	Capsaicin		99.88%	Yes
HY-N0172	Caffeic acid	Inhibitor	99.92%	Unkown
HY-10448A	Capsaicin (Purity 65%)		99.20%	Unkown
HY-10448R	Capsaicin (Standard)		99.38%	Unkown
HY-17568	Nonivamide	Agonist	98.74%	Unkown
HY-B1583	(Z)-Capsaicin		99.79%	Yes
HY-B1173	(+)-Camphor	Inhibitor	≥98.0%	Unkown
HY-124073	Dihydrocapsiate	Agonist	99.33%	Unkown
HY-16413	Protokylol hydrochloride	Agonist	/	Unkown

Clinical Phase

Bioactive Molecules (15)

Cat. No.	Product Name	Effect	Purity	Phase
HY-N2333	Resiniferatoxin	Agonist	99.77%	Phase 3
HY-W020468	Linopirdine		99.90%	Phase 3
HY-12777	Asivatrep	Antagonist	95.76%	Phase 3
HY-132596	Tivanisiran	Inhibitor	92.62%	Phase 3
HY-105285	Piromelatine		99.54%	Phase 3
HY-10633	SB-705498	Antagonist	99.98%	Phase 2
HY-118785	MSP-3	Agonist	98.53%	Phase 2
HY-137459	Vocacapsaicin	Agonist	/	Phase 2
HY-12914	V116517	Antagonist	/	Phase 2
HY-137459A	Vocacapsaicin hydrochloride	Antagonist	/	Phase 2
HY-19589	JTS-653	Antagonist	/	Phase 2
HY-10634	AMG 517	Antagonist	99.97%	Phase 1
HY-N8377	Capsiate	Agonist	99.85%	Phase 1
HY-16935	Mavatrep	Antagonist	99.67%	Phase 1
HY-12195	ABT-239	Antagonist	99.23%	Phase 1

Pre-clinical Phase

Bioactive Molecules (109)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15640	Capsazepine		≥99.0%	Unkown
HY-10863	Anandamide		≥99.0%	Unkown
HY-N0285	Imperatorin		98.72%	Unkown
HY-101736	AMG9810	Antagonist	99.76%	Unkown
HY-12245	SB-366791	Antagonist	98.11%	Unkown
HY-N0361	Dihydrocapsaicin		99.93%	Unkown
HY-101507	Zerencotrep	Inhibitor	99.47%	Unkown
HY-N6825	Hydroxy-α-sanshool	Agonist	99.57%	Unkown
HY-19960	BCTC		99.66%	Unkown
HY-107436	LE135		≥99.0%	Unkown
HY-103368	Eact	Activator	98.86%	Unkown
HY-N0447	8-Gingerol		99.82%	Unkown
HY-157131	TRPV2-selective blocker 1	Inhibitor	99.84%	Unkown
HY-P3467	(Thr4,Gly7)-Oxytocin		99.86%	Unkown
HY-101448	TMI-1		99.59%	Unkown
HY-108448	N-Oleoyldopamine	Agonist	99.47%	Unkown
HY-18662	RQ-00203078	Antagonist	99.84%	Unkown
HY-N8264	Moringin	Agonist	99.95%	Unkown
HY-N1471	Liquiritin apioside		99.60%	Unkown
HY-N6962	α-Spinasterol		99.15%	Unkown
HY-108460	A-784168	Inhibitor	≥99.0%	Unkown
HY-100129	JNJ-17203212	Antagonist	99.94%	Unkown
HY-101323	Olvanil	Agonist	≥99.0%	Unkown
HY-121636	Resolvin D2	Inhibitor	99.90%	Unkown
HY-144372	TRPV1 antagonist 3	Antagonist	99.30%	Unkown
HY-132596A	Tivanisiran sodium		96.85%	Unkown
HY-120963	N-Oleoyl Taurine		≥99.0%	Unkown
HY-100668	JYL 1421	Antagonist	99.54%	Unkown
HY-120294	Chrysin 6-C-glucoside 8-C-arabinoside	Inhibitor	99.11%	Unkown
HY-136363	MDR-652	Agonist	99.02%	Unkown
HY-W014394	Vanillyl butyl ether	Agonist	99.67%	Unkown
HY-101389	(R)-Methanandamide	Agonist	/	Unkown
HY-114017	Libvatrep	Antagonist	99.54%	Unkown
HY-120962	N-Arachidonoyl Taurine	Activator	≥99.0%	Unkown
HY-160900	RN-1665	Antagonist	99.93%	Unkown
HY-108458	SB 452533	Antagonist	99.11%	Unkown
HY-10863S	Anandamide-d8		99.90%	Unkown
HY-109841	Oleoyl serotonin	Inhibitor	≥99.0%	Unkown
HY-110018	N-Arachidonyldopamine	Agonist	98.36%	Unkown
HY-12428	A-1165442	Antagonist	99.92%	Unkown
HY-135882	OMDM-6	Agonist	/	Unkown
HY-P1441A	Mambalgin 1 TFA	Inhibitor	95.72%	Unkown
HY-124001	N-Docosanoyl taurine	Activator	≥99.0%	Unkown
HY-131986	LASSBio-1135	Antagonist	99.05%	Unkown
HY-103337	N-Arachidonoylserotonin		≥98.0%	Unkown
HY-10635	ABT-102	Antagonist	/	Unkown
HY-121636S	Resolvin D2-d5	Inhibitor	≥99.0%	Unkown
HY-N7536	Voacangine		98.78%	Unkown
HY-113654	AMG 7905	Antagonist	/	Unkown
HY-158110	Phenylcapsaicin	Activator	99.77%	Unkown
HY-10448S1	Capsaicin-d3		/	Unkown
HY-10448S4	Capsaicin-d7		/	Unkown
HY-108455	N-Palmitoyl dopamine		/	Unkown
HY-108576	Linopirdine dihydrochloride	Agonist	/	Unkown
HY-110145	MRS 1477	Modulator	/	Unkown
HY-110292	A-425619	Antagonist	/	Unkown
HY-111036	AMG0347	Antagonist	/	Unkown
HY-111038	Capsiconiate	Agonist	/	Unkown
HY-111218	TRPV1 antagonist 5	Antagonist	/	Unkown
HY-114630	Protokylol	Agonist	/	Unkown
HY-120174	SU200		/	Unkown
HY-121080	AMG8163	Antagonist	/	Unkown
HY-124382	AS1928370		/	Unkown
HY-128479	JYL-273	Agonist	/	Unkown
HY-135881	OMDM-5	Agonist	/	Unkown
HY-137988	Palvanil	Modulator	/	Unkown
HY-147707	CB2 receptor antagonist 1		/	Unkown
HY-148751	TRPV1 activator-1	Activator	/	Unkown
HY-148752	TRPV1 activator-2	Activator	/	Unkown
HY-150030	CB1/2 agonist 4	Agonist	/	Unkown
HY-157766	FAAH/TRPV1 blocker-1	Inhibitor	/	Unkown
HY-161273	TRPV1 antagonist 6	Antagonist	/	Unkown
HY-161420	TRPV1 antagonist 7	Antagonist	/	Unkown
HY-162856	TRPV1-IN-2	Inhibitor	/	Unkown
HY-162908	TRPV1/CB2 agonist 1	Agonist	/	Unkown
HY-170839	TRPV1-IN-3	Inhibitor	/	Unkown
HY-172774	TRPV1 antagonist 10		/	Unkown
HY-176063	TRPV1 antagonist 11		/	Unkown
HY-N0361S	Dihydrocapsaicin-d3		/	Unkown
HY-N2941	Bisandrographolide C	Activator	/	Unkown
HY-P10464	Tat-AKAP79 (326-336)	Inhibitor	/	Unkown
HY-P10465	TRPV1-Tat	Antagonist	/	Unkown
HY-P1175	L-R4W2	Antagonist	/	Unkown
HY-P1175A	L-R4W2 TFA	Antagonist	/	Unkown
HY-RS15121	TRPV1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W517163	MK-2295	Antagonist	/	Unkown
HY-W790266	Polygodial pyridazine	Agonist	/	Unkown
HY-10635A	(S)-ABT-102	Antagonist	/	Unkown
HY-110091	TRPV1 antagonist 9	Antagonist	/	Unkown
HY-110209	AC4	Antagonist	/	Unkown
HY-117683	BCTP	Antagonist	/	Unkown
HY-117922	JYL-79	Agonist	/	Unkown
HY-120476	JNJ-39729209	Inhibitor	/	Unkown
HY-121122	A778317	Antagonist	/	Unkown
HY-121465	Stearoyl Serotonin		/	Unkown
HY-123374	(Rac)-AMG 628	Antagonist	/	Unkown
HY-123428	MSK-195	Agonist	/	Unkown
HY-133166	A-889425	Antagonist	/	Unkown
HY-167868	DWP-05195		/	Unkown
HY-16935S	Mavatrep-d6	Antagonist	/	Unkown
HY-169780	(S)-AMG-628	Antagonist	/	Unkown
HY-N10612	Petasin		/	Unkown
HY-P10654	RhTx	Activator	/	Unkown
HY-RS16501	Trpv1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS22933	Trpv1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W554764	Cyclo(-asp-gly)	Activator	/	Unkown
HY-W708469	Resolvin D2 methyl ester	Inhibitor	/	Unkown
HY-W747573	N-Linolenoylethanolamine	Agonist	/	Unkown
HY-W931056	AMG-628	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Trpv1	NCBI	NCBI:7442

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