H2ax - H2A.X variant histone Gene

Mus musculus

Also known as H2A.X; H2afx; Hist5-2ax; gammaH2ax

Gene ID: 15270 | Gene type: protein coding

About H2ax

Summary

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. [provided by RefSeq, Nov 2015]

H2ax Products(1)

mRNA	Protein	Name
NM_010436.2	NP_034566.1	histone H2AX

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables damaged DNA binding	IDA IDA: Inferred from direct assay	11934988	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17304220	MGI

Biological Process GO Annotation	Evidence	Reference	Source
NOT acts upstream of or within DNA damage checkpoint signaling	IMP IMP: Inferred from mutant phenotype	11934988	MGI
acts upstream of or within DNA repair	IDA IDA: Inferred from direct assay	15364958	MGI
acts upstream of or within DNA repair	IMP IMP: Inferred from mutant phenotype	11934988	MGI
acts upstream of or within double-strand break repair via homologous recombination	IMP IMP: Inferred from mutant phenotype	11934988	MGI
acts upstream of or within spermatogenesis	IMP IMP: Inferred from mutant phenotype	11934988	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in XY body	IDA IDA: Inferred from direct assay	18070917	MGI
located in chromatin	IDA IDA: Inferred from direct assay	11934988	MGI
located in chromosome	IDA IDA: Inferred from direct assay	23039116	MGI
located in condensed nuclear chromosome	IDA IDA: Inferred from direct assay	20551173	MGI
located in male germ cell nucleus	IDA IDA: Inferred from direct assay	14611631	MGI
located in nucleus	IDA IDA: Inferred from direct assay	20360685	MGI
located in replication fork	IDA IDA: Inferred from direct assay	15364958	MGI
located in site of double-strand break	IDA IDA: Inferred from direct assay	22699483	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

histone H2AX

H2A histone family, member X	H2a/x
histone 5 protein 2ax	histone H2A.x

H2ax Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	H2ax	P27661	Fancd2	Mus musculus	Q80V62	Anti Bait CoIP	17304220
Intra	H2ax	P27661	Aifm1	Mus musculus	Q9Z0X1	Anti Tag CoIP	20360685
Intra	H2ax	P27661	Aifm1	Mus musculus	Q9Z0X1	Confocal	20360685

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Purity	Phase
HY-12037A	Rigosertib	99.01%	Phase 3
HY-12037	Rigosertib sodium	99.57%	Phase 3
HY-18174	Prexasertib	98.74%	Phase 2
HY-18174A	Prexasertib dihydrochloride	99.41%	Phase 2
HY-18174E	Prexasertib dimesylate	99.04%	Phase 2
HY-18174B	Prexasertib Mesylate Hydrate	/	Phase 2
HY-18174C	Prexasertib mesylate	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (19)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-117693	(E/Z)-Mirin	Inhibitor	/	Unkown
HY-123834	FEN1-IN-1		99.85%	Unkown
HY-101089	RHPS4		99.88%	Unkown
HY-122181B	OTS186935 hydrochloride	Inhibitor	99.58%	Unkown
HY-N0316	Mollugin		99.48%	Unkown
HY-122181	OTS186935	Inhibitor	98.55%	Unkown
HY-103241	Ro 90-7501		99.10%	Unkown
HY-122182	OTS193320		98.64%	Unkown
HY-RS05957	H2AX Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-122181A	OTS186935 trihydrochloride	Inhibitor	/	Unkown
HY-117688	WJ35435		/	Unkown
HY-121777	SFOM-0046	Inhibitor	/	Unkown
HY-145288	Antitumor agent-36		/	Unkown
HY-145289	Antitumor agent-37		/	Unkown
HY-162985	JHD205	Inhibitor	/	Unkown
HY-168877	FMP	Activator	/	Unkown
HY-18174H	Prexasertib lactate		/	Unkown
HY-RS16644	H2ax Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23078	H2ax Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	H2ax	NCBI	NCBI:3014

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