2. Cell Cycle/DNA Damage Apoptosis Protein Tyrosine Kinase/RTK
  3. TOPK Apoptosis c-Myc MDM-2/p53 FAK Src
  4. SKLB-C05

SKLB-C05 is a novel selective, orally active TOPK inhibitor, with an IC50 of 0.5 nM. SKLB-C05 selectively inhibit TOPK kinase. SKLB-C05 induces Apoptosis, downregulates c-Myc, γ-H2AX, activates p53, blocks FAK/Src medicated migration-related signaling. SKLB-C05 disturbs cell mitosis. SKLB-C05 shows anticancer activity only against TOPK-positive colorectal cancer.

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SKLB-C05

SKLB-C05 Chemical Structure

CAS No. : 2300981-68-2

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SKLB-C05 Related Antibodies

Top Publications Citing Use of Products

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Lck Fyn Blk Fgr Hck Lyn Yes SRC-3

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Description

SKLB-C05 is a novel selective, orally active TOPK inhibitor, with an IC50 of 0.5 nM. SKLB-C05 selectively inhibit TOPK kinase. SKLB-C05 induces Apoptosis, downregulates c-Myc, γ-H2AX, activates p53, blocks FAK/Src medicated migration-related signaling. SKLB-C05 disturbs cell mitosis. SKLB-C05 shows anticancer activity only against TOPK-positive colorectal cancer[1].

IC50 & Target

IC50: 0.5 nM[1]
Molecular Weight

394.89

Formula

C23H23ClN2O2
CAS No.
SMILES

O=C1NC2=C(C)C=C(O)C(C3=CC=C([C@H](C)CN)C=C3)=C2C4=C1C=CC=C4.Cl
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SKLB-C05 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SKLB-C052300981-68-2TOPKApoptosisc-MycMDM-2/p53FAKSrcT-LAK cell-originated protein kinaseMycPTK2 protein tyrosine kinase 2PTK2Focal adhesion kinaseHCT116antitumorSW480DLD-1SD ratInhibitorinhibitorinhibit

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