2. Gene
  3. Cp - ceruloplasmin Gene

Cp - ceruloplasmin Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as D3Ertd555e

Gene ID: 12870 | Gene type: protein coding

About Cp

Summary

The protein encoded by this gene is a copper-containing glycoprotein found soluble in the serum and GPI-anchored in Other tissues. It oxidizes Fe(II) to Fe(III) and is proposed to play an important role in iron homeostasis. In humans mutations of this gene cause aceruloplasminemia, which is characterized by retinal degeneration, diabetes, anemia and neurological symptoms. In mouse deficiency of this gene in combination with a deficiency of its homolog hephaestin causes retinal degeneration and serves as a pathophysiological model for aceruloplasminemia and age-related macular degeneration. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]

Cp Products(10)

mRNA Protein Name
NM_001276248.2 NP_001263177.1 ceruloplasmin isoform c precursor
NM_001276250.2 NP_001263179.1 ceruloplasmin isoform c precursor
NM_001374677.1 NP_001361606.1 ceruloplasmin isoform d precursor
NM_001409646.1 NP_001396575.1 ceruloplasmin isoform a precursor
NM_001409647.1 NP_001396576.1 ceruloplasmin isoform a precursor
NM_001409648.1 NP_001396577.1 ceruloplasmin isoform e precursor
NM_001409649.1 NP_001396578.1 ceruloplasmin isoform f precursor
NM_001409650.1 NP_001396579.1 ceruloplasmin isoform g precursor
NM_001409651.1 NP_001396580.1 ceruloplasmin isoform h precursor
NM_007752.4 NP_031778.2 ceruloplasmin isoform b precursor
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables copper ion binding IDA
IDA: Inferred from direct assay
15634671 MGI
enables ferroxidase activity IDA
IDA: Inferred from direct assay
16436657 MGI
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
16436657 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ceruloplasmin

ferroxidase

Related Agents

Approval
Bioactive Molecules (34)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-40354 Tofacitinib 99.99% Yes
HY-50896 Erlotinib 99.99% Yes
HY-14275 Verapamil 99.96% Yes
HY-A0064 Verapamil hydrochloride 99.98% Yes
HY-17506 Azithromycin Inhibitor ≥98.0% Yes
HY-40354A Tofacitinib citrate 99.94% Yes
HY-12008 Erlotinib Hydrochloride 99.94% Yes
HY-B0334 Sulbactam Inhibitor 99.75% Unkown
HY-10019 Varenicline Agonist 99.92% Yes
HY-B0253 Piroxicam Inhibitor 99.78% Unkown
HY-14542 Ziprasidone Antagonist 99.81% Unkown
HY-B0210A Cefoperazone sodium salt Inhibitor 99.72% Yes
HY-10021 Varenicline Tartrate 99.96% Yes
HY-B0334A Sulbactam sodium Inhibitor 99.66% Unkown
HY-10020 Varenicline Hydrochloride Agonist 99.95% Yes
HY-B0254 Glipizide Inhibitor 99.83% Unkown
HY-A0038 Lasofoxifene tartrate Modulator 99.93% Unkown
HY-13538 Gemcitabine elaidate 99.14% Unkown
HY-17506A Azithromycin hydrate Inhibitor ≥98.0% Yes
HY-17484 Ampiroxicam Inhibitor 98.43% Unkown
HY-13010 Laquinimod 99.46% Yes
HY-17407 Ziprasidone hydrochloride monohydrate Antagonist 98.11% Unkown
HY-A0037 Lasofoxifene 99.27% Unkown
HY-B0915 Orbifloxacin Inhibitor 99.78% Unkown
HY-108880 Carindacillin sodium Inhibitor 96.73% Unkown
HY-B0210AR Cefoperazone (sodium salt) (Standard) Inhibitor / Unkown
HY-108288 Sulbactam pivoxil Inhibitor ≥98.0% Unkown
HY-10019A Varenicline dihydrochloride Agonist 99.21% Yes
HY-A0064R Verapamil (hydrochloride) (Standard) / Unkown
HY-B0501 Danofloxacin mesylate Inhibitor 99.87% Unkown
HY-14542A Ziprasidone hydrochloride Antagonist / Unkown
HY-14542B Ziprasidone mesylate trihydrate Antagonist / Unkown
HY-14542C Ziprasidone mesylate Antagonist / Unkown
HY-12008A Erlotinib mesylate / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P9918 Tremelimumab 99.50% Unkown
HY-P99965 Crovalimab Inhibitor 98.61% Unkown
Clinical Phase
Bioactive Molecules (31)
Cat. No. Product Name Effect
Purity Phase
HY-N0678 Icaritin Inducer 99.27% Phase 4
HY-124498 Oxantel Inhibitor / Phase 4
HY-10211 Tanespimycin 99.01% Phase 3
HY-13223 Crenolanib 99.68% Phase 3
HY-105284 Sulopenem Inhibitor 99.70% Phase 3
HY-12089 Torcetrapib Inhibitor 99.88% Phase 3
HY-105028 Tenidap Inhibitor 99.32% Phase 3
HY-10871 Otenabant Antagonist 99.23% Phase 3
HY-14941 Elacytarabine ≥98.0% Phase 3
HY-10871A Otenabant Hydrochloride Antagonist / Phase 3
HY-W062904 Laquinimod sodium Inhibitor / Phase 3
HY-105086 Pamaqueside Inhibitor / Phase 3
HY-W018061 Traxoprodil Antagonist 99.92% Phase 2
HY-14674 CP-724714 98.72% Phase 2
HY-13302 CP-547632 Inhibitor 99.16% Phase 2
HY-13302B CP-547632 hydrochloride Inhibitor 99.88% Phase 2
HY-14839 Evatanepag Agonist 99.78% Phase 2
HY-13538A Gemcitabine elaidate hydrochloride 99.89% Phase 2
HY-19687 Zopolrestat Inhibitor 99.92% Phase 2
HY-10049 CP 122721 Antagonist / Phase 2
HY-105192 CP-122288 Agonist / Phase 2
HY-14129 CP 316311 Antagonist / Phase 2
HY-149769 CP-506 Substrate / Phase 2
HY-16372 CP 461 / Phase 2
HY-19193 CP-105696 Antagonist 99.93% Phase 1
HY-16373 CP-609754 Inhibitor 99.21% Phase 1
HY-12946 BI 653048 Inhibitor 99.84% Phase 1
HY-P1717 AMY-101 Inhibitor / Phase 1
HY-13223A Crenolanib benzenesulfonate / Phase 1
HY-12946A BI 653048 phosphate Inhibitor / Phase 1
HY-U00401 (Rac)-CP-609754 Inhibitor / Phase 1
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99197 Figitumumab Inhibitor 96.89% Phase 3
Pre-clinical Phase
Bioactive Molecules (244)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12815 MCC950 Inhibitor 99.62% Unkown
HY-12815A MCC950 sodium Inhibitor 99.75% Unkown
HY-12050 CP-673451 Inhibitor 99.69% Unkown
HY-B1368 Fenclonine Inhibitor 99.92% Unkown
HY-108347 CP-100356 hydrochloride Inhibitor 99.68% Unkown
HY-112136 TAO Kinase inhibitor 1 99.81% Unkown
HY-P1717A AMY-101 TFA Inhibitor 99.89% Unkown
HY-13525 CP-91149 99.80% Unkown
HY-139330 MGH-CP1 Inducer 99.56% Unkown
HY-P1717B AMY-101 acetate Inhibitor 99.93% Unkown
HY-12506A Naspm trihydrochloride Inhibitor 98.50% Unkown
HY-108615 CP-316819 Inhibitor ≥99.0% Unkown
HY-100207 CP21R7 Inhibitor 99.74% Unkown
HY-W018845 [Ir(Cp-)Cl2]2 ≥99.0% Unkown
HY-15259 CP-640186 Inhibitor 99.72% Unkown
HY-103068 Diethyl-pythiDC 99.90% Unkown
HY-115319 CP-24879 hydrochloride 99.59% Unkown
HY-12506 Naspm Inhibitor 96.30% Unkown
HY-15662 Tulathromycin A Inhibitor ≥98.0% Unkown
HY-49116 CP26 Inhibitor ≥98.0% Unkown
HY-125835 CP-10 Inhibitor 98.41% Unkown
HY-123772 CDK5 inhibitor 20-223 Inhibitor 99.62% Unkown
HY-18343A CP-31398 dihydrochloride p53 Activator 99.63% Unkown
HY-11002 CP-466722 Inhibitor 99.74% Unkown
HY-B1161A S-Methoprene Antagonist 98.58% Unkown
HY-130257 CP5V Inhibitor 99.31% Unkown
HY-W019734 [Rh(Cp-)Cl2]2 98.20% Unkown
HY-14899 Taprenepag Agonist 98.79% Unkown
HY-15259A CP-640186 hydrochloride Inhibitor 99.90% Unkown
HY-150082 CP681301 Inhibitor 99.18% Unkown
HY-125843 Pomalidomide-PEG1-C2-N3 99.91% Unkown
HY-103151 CP94253 hydrochloride Agonist 98.84% Unkown
HY-113955 CP-346086 99.02% Unkown
HY-130841 Apcin-A Inhibitor ≥98.0% Unkown
HY-17506S Azithromycin-d3 Inhibitor ≥98.0% Unkown
HY-120160 Darglitazone Agonist 99.19% Unkown
HY-15243 Capromorelin Tartrate Agonist 98.19% Unkown
HY-19396 Ingliforib Inhibitor 99.07% Unkown
HY-12129 CP 154526 hydrochloride Antagonist 99.76% Unkown
HY-13340 VU0152100 Modulator 98.98% Unkown
HY-105064D Zoniporide hydrochloride hydrate Inhibitor 99.37% Unkown
HY-116006 Bis-PEG5-acid 99.90% Unkown
HY-130296 Palbociclib-propargyl 95.23% Unkown
HY-40354AS Tofacitinib-d3 citrate 99.14% Unkown
HY-14130 CP 376395 Antagonist 99.68% Unkown
HY-105445 CP-113818 Inhibitor 99.13% Unkown
HY-13256 Desmethyl Erlotinib hydrochloride 99.23% Unkown
HY-113421 Linoleoyl ethanolamide ≥98.0% Unkown
HY-116530 9-Cyclopentyladenine monomethanesulfonate Inhibitor 99.16% Unkown
HY-19360 Sulprostone Agonist ≥99.0% Unkown
HY-103070 PythiDC Inhibitor 99.33% Unkown
HY-107634 CP-20961 Inducer 98.34% Unkown
HY-116699 CP-868388 free base Agonist 99.66% Unkown
HY-12008S Erlotinib-d6 hydrochloride 98.13% Unkown
HY-124815 CP-312 Inducer 99.69% Unkown
HY-15543A CP-809101 hydrochloride Agonist 99.37% Unkown
HY-A0064S Verapamil-d3 hydrochloride 99.57% Unkown
HY-119721 CP-424174 Inhibitor 98.03% Unkown
HY-164605 (6S)-CP-470711 Inhibitor 98.75% Unkown
HY-130452 NOS1-IN-1 Inhibitor ≥95.0% Unkown
HY-101357A CP 93129 dihydrochloride Agonist ≥99.0% Unkown
HY-105064 Zoniporide Inhibitor 99.89% Unkown
HY-116893 Diethyl bipy55'DC Inhibitor 98.79% Unkown
HY-118140 ZCZ011 Modulator 99.43% Unkown
HY-12095 CB1 inverse agonist 2 Agonist 99.15% Unkown
HY-121755 Tibric acid / Unkown
HY-13256A Desmethyl Erlotinib 98.77% Unkown
HY-136609 5-AMAM-2-CP Agonist 98.21% Unkown
HY-138879 CP-601927 Agonist 98.24% Unkown
HY-40354S Tofacitinib-13C3 97% Unkown
HY-B0254S Glipizide-d11 Inhibitor 96.36% Unkown
HY-W018061C (R,R)-Traxoprodil Antagonist 99.00% Unkown
HY-13010S Laquinimod-d5 Inhibitor 98.25% Unkown
HY-B0334AS Sulbactam-d5 sodium Inhibitor 99.90% Unkown
HY-131959 (S,R,S)-AHPC-PEG5-Boc 95.29% Unkown
HY-101803 CP671305 Inhibitor 99.95% Unkown
HY-108482 CP-96,345 Inhibitor ≥99.0% Unkown
HY-108623 Atizoram Inhibitor 96.3% Unkown
HY-112199 CP-447697 Antagonist 99.70% Unkown
HY-123039 CP-532623 Inhibitor ≥99.0% Unkown
HY-13302C CP-547632 TFA Inhibitor 99.42% Unkown
HY-136608 5-AAM-2-CP Agonist 99.22% Unkown
HY-138879A (Rac)-CP-601927 hydrochloride Agonist 99.72% Unkown
HY-138879B CP-601932 Agonist 99.74% Unkown
HY-15541 Zaltidine Antagonist 99.49% Unkown
HY-163101 CP-96021 Antagonist 98.04% Unkown
HY-18663 CP-465022 Antagonist 98.47% Unkown
HY-50896S Erlotinib-d6 Inhibitor / Unkown
HY-B0253S Piroxicam-d3 Inhibitor 99.68% Unkown
HY-W011085 CP-471474 Inhibitor 99.2% Unkown
HY-101639 CP-409092 Agonist / Unkown
HY-118639 CP-74006 Inhibitor 98.86% Unkown
HY-17506S1 Azithromycin-13C,d3 99.90% Unkown
HY-U00004 OSIP-486823 Inhibitor ≥98.0% Unkown
HY-145126 CP-628006 Activator / Unkown
HY-18343 CP-31398 p53 Activator / Unkown
HY-10019AS1 Varenicline-d4 hydrochloride Agonist / Unkown
HY-10019S Varenicline-d4 Agonist / Unkown
HY-10019S1 Varenicline-15N,13C,d2 Agonist / Unkown
HY-10020S Varenicline-15N3 hydrochloride Agonist / Unkown
HY-100280 Pirolate Antagonist / Unkown
HY-100332 CP 375 / Unkown
HY-10049A CP 122721 hydrochloride Antagonist / Unkown
HY-101357 CP 93129 Agonist / Unkown
HY-101558B Elzasonan hydrochloride Antagonist / Unkown
HY-103092 CP-135807 Agonist / Unkown
HY-103151A CP94253 Agonist / Unkown
HY-103379 CP 376395 hydrochloride Antagonist / Unkown
HY-105028S Tenidap-d3 Inhibitor / Unkown
HY-105064B Zoniporide hydrochloride Inhibitor / Unkown
HY-105064C Zoniporide dihydrochloride Inhibitor / Unkown
HY-105157 Icopezil Inhibitor / Unkown
HY-105205 Terlakiren Inhibitor / Unkown
HY-107013 CP-544439 Inhibitor / Unkown
HY-107213 Tulathromycin B Inhibitor / Unkown
HY-107233 Saponin CP4 / Unkown
HY-107235 Saponin CP6 / Unkown
HY-108571 CP-775146 Agonist 98.70% Unkown
HY-109855 CP-67015 Inhibitor / Unkown
HY-112742 CP-195543 Antagonist / Unkown
HY-113642 CP-67804 / Unkown
HY-113955A CP-346086 dihydrate / Unkown
HY-114540 CP-339818 / Unkown
HY-116082 CP 226269 Agonist 99.65% Unkown
HY-117172 CP320626 Inhibitor / Unkown
HY-117803 CP 461 free base / Unkown
HY-117868 NC-174 / Unkown
HY-118056 ABD459 Antagonist / Unkown
HY-118842 Sunepitron hydrochloride / Unkown
HY-120076 CP-293019 Antagonist / Unkown
HY-12008S1 Erlotinib-13C6 hydrochloride / Unkown
HY-120160A Darglitazone Sodium Agonist / Unkown
HY-12079 CP-481715 Antagonist / Unkown
HY-12130 CP 154526 Antagonist / Unkown
HY-12145 CP-99994 hydrochloride / Unkown
HY-121866 CP-84364 Inhibitor / Unkown
HY-122109A Levonantradol hydrochloride Agonist / Unkown
HY-122118 Lambast / Unkown
HY-122483 Diethyl pyimDC Inhibitor / Unkown
HY-123139 Flutroline / Unkown
HY-123203 CP-608039 Agonist / Unkown
HY-130205 Milacemide hydrochloride Inhibitor / Unkown
HY-13256AS1 Desmethyl Erlotinib-d4-1 / Unkown
HY-135254 CP-46665 dihydrochloride Inhibitor / Unkown
HY-136951 cp028 Inhibitor / Unkown
HY-14275S1 Verapamil-d7 / Unkown
HY-14411 JNK-1-IN-1 Inhibitor / Unkown
HY-14542S Ziprasidone-d8 Antagonist / Unkown
HY-146815 CP19 / Unkown
HY-14839A Evatanepag sodium Agonist / Unkown
HY-149495 CP-07 Degrader / Unkown
HY-150665S N-Dansyl-d6 1,4-diaminobutane, 97% (CP) / Unkown
HY-151267 SARS-CoV-2-IN-25 Inhibitor / Unkown
HY-151267A SARS-CoV-2-IN-25 disodium Inhibitor / Unkown
HY-15242 Capromorelin Activator / Unkown
HY-155044 TMV-IN-5 Inhibitor / Unkown
HY-155045 TMV-IN-6 Inhibitor / Unkown
HY-15541A Zaltidine dihydrochloride Antagonist / Unkown
HY-161597 PROTAC DYRK2 degrader 1 / Unkown
HY-162807 TMV-IN-10 Inhibitor / Unkown
HY-164749 K-Ras-IN-4 Inhibitor / Unkown
HY-167946 CP-866087 Antagonist / Unkown
HY-168971 Paeoniflorin-6′-O-benzene sulfonate / Unkown
HY-169232 PCC16 chloride Degrader / Unkown
HY-16946 CP-610431 Inhibitor / Unkown
HY-171113 CP-LC-1074 / Unkown
HY-176027 CP-LC-1422 / Unkown
HY-18228 CP-352664 Inhibitor / Unkown
HY-18663A CP-465022 maleate Antagonist / Unkown
HY-18663B CP-465022 hydrochloride Antagonist / Unkown
HY-19048 CP-66948 Antagonist / Unkown
HY-50896S1 Erlotinib-13C6 / Unkown
HY-A0064S1 Verapamil-d6 hydrochloride / Unkown
HY-B0253S1 Piroxicam-d4 Inhibitor / Unkown
HY-B0334AS1 Sulbactam-d2 sodium / Unkown
HY-B0501S Danofloxacin-d3 mesylate Inhibitor / Unkown
HY-B0915S Orbifloxacin-d5 hydrochloride Inhibitor / Unkown
HY-D1346 610CP / Unkown
HY-D1418 CP-BP-SFAC / Unkown
HY-N10268 3-Hydroxyterphenyllin / Unkown
HY-P10384 SPSB2-iNOS inhibitory cyclic peptide-2 Inhibitor / Unkown
HY-P10385 SPSB2-iNOS inhibitory cyclic peptide-3 / Unkown
HY-P10828 MAPI Inhibitor / Unkown
HY-P2024 CP-85339 Inhibitor / Unkown
HY-RS03079 CP Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-U00070 Dirlotapide ≥99.0% Unkown
HY-W008914 (E/Z)-CP-724714 Inhibitor / Unkown
HY-W018061A Traxoprodil mesylate Antagonist / Unkown
HY-W115746A Ethyl cellulose (viscosity 10 cP) / Unkown
HY-W115746B Ethyl cellulose (viscosity 300 cP) / Unkown
HY-W772850 Fenclonine hydrochloride Inhibitor / Unkown
HY-10019S2 Varenicline-13C15N Agonist / Unkown
HY-100316 CP-96486 Antagonist / Unkown
HY-101731 CP-96021 hydrochloride Antagonist / Unkown
HY-105028A Tenidap sodium Inhibitor / Unkown
HY-105284A Sulopenem sodium Inhibitor / Unkown
HY-10814 CP-810123 Agonist / Unkown
HY-108574 CP 339818 hydrochloride Inhibitor 99.61% Unkown
HY-111129 CP-66713 Antagonist / Unkown
HY-113421S Linoleoyl ethanolamide-d4 / Unkown
HY-123289 CP-690550A Inhibitor / Unkown
HY-123311 CP59430 Antagonist / Unkown
HY-123571 CP-199330 Antagonist / Unkown
HY-123582 CP-866,087 / Unkown
HY-129698 MS-073 Inhibitor / Unkown
HY-129785 CP-220629 Inhibitor / Unkown
HY-14275S Verapamil-d3 / Unkown
HY-14275S2 Verapamil-d6 / Unkown
HY-149769A CP-506 mesylate Substrate / Unkown
HY-150346 1cP-MiPLA / Unkown
HY-15543 CP-809101 Agonist / Unkown
HY-15661A OSI-413 free base / Unkown
HY-15662S Tulathromycin A-d7 Inhibitor / Unkown
HY-160901 CP-289,503 Inhibitor / Unkown
HY-163999 TMV-IN-12 Inhibitor / Unkown
HY-165129 CP102 / Unkown
HY-169723 CP 524515 Inhibitor / Unkown
HY-171185 CP-611,781 / Unkown
HY-171476 CP-865569 Antagonist / Unkown
HY-172014 CP-LC-0743 / Unkown
HY-172015 CP-LC-1143 / Unkown
HY-172016 CP-LC-0867 / Unkown
HY-172017 CP-LC-1254 / Unkown
HY-172018 CP-LC-0729 / Unkown
HY-172059 3C-P hydrochloride / Unkown
HY-40354S1 Tofacitinib-13C3,15N / Unkown
HY-40354S2 Tofacitinib-13C,d3 / Unkown
HY-40354S3 Tofacitinib-13C / Unkown
HY-40354S5 Tofacitinib-d3 / Unkown
HY-50896S2 Erlotinib-d4 / Unkown
HY-50896S3 Erlotinib-d8 / Unkown
HY-B0253A Piroxicam olamine Inhibitor / Unkown
HY-B0334S Sulbactam-d3 Inhibitor / Unkown
HY-N13047 Ningnanmycin / Unkown
HY-P10200 CP7-FP13-2 Inhibitor / Unkown
HY-RS16625 Cp Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23060 Cp Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-U00008 CP-28888 Inducer / Unkown
HY-W020041 CP 53631 Inhibitor / Unkown
HY-W187279 Karrikin 2 / Unkown
HY-W614725 Apcin-A monohydrochloride Inhibitor / Unkown
HY-W653875 Azithromycin-d5 Inhibitor / Unkown
HY-U00354 CP-060 Antagonist / Unkown
HY-U00270 CP-319340(free base) / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P990147 Anti-Mouse VEGFR-2 Antibody (DC101-Mouse IgG2a) Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cp NCBI NCBI:1356
Canis familiaris Cp NCBI NCBI:442963
Macaca fascicularis Cp NCBI
Susscrofa domestica Cp NCBI
Rattus norvegicus Cp NCBI NCBI:24268
Macaca mulatta Cp NCBI NCBI:712210