NLRP3 - NLR family pyrin domain containing 3 Gene

Sus scrofa

Gene ID: 100514823 | Gene type: protein coding

About NLRP3

Primary_assembly 2: 56,892,243-56,977,228 reverse strand.Sscrofa11.1:CM000813.5

This gene has 1 transcript (splice variant), 87 orthologues, 16 paralogues and is associated with 1 phenotype. Broad expression in lung (RPKM 3.5), spleen (RPKM 2.5) and 8 other tissues.

NLRP3 Products(1)

mRNA	Protein	Name
NM_001256770.2	NP_001243699.1	NACHT, LRR and PYD domains-containing protein 3

NLRP3 Protein Structure

Pyrin_NALPs

FISNA

NACHT

NOD2_WH

LRR_RI

LRR_AMN1

LRR_RI

0
200
400
600
800
1036 a.a.

Protein Preferred Names

Protein Names

NACHT, LRR and PYD domains-containing protein 3

NACHT LRR and PYD domain-containing protein 3

pyrin domain containing protein 3

Related Agents

Approval

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0116	Stavudine	Inhibitor	99.87%	Yes
HY-16059	Arglabin	Inhibitor	99.87%	Unkown
HY-B0516	Articaine hydrochloride	Activator	98.46%	Unkown
HY-B0116A	Stavudine sodium	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Phase
HY-101092	QS-21	Activator	99.67%	Phase 3
HY-17629	Dapansutrile	Inhibitor	≥98.0%	Phase 3
HY-156034A	JT001 sodium	Inhibitor	/	Phase 3
HY-132831	Selnoflast	Inhibitor	98.58%	Phase 1
HY-139396	BMS-986299	Agonist	99.76%	Phase 1

Pre-clinical Phase

Bioactive Molecules (61)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100381	Nigericin sodium salt	Activator	99.37%	Unkown
HY-12815A	MCC950 sodium	Inhibitor	99.75%	Unkown
HY-12815	MCC950	Inhibitor	99.62%	Unkown
HY-103666	CY-09	Inhibitor	98.01%	Unkown
HY-116084	Trimethylamine N-oxide	Activator	≥98.0%	Unkown
HY-127019	Nigericin	Activator	99.37%	Unkown
HY-144226	NLRP3/AIM2-IN-3	Inhibitor	98.00%	Unkown
HY-N0633	Muscone	Inhibitor	≥98.0%	Unkown
HY-N0496	Ruscogenin	Inhibitor	99.59%	Unkown
HY-N0373	Licochalcone B	Inhibitor	99.93%	Unkown
HY-108915	Trimethylamine N-oxide dihydrate	Activator	≥98.0%	Unkown
HY-100581	CORM-3	Inhibitor	≥97.0%	Unkown
HY-152670	JC2-11	Inhibitor	98.02%	Unkown
HY-N2485	4'-Methoxyresveratrol	Activator	99.48%	Unkown
HY-130252	YQ128	Inhibitor	99.83%	Unkown
HY-137245A	Emlenoflast sodium	Inhibitor	98.76%	Unkown
HY-101868	INF39	Inhibitor	99.86%	Unkown
HY-150206	NLRP3-IN-13	Inhibitor	99.01%	Unkown
HY-137245	Emlenoflast	Inhibitor	98.19%	Unkown
HY-122920	Soyasaponin II	Inhibitor	99.81%	Unkown
HY-N3005	Britannin	Inhibitor	99.93%	Unkown
HY-151343	NLRP3-IN-10	Inhibitor	98.97%	Unkown
HY-130494	(±)11(12)-EET	Inhibitor	98.3%	Unkown
HY-W082785A	L6H21	Inhibitor	99.46%	Unkown
HY-153554	NLRP3-IN-18	Inhibitor	98.06%	Unkown
HY-W011082	NLRP3-IN-2	Inhibitor	98.00%	Unkown
HY-155751	HMGB1-IN-1	Inhibitor	99.37%	Unkown
HY-137888A	Oxidized ATP trisodium salt	Inhibitor	≥98.0%	Unkown
HY-148187	NLRP3-IN-11	Inhibitor	98.79%	Unkown
HY-155876	NLRP3 antagonist 2	Antagonist	97.58%	Unkown
HY-117432	JC-171	Inhibitor	98.41%	Unkown
HY-163159	NP3-562	Inhibitor	98.16%	Unkown
HY-153261	NLRP3-IN-17	Inhibitor	99.23%	Unkown
HY-162333	BAL-0028	Inhibitor	97.20%	Unkown
HY-121988	INF4E	Inhibitor	99.38%	Unkown
HY-163358	SLC3037	Inhibitor	99.85%	Unkown
HY-131040	NLRP3-IN-NBC6	Inhibitor	99.40%	Unkown
HY-161297	NT-0249	Inhibitor	/	Unkown
HY-164304	INF 195	Inhibitor	99.55%	Unkown
HY-150965	NDT-30805	Inhibitor	/	Unkown
HY-145087	NP3-146	Inhibitor	/	Unkown
HY-163744	NLRP3-IN-42	Inhibitor	/	Unkown
HY-146765	AMS-17	Inhibitor	/	Unkown
HY-145910	NLRP3-IN-6	Inhibitor	/	Unkown
HY-163494	NLRP3-IN-36	Inhibitor	/	Unkown
HY-168009	NLRP3-IN-45	Inhibitor	/	Unkown
HY-146594	NLRP3-IN-8	Inhibitor	/	Unkown
HY-132892	NLRP3-IN-4	Inhibitor	/	Unkown
HY-149123	NLRP3-IN-16	Inhibitor	/	Unkown
HY-163497	NLRP3-IN-38	Inhibitor	/	Unkown
HY-146802	NLRP3-IN-9	Inhibitor	/	Unkown
HY-161579	NLRP3-IN-39	Inhibitor	/	Unkown
HY-156034	NLRP3-IN-19	Inhibitor	/	Unkown
HY-161329	NLRP3-IN-32	Inhibitor	/	Unkown
HY-159482	SBN-284	Inhibitor	/	Unkown
HY-161727	P2Y14R antagonist 1	Inhibitor	/	Unkown
HY-162588	MC-ND-18	Degrader	/	Unkown
HY-149122	NLRP3-IN-15	Inhibitor	/	Unkown
HY-149121	NLRP3-IN-14	Inhibitor	/	Unkown
HY-145911	NLRP3-IN-7	Inhibitor	/	Unkown
HY-149087	MR2938	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	NLRP3	NCBI	NCBI:114548
Mus musculus	NLRP3	NCBI	NCBI:216799

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