Transmembrane Glycoprotein

Transmembrane glycoproteins are important components of cell membranes and are characterized by oligosaccharide chains covalently linked to polypeptide chains. Glycosylation sites are mainly located in their extracellular regions, achieved by N-linked glycosylation (linked to asparagine residues) or O-linked glycosylation (linked to serine or threonine residues). Sugar chains not only provide structural stability to proteins but also confer functional specificity. Many transmembrane glycoproteins are receptors, such as G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs). Most （clusters of differentiation）CD molecules are also transmembrane glycoproteins expressed on the surface of antigen-presenting cells^[1]^[2].

References:

[1]. L Franco, et al. The transmembrane glycoprotein CD38 is a catalytically active transporter responsible for generation and influx of the second messenger cyclic ADP-ribose across membranes. FASEB J. 1998 Nov;12(14):1507-20. [Content Brief]

[2]. Kumi Oshima, et al. SHPS-1, a multifunctional transmembrane glycoprotein. FEBS Lett. 2002 May 22;519(1-3):1-7. [Content Brief]

Transmembrane Glycoprotein Related Products (216):

By Effects:	Inhibitors (149) Ligands (3) Agonists (3) Antagonists (5) Activators (6) Modulators (3)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-P990236

Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A)	Inhibitor
Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A) is an anti-mouse/rat/monkey/human ICOS/CD278 IgG monoclonal antibody. Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A) has limited effectiveness in improving T cell function and immune activation. Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A) can be used for research on cancer and infection conditions such as gliomas and hepatitis B virus infection .

HY-P991475

MG-1131	Inhibitor
MG-1131 is a human monoclonal antibody (mAb) targeting TIGIT. MG-1131 activates NF-κB signaling in T cells and enhances NK-mediated tumor killing activity in a PVR-dependent manner. MG-1131 blocks TIGIT to increase IFN-γ secretion. MG-1131 can be used in anti-tumor immunity research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990364

Anti-CEACAM1/CD66a Antibody	Inhibitor
Anti-CEACAM1/CD66a Antibody is a human antibody expressed in CHO cells that targets CEACAM1/CD66a. The Anti-CEACAM1/CD66a Antibody is equipped with huIgG1 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 144.98 kDa. The isotype control for the Anti-CEACAM1/CD66a Antibody can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P991425

AT-1413	Inhibitor
AT-1413 is a human monoclonal antibody (mAb) targeting CD43. AT-1413 induces antibody-dependent cell-mediated cytotoxicity (ADCC) in melanoma cell lines and acute myeloid leukemia (AML) cells. AT-1413 has antitumor activity in AML mouse models. AT-1413 can be used in Acute myeloid leukaemia, Breast cancer, Malignant melanoma and Myelodysplastic syndromes research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P99790

Priliximab
Priliximab (CEN 000029) is an anti-CD4 humanized monoclonal antibody. Priliximab binds to CD4 on the surface of T cells, resulting in a significant and sustained reduction in circulating CD4⁺ T cells. Priliximab can be used in research of rheumatoid arthritis (RA).

HY-P9937

Arcitumomab	Inhibitor
Arcitumomab is a murine anti-carcinoembryonic antigen (CEA) monoclonal antibody Fab’ fragment. Arcitumomab can be labeled with technetium-99m and can be used for single-photon emission computed tomography (SPECT) imaging.

HY-P5745

TYVPANASL
TYVPANASL is a MHC I-binding CD8 T cell epitope of nine amino acids from HER2/neu. TYVPANASL can be used to prepare J-LEAPS vaccine.

HY-P1796A

Gp100 (619-627) acetate
Gp100 (619-627) acetate is amino acids 619 to 627 fragment of human melanoma antigen glycoprotein 100 (gp100). Gp100 has been a widely studied target for melanoma immunotherapy.

HY-P99436

Anatumomab mafenatox	Inhibitor
Anatumomab mafenatox (ABR-214936) is a 73 KDa recombinant protein to recognize the tumor-associated antigen 5T4, which is widely expressing in malignancy. Anatumomab mafenatox is between a modified form of SEA and a murine Fab. The main side effects of Anatumomab mafenatox are reported to include fever, low blood pressure, pain, nausea and drowsiness.

HY-P990157

Anti-Mouse Thy1/CD90 Antibody (M5/49.4.1)	Inhibitor
Anti-Mouse Thy1/CD90 Antibody (M5/49.4.1) is an anti-mouse Thy1/CD90 IgG2a monoclonal antibody. Anti-Mouse Thy1/CD90 Antibody (M5/49.4.1) can clear T cells from the spleen and bone marrow. Anti-Mouse Thy1/CD90 Antibody (M5/49.4.1) can be used for research on immunology and inflammation conditions such as colitis.

HY-125554

KDdiA-PC	Ligand
KDdiA-PC is one of the most potent CD36 ligands in oxidized LDL (oxLDL).

HY-P990572

DCBY02	Inhibitor	98.71%
DCBY02 is a monoclonal antibody targeting CD93 expressed in CHO cells. DCBY02 has a heavy chain of the mlgG type and a light chain of the mkappa type, with a predicted molecular weight (MW) of 150 kDa. The isotype control for DCBY02 can be referenced as Mouse IgG1 kappa, Isotype Control.

HY-P991082

Anti-LAMP1/CD107a Antibody	Inhibitor
Anti-LAMP1/CD107a Antibody (SAR-428926 antibody) is an anti-LAMP1 humanized monoclonal antibody. Anti-LAMP1/CD107a Antibody can be used for the antibody part of SAR-428926. Antibody Anti-LAMP1/CD107a Antibody can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P991217

EU-103	Inhibitor
EU-103 is a humanized monoclonal antibody targeting V-Set And Immunoglobulin Domain Containing 4 (VSIG4) with a K_D value ranging from 10⁻⁷ and 10⁻⁹. EU-103 blocks the interaction between VSIG4 and CD8+ T cells, promotes the conversion of M2 macrophages into M1 macrophages, induces the proliferation of CD8+ T cells and the secretion of pro-inflammatory cytokines, thereby inhibiting tumor growth. EU-103 is promising for research of cancers, such as bladder cancer, breast cancer, and colon cancer.

HY-P991386

PM-1021	Inhibitor
PM-1021 is a human monoclonal antibody (mAb) targeting TIGIT. PM-1021 can be used in cancer research.

HY-P990153

Anti-Mouse TIM-2 Antibody (RMT2-29)	Inhibitor
Anti-Mouse TIM-2 Antibody (RMT2-29) is a rat-derived Ig2a λ type antibody inhibitor, targeting to mouse TIM-2. Anti-Mouse TIM-2 Antibody (RMT2-29) reacts with mouse T cell immunoglobulin and mucin domain 2 (TIM-2) and blocks TIM-2 signaling. Anti-Mouse TIM-2 Antibody (RMT2-29) can be used for the research of immunology.

HY-P991558

RO-5429083	Inhibitor
RO-5429083 is a humanized monoclonal antibody inhibitor targeting CD44. RO-5429083 can be used for acute myeloid leukemia (AML) and solid tumors research.

HY-P991390

BAT-6021	Inhibitor
BAT-6021 is a human monoclonal antibody (mAb) targeting TIGIT. BAT-6021 can be used in Solid tumours research.

HY-P991393

ASP8374	Inhibitor
ASP8374 is a human IgG4 monoclonal antibody (mAb) targeting TIGIT. ASP8374 increases IL-2 production in Jurkat cells and IFN-γ and TNF-α production in human PBMCs. ASP8374 can be used in advanced solid tumors research. Recommended isotype control: Human IgG4 kappa, Isotype Control (HY-P99003).

HY-P991071

AK-001	Inhibitor
AK-001 is a fully human IgG1 antibody that targets Siglec-8. VRC-01 can be used for the study of chronic rhinosinusitis with nasal polyps. The isotype control for AK-001 can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

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