MHC

Major Histocompatibility Complex; MHC

MHC is a group of genes encoding proteins which are transferred to the cell surfaces to present the intracellular or extracellular, self or non-self antigens to the cells of the immune system, thereby helping T cells in differentiating self from non-self proteins, and initiating adaptive immune responses. MHC can be divided into 3 subtypes, MHC I, MHC II and MHC III, in which MHC I presents endogenous antigens (such as antigens produced by virus-infected cells or tumor cells) to activate cytotoxic T cells (CD8+ T cells); MHC II presents exogenous antigens (such as bacteria or parasites) to activate helper T cells (CD4+ T cells); MHC III does not directly participate in antigen presentation, but involves in immune regulation, inflammatory response and cell signaling. MHC is crucial for stem cell transplant (SCT), and could lead to graft-versus-host disease (GVHD)^[1]^[2].

References:

[1]. Deakin JE, et al., Evolution and comparative analysis of the MHC Class III inflammatory region. BMC Genomics. 2006 Nov 2;7:281. [Content Brief]

[2]. Sharma S K. Major Histocompatibility Complex[M]//Basics of Hematopoietic Stem Cell Transplant. Singapore: Springer Nature Singapore, 2023: 903-913.

MHC Isoform Specific Products:

MHC Isoform Comparison

MHC Related Products (64)
MHC Isoform Comparison

By Effects:	Ligands (4) Inhibitors (22) Substrate (1) Activator (1) Modulator (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-177091

AS2795440	Inhibitor
AS2795440 is a PIKfyve inhibitor. AS2795440 selectively inhibits proinflammatory cytokine such as IL-12p40 and IL-6 production and B cell activation without affecting Ca²⁺ signaling. AS2795440 significantly reduces joint inflammation and bone loss in adjuvant-induced arthritis (AIA) mice model. AS2795440 can be used for inflammatory and autoimmune diseases like rheumatoid arthritis, psoriasis and inflammatory bowel disease research.

HY-P5745A

TYVPANASL TFA
TYVPANASL TFA is a MHC I-binding CD8 T cell epitope of nine amino acids from HER2/neu. TYVPANASL TFA can be used to prepare J-LEAPS vaccine.

HY-P990188

Anti-Mouse MHC class II (I-A) Antibody (Y-3P)
Anti-Mouse MHC class II (I-A) Antibody (Y-3P) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse MHC class II. Anti-Mouse MHC class II (I-A) Antibody (Y-3P) reacts with mouse MHC Class II haplotypes I-Ab, I-Af, I-Ap, I-Aq, I-Ar, I-As, I-Au, I-Av, and weakly with I-Ak. Anti-Mouse MHC class II (I-A) Antibody (Y-3P) blocks MHC class II and inhibits expansion of regulate T cells. Anti-Mouse MHC class II (I-A) Antibody (Y-3P) can be used for the immunology research.

HY-P1745

InsB (9-23)
InsB (9-23) is an insulin B-chain peptide that binds to a class II histocompatibility complex (MHC) allele called I-Ag7. InsB (9-23) can be used to treat a number of autoimmune related diseases like Type 1 diabetes.

HY-160151

TP1L	Activator
TP1L is a potent and selective T-cell protein tyrosine phosphatase (TC-PTP) PROTAC degrader, with a DC₅₀ value of 35.8 nM. TP1L elevates the phosphorylation level of TC-PTP substrates including pSTAT1 and pJAK1. TP1L selectively enhances IFN-γ signaling and increases MHC-I expression. TP1L activates TCR signaling through increases phosphorylation of LCK. TP1L enhances CAR-T cell mediated tumor killing efficacy through activation of the CAR-T cells. TP1L can be used for the study of cancer. (Pink: TC-PTP ligand: (HY-138964), Blue: E3 ligase CRBN Ligand (HY-A0003), Black: Linker: (HY-140002)).

HY-P990161

Anti-Mouse TCR Vγ1.1/Cr4 Antibody (2.11)	Inhibitor
Anti-Mouse TCR Vγ1.1/Cr4 Antibody (2.11) is an anti-mouse TCR Vγ1.1/Cr4 IgG monoclonal antibody. Anti-Mouse TCR Vγ1.1/Cr4 Antibody (2.11) can deplete Vγ1 γδ T cells. Anti-Mouse TCR Vγ1.1/Cr4 Antibody (2.11) can be used for research on cancer and inflammation conditions such as mastitis and colon cancer.

HY-P990160

Anti-Rat TCR alpha/beta Antibody (R73)	Inhibitor
Anti-Rat TCR alpha/beta Antibody (R73) is an anti-mouse TCR alpha/beta IgG1 monoclonal antibody. Anti-Rat TCR alpha/beta Antibody (R73) suppresses immune response by depleting α/β⁺ T cells. Anti-Rat TCR alpha/beta Antibody (R73) can inhibit the expression of pro-inflammatory cytokines. Anti-Rat TCR alpha/beta Antibody (R73) can extend graft survival time by reducing infiltration of T cells and neutrophils. Anti-Rat TCR alpha/beta Antibody (R73) can be used for researches on inflammation, metabolic conditions and xenotransplantation such as arthritis, acute inflammatory peripheral neuropathy and diabetes.

HY-P11090

TpD
TpD is a chimeric T-helper epitope. TpD has a special site that cathepsin can cut. Immunization with TpD produces a strong antibody response. TpD promotes long-term CD4 immune responses in animals and humans. TpD binds well to many human MHC class II types, mainly HLA-DRB1. It also binds some other HLA alleles like DRB3, DRB4, DRB5, DP, and DQ. TpD can be used to improve the immune response of peptide vaccines.

HY-P991247

Anti-HLA-A2 (Hu8F4)	Inhibitor
Anti-HLA-A2 (Hu8F4) is a human monoclonal antibody (mAb) targeting HLA-A2. Anti-HLA-A2 (Hu8F4) can be used in Acute myeloid leukaemia research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P10382

M133 peptide
M133 peptide is a coronavirus-specific CD4 T cell epitope. M133 peptide is immunodominant in mice infected with the neurotropic coronavirus (the JHM strain of mouse hepatitis virus). M133 peptide forms a complex with MHC II molecules, which is recognized by specific TCRs, thereby activating CD4 T cells.

HY-P990159

Anti-Mouse TCRβ Antibody (HB218)	Inhibitor
Anti-Mouse TCRβ Antibody (HB218) is an anti-mouse TCRβ IgG2b monoclonal antibody. Anti-Mouse TCRβ Antibody (HB218) can deplete TCRβ⁺ T cells. Anti-Mouse TCRβ Antibody (HB218) can be used for research on inflammation conditions and cancer such as spontaneous dermatitis and squamous cell carcinoma (SCC).

HY-P11089

TP53 neoepitope	Substrate
TP53 neoepitope is a high-affinity antigenic peptide targeting HLA-A. TP53 neoepitope can triggers CD8⁺ T cell-mediated killing of TP53-mutant tumor cells. TP53 neoepitope is promising for research of solid tumors harboring TP53 hotspot mutations (e.g., R175H, R273H) .

HY-P991590

1D09C3
1D09C3 is a fully human anti-HLA-DR monoclonal antibody. 1D09C3 induces apoptosis and cell death involving a cascade of events, including ROS generation, JNK activation, mitochondrial membrane depolarization, and AIF release from mitochondria. 1D09C3 shows potent anti-tumor activity and increases overall survival and median survival in JVM-2 cells and GRANTA-519 cells xenograft mice models. 1D09C3 can be used for the researches of cancer, such as chronic lymphocytic leukemia (CLL).

HY-P990142

Anti-Mouse Vβ4 TCR Antibody (KT4)	Inhibitor
Anti-Mouse Vβ4 TCR Antibody (KT4) is an anti-mouse Vβ4 TCR IgG2b monoclonal antibody. Anti-Mouse Vβ4 TCR Antibody (KT4) can reduce the proportion of Vβ4⁺ T cells without affecting their function. Anti-Mouse Vβ4 TCR Antibody (KT4) can be used for research on immunology and infection conditions such as virus infection. Anti-Mouse Vβ4 TCR Antibody (KT4) is often used in flow cytometry.

HY-P990192

Anti-Mouse MHC Class I (H-2Kk) Antibody (AF3-12.1.3)	Inhibitor
Anti-Mouse MHC Class I (H-2Kk) Antibody (AF3-12.1.3) is a mouse-derived IgG1 type antibody inhibitor, targeting to mouse MHC Class I. Anti-Mouse MHC Class I (H-2Kk) Antibody (AF3-12.1.3) reacts with the mouse H-2Kk MHC class I alloantigen. Anti-Mouse MHC Class I (H-2Kk) Antibody (AF3-12.1.3) can be used for the researches of inflammation and immunology, such as obliterative airway disease.

HY-P11058

OVA(250-264)
OVA(250-264) (OVAvac) (OVAp) is an antigen peptide that can be from ovalbumin (OVA) presented by the class I MHC molecule, H-2Kb. OVA(250-264) combined withαMSLN (anti-MSLN antibody) significantly induces antigen-specific CD8⁺ T cell generation and infiltration for enhancing antitumor efficacy in orthotopic pancreatic cancer mice model. OVA(250-264) can be used for neoantigen vaccine development in pancreatic cancer immunotherapy research.

HY-P990190

Anti-Swine MHC Class I (SLAd) Antibody (74-11-10)	Inhibitor
Anti-Swine MHC Class I (SLAd) Antibody (74-11-10) is a mouse-derived IgG2b κ type antibody inhibitor, targeting to Swine MHC Class I. Anti-Swine MHC Class I (SLAd) Antibody (74-11-10) reacts with the swine leucocyte antigen (SLA) class I. Anti-Swine MHC Class I (SLAd) Antibody (74-11-10) can be used for the research of flow cytometry experiments.

HY-P10840

Tkip	Inhibitor
Tkip is a JAK2 specific inhibitor. Tkip can bind the JAK2 autophosphorylation site, inhibit the JAK2 autophosphorylation and the phosphorylation of the IFN-γ receptor subunit IFNGR-1. Tkip inhibits the antiviral activity of IFN-γ and the expression of MHC Class I molecules. Tkip can be used to study the IFN-γ signaling pathway.

HY-157171

Ac-YR-NH2	Modulator
Ac-YR-NH2 is a small molecule modulator of MHC class II antigen presentation. Ac-YR-NH2 can influence peptide binding by MHC II to influence immune response.

HY-P99135

Anti-Mouse MHC Class I (H-2Kb) Antibody (Y-3)	Inhibitor
Anti-Mouse MHC Class I (H-2Kb) Antibody (Y-3) is a mouse-derived IgG2b antibody inhibitor, targeting to mouse MHC Class I (H-2Kb). Anti-Mouse MHC Class I (H-2Kb) Antibody (Y-3) reacts with the mouse H-2Kb, H-2Kk, H-2Kq, H-2Kr, H-2ks MHC class I alloantigens and not H-2Kd. Anti-Mouse MHC Class I (H-2Kb) Antibody (Y-3) can block MHC Class I. Anti-Mouse MHC Class I (H-2Kb) Antibody (Y-3) can be used for immunology research.

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MHC

MHC Isoform Specific Products:

MHC Isoform Specific Products:

MHC Related Products (64)

MHC Isoform Comparison

MHC Related Products (64):