2. Signaling Pathways
  3. Immunology/Inflammation
  4. C-type Lectin-like Receptors (CTLRs)
  5. C-type Lectin-like Receptors (CTLRs) Inhibitor

C-type Lectin-like Receptors (CTLRs) Inhibitor

C-type Lectin-like Receptors (CTLRs) Inhibitors (11):

Cat. No. Product Name Effect Purity
  • HY-P9990
    Litifilimab
    		Inhibitor 99.51%
    Litifilimab (BIIB059) is a humanized anti-BDCA2 IgG1 monoclonal antibody administered subcutaneously. Litifilimab can inhibit the production of type I interferons, cytokines and chemokines. Litifilimab can be used in the research of diseases such as systemic lupus erythematosus.
  • HY-P990205
    Anti-Mouse/Human KLRG-1 Antibody (2F1)
    		Inhibitor
    Anti-Mouse/Human KLRG-1 Antibody (2F1) is a Syrian hamster-derived IgG type antibody inhibitor, targeting to mouse/human KLRG-1.
  • HY-P991295
    ABC-015
    		Inhibitor
    ABC-015 is a human monoclonal antibody (mAb) targeting KLRG1. ABC-015 can be used in multiple myeloma research.
  • HY-P991453
    Anti-CD371/CLEC12A Antibody (H6e7)
    		Inhibitor
    Anti-CD371/CLEC12A Antibody (H6e7) is a human monoclonal antibody (mAb) targeting CD371/CLEC12A. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001).
  • HY-W159303
    7-Hydroxy-2,2-dimethyl-4-chromanone
    		Inhibitor
    7-Hydroxy-2,2-dimethyl-4-chromanone (compound 41) is an inhibitor of DC-SIGN (Dendritic Cell-Specific Intercellular Adhesion Molecule 3 grabbing non-integrin), with an IC50 of 4.66 mM. DC-SIGN is the C-type lectin receptor presenting on the surface of both macrophages and dendritic cells.
  • HY-153489
    ISIS 329993
    		Inhibitor
    ISIS 329993 (ISIS-CRPRx) is an antisense oligonucleotide targeting to C-reactive protein (CRP). ISIS-CRPRx has been tested in a rodent model of rheumatoid arthritis (RA) and was shown to improve the clinical signs of arthritis
  • HY-155311
    NKG2D-IN-1
    		Inhibitor
    NKG2D-IN-1 (compound 21) is a natural killer group 2D receptor (NKG2D) inhibitor with IC50s of 0.3 µM and 0.7 µM in NKG2D/MICA and ULBP6 TR-FRET assays, respectively.
  • HY-155312
    NKG2D-IN-2
    		Inhibitor
    NKG2D-IN-2 (compound 47) is a natural killer group 2D receptor (NKG2D) inhibitor with IC50s of 0.1 µM and 0.2 µM in NKG2D/MICA and ULBP6 TR-FRET assays, respectively.
  • HY-P991610
    S-095029
    		Inhibitor
    S-095029 is a humanized IgG1 monoclonal antibody inhibitor targeting NKG2A. S-095029 significantly attenuates Fc-effector functions, inhibits the interaction with its ligand HLA-E, and increases the antibody-dependent cellular cytotoxicity mediated by other Fc-competent mAbs. S-095029 has a potent antitumor activity with enhancement of killing activity and cytokine secretion (IFNγ, TNF-α and CXCL9) of NK and γδ T-cells in co-culture with cancer cells.
  • HY-153489A
    ISIS 329993 sodium
    		Inhibitor
    ISIS 329993 sodium is an antisense oligonucleotide targeting to C-reactive protein (CRP). ISIS-CRPRx sodium has been tested in a rodent model of rheumatoid arthritis (RA) and was shown to improve the clinical signs of arthritis
  • HY-P991309
    ZM-008
    		Inhibitor
    ZM-008 is a human monoclonal antibody (mAb) targeting OCIL/CLEC2D. ZM-008 can be used in B-cell lymphoma, glioma and prostate cancer research.