Search Result

Pathways Recommended:	Metabolic Enzyme/Protease

Results for "

ubiquitin-specific protease

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (4) Autophagy (1) Deubiquitinase (25) IKK (1) JNK (1) MDM-2/p53 (3) Mitophagy (1) NF-κB (1) PROTACs (1)
By Research Areas:	Cancer (24) Inflammation/Immunology (1) Metabolic Disease (1) Neurological Disease (1)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Targets Recommended: Virus Protease HCV Protease HIV Protease Protease Activated Receptor (PAR) Ser/Thr Protease E1/E2/E3 Enzyme PSMA ClpP Serpin SNIPERs Enteropeptidase BMI1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-148099

USP1-IN-2	Deubiquitinase	Cancer
USP1-IN-2 (Compound I-193) is a potent ubiquitin-specific protease 1 (USP1) inhibitor with an IC₅₀ of less than about 50 nM .

HY-17540

HBX 19818 15+ Cited Publications	Deubiquitinase	Cancer
HBX 19818 is a specific inhibitor of ubiquitin-specific protease 7 (USP7), with an IC₅₀ of 28.1 μM.

HY-15667

P005091 15+ Cited Publications P5091	Deubiquitinase	Cancer
P005091 is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with an EC₅₀ of 4.2 μM.

HY-50736

DUB-IN-1 5 Publications Verification	Deubiquitinase	Cancer
DUB-IN-1 is an active inhibitor of ubiquitin-specific proteases (USPs), with an IC₅₀ of 0.85 μM for USP8 .

HY-146887

USP7-IN-9	Deubiquitinase Apoptosis	Cancer
USP7-IN-9 is a highly potent ubiquitin-specific protease 7 (USP7) inhibitor with an IC₅₀ value of 40.8 nM. USP7-IN-9 can induce apoptosis and arrest cell progression at G0/G1 and S phases in RS4; 11 cells. USP7-IN-9 reduces the protein levels of oncoproteins MDM2 and DNMT1 and increases the protein levels of tumor suppressors p53 and p21 .

HY-148481A

USP7-IN-10 hydrochloride	Deubiquitinase	Cancer
USP7-IN-10 hydrochloride (compound 1) is a potent ubiquitin-specific protease 7 (USP7) inhibitor, with an IC₅₀ of 13.39 nM .

HY-16709

USP7-IN-1 5+ Cited Publications	Deubiquitinase	Cancer
USP7-IN-1 is a selective and reversible inhibitor of ubiquitin-specific protease 7 (USP7), with an IC₅₀ of 77 μM, and can be used for the research of cancer.

HY-153045

BAY-805 2 Publications Verification	Deubiquitinase	Cancer
BAY-805 is a selective inhibitor of ubiquitin-specific protease USP21. BAY-805 has high selectivity for deubiquitinating enzyme (DUB) targets, kinases, proteases and other common target enzymes .

HY-138698

FT206	Deubiquitinase	Cancer
FT206 is the inhibitor for ubiquitin-specific protease that inhibits USP28 and USP25 with IC₅₀s of 0.15 μM and 1.01 μM .

HY-148481

USP7-IN-10	Deubiquitinase	Cancer
USP7-IN-10 (compound 1) is a potent ubiquitin-specific protease 7 (USP7) inhibitor, with an IC₅₀ of 13.39 nM .

HY-13865

P 22077 15+ Cited Publications	Deubiquitinase	Cancer
P 22077 is a cell-permeable ubiquitin-specific protease 7 (USP7) inhibitor with an EC₅₀ of 8.01 μM. P 22077 also inhibits USP47 with an EC₅₀ of 8.74 μM.

HY-112128

USP7-IN-3	Deubiquitinase MDM-2/p53	Cancer
USP7-IN-3 (Compound 5) is an effective and selective allosteric inhibitor of ubiquitin-specific protease 7 (USP7). USP7-IN-3 can be used for research on acute lymphoblastic leukemia .

HY-148482

USP7-IN-11	Deubiquitinase	Cancer
USP7-IN-11 is a potent ubiquitin-specific protease 7 (USP7) (Deubiquitinase) inhibitor with an IC₅₀ of 0.37 nM. USP7-IN-11 has anticancer effects (WO2022048498A1; Example 187) .

HY-13487

USP7/USP47 inhibitor 3 Publications Verification	Deubiquitinase	Cancer
USP7/USP47 inhibitor is a selective ubiquitin-specific protease 7/47 (USP7/USP47) inhibitor, with EC₅₀s of 0.42 μM and 1.0 μM, respectively.

HY-101666

HBX 41108 2 Publications Verification	Deubiquitinase Apoptosis MDM-2/p53	Metabolic Disease Cancer
HBX 41108 is an inhibitor of ubiquitin-specific protease 7 (USP7) with an IC₅₀ of 424 nM. HBX 41108 inhibits USP7-mediated p53 deubiquitination to stabilize p53 and inhibits cancer cell growth. BX 41108 can be used in cancer and diabetes research .

HY-134817

USP7-IN-8 1 Publications Verification	Deubiquitinase	Cancer
USP7-IN-8 (example 81) is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC₅₀ of 1.4 μM in an Ub-Rho110 assay. USP7-IN-8 shows no activity against USP47 and USP5. USP7-IN-8 has anticancer effects .

HY-148369

U7D-1	PROTACs Deubiquitinase Apoptosis MDM-2/p53	Cancer
U7D-1 is a first-in-class potent and selective USP7 (ubiquitin-specific protease 7) PROTAC degrader, with a DC₅₀ of 33 nM in RS4;11 cells. U7D-1 shows anticancer activity. U7D-1 induces apoptosis in Jeko-1 cells .

HY-160700

TNG348	Deubiquitinase JNK	Cancer
TNG348 is an orally available allosteric inhibitor of the ubiquitin-specific protease USP1. TNG348 specifically and efficiently inhibits the activity of USP1, inhibiting its deubiquitination of proliferative PCNA and FANCD2, thereby disrupting the DNA repair process. TNG348 has inhibitory activity against breast and ovarian cancers carrying BRCA1/2 mutations and other homologous recombination defects (HRD) .

HY-141659

CMPD-39 2 Publications Verification	Mitophagy Deubiquitinase	Neurological Disease
CMPD-39 is a selective non-covalent inhibitor of the ubiquitin-specific protease USP30 (IC₅₀=~20 nM), with high selectivity over other DUB family members (1-100 μM). CMPD-39 inhibits the deubiquitinating activity of USP30, enhances the ubiquitination of mitochondrial proteins TOMM20 and SYNJ2BP; thus, CMPD-39 promotes phosphoubuitin accumulation, thereby accelerating mitochondrial autophagy (mitophagy) and peroxisomal autophagy (pexophagy). CMPD-39 significantly restores impaired mitochondrial function in dopaminergic neurons derived from Parkinson's disease patients .

HY-129169

USP7-IN-6	Deubiquitinase	Cancer
USP7-IN-6 is a potent ubiquitin specific protease 7 (USP7) inhibitor, extracted from patent WO2017212010A1, example 25, has an IC₅₀ of 6.8 nM .

HY-13453

BAY 11-7082 Maximum Cited Publications 343 Publications Verification BAY 11-7821	IKK Deubiquitinase Autophagy Apoptosis NF-κB	Inflammation/Immunology Cancer
BAY 11-7082 is an IκBα phosphorylation and NF-κB inhibitor. BAY 11-7082 selectively and irreversibly inhibits the TNF-α-induced phosphorylation of IκB-α, and decreases NF-κB and expression of adhesion molecules. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 (IC₅₀=0.19, 0.96 μM, respectively). BAY 11-7082 inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells .

HY-153045A

BAY-728	Deubiquitinase	Cancer
BAY-728 can be used as a negative control of BAY-805. BAY-805 is a potent and selective Inhibitor of USP21 .

HY-170921

USP1-IN-11	Deubiquitinase	Cancer
USP1-IN-11 (compound 38-P2) is a selective, reversible, and noncompetitive *USP1 (Ubiquitin-specific* protease 1) inhibitor. USP1-IN-11 activates the DDR (DNA damage repair) pathway, induces cell cycle arrest and cell Apoptosis**, and inhibits cell survival. USP1-IN-11 enhances the sensitivity of Olaparib (HY-10162)-resistant cells to Olaparib (HY-10162) and shows a synergetic effect with Andrographolide (HY-N0191) in BRCA-proficient cancer cells. USP1-IN-11 displays significant, dose-dependent antitumor efficacy in the MDA-MB-436 xenograft model .

HY-162633

USP1-IN-9	Deubiquitinase	Cancer
USP1-IN-9 (Compound 1m) is reversible and noncompetitive ubiquitin-specific proteases (USP1) inhibitors with an IC₅₀ of 8.8 nM, which is designed and synthesized to pyrido[2,3-d]pyrimidin-7(8H)-one derivative based on the disclosed structure of ML323(HY-17543) and KSQ-4279(HY-145471). USP1-IN-9 displays excellent USP1/UAF inhibition and exhibits strong antiproliferation effect in breast cancer cells. USP1-IN-9 can generate enhanced cell killing with PARP inhibitor olaparib(HY-10162) in olaparib-resistant MDA-MB-436/OP cells, which is promising for research in the field of cancer .

HY-117370

USP25/28 inhibitor AZ1 1 Publications Verification AZ1	Deubiquitinase	Cancer
USP25/28 inhibitor AZ1 (AZ1) is an orally active, selective, noncompetitive, dual ubiquitin specific protease (USP) 25/28 inhibitor with IC₅₀s of 0.7 μM and 0.6 μM, respectively. USP25/28 inhibitor AZ1 attenuates colitis and tumorigenesis in the mice model .

Recombinant Proteins Recommended:

Ubiquitin-Specific Protease

Species:	Human (47)
Tag:	His (15) Tag Free (19) GST (11) Flag (5)
Source:	Sf9 insect cells (27) E. coli (20)

Cat. No.	Compare	Product Name	Species	Source

HY-P701422

	USP48 Protein, Human (sf9, FLAG) USP48; ubiquitin carboxyl-terminal hydrolase 48; Deubiquitinating enzyme 48; ubiquitin thioesterase 48; ubiquitin-specific peptidase 48; ubiquitin-specific protease 48; ubiquitin-specific-processing protease 48	Human	Sf9 insect cells
	USP48 protein, a deubiquitinase, hydrolyzes ubiquitin bonds at the C-terminal Gly, processing poly-ubiquitin precursors and ubiquitinated proteins. It may regulate NF-kappa-B activation by the TNF receptor superfamily via RELA and TRAF2 interactions. With potential roles at postsynaptic sites, USP48 exhibits multifunctionality, influencing ubiquitin processing and signaling pathways involved in immune response and synaptic function. USP48 Protein, Human (sf9, FLAG) is the recombinant human-derived USP48 protein, expressed by sf9 insect cells , with C-Flag labeled tag.

HY-P701349

	USP2 Protein, Human USP2; ubiquitin carboxyl-terminal hydrolase 2; 41 kDa ubiquitin-specific protease; Deubiquitinating enzyme 2; ubiquitin thioesterase 2; ubiquitin-specific-processing protease 2	Human	E. coli
	USP2 catalytic domain proteins act as hydrolases and target polyubiquitinated proteins such as MDM2, MDM4, and CCND1. Both isoform 1 and isoform 4 exhibit ubiquitin-specific peptidase and isopeptidase activities. USP2 Protein, Human is the recombinant human-derived USP2 protein, expressed by E. coli , with tag free.

HY-P701431

	USP9X Protein, Human (GST) USP9X; Probable ubiquitin carboxyl-terminal hydrolase FAF-X; Deubiquitinating enzyme FAF-X; Fat facets in mammals; hFAM; Fat facets protein-related; X-linked; ubiquitin thioesterase FAF-X; ubiquitin-specific protease 9; X chromosome; ubiquitin-specific-processing protease FAF-X	Human	E. coli
	The USP9X protein serves as a deubiquitinase, playing a crucial role in processing ubiquitin precursors and preventing protein degradation. It exhibits specificity in hydrolyzing various polyubiquitin chain linkages, including "Lys-63", "Lys-48", "Lys-29" and "Lys-33". USP9X Protein, Human (GST) is the recombinant human-derived USP9X protein, expressed by E. coli , with N-GST labeled tag.

HY-P701450

	USP30 Protein, Human (sf9) USP30; ubiquitin carboxyl-terminal hydrolase 30; Deubiquitinating enzyme 30; ubiquitin thioesterase 30; ubiquitin-specific-processing protease 30; Ub-specific protease 30	Human	Sf9 insect cells
	USP30 protein is anchored on the outer mitochondrial membrane and severely inhibits mitophagy by antagonizing Parkin (PRKN). Hydrolyzing ubiquitin on RHOT1/MIRO1 and target proteins such as TOMM20 and USP30 blocks Parkin-mediated mitophagy, thereby regulating the clearance of damaged mitochondria. USP30 Protein, Human (sf9) is the recombinant human-derived USP30 protein, expressed by sf9 insect cells , with tag free.

HY-P79457

	USP2 Catalytic Domain Protein, Human (His) ubiquitin specific Peptidase 2; UBP41; ubiquitin-specific-Processing protease 2; ubiquitin Carboxyl-Terminal Hydrolase 2; 41 KDa ubiquitin-specific protease; Deubiquitinating Enzyme 2; ubiquitin-specific protease 2	Human	E. coli
	USP2 catalytic domain proteins act as hydrolases and target polyubiquitinated proteins such as MDM2, MDM4, and CCND1. Both isoform 1 and isoform 4 exhibit ubiquitin-specific peptidase and isopeptidase activities. USP2 Catalytic Domain Protein, Human (His) is the recombinant human-derived USP2 Catalytic Domain protein, expressed by E. coli , with N-6*His labeled tag.

HY-P701434

	USP9Y Protein, Human USP9Y; Probable ubiquitin carboxyl-terminal hydrolase FAF-Y; Deubiquitinating enzyme FAF-Y; Fat facets protein-related; Y-linked; ubiquitin thioesterase FAF-Y; ubiquitin-specific protease 9; Y chromosome; ubiquitin-specific-processing protease FAF-Y	Human	E. coli
	The USP9Y protein is a multifunctional ubiquitin proteolytic enzyme that performs critical processing of ubiquitin precursors and ubiquitinated proteins. Its multifaceted roles make USP9Y a key regulator of protein turnover, preventing degradation by efficiently removing the ubiquitin moiety. USP9Y Protein, Human is the recombinant human-derived USP9Y protein, expressed by E. coli , with tag free.

HY-P701433

	USP9Y Protein, Human (GST) USP9Y; Probable ubiquitin carboxyl-terminal hydrolase FAF-Y; Deubiquitinating enzyme FAF-Y; Fat facets protein-related; Y-linked; ubiquitin thioesterase FAF-Y; ubiquitin-specific protease 9; Y chromosome; ubiquitin-specific-processing protease FAF-Y	Human	E. coli
	The USP9Y protein is a multifunctional ubiquitin proteolytic enzyme that performs critical processing of ubiquitin precursors and ubiquitinated proteins. Its multifaceted roles make USP9Y a key regulator of protein turnover, preventing degradation by efficiently removing the ubiquitin moiety. USP9Y Protein, Human (GST) is the recombinant human-derived USP9Y protein, expressed by E. coli , with N-GST labeled tag.

HY-P701432

	USP9X Protein, Human USP9X; Probable ubiquitin carboxyl-terminal hydrolase FAF-X; Deubiquitinating enzyme FAF-X; Fat facets in mammals; hFAM; Fat facets protein-related; X-linked; ubiquitin thioesterase FAF-X; ubiquitin-specific protease 9; X chromosome; ubiquitin-specific-processing protease FAF-X	Human	E. coli
	The USP9X protein serves as a deubiquitinase, playing a crucial role in processing ubiquitin precursors and preventing protein degradation. It exhibits specificity in hydrolyzing various polyubiquitin chain linkages, including "Lys-63", "Lys-48", "Lys-29" and "Lys-33". USP9X Protein, Human is the recombinant human-derived USP9X protein, expressed by E. coli , with tag free.

HY-P701451

	USP30 Protein, Human (sf9, His) USP30; ubiquitin carboxyl-terminal hydrolase 30; Deubiquitinating enzyme 30; ubiquitin thioesterase 30; ubiquitin-specific-processing protease 30; Ub-specific protease 30	Human	Sf9 insect cells
	USP30 protein is anchored on the outer mitochondrial membrane and severely inhibits mitophagy by antagonizing Parkin (PRKN). Hydrolyzing ubiquitin on RHOT1/MIRO1 and target proteins such as TOMM20 and USP30 blocks Parkin-mediated mitophagy, thereby regulating the clearance of damaged mitochondria. USP30 Protein, Human (sf9, His) is the recombinant human-derived USP30 protein, expressed by sf9 insect cells , with N-8*His labeled tag.

HY-P701417

	USP44 Protein, Human USP44; ubiquitin carboxyl-terminal hydrolase 44; Deubiquitinating enzyme 44; ubiquitin thioesterase 44; ubiquitin-specific-processing protease 44	Human	E. coli
	The USP44 protein is a key deubiquitinase that regulates the spindle assembly checkpoint and prevents premature initiation of anaphase by deubiquitinating CDC20. This stabilizes the MAD2L1-CDC20-APC/C complex and enhances the spindle assembly checkpoint. USP44 Protein, Human is the recombinant human-derived USP44 protein, expressed by E. coli , with tag free.

HY-P701419

	USP46 Protein, Human USP46; ubiquitin carboxyl-terminal hydrolase 46; Deubiquitinating enzyme 46; ubiquitin thioesterase 46; ubiquitin-specific-processing protease 46	Human	E. coli
	USP46 protein, as a deubiquitinating enzyme, may participate in behavioral regulation by regulating the effects of GABA. Suggested to mediate deubiquitination of GAD1/GAD67, affecting processes related to GABAergic neurotransmission. USP46 Protein, Human is the recombinant human-derived USP46 protein, expressed by E. coli , with tag free.

HY-P701441

	USP21 Protein, Human USP21; ubiquitin carboxyl-terminal hydrolase 21; Deubiquitinating enzyme 21; ubiquitin thioesterase 21; ubiquitin-specific-processing protease 21	Human	E. coli
	USP21 protein is a multifunctional deubiquitinase that plays a key role in the regulation of epigenetic transcriptional repression by deubiquitinating histone H2A. As a coactivator, it relieves the inhibition of dimethylation and trimethylation of histone H3 at "Lys-4", thereby regulating transcription initiation. USP21 Protein, Human is the recombinant human-derived USP21 protein, expressed by E. coli , with tag free.

HY-P702838

	USP1 Protein, Human (His) ubiquitin carboxyl-terminal hydrolase 1; Deubiquitinating enzyme 1 (hUBP); ubiquitin thioesterase 1; ubiquitin-specific-processing protease 1	Human	E. coli
	USP1 Protein, Human (His) is the recombinant human-derived USP1, expressed by E. coli , with N-6*His labeled tag. ,

HY-P701413

	USP16 Protein, Human (sf9) USP16; ubiquitin carboxyl-terminal hydrolase 16; Deubiquitinating enzyme 16; ubiquitin thioesterase 16; ubiquitin-processing protease UBP-M; ubiquitin-specific-processing protease 16	Human	Sf9 insect cells
	The USP16 protein is a specific deubiquitinase that targets "Lys-120" of histone H2A (H2AK119Ub), a tag associated with epigenetic transcriptional repression. By catalytically removing this ubiquitin moiety, USP16 acts as a coactivator, promoting subsequent phosphorylation of histone H3 (H3S10ph) 'Ser-11' to achieve mitotic chromosome segregation. USP16 Protein, Human (sf9) is the recombinant human-derived USP16 protein, expressed by sf9 insect cells , with tag free.

HY-P701442

	USP21 Protein, Human (GST) USP21; ubiquitin carboxyl-terminal hydrolase 21; Deubiquitinating enzyme 21; ubiquitin thioesterase 21; ubiquitin-specific-processing protease 21	Human	E. coli
	USP21 protein is a multifunctional deubiquitinase that plays a key role in the regulation of epigenetic transcriptional repression by deubiquitinating histone H2A. As a coactivator, it relieves the inhibition of dimethylation and trimethylation of histone H3 at "Lys-4", thereby regulating transcription initiation. USP21 Protein, Human (GST) is the recombinant human-derived USP21 protein, expressed by E. coli , with N-GST labeled tag.

HY-P703671

	USP14 Protein, Human ubiquitin carboxyl-terminal hydrolase 14; Deubiquitinating enzyme 14; ubiquitin thioesterase 14; ubiquitin-specific-processing protease 14; USP14; TGT	Human	E. coli

HY-P701412

	USP16 Protein, Human (sf9, His) USP16; ubiquitin carboxyl-terminal hydrolase 16; Deubiquitinating enzyme 16; ubiquitin thioesterase 16; ubiquitin-processing protease UBP-M; ubiquitin-specific-processing protease 16	Human	Sf9 insect cells
	The USP16 protein is a specific deubiquitinase that targets "Lys-120" of histone H2A (H2AK119Ub), a tag associated with epigenetic transcriptional repression. By catalytically removing this ubiquitin moiety, USP16 acts as a coactivator, promoting subsequent phosphorylation of histone H3 (H3S10ph) 'Ser-11' to achieve mitotic chromosome segregation. USP16 Protein, Human (sf9, His) is the recombinant human-derived USP16 protein, expressed by sf9 insect cells , with N-8*His labeled tag.

HY-P71418

	USP14 Protein, Human (His) 1 Publications Verification ubiquitin Carboxyl-Terminal Hydrolase 14; Deubiquitinating Enzyme 14; ubiquitin Thioesterase 14; ubiquitin-specific-Processing protease 14; USP14; TGT	Human	E. coli
	USP14 is a proteasome-associated deubiquitinase that regulates ubiquitin dynamics by releasing ubiquitin from proteins marked for degradation. As a reversible proteasome subunit, USP14 ensures ubiquitin replenishment. USP14 Protein, Human (His) is the recombinant human-derived USP14 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P701418

	USP46 Protein, Human (His, GST) USP46; ubiquitin carboxyl-terminal hydrolase 46; Deubiquitinating enzyme 46; ubiquitin thioesterase 46; ubiquitin-specific-processing protease 46	Human	E. coli
	USP46 protein, as a deubiquitinating enzyme, may participate in behavioral regulation by regulating the effects of GABA. Suggested to mediate deubiquitination of GAD1/GAD67, affecting processes related to GABAergic neurotransmission. USP46 Protein, Human (His, GST) is the recombinant human-derived USP46 protein, expressed by E. coli , with N-6*His, N-GST labeled tag.

HY-P701426

	USP51 Protein, Human (sf9) USP51; ubiquitin carboxyl-terminal hydrolase 51; Deubiquitinating enzyme 51; ubiquitin thioesterase 51; ubiquitin-specific-processing protease 51	Human	Sf9 insect cells
	The USP51 protein uniquely regulates the DNA damage response by deubiquitinating the "Lys-14" (H2AK13Ub) and "Lys-16" (H2AK15Ub) residues of histone H2A at double-strand breaks. After DNA damage, USP51 is recruited to chromatin and regulates TP53BP1 and BRCA1 assembly/disassembly, which is critical for DNA repair. USP51 Protein, Human (sf9) is the recombinant human-derived USP51 protein, expressed by sf9 insect cells , with tag free.

HY-P701443

	USP22 Protein, Human (sf9) USP22; ubiquitin carboxyl-terminal hydrolase 22; Deubiquitinating enzyme 22; ubiquitin thioesterase 22; ubiquitin-specific-processing protease 22	Human	Sf9 insect cells
	USP22 protein is a histone deubiquitinating enzyme in the SAGA complex that catalyzes the deubiquitination of histones H2A and H2B and acts as a coactivator. Activators such as MYC facilitate its recruitment to gene promoters, which is critical for transcriptional activation. USP22 Protein, Human (sf9) is the recombinant human-derived USP22 protein, expressed by sf9 insect cells , with tag free.

HY-P701446

	USP28 Protein, Human (sf9) USP28; ubiquitin carboxyl-terminal hydrolase 28; Deubiquitinating enzyme 28; ubiquitin thioesterase 28; ubiquitin-specific-processing protease 28	Human	Sf9 insect cells
	The USP28 protein serves as a deubiquitinase and plays a key role in the DNA damage response checkpoint and the stability of the MYC proto-oncogene. It selectively deubiquitinates DNA damage pathway proteins such as CLSPN, thereby regulating apoptosis. USP28 Protein, Human (sf9) is the recombinant human-derived USP28 protein, expressed by sf9 insect cells , with tag free.

HY-P701448

	USP29 Protein, Human (sf9) USP29; ubiquitin carboxyl-terminal hydrolase 29; Deubiquitinating enzyme 29; ubiquitin thioesterase 29; ubiquitin-specific-processing protease 29	Human	Sf9 insect cells
	USP29 protein, as a deubiquitinating enzyme, plays a crucial role in innate antiviral immunity by mediating "Lys-48" deubiquitination of CGAS. This effect stabilizes CGAS, an important sensor of the cellular response to viral infection, emphasizing the importance of USP29 in regulating CGAS activity. USP29 Protein, Human (sf9) is the recombinant human-derived USP29 protein, expressed by sf9 insect cells , with tag free.

HY-P701454

	USP37 Protein, Human (sf9) USP37; ubiquitin carboxyl-terminal hydrolase 37; Deubiquitinating enzyme 37; ubiquitin thioesterase 37; ubiquitin-specific-processing protease 37	Human	Sf9 insect cells
	The USP37 protein is a multifunctional deubiquitinase that regulates critical cellular processes. During the G1/S transition, it deubiquitinates cyclin A, promotes S phase entry, and enhances activity through Ser-628 phosphorylation. USP37 Protein, Human (sf9) is the recombinant human-derived USP37 protein, expressed by sf9 insect cells , with tag free.

HY-P702063

	USP11 Protein, Human (sf9) 1 Publications Verification USP11; ubiquitin carboxyl-terminal hydrolase 11; Deubiquitinating enzyme 11; ubiquitin thioesterase 11; ubiquitin-specific-processing protease 11	Human	Sf9 insect cells
	The USP11 protein is a multifunctional protease that selectively removes ubiquitin from target proteins and polyubiquitin chains, thereby hindering their proteasomal degradation. It shows a preference for “Lys-6” and “Lys-63” linked ubiquitin chains and less activity towards other linkages. USP11 Protein, Human (sf9) is the recombinant human-derived USP11 protein, expressed by sf9 insect cells , with tag free.

HY-P702565

	USP10 Protein, Human (sf9) USP10; ubiquitin carboxyl-terminal hydrolase 10; Deubiquitinating enzyme 10; ubiquitin thioesterase 10; ubiquitin-specific-processing protease 10	Human	Sf9 insect cells
	USP10 is a multifunctional hydrolase that plays a critical regulatory role in a variety of cellular processes. It stabilizes the tumor suppressor p53/TP53 by deubiquitinating the tumor suppressor p53/TP53 in the cytoplasm, thereby counteracting MDM2-mediated degradation. USP10 Protein, Human (sf9) is the recombinant human-derived USP10 protein, expressed by sf9 insect cells , with tag free.

HY-P701421

	USP47 Protein, Human (sf9, FLAG) USP47; ubiquitin carboxyl-terminal hydrolase 47; Deubiquitinating enzyme 47; ubiquitin thioesterase 47; ubiquitin-specific-processing protease 47	Human	Sf9 insect cells
	The USP47 protein is a ubiquitin-specific protease that deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizes POLB, and regulates base excision repair (BER). In addition to DNA repair, USP47 is an important regulator of cell growth and genome integrity. USP47 Protein, Human (sf9, FLAG) is the recombinant human-derived USP47 protein, expressed by sf9 insect cells , with C-Flag labeled tag.

HY-P701447

	USP28 Protein, Human (sf9, His) 1 Publications Verification USP28; ubiquitin carboxyl-terminal hydrolase 28; Deubiquitinating enzyme 28; ubiquitin thioesterase 28; ubiquitin-specific-processing protease 28	Human	Sf9 insect cells
	The USP28 protein serves as a deubiquitinase and plays a key role in the DNA damage response checkpoint and the stability of the MYC proto-oncogene. It selectively deubiquitinates DNA damage pathway proteins such as CLSPN, thereby regulating apoptosis. USP28 Protein, Human (sf9, His) is the recombinant human-derived USP28 protein, expressed by sf9 insect cells , with N-8*His labeled tag.

HY-P701449

	USP29 Protein, Human (sf9, FLAG) USP29; ubiquitin carboxyl-terminal hydrolase 29; Deubiquitinating enzyme 29; ubiquitin thioesterase 29; ubiquitin-specific-processing protease 29	Human	Sf9 insect cells
	USP29 protein, as a deubiquitinating enzyme, plays a crucial role in innate antiviral immunity by mediating "Lys-48" deubiquitination of CGAS. This effect stabilizes CGAS, an important sensor of the cellular response to viral infection, emphasizing the importance of USP29 in regulating CGAS activity. USP29 Protein, Human (sf9, FLAG) is the recombinant human-derived USP29 protein, expressed by sf9 insect cells , with N-Flag labeled tag.

HY-P701455

	USP37 Protein, Human (sf9, His) USP37; ubiquitin carboxyl-terminal hydrolase 37; Deubiquitinating enzyme 37; ubiquitin thioesterase 37; ubiquitin-specific-processing protease 37	Human	Sf9 insect cells
	The USP37 protein is a multifunctional deubiquitinase that regulates critical cellular processes. During the G1/S transition, it deubiquitinates cyclin A, promotes S phase entry, and enhances activity through Ser-628 phosphorylation. USP37 Protein, Human (sf9, His) is the recombinant human-derived USP37 protein, expressed by sf9 insect cells , with N-8*His labeled tag.

HY-P702062

	USP11 Protein, Human (sf9, GST) USP11; ubiquitin carboxyl-terminal hydrolase 11; Deubiquitinating enzyme 11; ubiquitin thioesterase 11; ubiquitin-specific-processing protease 11	Human	Sf9 insect cells
	The USP11 protein is a multifunctional protease that selectively removes ubiquitin from target proteins and polyubiquitin chains, thereby hindering their proteasomal degradation. It shows a preference for “Lys-6” and “Lys-63” linked ubiquitin chains and less activity towards other linkages. USP11 Protein, Human (sf9, GST) is the recombinant human-derived USP11 protein, expressed by sf9 insect cells , with N-GST labeled tag.

HY-P702600

	USP21 Protein, Human (356a.a) USP21; ubiquitin carboxyl-terminal hydrolase 21; Deubiquitinating enzyme 21; ubiquitin thioesterase 21; ubiquitin-specific-processing protease 21	Human	E. coli
	USP21 protein is a multifunctional deubiquitinase that plays a key role in the regulation of epigenetic transcriptional repression by deubiquitinating histone H2A. As a coactivator, it relieves the inhibition of dimethylation and trimethylation of histone H3 at "Lys-4", thereby regulating transcription initiation. USP21 Protein, Human (356a.a) is the recombinant human-derived USP21, expressed by E. coli , with tag Free labeled tag. ,

HY-P703274

	USP3 Protein, Human (Active, sf9, GST) ubiquitin carboxyl-terminal hydrolase 3; Deubiquitinating enzyme 3; ubiquitin thioesterase 3; ubiquitin-specific-processing protease 3; USP3; Homo sapiens; Human; Chromatin regulator; Hydrolase; protease; Thiol protease; 3.4.19.12	Human	Sf9 insect cells
	USP3 Protein, Human (Active, sf9, GST) is the recombinant human-derived USP3, expressed by sf9 insect cells , with GST labeled tag. ,

HY-P701420

	USP47 Protein, Human (sf9, His, FLAG) USP47; ubiquitin carboxyl-terminal hydrolase 47; Deubiquitinating enzyme 47; ubiquitin thioesterase 47; ubiquitin-specific-processing protease 47	Human	Sf9 insect cells
	The USP47 protein is a ubiquitin-specific protease that deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizes POLB, and regulates base excision repair (BER). In addition to DNA repair, USP47 is an important regulator of cell growth and genome integrity. USP47 Protein, Human (sf9, His, FLAG) is the recombinant human-derived USP47 protein, expressed by sf9 insect cells , with C-Flag, N-8*His labeled tag.

HY-P701425

	USP51 Protein, Human (sf9, His, FLAG) USP51; ubiquitin carboxyl-terminal hydrolase 51; Deubiquitinating enzyme 51; ubiquitin thioesterase 51; ubiquitin-specific-processing protease 51	Human	Sf9 insect cells
	The USP51 protein uniquely regulates the DNA damage response by deubiquitinating the "Lys-14" (H2AK13Ub) and "Lys-16" (H2AK15Ub) residues of histone H2A at double-strand breaks. After DNA damage, USP51 is recruited to chromatin and regulates TP53BP1 and BRCA1 assembly/disassembly, which is critical for DNA repair. USP51 Protein, Human (sf9, His, FLAG) is the recombinant human-derived USP51 protein, expressed by sf9 insect cells , with N-Flag, N-8*His labeled tag.

HY-P702584

	USP10 Protein, Human (sf9, His, GST) USP10; ubiquitin carboxyl-terminal hydrolase 10; Deubiquitinating enzyme 10; ubiquitin thioesterase 10; ubiquitin-specific-processing protease 10	Human	Sf9 insect cells
	USP10 is a multifunctional hydrolase that plays a critical regulatory role in a variety of cellular processes. It stabilizes the tumor suppressor p53/TP53 by deubiquitinating the tumor suppressor p53/TP53 in the cytoplasm, thereby counteracting MDM2-mediated degradation. USP10 Protein, Human (sf9, His, GST) is the recombinant human-derived USP10, expressed by sf9 insect cells , with His, GST labeled tag. ,

HY-P703673

	USP5 Protein, Human (His) ubiquitin carboxyl-terminal hydrolase 5; Deubiquitinating enzyme 5; Isopeptidase T; ubiquitin thioesterase 5; ubiquitin-specific-processing protease 5; USP5; ISOT	Human	E. coli

HY-P703672

	USP14 Protein, Human (399a.a, His) ubiquitin carboxyl-terminal hydrolase 14; Deubiquitinating enzyme 14; ubiquitin thioesterase 14; ubiquitin-specific-processing protease 14; USP14; TGT	Human	E. coli

HY-P701411

	USP15 Protein, Human (sf9) USP15; ubiquitin carboxyl-terminal hydrolase 15; Deubiquitinating enzyme 15; ubiquitin thioesterase 15; ubiquitin-specific-processing protease 15; Unph-2; Unph4	Human	Sf9 insect cells
	USP15 is a hydrolase that complexly regulates cellular processes by deubiquitinating various target proteins in pathways such as TGF-β receptor, NF-κ-B, and RNF41/NRDP1-PRKN. In TGF-β signaling, it promotes R-SMAD deubiquitination or stabilizes TGFBR1, thereby enhancing pathway activity. USP15 Protein, Human (sf9) is the recombinant human-derived USP15 protein, expressed by Sf9 insect cells , with tag free.

HY-P701430

	USP6 Protein, Human (sf9) USP6; ubiquitin carboxyl-terminal hydrolase 6; Deubiquitinating enzyme 6; Proto-oncogene TRE-2; ubiquitin thioesterase 6; ubiquitin-specific-processing protease 6	Human	Sf9 insect cells
	USP6 protein is an ATP-independent isopeptidase with unique deubiquitinase activity that can cleave the C-terminus of ubiquitin and catalyze its own deubiquitination. Notably, it coordinates ARF6 plasma membrane localization and selectively affects ARF6-dependent endocytic protein trafficking. USP6 Protein, Human (sf9) is the recombinant human-derived USP6 protein, expressed by sf9 insect cells , with tag free.

HY-P701444

	USP25 Protein, Human USP25; ubiquitin carboxyl-terminal hydrolase 25; Deubiquitinating enzyme 25; USP on chromosome 21; ubiquitin thioesterase 25; ubiquitin-specific-processing protease 25	Human	E. coli
	The USP25 protein acts as a deubiquitinating enzyme and plays a key role in the hydrolysis of the ubiquitin moiety conjugated to the substrate. This function enables processing of newly synthesized ubiquitin, recycling of ubiquitin molecules, and editing of polyubiquitin chains, thus preventing proteasomal degradation of substrates. USP25 Protein, Human is the recombinant human-derived USP25 protein, expressed by E. coli , with tag free.

HY-P701429

	USP6 Protein, Human (sf9, GST) USP6; ubiquitin carboxyl-terminal hydrolase 6; Deubiquitinating enzyme 6; Proto-oncogene TRE-2; ubiquitin thioesterase 6; ubiquitin-specific-processing protease 6	Human	Sf9 insect cells
	USP6 protein is an ATP-independent isopeptidase with unique deubiquitinase activity that can cleave the C-terminus of ubiquitin and catalyze its own deubiquitination. Notably, it coordinates ARF6 plasma membrane localization and selectively affects ARF6-dependent endocytic protein trafficking. USP6 Protein, Human (sf9, GST) is the recombinant human-derived USP6 protein, expressed by sf9 insect cells , with N-GST labeled tag.

HY-P701445

	USP25 Protein, Human (His) USP25; ubiquitin carboxyl-terminal hydrolase 25; Deubiquitinating enzyme 25; USP on chromosome 21; ubiquitin thioesterase 25; ubiquitin-specific-processing protease 25	Human	E. coli
	The USP25 protein acts as a deubiquitinating enzyme and plays a key role in the hydrolysis of the ubiquitin moiety conjugated to the substrate. This function enables processing of newly synthesized ubiquitin, recycling of ubiquitin molecules, and editing of polyubiquitin chains, thus preventing proteasomal degradation of substrates. USP25 Protein, Human (His) is the recombinant human-derived USP25 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P701410

	USP15 Protein, Human (sf9, GST) USP15; ubiquitin carboxyl-terminal hydrolase 15; Deubiquitinating enzyme 15; ubiquitin thioesterase 15; ubiquitin-specific-processing protease 15; Unph-2; Unph4	Human	Sf9 insect cells
	USP15 is a hydrolase that complexly regulates cellular processes by deubiquitinating various target proteins in pathways such as TGF-β receptor, NF-κ-B, and RNF41/NRDP1-PRKN. In TGF-β signaling, it promotes R-SMAD deubiquitination or stabilizes TGFBR1, thereby enhancing pathway activity. USP15 Protein, Human (sf9, GST) is the recombinant human-derived USP15 protein, expressed by Sf9 insect cells , with N-GST labeled tag.

HY-P703651

	USP8 Protein, Human (sf9) ubiquitin carboxyl-terminal hydrolase 8; Deubiquitinating enzyme 8; ubiquitin isopeptidase Y (hUBPy); ubiquitin thioesterase 8; ubiquitin-specific-processing protease 8; KIAA0055; UBPY	Human	Sf9 insect cells

HY-P703652

	USP8 Protein, Human (sf9, His, GST) ubiquitin carboxyl-terminal hydrolase 8; Deubiquitinating enzyme 8; ubiquitin isopeptidase Y (hUBPy); ubiquitin thioesterase 8; ubiquitin-specific-processing protease 8; KIAA0055; UBPY	Human	Sf9 insect cells

HY-P71182

	OTUB2 Protein, Human (GST) ubiquitin Thioesterase OTUB2; Deubiquitinating Enzyme OTUB2; OTU Comain-Containing ubiquitin Aldehyde-Binding Protein 2; Otubain-2; ubiquitin-specific-Processing protease OTUB2; OTUB2; C14orf137; OTB2; OTU2	Human	E. coli
	OTUB2 is a hydrolase that efficiently removes conjugated ubiquitin from proteins in vitro, implying a crucial role in preventing protein degradation and regulating turnover. Its deubiquitinating activity targets “Lys-11”, “Lys-48” and “Lys-63” linked polyubiquitin chains, with preference for the latter. OTUB2 Protein, Human (GST) is the recombinant human-derived OTUB2 protein, expressed by E. coli , with N-GST labeled tag.

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HY-P80926

	USP7 Antibody (YA657) Deubiquitinating enzyme 7; HAUSP; herpes virus associated; Herpes virus associated ubiquitin specific protease; Herpesvirus-associated ubiquitin-specific protease; TEF 1; tef-1; TEF1; ubiquitin carboxyl terminal hydrolase 7; ubiquitin carboxyl-terminal hy	WB	Human
	USP7 Antibody (YA657) is a non-conjugated and Mouse origined monoclonal antibody about 128 kDa, targeting to USP7 (3E4). It can be used for WB assays with tag free, in the background of Human.

HY-P81738

	OTUB1 Antibody (YA1483) OTUB1; OTB1; OTU1; HSPC263; ubiquitin thioesterase OTUB1; Deubiquitinating enzyme OTUB1; OTU domain-containing ubiquitin aldehyde-binding protein 1; Otubain-1; hOTU1; ubiquitin-specific-processing protease OTUB1	WB, IP	Human, Mouse, Rat
	OTUB1 Antibody (YA1483) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1483), targeting OTUB1, with a predicted molecular weight of 31 kDa (observed band size: 31 kDa). OTUB1 Antibody (YA1483) can be used for WB, IP experiment in human, mouse, rat background.

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