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Results for "

sox2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (3) Apoptosis (4) c-Myc (2) CDK (1) DNA/RNA Synthesis (1) HDAC (2) Histone Acetyltransferase (1) Histone Demethylase (2) MDM-2/p53 (1) mRNA (1) Oct3/4 (4) RAR/RXR (1) Reactive Oxygen Species (ROS) (1) Small Interfering RNA (siRNA) (4) STAT (1) TET Protein (1) YAP (2)
By Research Areas:	Cancer (9) Cardiovascular Disease (3) Inflammation/Immunology (3) Metabolic Disease (1) Neurological Disease (4)
Oligonucleotides:	Rat Pre-designed siRNA Sets (2) Mouse Pre-designed siRNA Sets (1) mRNA (1) Human Pre-designed siRNA Sets (1) siRNAs (4)

Inhibitors & Agonists

Screening Libraries

Natural
Products

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-18772

O4I2	Oct3/4	Others
O4I2 is a potent Oct3/4 inducer. O4I2 induces the expression of pluripotent-associated genes Lin28, Sox2 and Nanog, and suppresses Rex1 .

HY-B1238

Pronethalol 1 Publications Verification (±)-Pronethalo	Adrenergic Receptor	Cardiovascular Disease Neurological Disease
Pronethalol ((±)-Pronethalo) is a non-selective β-adrenergic antagonist. Pronethalol is a potent inhibitor of *Sox2* expression. Pronethalol protects against and to reverse Digitalis-induced ventricular arrhythmias and limits the cerebral arteriovenous malformation (AVMs) ^[2].

HY-RS16652

Sox2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Sox2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sox2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sox2 Mouse Pre-designed siRNA Set A Sox2 Mouse Pre-designed siRNA Set A

HY-RS23087

Sox2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Sox2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sox2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sox2 Rat Pre-designed siRNA Set A Sox2 Rat Pre-designed siRNA Set A

HY-RS13591

SOX2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SOX2 Human Pre-designed siRNA Set A contains three designed siRNAs for SOX2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SOX2 Human Pre-designed siRNA Set A SOX2 Human Pre-designed siRNA Set A

HY-174539

*Human SOX2* mRNA**	mRNA	Neurological Disease
Human SOX2 mRNA encodes the human SRY-box transcription factor 2 (SOX2) protein, a member of the SRY-related HMG-box (SOX) family of transcription factors. SOX2 involves in the regulation of embryonic development and in the determination of cell fate. In addition, SOX2 is also required for stem-cell maintenance in the central nervous system and could regulate gene expression in the stomach.

HY-B1238A

Pronethalol hydrochloride (±)-Pronethalo hydrochloride	Adrenergic Receptor	Cardiovascular Disease Neurological Disease
Pronethalol ((±)-Pronethalo) is a non-selective β-adrenergic antagonist. Pronethalol is a potent inhibitor of *Sox2* expression. Pronethalol protects against and to reverse Digitalis-induced ventricular arrhythmias, and limits the cerebral arteriovenous malformation (AVMs) ^[2].

HY-N15201

Betavulgarin	STAT	Cancer
Betavulgarin is an anticancer agent. Betavulgarin can be isolated from Sugar Beet (Beta vulgaris). Betavulgarin suppresses the proliferation, migration, colony formation, and mammosphere formation of breast cancer cells, and reduces the size of the CD44 ⁺/CD24 ⁻ subpopulation and the expression of the self-renewal- related genes C-Myc, Nanog and Oct4. Betavulgarin promotes BCSCs death through the regulation of Stat3/Sox2 signaling .

HY-143443

DS17701585	Histone Acetyltransferase Histone Demethylase	Cancer
DS17701585 (Compound 11) is a highly selective, orally active EP300 and CBP inhibitor with IC₅₀ values of 0.040, 0.15, 0.45 and 0.70 µM against CBP, EP300, H3K27 and *SOX2*. DS17701585 can be used for cancer research .

HY-B1238R

Pronethalol (Standard)	Adrenergic Receptor	Cardiovascular Disease Neurological Disease
Pronethalol (Standard) is the analytical standard of Pronethalol. This product is intended for research and analytical applications. Pronethalol ((±)-Pronethalo) is a non-selective β-adrenergic antagonist. Pronethalol is a potent inhibitor of Sox2 expression. Pronethalol protects against and to reverse Digitalis-induced ventricular arrhythmias and limits the cerebral arteriovenous malformation (AVMs) ^[2].

HY-168885

ZSH-512	Apoptosis RAR/RXR	Cancer
ZSH-512 is a potent RARγ inhibitor. ZSH-512 shows antiproliferation activity. ZSH-512 induces apoptosis. ZSH-512 decreases CD133, NANOG, SOX2, and EPCAM protein expression. ZSH-512 shows anticancer activity. ZSH-512 has the potential for the research of colorectal cancer .

HY-173076

HDAC11-IN-1	HDAC YAP	Inflammation/Immunology
HDAC11-IN-1 (Compound 14-N ^C6OH) is a selective macrocyclic inhibitor of HDAC11 with a K_i of 40 nM. HDAC11-IN-1 exhibits good cell permeability and can inhibit the expression of YAP1 and *SOX2* .

HY-173076A

HDAC11-IN-1 TFA	HDAC YAP	Inflammation/Immunology
HDAC11-IN-1 (Compound 14-N ^C6OH) TFA is a selective macrocyclic inhibitor of HDAC11 with a K_i of 40 nM. HDAC11-IN-1 TFA exhibits good cell permeability and can inhibit the expression of YAP1 and *SOX2* .

HY-119666

Rooperol	Apoptosis Reactive Oxygen Species (ROS) MDM-2/p53 Oct3/4	Inflammation/Immunology Cancer
Rooperol is a norlignan analog with antitumor, anti-inflammatory, and antioxidant activities. Rooperol induces apoptosis in CSCs through a mitochondrial-induced increase in ROS and a p53-dependent pathway, while also downregulating the expression of key stem cell regulatory factors, such as Oct4, Nanog, and *Sox2*, ultimately exerting its anticancer effects ^[2] .

HY-150082

CP681301	CDK DNA/RNA Synthesis	Cancer
CP681301 is a potent CDK5 inhibitor. CP681301 shows antiproliferative activity. CP681301 decreases the expression of CD133, OLIG2, SOX2, KI67, pCDK5 protein level in GSCs (Glioma stem cells). CP681301 reduces self-renewal in mouse glioma xenografts. CP681301 shows anti-tumor activity in Drosophila .

HY-12303

OAC1 1 Publications Verification	Oct3/4 TET Protein	Cancer
OAC1 is a potent Oct4 activator. OAC1 activates Oct4 and Nanog promoters and enhances induced pluripotent stem cells (iPSC) formation. OAC1 activates OCT4 through upregulation of HOXB4 expression. OAC1 increases transcription of the Oct4-Nanog-Sox2 triad and TET1. OAC1 facilitates the reprogramming of cells by enhancing efficiency and shortening the reprogramming time ^[2].

HY-165606

SB-T-1214	Oct3/4 c-Myc Apoptosis	Cancer
SB-T-1214 (SBT) is a taxane. SB-T-1214 efficiently inhibits expression of stem cell-related genes (Oct4, *Sox2, and c-Myc) and induces apoptosis* of colon cancer spheroids with drug resistant tumorigenic CD133 ⁺/CD44 ⁺ cells. SB-T-1214 strongly represses tumor growth in Pgp+ DLD-1 human colon tumor xenografts mice model. SB-T-1214 can be used for antitumor research, especially against tumors with drug resistance, such as colon, pancreatic and renal cancers ^[2].

HY-175164

SVC112	Apoptosis c-Myc	Cancer
SVC112 is a translation elongation inhibitor that prevents the cyclic dissociation of EF2 from the ribosome, thereby inhibiting the elongation step of translation. SVC112 shows activity in growth inhibition among cancer cell lines of various origins (acute myeloid leukemia (AML), multiple myeloma (Myeloma), colorectal cancer (CRC), and head and neck squamous cell carcinoma (HNSCC)). SVC112 preferentially impedes ribosomal processing of mRNAs, and decreaseds CSC-related proteins including Myc and Sox2. SVC112 induces apoptosis in hematologic cancer cell lines, while phosphorylation of c-Myc correlates with sensitivity to SVC112 in colorectal cancer cell lines. SVC112 inactivates HNSCC stem cells in vitro and prevents the regrowth of HNSCC tumor xenografts in mice. SVC112 can be used for the study of HNSCC ^[2].

HY-RS24311

Qsox1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Qsox1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Qsox1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Qsox1 Rat Pre-designed siRNA Set A Qsox1 Rat Pre-designed siRNA Set A

HY-15313B

CBB1007 hydrochloride	Histone Demethylase	Metabolic Disease Cancer
CBB1007 hydrochloride is a reversible and selective LSD1 inhibitor with an IC₅₀ of 5.27 µM for human LSD1. CBB1007 hydrochloride significantly blocks the demethylase activity of LSD1 on H3K4Me2 and H3K4Me. CBB1007 hydrochloride shows selectivity for LSD1 over LSD2 or JARID1A, and induces differentiation-related genes in pluripotent cells. CBB1007 hydrochloride is studied in non-pluripotent cancer research, targeting teratocarcinoma, embryonic carcinoma, and seminoma ^[2].

Cat. No.	Product Name

HY-L039

Reprogramming Compound Library	2,651 compounds
Techniques for reprogramming somatic cells create new opportunities for drug screening, disease modeling, artificial organ development, and cell therapy. The development of reprogramming techniques has grown exponentially since Yamanaka reprogrammed somatic cells to become induced pluripotent stem cells (iPSCs) using four transcription factors, OCT4, SOX2, KLF4, and c-MYC in 2006. Despite the development of efficient reprogramming methods, most methods are inappropriate for clinical applications because they carry the risk of integrating exogenous genetic factors or use oncogenes. Alternative approaches, such as those based on miRNA, non-viral genes, non-integrative vectors, and small molecules, have been studied as possible solutions to the problems. Among these alternatives, small molecules are attractive options for clinical applications. Reprogramming using small molecules is inexpensive and easy to control in a concentration- and time-dependent manner. It offers a high level of cell permeability, ease of synthesis and standardization, and it is appropriate for mass-producing cells. MCE Reprogramming Compound Library contains a unique collection of 2,651 compounds that act on reprogramming signaling pathways. These compounds are potential stimulators for reprogramming. This library is a useful tool for researching reprogramming and regenerative medicine.

Reprogramming Compound Library

2,651 compounds

Techniques for reprogramming somatic cells create new opportunities for drug screening, disease modeling, artificial organ development, and cell therapy. The development of reprogramming techniques has grown exponentially since Yamanaka reprogrammed somatic cells to become induced pluripotent stem cells (iPSCs) using four transcription factors, OCT4, SOX2, KLF4, and c-MYC in 2006. Despite the development of efficient reprogramming methods, most methods are inappropriate for clinical applications because they carry the risk of integrating exogenous genetic factors or use oncogenes. Alternative approaches, such as those based on miRNA, non-viral genes, non-integrative vectors, and small molecules, have been studied as possible solutions to the problems. Among these alternatives, small molecules are attractive options for clinical applications. Reprogramming using small molecules is inexpensive and easy to control in a concentration- and time-dependent manner. It offers a high level of cell permeability, ease of synthesis and standardization, and it is appropriate for mass-producing cells.

MCE Reprogramming Compound Library contains a unique collection of 2,651 compounds that act on reprogramming signaling pathways. These compounds are potential stimulators for reprogramming. This library is a useful tool for researching reprogramming and regenerative medicine.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N15201

Betavulgarin	Structural Classification Natural Products Terpenoids Source classification Diterpenoids Beta vulgaris Linn. Plants Chenopodiaceae	STAT
Betavulgarin is an anticancer agent. Betavulgarin can be isolated from Sugar Beet (Beta vulgaris). Betavulgarin suppresses the proliferation, migration, colony formation, and mammosphere formation of breast cancer cells, and reduces the size of the CD44 ⁺/CD24 ⁻ subpopulation and the expression of the self-renewal- related genes C-Myc, Nanog and Oct4. Betavulgarin promotes BCSCs death through the regulation of Stat3/Sox2 signaling .

Cat. No.	Compare	Product Name	Species	Source

HY-P701993

	Sox2 Protein, Human sox2; Transcription factor sox-2	Human	E. coli
	Sox2 protein is a key transcription factor that forms a trimeric complex with OCT4 and controls the expression of genes critical for embryonic development (YES1, FGF4, UTF1, ZFP206). It binds the NANOG enhancer and is critical for early embryogenesis and stem cell pluripotency. Sox2 Protein, Human is the recombinant human-derived Sox2 protein, expressed by E. coli , with tag free.

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Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80334

	SOX2 Antibody (YA066) 1 Publications Verification	IHC-P	Human
	SOX2 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 34 kDa, targeting to SOX2. It can be used for IHC-P assays with tag free, in the background of Human.

HY-P85375

	SOX2 Antibody (YA5067) sox2; Transcription factor sox-2	WB, IHC-P, ICC/IF, ELISA	Human
	SOX2 Antibody (YA5067) is a mouse-derived and non-conjugated monoclonal antibody, targeting to SOX-2. It can be applicated for WB, IHC-P, ICC/IF, ELISA assays, in the background of human.

HY-P84348

	SOX2 Antibody (YA4045) ANOP3; MCOPS3	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat, Rabbit, Monkey
	SOX2 Antibody (YA4045) is a mouse-derived and non-conjugated IgG1 antibody, targeting to SOX2. It can be applicated for WB, IHC-P, ICC/IF, FC, ELISA assays, in the background of human, mouse, rat, rabbit, monkey.