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Results for "

slow

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Acyltransferase (2) Adenosine Receptor (2) Adenylate Cyclase (1) Adrenergic Receptor (4) Akt (3) Aminopeptidase (2) AMPK (2) Amyloid-β (9) Anaplastic lymphoma kinase (ALK) (1) Androgen Receptor (1) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (2) Apoptosis (12) Aquaporin (2) Arginase (4) Atg7 (2) Atg8/LC3 (2) Autophagy (3) Bacterial (16) Beta-secretase (1) Biochemical Assay Reagents (15) Calcium Channel (17) CaMK (2) Cannabinoid Receptor (2) Cathepsin (1) CD38 (2) CDK (1) CFTR (3) Chloride Channel (2) Cholecystokinin Receptor (1) Cholinesterase (ChE) (4) COX (2) DNA/RNA Synthesis (5) Drug Derivative (1) Drug Isomer (1) Drug Metabolite (5) E1/E2/E3 Enzyme (1) Elastase (1) Endogenous Metabolite (19) Enteropeptidase (2) ERK (2) Estrogen Receptor/ERR (1) FAAH (1) FAK (1) Ferroptosis (2) Fluorescent Dye (2) Furin (1) GABA Receptor (11) GCGR (1) GLP Receptor (1) Glutaminase (1) Glutathione Peroxidase (2) Glycosidase (1) HCN Channel (3) HDAC (4) Herbicide (3) Histone Acetyltransferase (3) Histone Demethylase (5) Histone Methyltransferase (1) HSP (3) HSV (1) iGluR (3) Insecticide (1) Integrin (1) Interleukin Related (3) Isotope-Labeled Compounds (13) JNK (2) Lactate Dehydrogenase (1) Leukotriene Receptor (1) Lipase (1) Lipoxygenase (1) LPL Receptor (1) mAChR (3) MAGL (1) MDM-2/p53 (1) Mitosis (1) MMP (2) Monoamine Oxidase (1) Monoamine Transporter (1) Myosin (1) nAChR (3) Neprilysin (1) NF-κB (3) NO Synthase (4) Nucleoside Antimetabolite/Analog (2) Opioid Receptor (3) Orphan Receptor (1) Parasite (3) PCSK9 (1) Peptide-Drug Conjugates (PDCs) (1) Phosphatase (1) Phosphodiesterase (PDE) (1) Phospholipase (2) Potassium Channel (11) Prolyl Endopeptidase (PREP) (1) Prostaglandin Receptor (4) Reactive Oxygen Species (ROS) (1) Reference Standards (19) Renin (1) SARS-CoV (1) Sodium Channel (10) STAT (2) Stearoyl-CoA Desaturase (SCD) (1) TGF-beta/Smad (1) Thyroid Hormone Receptor (1) Tyrosinase (2) VD/VDR (1) VEGFR (1) Wnt (2) YAP (3) α-synuclein (1)
By Research Areas:	Cancer (58) Cardiovascular Disease (50) Endocrinology (9) Infection (13) Inflammation/Immunology (32) Metabolic Disease (17) Neurological Disease (68)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Fillers (1) Aptamers (1) Polymers (10) Cholesterol (1)

240

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

MCE Kits

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

L-364,373 R-L3	Potassium Channel	Cardiovascular Disease
L-364,373 (R-L3) is a voltage-gated Kv7.1 (KCNQ1)/mink channels activator. L-364,373 activates Iks (slow delayed rectifier potassium current) and shortens action potential duration in guinea pig cardiac myocytes, and suppresses early afterdepolarizations in rabbit ventricular myocytes .

ONO-0300302	LPL Receptor	Endocrinology Cancer
ONO-0300302 is an orally active and potent LPA1 (lysophosphatidic acid receptor 1) antagonist, with an IC₅₀ of 0.086 μM. ONO-0300302 is a slow tight binding inhibitor, and its binding affinity increases with time, with K_d of 0.34 nM (37 °C, 2 h). ONO-0300302 can be used for benign prostatic hyperplasia (BPH) research .

Diltiazem hydrochloride 5+ Cited Publications CRD-401	Calcium Channel	Cardiovascular Disease Cancer
Diltiazem hydrochloride is a Ca ²⁺ influx inhibitor (slow channel blocker or calcium antagonist).

Bicuculline Maximum Cited Publications 27 Publications Verification (+)-Bicuculline	GABA Receptor	Neurological Disease
Bicuculline ((+)-Bicuculline) is A competing neurotransmitter GABA_A receptor antagonist (IC₅₀=2 μM). Bicuculline also blocks Ca ²⁺ activating potassium (SK) channels and subsequently blocks slow post-hyperpolarization (slow AHP). Bicuculline has anticonvulsant activity. Bicuculline can be used to induce seizures in mice .

(BrMT)2	Potassium Channel	Others
(BrMT)2 (compound 2) is a non-peptide snail toxin that slows down the activation of Kv1.1 channels .

(-)-Chromanol 293B	Potassium Channel	Cardiovascular Disease
(-)-Chromanol 293B is a potent and selective inhibitor of the slow component of delayed rectifier K ⁺ current (IKs). (-)-Chromanol 293B can be used for the research of antiarrhythmic .

Telenzepine	mAChR	Neurological Disease
Telenzepine is an antimuscarinic agent with Kis of 0.94 nM (M1 mAChR) and 17.8 nM (M2 mAChR) binding to muscarinic receptors. Telenzepine effectively blocks synaptic transmission promoted by muscarinic or M1 receptor agonists. Thus, Telenzepine can reduce the amplitude of extracellular slow excitatory postsynaptic potentials (EC50=38 nM) and slow inhibitory postsynaptic potentials (EC50=253 nM) .

Tribenuron	Herbicide	Others
Tribenuron, a slow acting sulfonylurea herbicide, controls broadleaf weed .

Oxonol V	Fluorescent Dye	Others
Oxonol V is a slow-response sensitive probe for measuring cellular membrane potential.

Etripamil hydrochloride MSP-2017 hydrochloride; (-)-MSP-2017 hydrochloride	Calcium Channel	Neurological Disease
Etripamil (MSP-2017) hydrochloride is a short-acting, L-type calcium channel antagonist that can be used in the study of paroxysmal supraventricular tachycardia (PSVT). Etripamil hydrochloride inhibits calcium influx through slow calcium channels, thereby slowing atrioventricular node conduction and prolonging the atrioventricular node refractory period.

Phthalylsulfacetamide	Bacterial	Infection
Phthalylsulfacetamide is a sulfa drug, after oral administration, slowly decompose in the intestine,and release sulfacetamide ,generating antibacterial effect.

Ketoprofen L-thyroxine ester	COX	Metabolic Disease
Ketoprofen L-thyroxine ester is a prodrug of Ketoprofen. Ketoprofen L-thyroxine ester reservoir and release ketoprofen slowly in the brain .

Amastatin	Aminopeptidase	Others
Amastatin is A slow, tightly bound, competitive inhibitor of aminopeptidase (AP) with an IC₅₀ of 0.54 μg/mL for AP-A .

AChE-IN-28	Cholinesterase (ChE)	Neurological Disease
AChE-IN-28 (Compound 2h) is a selective slow-binding inhibitor of acetylcholinesterase with an IC₅₀ of 0.2 nM .

Disobutamide SC-31828	Others	Cardiovascular Disease
Disobutamide is an antianhythmic agent. Disobutamide slows conduction throughout the atrioventricular conduction system of the isolated perfused rabbit heart .

(Glu20)-Amyloid β-Protein (1-42)	Amyloid-β	Neurological Disease
(Glu20)-Amyloid β-Protein (1-42) is a slower fibrillizing variant of amyloid β-protein (Aβ). The Glu20 mutation reduces the aggregation propensity of Aβ42 and prevents accumulation of the slowly fibrillizing peptide. Amyloid β-protein is the primary component of both vascular and parenchymal amyloid deposits in Alzheimer's disease .

Photoregulin1	Orphan Receptor	Others
Photoregulin1 is a compound with the potential to inhibit retinitis pigmentosa that modulates gene expression in retinal cells and slows the degeneration of photoreceptors in a mouse model.

Procaine 1 Publications Verification	Histone Demethylase DNA/RNA Synthesis Bacterial	Neurological Disease Cancer
Procaine is a DNA-demethylating agent. Procaine acts through multiple targets and has a slow onset and a short duration of action .

Procaine hydrochloride 1 Publications Verification	Histone Demethylase DNA/RNA Synthesis Bacterial	Neurological Disease Cancer
Procaine hydrochloride is a DNA-demethylating agent. Procaine hydrochloride acts through multiple targets and has a slow onset and a short duration of action .

4-Hydroxybenzamide	Others	Cardiovascular Disease
4-Hydroxybenzamide, found in the herb of Berberis pruinosa, is a known natural product that has potential to slow down the progression of atherosclerosis .

Leritrelvir RAY1216	SARS-CoV	Infection
Leritrelvir (RAY1216) is an orally active SARS-CoV-2 main protease slow-tight inhibitor with a K_i of 8.6 nM .

PDE10-IN-6	Phosphodiesterase (PDE)	Others
PDE10-IN-6 is a phosphodiesterase-10 inhibitor that inhibits the breakdown of cAMP and cGMP, thereby slowing or halting their hydrolysis.

Etripamil MSP-2017; (-)-MSP-2017	Calcium Channel	Cardiovascular Disease
Etripamil (MSP-2017) is a short-acting, L-type calcium-channel antagonist. Etripamil inhibits calcium influx through slow calcium channels, thereby slowing AV node conduction and prolonging the AV node refractory period. Etripamil increases heart rate and decreases systolic blood pressure. Etripamil can be used in the study of paroxysmal supraventricular tachycardia (PSVT) .

β-Pompilidotoxin β-PMTX	Sodium Channel	Neurological Disease
β-Pompilidotoxin (β-PMTX), a wasp venom, can slow sodium channel inactivation and increases steady-state sodium current in cells .

Bicuculline (Standard) (+)-Bicuculline (Standard)	Reference Standards GABA Receptor	Neurological Disease
Bicuculline (Standard) is the analytical standard of Bicuculline. This product is intended for research and analytical applications. Bicuculline ((+)-Bicuculline) is A competing neurotransmitter GABAA receptor antagonist (IC₅₀=2 μM). Bicuculline also blocks Ca2+ activating potassium (SK) channels and subsequently blocks slow post-hyperpolarization (slow AHP). Bicuculline has anticonvulsant activity. Bicuculline can be used to induce seizures in mice .

Ara-F-NAD+ sodium	CD38	Neurological Disease
Ara-F-NAD+ sodium is an arabino analogue of NAD ⁺. Ara-F-NAD+ sodium is a potent, reversible and slow-binding CD38 NADase inhibitor .

Ara-F-NAD+	CD38	Neurological Disease
Ara-F-NAD+ is an arabino analogue of NAD ⁺. Ara-F-NAD+ is a potent, reversible and slow-binding CD38 NADase inhibitor .

BEC hydrochloride 1 Publications Verification	Arginase	Metabolic Disease
BEC hydrochloride is a slow-binding and competitive Arginase II inhibitor with K_i of 0.31 μM and 30 nM at pH 7.5 and pH 9.5, respectively .

DETA NONOate 5 Publications Verification Diethylamine NONOate; NOC-18	NO Synthase	Cardiovascular Disease
DETA NONOate (NOC 18) is an exogenous nitric oxide (NO) donor. DETA NONOate shows a slow release normal amounts of NO and long-acting .

Diltiazem hydrochloride (Standard) CRD-401 (Standard)	Reference Standards Calcium Channel	Cardiovascular Disease Cancer
Diltiazem (hydrochloride) (Standard) is the analytical standard of Diltiazem (hydrochloride). This product is intended for research and analytical applications. Diltiazem hydrochloride is a Ca ²⁺ influx inhibitor (slow channel blocker or calcium antagonist).

Diltiazem-d3 hydrochloride	Calcium Channel	Cardiovascular Disease
Diltiazem-d₃ (hydrochloride) is the deuterium labeled Diltiazem hydrochloride. Diltiazem hydrochloride is a Ca2+ influx inhibitor (slow channel blocker or calcium antagonist)[1][2].

MRS8247	Adenosine Receptor	Others
MRS8247 is a positive allosteric modulator (PAM) of the A3 adenosine receptor (A3AR) that can also slow the dissociation rate of agonists .

GW-597901	Adrenergic Receptor	Others
GW-597901 is a compound with bronchodilator activity that has a stronger bronchodilator effect than salbutamol in a human lung reperfusion model, but with a slightly slower onset of action.

β-Pompilidotoxin TFA β-PMTX TFA	Sodium Channel	Neurological Disease
β-Pompilidotoxin TFA (β-PMTX TFA), a wasp venom, can slow sodium channel inactivation and increases steady-state sodium current in cells .

Resinacein L	Glycosidase	Metabolic Disease
Resinacein L is an inhibitor for α-glucosidase with an IC₅₀ of 0.635 mM. Resinacein L slows down the digestion and absorption of carbohydrates, thereby decreasing postprandial blood glucose .

Clidinium bromide Ro 2-3773	mAChR	Neurological Disease
Clidinium bromide is a quaternary amine antimuscarinic agent. Clidinium bromide may help symptoms of cramping and abdominal/stomach pain by decreasing stomach acid, and slowing the intestines in vivo .

HC-056456 2 Publications Verification 3,4-Bis(2-thienoyl)-1,2,5-oxadiazole-N-oxide	Calcium Channel	Others
HC-056456 is an effective but not perfectly-selective blocker of CatSper channels. The [Na ⁺]_i rise is slowed by HC-056456 (IC₅₀~3 µM).

Amastatin hydrochloride 1 Publications Verification	Aminopeptidase Bacterial	Infection
Amastatin hydrochloride is a slow, tight binding, competitive aminopeptidase (AP) inhibitor with K_i values of 0.26 nM, 30 nM, 52 nM for Aeromonas aminopeptidase, cytosolic leucine aminopeptidase, microsomal aminopeptidase .

LY2828360	Cannabinoid Receptor	Neurological Disease
LY2828360 is a slowly acting but efficacious G protein-biased cannabinoid (CB₂) agonist, inhibiting cAMP accumulation and activating ERK1/2 signaling.

Diltiazem-(acetoxy-d3) hydrochloride	Isotope-Labeled Compounds Calcium Channel	Cardiovascular Disease
Diltiazem-(acetoxy-d₃) (hydrochloride) is the deuterium labeled Diltiazem hydrochloride. Diltiazem hydrochloride is a Ca2+ influx inhibitor (slow channel blocker or calcium antagonist)[1][2].

FFAGLDD	MMP	Cancer
FFAGLDD is MMP9 selective cleavage peptides, which used for cytosolic delivery of Doxorubi-cin (DOX) and achieve temporally and spatially controlled slow drug delivery and release .

EGTA-AM 5+ Cited Publications EGTA Acetoxymethyl ester	Biochemical Assay Reagents	Neurological Disease
EGTA-AM is a membrane permeable form of EGTA, can be passively loaded into cells to generate intracellular EGTA; EGTA-AM is also a Ca ²⁺ chelator with slow chelating dynamics.

Sut-8701	Cholecystokinin Receptor	Neurological Disease
Sut-8701 is a Cholecystokinin (HY-P2932) analog that effectively slows the degenerative process of Alzheimer's disease by protecting the integrity of cholinergic neurons in the nucleus basalis .

H-Pro-Hyp-OH	Biochemical Assay Reagents	Others
H-Pro-Hyp-OH is a collagen peptide composed of proline (Pro) and hydroxyproline (Hyp). H-Pro-Hyp-OH can be used in research on slowing down facial aging .

FFAGLDD TFA	MMP	Cancer
FFAGLDD TFA is MMP9 selective cleavage peptides, which used for cytosolic delivery of Doxorubi-cin (DOX) and achieve temporally and spatially controlled slow drug delivery and release .

2,3-Dimethylethcathinone hydrochloride 2,3-Dmec hydrochloride	Drug Derivative	Neurological Disease
2,3-Dimethylethcathinone (2,3-Dmec) hydrochloride, a cathinone, is an analog of Ethcathinone. Ethcathinone increases the peak dopamine efflux after electrical stimulation and slows dopamine reuptake in rats .

Cat. No.	Product Name

HY-L117

Calcium Channel Blocker Library

177 compounds

Calcium channel blockers (CCBs), also called calcium antagonists are compounds that slow the movement of calcium (Ca2+) through calcium channels into the cells of the heart and blood vessel walls. Calcium causes the heart and arteries to squeeze more strongly. By blocking calcium, calcium channel blockers allow blood vessels to relax and open. So calcium channel blockers are usually used to lower blood pressure, relieve chest pain (angina) and control an irregular heartbeat.

MCE supplies a unique collection of 177 calcium channel blockers and antagonists, all of which have the identified inhibitory effect on calcium channel. MCE Calcium Channel Blocker Library is a useful tool for discovery of antihypertensive drugs and cardiovascular disease research.

HY-L085

Anti-Parkinson's Disease Compound Library

1,725 compounds

Parkinson’s disease (PD), the second most common age-associated neurodegenerative disorder, is characterized by the loss of dopaminergic (DA) neurons and the presence of α-synuclein-containing aggregates in the substantia nigra pars compacta (SNpc). Motor features such as tremor, rigidity, bradykinesia and postural instability are common traits of PD. To date, there is no treatment to stop or at least slow down the progression of the disease. The etiology and pathogenesis of PD is still elusive, however, a large body of evidence suggests a prominent role of oxidative stress, inflammation, apoptosis, mitochondrial dysfunction and proteasome dysfunction in the pathogenesis of PD.

MCE offers a unique collection of 1,725 compounds with anti- Parkinson’s Disease activities or targeting the unique targets of PD. MCE Anti- Parkinson's Disease Compound Library is a useful tool for exploring the mechanism of PD and discovering new drugs for PD.

HY-L070

Neuroprotective Compound Library

1,471 compounds

Neurodegenerative diseases are characterised by progressive dysfunction and death of neurons, such as Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis (MS). Neuroprotection is an approach to preserve neurons so that neurons cannot be hurt by different pathological factors in neurodegenerative diseases. Neuroprotectors are some agonists and antagonists targeting some key targets in neuroprotactive signal pathways, such as calcium and sodium channel blockers, GABA receptor agonists, NMDA receptor Antagonists, etc. Current neuroprotectors cannot reverse existing damage, but they may protect against further nerve damage and slow down any degeneration of the central nervous system (CNS) and still play important roles in the treatment of neurodegenerative diseases.

MCE offers a unique collection of 1,471 compounds with potential neuroprotective activities. These compounds mainly act on some key targets in neuroprotetive signal pathways, such as calcium channel, sodium channel, adenosine A1 receptor, etc. MCE Neuroprotective Compopund Library is a useful tool in neuroprotective drug discovery.

Cat. No.	Product Name	Type

HY-130210

Oxonol V	Fluorescent Dyes/Probes
Oxonol V is a slow-response sensitive probe for measuring cellular membrane potential.

HY-W440303

1,1',3,3,3',3'-Hexamethylindotricarbocyanine perchlorate HITC	Fluorescent Dyes/Probes
1,1',3,3,3',3'-Hexamethylindotricarbocyanine perchlorate (HITC) is a long-wavelength, membrane-potential sensitive dye. It is a slow-response potentiometric fluorophore and has also been used as a laser dye for infrared lasers.

Cat. No.	Product Name	Type

HY-D0973

EGTA-AM 5+ Cited Publications EGTA Acetoxymethyl ester	Chelators
EGTA-AM is a membrane permeable form of EGTA, can be passively loaded into cells to generate intracellular EGTA; EGTA-AM is also a Ca ²⁺ chelator with slow chelating dynamics.

HY-W012898

Dimethylglyoxime Biacetyl dioxime	Biochemical Assay Reagents
Dimethylglyoxime (Biacetyl dioxime) belongs to the class of oximes and consists of two acetyl groups attached to a nitrogen atom, which in turn is attached to another nitrogen atom through a diimine bond. Dimethylglyoxime is a specific chelator of Ni that inhibits or slows the aggregation of Aβ peptides in vitro .

HY-Y0669R

Pipecolic acid (Standard)

Cell Assay Reagents

Pipecolic acid (Standard) is the analytical standard of Pipecolic acid. This product is intended for research and analytical applications. Pipecolic acid is a metabolite of lysine and an important precursor for many useful microbial secondary metabolites. Pipecolic acid slows ferroptosis in diabetic retinopathy by inhibiting the YAP-GPX4 signaling pathway. In addition, Pipecolic acid can be used as a diagnostic marker for pyridoxine-dependent epilepsy .

HY-155918

mPEG-CHO (MW 1000)

mPEG-Aldehyde (MW 1000)

Drug Delivery

mPEG-CHO (MW 1000) participates in the formation of a three-dimensional porous scaffold that carries active substances to form a delivery vehicle. The -CHO functional group interacts with the -NH2 functional group of the chitosan chain to form a glutaraldehyde-type adduct to functionalize mPEG. This functionalization and cross-linking can affect the rigidity of the delivery system, allowing slow release of the cross-linked conjugate system.

HY-155921

mPEG-CHO (MW 5000)

mPEG-Aldehyde (MW 5000)

Drug Delivery

mPEG-CHO (MW 5000) participates in the formation of a three-dimensional porous scaffold which carries active substances to form a delivery vehicle. The -CHO functional group interacts with the -NH2 functional group of the chitosan chain to form a glutaraldehyde-type adduct to functionalize mPEG. This functionalization and cross-linking can affect the rigidity of the delivery system, allowing slow release of the cross-linked conjugate system.

HY-155920

mPEG-CHO (MW 3400)

mPEG-Aldehyde (MW 3400)

Drug Delivery

mPEG-CHO (MW 3400) participates in the formation of a three-dimensional porous scaffold which carries active substances to form a delivery vehicle. The -CHO functional group interacts with the -NH2 functional group of the chitosan chain to form a glutaraldehyde-type adduct to functionalize mPEG. This functionalization and cross-linking can affect the rigidity of the delivery system, allowing slow release of the cross-linked conjugate system.

HY-155917

mPEG-CHO (MW 750)

mPEG-Aldehyde (MW 750)

Drug Delivery

mPEG-CHO (MW 750) participates in the formation of a three-dimensional porous scaffold which carries active substances to form a delivery vehicle. The -CHO functional group interacts with the -NH2 functional group of the chitosan chain to form a glutaraldehyde-type adduct to functionalize mPEG. This functionalization and cross-linking can affect the rigidity of the delivery system, allowing slow release of the cross-linked conjugate system.

HY-155922

mPEG-CHO (MW 10000)

mPEG-Aldehyde (MW 10000)

Drug Delivery

mPEG-CHO (MW 10000) participates in the formation of a three-dimensional porous scaffold which carries active substances to form a delivery vehicle. The -CHO functional group interacts with the -NH2 functional group of the chitosan chain to form a glutaraldehyde-type adduct to functionalize mPEG. This functionalization and cross-linking can affect the rigidity of the delivery system, allowing slow release of the cross-linked conjugate system.

HY-155916

mPEG-CHO (MW 550)

mPEG-Aldehyde (MW 550)

Drug Delivery

mPEG-CHO (MW 550) participates in the formation of a three-dimensional porous scaffold which carries active substances to form a delivery vehicle. The -CHO functional group interacts with the -NH2 functional group of the chitosan chain to form a glutaraldehyde-type adduct to functionalize mPEG. This functionalization and cross-linking can affect the rigidity of the delivery system, allowing slow release of the cross-linked conjugate system.

HY-155923

mPEG-CHO (MW 20000)

mPEG-Aldehyde (MW 20000)

Drug Delivery

mPEG-CHO (MW 20000) participates in the formation of a three-dimensional porous scaffold which carries active substances to form a delivery vehicle. The -CHO functional group interacts with the -NH2 functional group of the chitosan chain to form a glutaraldehyde-type adduct to functionalize mPEG. This functionalization and cross-linking can affect the rigidity of the delivery system, allowing slow release of the cross-linked conjugate system.

HY-155919

mPEG-CHO (MW 2000)

mPEG-Aldehyde (MW 2000)

Drug Delivery

mPEG-CHO (MW 2000) participates in the formation of a three-dimensional porous scaffold which carries active substances to form a delivery vehicle. The -CHO functional group interacts with the -NH2 functional group of the chitosan chain to form a glutaraldehyde-type adduct to functionalize mPEG. This functionalization and cross-linking can affect the rigidity of the delivery system, allowing slow release of the cross-linked conjugate system.

HY-155915

mPEG-CHO (MW 350)

mPEG-Aldehyde (MW 350)

Drug Delivery

mPEG-CHO (MW 350) participates in the formation of a three-dimensional porous scaffold which carries active substances to form a delivery vehicle. The -CHO functional group interacts with the -NH2 functional group of the chitosan chain to form a glutaraldehyde-type adduct to functionalize mPEG. This functionalization and cross-linking can affect the rigidity of the delivery system, allowing slow release of the cross-linked conjugate system.

HY-131384

8,11,14-Eicosatriynoic acid

8,11,14-Icosatriynoic acid

Biochemical Assay Reagents

8,11,14-Eicosatriynoic Acid, as an inhibitor of prostaglandin, leukotriene biosynthesis, and arachidonic acid-induced platelet aggregation, blocks human 12-lipoxygenase (12-LO), cyclooxygenase (COX)and 5-lipoxygenase (5-LO) with IC50 values of 0.46 μM, 14 μMand 25 μM, respectively. In addition, 8,11,14-Eicosatriynoic Acid inhibits the action of slow-reacting substances of allergic reactions, with IC50 value of 10 μM. Lipoxygenase is widely found in fungi, plants and animals. 12-LO involves in many important disease states and may play a role in oxidative glutamate toxicity. COX enzymes play complex roles in human physiology and pathology involving the neuronal, immune, renal, cardiovascular, gastrointestinal and reproductive systems. COX enzymes are blocked by aspirin and a variety of other NSAIDs, which makes them clinically important. 5-LO involves in cancer pathology. It is expressed by a variety of cancer cells, including colon, lung, breast, and prostate cancers, and promotes cancer cell growth and neovascularization . 8,11,14-Eicosatriynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Product Name	Target	Research Area

HY-P1084

β-Pompilidotoxin β-PMTX	Sodium Channel	Neurological Disease
β-Pompilidotoxin (β-PMTX), a wasp venom, can slow sodium channel inactivation and increases steady-state sodium current in cells .

HY-W337672

H-Pro-Hyp-OH	Biochemical Assay Reagents	Others
H-Pro-Hyp-OH is a collagen peptide composed of proline (Pro) and hydroxyproline (Hyp). H-Pro-Hyp-OH can be used in research on slowing down facial aging .

HY-P3846

(Glu20)-Amyloid β-Protein (1-42)	Amyloid-β	Neurological Disease
(Glu20)-Amyloid β-Protein (1-42) is a slower fibrillizing variant of amyloid β-protein (Aβ). The Glu20 mutation reduces the aggregation propensity of Aβ42 and prevents accumulation of the slowly fibrillizing peptide. Amyloid β-protein is the primary component of both vascular and parenchymal amyloid deposits in Alzheimer's disease .

HY-P1084A

β-Pompilidotoxin TFA β-PMTX TFA	Sodium Channel	Neurological Disease
β-Pompilidotoxin TFA (β-PMTX TFA), a wasp venom, can slow sodium channel inactivation and increases steady-state sodium current in cells .

HY-P2004

FFAGLDD	MMP	Cancer
FFAGLDD is MMP9 selective cleavage peptides, which used for cytosolic delivery of Doxorubi-cin (DOX) and achieve temporally and spatially controlled slow drug delivery and release .

HY-P2004A

FFAGLDD TFA	MMP	Cancer
FFAGLDD TFA is MMP9 selective cleavage peptides, which used for cytosolic delivery of Doxorubi-cin (DOX) and achieve temporally and spatially controlled slow drug delivery and release .

HY-P5833

κ-Bungarotoxin κ-Bgt	nAChR	Neurological Disease
κ-Bungarotoxin (κ-Bgt) is a potent, selective, and slowly reversible antagonist of α3β2 neuronal nicotinic acetylcholine receptors with an IC₅₀ of 2.30 nM .

HY-P5772

Jingzhaotoxin-II	Sodium Channel	Neurological Disease
Jingzhaotoxin-II, a 32 amino acid residues including two acidic and two basic residues, is a neurotoxin. Jingzhaotoxin-II inhibits voltage-gated sodium channels (VGSC) that significantly slows rapid inactivation of TTX-resistant (TTX-R) VGSC on cardiac myocytes with the IC₅₀ of 0.26 μM .

HY-P5872

Jingzhaotoxin XI JZTX-XI	Sodium Channel	Neurological Disease
Jingzhaotoxin XI (JZTX-XI) is a sodium conductance inhibitor with an IC₅₀ of 124 nM. Jingzhaotoxin XI slows the fast inactivation (EC₅₀=1.18±0.2 μM) of Na_v1.5 expressed in Chinese hamster ovary (CHO-K1) cells .

HY-P1833

Egg Laying Hormone, aplysia	Peptides	Neurological Disease
Egg Laying Hormone, aplysia is a neuropeptide synthesized by the bag cell neurons, which contains 36 amino acids and can stimulate egglaying and ovulation in Aplysia via electrical discharge triggering of neurons. Egg-laying hormone of Aplysia induces a voltage-dependent slow inward current carried by Na' in an identified motoneuron .

HY-P10018

Bamadutide SAR425899	GLP Receptor GCGR	Metabolic Disease
Bamadutide (SAR425899) is a potent dual glucagon-like peptide-1 receptor/glucagon receptor (GLP-1R/GCGR) agonist. Bamadutide improves post-meal blood glucose control by significantly enhancing β-cell function and slowing down the rate of glucose absorption in the body. Bamadutide can be used for the research of metabolic diseases such as type 2 diabetes .

HY-P4886A

Amyloid β-Protein (3-42) TFA	Amyloid-β	Neurological Disease
Amyloid β-Protein (3-42) TFA is a precursor of Pyr peptide. Pyroglutamic acid-modified Aβ (pEAβ) (3-42) is the core of the amyloid plaque in Alzheimer's disease. pEAβ (3-42) accelerates the aggregation of Aβ(1-42), while Aβ(1-42) significantly slows down the primary and secondary nucleation of pEAβ(3-42).

HY-P4886

Amyloid β-Protein (3-42)	Amyloid-β	Neurological Disease
Amyloid β-Protein (3-42) is the precursor of Pyr peptide. Pyroglutamate-modified Aβ (pEAβ) (3-42) is the core of the amyloid template block in Alzheimer's disease. pEAβ(3-42) accelerated the aggregation of Aβ(1-42), while Aβ(1-42) significantly slowed the primary and secondary nucleation of pEAβ(3-42) .

HY-P10783

BGC0222	Peptide-Drug Conjugates (PDCs) Integrin	Cancer
BGC0222 is a novel prodrug of Irinotecan (HY-16562). BGC0222, as a PEG-cRGD-conjugated Irinotecan (HY-16562) derivative, could slowly and steadily release Irinotecan (HY-16562). BGC0222 binds to α_Vβ₃ with IC₅₀ values of 4.25 μM (α_Vβ₃) and 58.7 μM (α_Vβ₅). BGC0222 possesses the property of inducing neovascularization. BGC0222 exhibits good antiproliferation activity in many tumors .

Cat. No.	Product Name

HY-K1048

AntiFade Reagent (with DAPI) 4 Publications Verification
AntiFade Reagent (with DAPI) is used to slow the fluorescence quenching.

HY-K1047

AntiFade Mounting Medium (with DAPI) 3 Publications Verification
AntiFade Mounting Medium (with DAPI) is a sealing reagent used to slow the fluorescence quenching.

HY-K1042

AntiFade Mounting Medium Maximum Cited Publications 11 Publications Verification
MCE AntiFade Mounting Medium can slow the fluorescence quenching of various common fluorescent dyes with simple operation and good anti-fluorescence quenching effect.

HY-E0001

Cooling Rack
MCE^® Cooling Rack can be used to prevent enzymes from becoming inactive as well as for PCR sample preparation, sample transport, and to slow thawing of frozen samples throughout your entire lab workflow.

HY-KE8005

T7 Endonuclease I
T7 Endonuclease I can recognize and cleave incompletely paired DNA, cruciform structure DNA, Holliday structure or crossover DNA, heterologous double-stranded DNA, or cleave nicked double-stranded DNA at a slower rate.

Cat. No.	Product Name	Target	Research Area

HY-P99935

Elarekibep PRS-060; AZD1402	Inhibitory Antibodies	Inflammation/Immunology
Elarekibep (PRS-060) (AZD1402) is a high affinity, slowly dissociating, long-acting full antagonist of IL-4Ra. Elarekibep can be used for the research of T2 endotype asthma .

HY-P9951A

Ranibizumab (anti-VEGF) 1 Publications Verification RG-6321 (anti-VEGF)	VEGFR	Cardiovascular Disease
Ranibizumab (RG-6321) (anti-VEGF) is a humanized anti-VEGF monoclonal antibody fragment and can recognize all VEGF-A isoforms (VEGF110, VEGF121, and VEGF165) . Ranibizumab (anti-VEGF) slows vision loss in vivo and is used for wet age-related macular degeneration (AMD) research .

Species:	Human (2)
Tag:	His (1) Avi (1) Flag (1)
Source:	Sf9 insect cells (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P72094

	ATP2A2 Protein, Human (His) Atp2a2; ATP2B; ATPase Ca++ transporting cardiac muscle slow twitch 2; Calcium pump 2; ATPase 2	Human	E. coli
	The ATP2A2 protein is a magnesium-dependent enzyme that hydrolyzes ATP and transfers calcium from the cytoplasm to the sarcoplasmic reticulum. It participates in autophagy during starvation and interacts with VMP1 to achieve ER isolating membrane contact. ATP2A2 Protein, Human (His) is the recombinant human-derived ATP2A2 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P702762

	NTRK1/TrkA-I Protein, Human (Biotinylated, sf9, Flag, Avi) High affinity nerve growth factor receptor; Neurotrophic tyrosine kinase receptor type 1; NTRK-1; NTRK1; slow nerve growth factor receptor; p140-TrkA; Trk-A; Trk; Trka; TRK1-transforming tyrosine kinase protein; TRKAOncogene TRK; TRKTRK1; tyrosine kinase receptor A	Human	Sf9 insect cells
	TrkA protein is an important receptor tyrosine kinase that regulates the development of the central and peripheral nervous systems and affects the proliferation, differentiation, and survival of neurons. As a high-affinity receptor for NGF, TrkA is activated upon NGF binding through homodimerization and autophosphorylation. NTRK1/TrkA-I Protein, Human (Biotinylated, sf9, Flag, Avi) is the recombinant human-derived NTRK1/TrkA-I, expressed by Sf9 insect cells , with Avi, Flag labeled tag. ,

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HY-P87094

	Slow Skeletal Myosin Heavy chain Antibody (YA6787) Beta myosin heavy chain antibody; cardiac muscle beta isoform antibody; CMD1S antibody; CMH1 antibody; MPD1 antibody; MYH7 antibody; MYH7_HUMAN antibody; Myhc slow antibody; MyHC-beta antibody; MyHC-slow antibody; Beta myosin heavy chain antibody; cardiac muscle beta isoform antibody; CMD1S antibody; CMH1 antibody; MPD1 antibody; MYH7 antibody; MYH7_HUMAN antibody; Myhc slow antibody; MyHC-beta antibody; MyHC-slow antibody; MYHCB antibody; Myopathy, distal 1 antibody; Myosin heavy chain (AA 1-96) antibody; Myosin heavy chain 7 antibody; Myosin heavy chain antibody; Myosin heavy chain slow isoform antibody; Myosin heavy chain, cardiac muscle beta isoform antibody; Myosin, heavy chain 7, cardiac muscle, beta antibody; Myosin, heavy polypeptide 7, cardiac muscle, beta antibody; Myosin-7 antibody; Rhabdomyosarcoma antigen MU RMS 40.7A antibody; SPMD antibody; SPMM antibody	WB, IHC-P, IF-Tissue, IHC-F	Human, Mouse, Rat

HY-P85290

	MYL3 Antibody (YA4982) MYL3; Myosin light chain 3; Cardiac myosin light chain 1; CMLC1; Myosin light chain 1; slow-twitch muscle B/ventricular isoform; MLC1SB; Ventricular/slow twitch myosin alkali light chain	WB, IHC-P, ICC/IF, ELISA	Human
	MYL3 Antibody (YA4982) is a mouse-derived and non-conjugated monoclonal antibody, targeting to MYL3. It can be applicated for WB, IHC-P, ICC/IF, ELISA assays, in the background of human.

HY-P83658

	CTSE Antibody CATE antibody; CATE_HUMAN antibody; Cathepsin E antibody; Cathepsin E form II antibody; CTSE antibody; Erythrocyte membrane aspartic proteinase antibody; slow moving proteinase antibody;	WB, IHC-P	Human, Mouse, Rat
	CTSE Antibody is a rabbit-derived non-conjugated IgG antibody, targeting CTSE, with a predicted molecular weight of 43 kDa (observed band size: 48 kDa). CTSE Antibody can be used for WB, IHC-P experiments in human, mouse, rat backgrounds.

HY-P82186

	SERCA2 ATPase Antibody (YA1931) ATP2A2; ATP2B; Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; SERCA2; SR Ca(2+)-ATPase 2; Calcium pump 2; Calcium-transporting ATPase sarcoplasmic reticulum type; slow twitch skeletal muscle isoform; Endoplasmic reticulum class 1/2 Ca(2+) ATPase	WB, IHC-F, IHC-P, ICC/IF	Human, Rat
	SERCA2 ATPase Antibody (YA1931) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1931), targeting SERCA2 ATPase, with a predicted molecular weight of 115 kDa (observed band size: 115 kDa). SERCA2 ATPase Antibody (YA1931) can be used for WB, IHC-F, IHC-P, ICC/IF experiment in human, rat background.

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Cat. No.	Product Name		Classification

HY-W001538

S-Propargylcysteine SPRC		Alkynes
S-Propargylcysteine (SPRC), a structural analog of S-allyl cysteine (SAC), is a slow H₂S-releasing compound. S-Propargylcysteine reduces Ca ²⁺ accumulation and inflammatory cytokines, inhibits STAT3, and elevates p53 and Bax. S-Propargylcysteine has anti-inflammatory activity and protects mice against acute pancreatitis. S-Propargylcysteine also has cardioprotective, neuroprotective acitivties .

Cat. No.	Product Name		Classification

HY-B2247A

PLGA (75:25) 1 Publications Verification poly(lactic-co-glycolic acid) (75:25)		Polymers
PLGA (75:25) is a low toxicity, biocompatible and biodegradable controlled drug delivery carrier, can achieve slow release in the organism. PLGA (75:25) is a copolymer of 75% poly lactic acid (PLA) and 25% poly glycolic acid (PGA). PLGA (75:25) has been extensively studied as delivery vehicles for agents, proteins and various other macromolecules such as DNA, RNA and peptides .

HY-160043

AL6 aptamer sodium		Aptamers
AL6 aptamer sodium is a short-chain nucleic acid aptamer chemically synthesized in vitro. AL6 aptamer sodium specifically targets Angiopoietin (Ang) for the specific detection of Ang. The AL6 aptamer binds to Ang, causing the rotational motion of the fluorophore on the AL6 aptamer to become slower. The concentration of Ang in the test solution can be quantified by detecting the anisotropy of AL6 aptamer/Ang .

HY-155918

mPEG-CHO (MW 1000) mPEG-Aldehyde (MW 1000)		Polymers
mPEG-CHO (MW 1000) participates in the formation of a three-dimensional porous scaffold that carries active substances to form a delivery vehicle. The -CHO functional group interacts with the -NH2 functional group of the chitosan chain to form a glutaraldehyde-type adduct to functionalize mPEG. This functionalization and cross-linking can affect the rigidity of the delivery system, allowing slow release of the cross-linked conjugate system.

HY-155921

mPEG-CHO (MW 5000) mPEG-Aldehyde (MW 5000)		Polymers
mPEG-CHO (MW 5000) participates in the formation of a three-dimensional porous scaffold which carries active substances to form a delivery vehicle. The -CHO functional group interacts with the -NH2 functional group of the chitosan chain to form a glutaraldehyde-type adduct to functionalize mPEG. This functionalization and cross-linking can affect the rigidity of the delivery system, allowing slow release of the cross-linked conjugate system.

HY-155920

mPEG-CHO (MW 3400) mPEG-Aldehyde (MW 3400)		Polymers
mPEG-CHO (MW 3400) participates in the formation of a three-dimensional porous scaffold which carries active substances to form a delivery vehicle. The -CHO functional group interacts with the -NH2 functional group of the chitosan chain to form a glutaraldehyde-type adduct to functionalize mPEG. This functionalization and cross-linking can affect the rigidity of the delivery system, allowing slow release of the cross-linked conjugate system.

HY-155917

mPEG-CHO (MW 750) mPEG-Aldehyde (MW 750)		Polymers
mPEG-CHO (MW 750) participates in the formation of a three-dimensional porous scaffold which carries active substances to form a delivery vehicle. The -CHO functional group interacts with the -NH2 functional group of the chitosan chain to form a glutaraldehyde-type adduct to functionalize mPEG. This functionalization and cross-linking can affect the rigidity of the delivery system, allowing slow release of the cross-linked conjugate system.

HY-155922

mPEG-CHO (MW 10000) mPEG-Aldehyde (MW 10000)		Polymers
mPEG-CHO (MW 10000) participates in the formation of a three-dimensional porous scaffold which carries active substances to form a delivery vehicle. The -CHO functional group interacts with the -NH2 functional group of the chitosan chain to form a glutaraldehyde-type adduct to functionalize mPEG. This functionalization and cross-linking can affect the rigidity of the delivery system, allowing slow release of the cross-linked conjugate system.

HY-155916

mPEG-CHO (MW 550) mPEG-Aldehyde (MW 550)		Polymers
mPEG-CHO (MW 550) participates in the formation of a three-dimensional porous scaffold which carries active substances to form a delivery vehicle. The -CHO functional group interacts with the -NH2 functional group of the chitosan chain to form a glutaraldehyde-type adduct to functionalize mPEG. This functionalization and cross-linking can affect the rigidity of the delivery system, allowing slow release of the cross-linked conjugate system.

HY-155923

mPEG-CHO (MW 20000) mPEG-Aldehyde (MW 20000)		Polymers
mPEG-CHO (MW 20000) participates in the formation of a three-dimensional porous scaffold which carries active substances to form a delivery vehicle. The -CHO functional group interacts with the -NH2 functional group of the chitosan chain to form a glutaraldehyde-type adduct to functionalize mPEG. This functionalization and cross-linking can affect the rigidity of the delivery system, allowing slow release of the cross-linked conjugate system.

HY-155919

mPEG-CHO (MW 2000) mPEG-Aldehyde (MW 2000)		Polymers
mPEG-CHO (MW 2000) participates in the formation of a three-dimensional porous scaffold which carries active substances to form a delivery vehicle. The -CHO functional group interacts with the -NH2 functional group of the chitosan chain to form a glutaraldehyde-type adduct to functionalize mPEG. This functionalization and cross-linking can affect the rigidity of the delivery system, allowing slow release of the cross-linked conjugate system.

HY-155915

mPEG-CHO (MW 350) mPEG-Aldehyde (MW 350)		Polymers
mPEG-CHO (MW 350) participates in the formation of a three-dimensional porous scaffold which carries active substances to form a delivery vehicle. The -CHO functional group interacts with the -NH2 functional group of the chitosan chain to form a glutaraldehyde-type adduct to functionalize mPEG. This functionalization and cross-linking can affect the rigidity of the delivery system, allowing slow release of the cross-linked conjugate system.

HY-113289

Brassicasterol		Cholesterol
Brassicasterol is a metabolite of Ergosterol and has cardiovascular protective effects. Brassicasterol exerts anticancer effects in prostate cancer through dual targeting of AKT and androgen receptor signaling pathways. Brassicasterol inhibits HSV-1 (IC₅₀=1.2 μM) and Mycobacterium tuberculosis. Brassicasterol also inhibits sterol δ 24-reductase, slowing the progression of atherosclerosis. Brassicasterol is also a cerebrospinal fluid biomarker for Alzheimer's disease .

HY-N0538

Xylitol Xylite		Fillers
Xylitol can be classified as a polyol and sugar alcohol, exhibiting inhibitory activity on cancer cell proliferation. It induces autophagy (Autophagy) and cell death in A549 cells by activating the autophagy signaling pathway, as evidenced by the increased expression of LC3-II and Atg5-Atg12 upon Xylitol treatment. Additionally, Xylitol inhibits acetaldehyde production by Candida species, thereby reducing their carcinogenic potential. In vivo, Xylitol induces alterations in the gut microbiota of mice, which may enhance cholesterol accumulation and upregulate hepatic ChREBP, while also slowing tumor growth in the B16F10 melanoma C57BL/6 mouse model .

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