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  4. Ivospemin hydrochloride

Ivospemin hydrochloride  (Synonyms: SBP-101 hydrochloride)

Cat. No.: HY-132822A
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Ivospemin (SBP-101) hydrochloride is an antineoplastic spermine analog. Ivospemin hydrochloride has shown efficacy in slowing pancreatic and ovarian tumor progression in vitro and in vivo. Ivospemin hydrochloride shows modest induction of polyamine catabolism, but stronger repression of ornithine decarboxylase activity. Ivospemin hydrochloride is promising for research of cancers.

For research use only. We do not sell to patients.

Ivospemin hydrochloride

Ivospemin hydrochloride Chemical Structure

CAS No. : 259657-09-5

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Ivospemin hydrochloride Related Antibodies

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Description

Ivospemin (SBP-101) hydrochloride is an antineoplastic spermine analog. Ivospemin hydrochloride has shown efficacy in slowing pancreatic and ovarian tumor progression in vitro and in vivo. Ivospemin hydrochloride shows modest induction of polyamine catabolism, but stronger repression of ornithine decarboxylase activity. Ivospemin hydrochloride is promising for research of cancers[1][2][3].

In Vitro

Ivospemin hydrochloride (500 nM to 10 µM, 96 h) reduces cell viability in human ovarian adenocarcinoma cells with IC50 values ranging between 0.95 µM and 3.24 µM regardless of cisplatin sensitivity[2].

IC50 values following Ivospemin treatment in human ovarian adenocarcinoma cell lines[1]

Cell Line CaOV-3 A2780 OV90 ACRP
Ivospemin 96 h IC50 2.56 µM 0.95 µM 3.24 µM 1.41 µM

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ivospemin hydrochloride Related Antibodies

Cell Viability Assay[2]

Cell Line: A2780, OV90, ACRP, and CaOV-3 cell lines
Concentration: 500 nM to 10 µM
Incubation Time: 96 h
Result: Reduced cell viability in A2780, OV90, ACRP, and CaOV-3 cell lines.
In Vivo

Ivospemin hydrochloride (24 mg/kg, i.p., 2qw×3, alternating weeks for 60 days) increases survival by delaying disease onset and decreasing overall tumor burden in a murine ovarian adenocarcinoma model[2][3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Murine Ovarian Adenocarcinoma Model[2][3]
Dosage: 24 mg/kg
Administration: i.p., 2qw×3, alternating weeks for 60 days
Result: Produced a 20% increase in median survival from 43 days to 52 days post-injection, extended the time to ascites formation to 46.9 days, an increase of 13% combined with Gemcitabine (HY-17026) or Topotecan (HY-13768).
Molecular Weight

464.34

Formula

C16H42Cl4N4O2
CAS No.
SMILES

CCNCC[C@H](O)CNCCCCNC[C@@H](O)CCNCC.Cl.Cl.Cl.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Ivospemin hydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ivospemin259657-09-5SBP-101SBP101SBP 101Drug DerivativeDrug derivativespermine analogtumorpolyamine catabolismornithine decarboxylaseInhibitorinhibitorinhibit

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