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Results for "

regions

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (3) Amyloid-β (2) Antibiotic (2) Apoptosis (4) Autophagy (3) AUTOTACs (2) Bacterial (2) Biochemical Assay Reagents (5) CD28 (1) CDK (1) Cytochrome P450 (1) DNA Methyltransferase (1) DNA Stain (2) DNA/RNA Synthesis (4) Dopamine Receptor (1) Dopamine β-hydroxylase (1) Drug Derivative (1) EGFR (1) Endogenous Metabolite (3) Endonuclease (1) FAAH (1) FAP (1) Fluorescent Dye (4) GSK-3 (2) HCV (3) Histone Demethylase (2) iGluR (1) MDM-2/p53 (1) Melanocortin Receptor (1) mGluR (1) Opioid Receptor (1) PD-1/PD-L1 (2) PSMA (1) Radionuclide-Drug Conjugates (RDCs) (1) Ras (1) Small Interfering RNA (siRNA) (5) Somatostatin Receptor (2) Src (1) TNF Receptor (1) Toll-like Receptor (TLR) (1) TRP Channel (1) VEGFR (2) Virus Protease (1) YAP (1)
By Research Areas:	Cancer (22) Cardiovascular Disease (3) Endocrinology (1) Infection (7) Inflammation/Immunology (3) Neurological Disease (18)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (4) siRNAs (5)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Peptides

Inhibitory Antibodies

Natural
Products

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P2754

Micrococcal nuclease	Endonuclease	Infection
Micrococcal nuclease is an endonuclease derived from Staphylococcus aureus. Micrococcal nuclease is able to digest both single and double-stranded DNA (ssDNA and dsDNA) and RNA, and can cleave and hydrolyze the AT or AU-rich regions specifically. Micrococcal nuclease could be used as an indicator of Staphylococcus aureus contamination .

HY-124001

N-Docosanoyl taurine	TRP Channel	Neurological Disease
N-Docosanoyl taurine is a lipoamino acid. N-Docosanoyl taurine is a discriminatory metabolity that drive the classification of brain regions .

HY-19740

BIA 10-2474 2 Publications Verification	FAAH Autophagy	Neurological Disease
BIA 10-2474 is an inhibitor of fatty acid amide hydrolase (FAAH) with IC₅₀ values of 50 to 70mg/kg in various rat brain regions.

HY-P99293

Galiximab IDEC 114; Anti-Human CD80 Recombinant Antibody	CD28 Apoptosis	Cancer
Galiximab (IDEC-114) is a primatized monoclonal IgG1 antibody targeting CD80. Galiximab variable regions are primatized, and the constant regions are humanized. Galiximab induces antibody-dependent cellular cytotoxicity by blocking CD80-CD28 binding. Galiximab has antitumor activity and can induce apoptosis in tumor cells. Galiximab can be used in the research of relapsed Hodgkin lymphoma and solid tumors .

HY-139440

DL-Leucyl-DL-phenylalanine	Biochemical Assay Reagents	Others
DL-Leucyl-DL-phenylalanine is a dipeptide and can be used as a substrate to detecte two regions of dipeptidase staining on a gel in Drosophila simulans as well as in Drosophila melanogaster .

HY-135507

NAS-181	5-HT Receptor	Neurological Disease
NAS-181 is a potent and selective rat 5-hydroxytryptamine1B (r5-HT1B) antagonist with an K_i value of 47 nM. NAS-181 increases the 5-HTP accumulation in rat brain regions .

HY-114578

PD 118717	Dopamine Receptor 5-HT Receptor	Neurological Disease
PD 118717 is a selective dopamine (DA) D-2 autoreceptor agonist. PD 118717 has significant affinity for 5-HT1A but not 5-HT1B and 5-HT2 receptors. PD 118717 is active in antagonizing the tau-Butyrolactone-induced accumulation of dopa in rat striatum and mesolimbic regions. PD 118717 exhibits an antipsychotic-like profile .

HY-142701

SSTR4 agonist 4	Somatostatin Receptor	Neurological Disease
SSTR4 agonist 4 is a potent agonist of SSTR4. SSTR4 is expressed at relatively high levels in the hippocampus and neocortex, memory and learning regions, and Alzheimer's disease pathology. SSTR4 agonists are potent in rodent models of pain associated with acute and chronic associated anti-peripheral nociceptive and anti-inflammatory activity. SSTR4 agonist 4 has the potential for the research of pain (extracted from patent WO2021233428A1, compound 14) .

HY-142700

SSTR4 agonist 3	Somatostatin Receptor	Neurological Disease
SSTR4 agonist 3 is a potent agonist of SSTR4. SSTR4 is expressed at relatively high levels in the hippocampus and neocortex, memory and learning regions, and Alzheimer's disease pathology. SSTR4 agonists are potent in rodent models of pain associated with acute and chronic associated anti-peripheral nociceptive and anti-inflammatory activity. SSTR4 agonist 3 has the potential for the research of pain (extracted from patent WO2021233427A1, compound 14) .

HY-P991512

SGN-30	Apoptosis	Cancer
SGN-30 is a chimeric antibody derived from a mouse antihuman CD30 antibody, AC10, with the variable regions of AC10 and human α 1 heavy chain and κ light chain constant regions. SGN-30 induces apoptosis and cell-cycle arrest in cancer cells. SGN-30 can be used for the study of Hodgkin lymphoma (HL) and anaplastic large cell lymphoma (ALCL) .

HY-121789

Proadifen	Cytochrome P450	Others
Proadifen is a compound that inhibits cytochrome P450 activity, which can change the excitability of catecholamine-secreting neurons in the brain and have different effects on neurons in different brain regions.

HY-P10613

RERMS	Amyloid-β	Neurological Disease
RERMS are bioactive peptides produced from the active regions of amyloid-β and A4 protein precursors that promote fibroblast growth and can be used in the study of neurodegenerative diseases .

HY-W700975

12-Ketostearic acid sodium	Biochemical Assay Reagents	Others
12-Ketostearic acid sodium is a synthetic membrane probe that binds to the hydrophobic regions in lipid bilayer membranes. The terminal carboxylic acid can react with primary amine groups to form a stable amide bond.

HY-P991132

Efclarofusp alfa	VEGFR	Cardiovascular Disease Cancer
Efclarofusp alfa is a CHO-expressed humanized antibody consisting of VEGFR-1 and VEGFR-2 regions fused to human IgG1 Fc. Efclarofusp alfa is an angiogenesis inhibitor .

HY-RS27429

Dpy30 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Dpy30 Rat Pre-designed siRNA Set A includes three pairs of siRNAs designed to target different regions of the Dpy30 (Rat) gene, as well as negative controls, FAM-labeled negative controls, and positive controls.

Dpy30 Rat Pre-designed siRNA Set A Dpy30 Rat Pre-designed siRNA Set A

HY-RS14805

TNFRSF13C Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TNFRSF13C Human Pre-designed siRNA Set A includes three pairs of siRNAs designed for different regions of the TNFRSF13C (Human) gene, as well as negative controls, FAM-labeled negative controls, and positive controls.

TNFRSF13C Human Pre-designed siRNA Set A TNFRSF13C Human Pre-designed siRNA Set A

HY-RS15466

UNC13C Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
UNC13C Human Pre-designed siRNA Set A includes three pairs of siRNAs designed for different regions of the UNC13C (Human) gene, as well as negative controls, FAM-labeled negative controls, and positive controls.

UNC13C Human Pre-designed siRNA Set A UNC13C Human Pre-designed siRNA Set A

HY-RS15674

VPS13C Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
VPS13C Human Pre-designed siRNA Set A includes three pairs of siRNAs designed for different regions of the VPS13C (Human) gene, as well as negative controls, FAM-labeled negative controls, and positive controls.

VPS13C Human Pre-designed siRNA Set A VPS13C Human Pre-designed siRNA Set A

HY-B0990

Thiostrepton 20+ Cited Publications	Bacterial Antibiotic YAP	Infection
Thiostrepton is a thiazole antibiotic which selectively inhibits FOXM1. FOXM1 binds to YAP/TEAD complex. YAP/TEAD/FOXM1 complex binding at regulatory regions of genes governing cell cycle may impact cell proliferation .

HY-P99830

Conbercept KH902	VEGFR	Cardiovascular Disease
Conbercept (KH902) is a recombinant fusion protein composed of VEGFR-1 (second domain) and VEGFR-2 (third and fourth domains) regions fused to human IgG1 Fc. Conbercept is a vascular endothelial growth factor (VEGF) inhibitor .

HY-103048A

PD-1/PD-L1-IN 3 TFA	PD-1/PD-L1	Cancer
PD-1/PD-L1-IN 3 TFA, a macrocyclic peptide, is a potent and selective inhibitor of the PD-1/PD-L1 and CD80/PD-L1 interactions extracted from patent WO2014151634A1, compound No.1. PD-1/PD-L1-IN 3 TFA interferes with PD-L1 binding to PD-1 and CD80 by binding to PD-L1, with IC₅₀s of 5.60 nM and 7.04 nM, respectively. PD-1/PD-L1-IN 3 TFA can be used for the research of various diseases, including cancer and infectious diseases .

HY-103048

PD-1/PD-L1-IN 3	PD-1/PD-L1	Cancer
PD-1/PD-L1-IN 3, a macrocyclic peptide, is a potent and selective inhibitor of the PD-1/PD-L1 and CD80/PD-L1 interactions extracted from patent WO2014151634A1, compound No.1. PD-1/PD-L1-IN 3 interferes with PD-L1 binding to PD-1 and CD80 by binding to PD-L1, with IC₅₀s of 5.60 nM and 7.04 nM, respectively. PD-1/PD-L1-IN 3 can be used for the research of various diseases, including cancer and infectious diseases .

HY-18678

Bremelanotide 1 Publications Verification PT-141	Melanocortin Receptor	Endocrinology
Bremelanotide (PT-141) is an analogue of α-melanocyte-stimulating hormone (α-MSH). Bremelanotide activates the mPOA and other hypothalamic and limbic regions of the brain involved in sexual behavior. Bremelanotide can be used for researching hypoactive sexual desire disorders .

HY-D1660

Acridine homodimer NSC 219743	DNA Stain	Others
Acridine homodimer (NSC 219743), acridine dimer, is a fluorescence dye. Acridine homodimer emits a blue-green fluorescence when bound to DNA. Acridine homodimer has extremely high affinity for AT-rich regions of nucleic acids, can be used for chromosome banding .

HY-120757

LP-130	Virus Protease	Others
LP-130 is a statin-based inhibitor that is a universal inhibitor with nanomolar inhibitory activity against all tested retroviral proteases. Crystal structure studies of its binding to different retroviral proteases have shown that it can adapt to different active site regions to achieve inhibition.

HY-D1775

LysoTracker Blue DND-22	Fluorescent Dye	Neurological Disease Cancer
LysoTracker blue DND-22 is a blue fluorescent dye (Ex/Em: 373/422 nm). LysoTracker blue DND-22 stains acidic regions in living cells. LysoTracker blue DND-22 is used in the researches of neurodegenerative diseases and leukemia .

HY-D1020

7-Aminoactinomycin D 5+ Cited Publications 7-AAD	DNA/RNA Synthesis Bacterial DNA Stain Antibiotic	Infection Cancer
7-Aminoactinomycin D (7-AAD) a fluorescent DNA stain, is a potent RNA polymerase inhibitor. 7-Aminoactinomycin D selectively binds to GC regions of the DNA. 7-Aminoactinomycin D also has antibacterial effects .

HY-161743

PBA-1105	AUTOTACs Autophagy	Neurological Disease Cancer
PBA-1105 is an autophagy-targeting chimera (AUTOTAC) that induces p62 self-oligomerization. PBA-1105 selectively binds to exposed hydrophobic regions of misfolded proteins, facilitating their degradation via the autophagic pathway. PBA-1105 increases the autophagic flux of Ub-conjugated aggregates .

HY-136980

Aspartylglutamate Asp-Glu	Endogenous Metabolite	Neurological Disease
Aspartylglutamate (Asp-Glu) is a dipeptide that exhibits excitatory activity, as it has been shown to depolarize CA1 pyramidal neurons and increase conductance in response to stimulation. Aspartylglutamate selectively binds to certain glutamate receptors and demonstrates potent effects in specific regions of the hippocampus, particularly in the stratum radiatum where it enhances excitatory neurotransmission.

HY-163942

GSK_WRN4	DNA/RNA Synthesis	Cancer
GSK_WRN4 is a WRN helicase inhibitor (pIC₅₀=7.6) with anticancer activity. GSK_WRN4 selectively inhibits the growth of MSI tumor cells in vitro and in vivo by inducing DNA double-strand breaks, particularly at expanded TA repeats and DNA damage regions .

HY-E70016

Terminal deoxyribonucleotidyltransferase TdT	DNA/RNA Synthesis	Others Cancer
Terminal deoxyribonucleotidyltransferase (TdT) catalyses the condensation of deoxyribonucleotide triphosphates onto the 3' hydroxyl ends of DNA strands and adds N-regions to gene segment junctions during V(D)J recombination. Terminal deoxyribonucleotidyltransferase is expressed in immature, pre-B, pre-T lymphoid cells, and acute lymphoblastic leukemia/lymphoma cells .

HY-P4027

HCV-1 e2 Protein (554-569)	HCV	Infection
HCV-1 e2 Protein (554-569) is one of the main antigenic regions of HCV envelope 2 (e2) protein. The HCV-1 e2 Protein (554-569) contains a putative n-glycosylation site, which was previously thought to influence the immune recognition of e2 .

HY-114712

SJ572403 3 Publications Verification SJ403	CDK	Others
SJ572403 (SJ403) is a p27 ^Kip1 inhibitor. SJ572403 has high specificity for specific regions within the D2 subdomain of p27-KID with a K_d value of 2.2 mM. SJ572403 can be used for the research of diseases associated with intrinsically disordered proteins (IDPs) .

HY-P991513

BI-655064	TNF Receptor	Inflammation/Immunology
BI-655064, a humanised anti-CD40 antibody with has fragment crystallisable (Fc) regions with two mutations that prevent Fc-mediated antibody-dependent or complement-mediated cellular cytotoxicity and platelet activation. BI-655064 can be used for the study of autoimmune disease, such as lupus nephritis and rheumatoid arthritis (RA) .

HY-D0986

TMA-DPH 5+ Cited Publications	Fluorescent Dye	Others
TMA-DPH is a hydrophobic fluorescent membrane probe (Ex=355 nm; Em=430 nm). TMA-DPH is able to anchor on the cell surface and localize to different regions of the phospholipid bilayer. By analyzing the fluorescence polarization values of TMA-DPH in the plasma membrane and membrane substructures, the fluidity of the cell membrane can be determined .

HY-163667

Atoxifent	Opioid Receptor	Neurological Disease
Atoxifent is a potent μ-opioid receptor agonist (EC₅₀=0.39 nM). These receptors are found in brain regions that control pain, emotions, habitual learning, and cognition. Atoxifent exhibits strong analgesic effects and a lower risk of respiratory depression. Atoxifent can be used for research in opioid pharmacology and signal transduction .

HY-161743A

PBA-1105 TFA	AUTOTACs Autophagy	Neurological Disease Cancer
PBA-1105 TFA is an autophagy-targeting chimera (AUTOTAC) that induces p62 self-oligomerization. PBA-1105 TFA selectively binds to exposed hydrophobic regions of misfolded proteins, facilitating their degradation via the autophagic pathway. PBA-1105 TFA increases the autophagic flux of Ub-conjugated aggregates .

HY-P4027A

HCV-1 e2 Protein (554-569) (TFA)	HCV	Infection
HCV-1 e2 Protein (554-569) TFA is one of the main antigenic regions of HCV envelope 2 (e2) protein. The HCV-1 e2 Protein (554-569) TFA contains a putative N-glycosylation site, which was previously thought to influence the immune recognition of e2 .

HY-137265

Aminomethyltrioxsalen hydrochloride	Biochemical Assay Reagents	Others
Aminomethyltrioxsalen hydrochloride is a derivative of Psoralen (HY-N0053). Aminomethyltrioxsalen hydrochloride penetrate intact cells and form interstrand crosslinks between pyrimidine residues of nucleic acid helices upon irradiation with ultraviolet light as a bifunctional nucleic acid intercalating agent, which can be used as a probe for double-stranded regions in heterogeneous nuclear RNA (hnRNA) to detect the secondary structure of hnRNA .

HY-100468

REV7/REV3L-IN-1 1 Publications Verification	DNA/RNA Synthesis	Cancer
REV7/REV3L-IN-1 is a REV7/REV3L interaction inhibitor with an IC₅₀ of 78 μM, which directly binds to REV7 in nuclear magnetic resonance analyses, and inhibits the reactivation of a reporter plasmid containing an interstrand crosslink (ICL) in between the promoter and reporter regions .

HY-164899

2A3	Biochemical Assay Reagents	Others
2A3 is a highly efficient and precise SHAPE reagent with powerful biomembrane penetration capabilities, suitable for both in vivo and in vitro RNA structure detection. 2A3 can not only effectively probe most RNA loops but also better capture local nucleotide dynamics, thus enabling it to readily detect regions of ribonucleoprotein complexes that are typically inaccessible to other compounds .

HY-164645

pan-KRAS-IN-16	Ras	Cancer
pan-KRAS-IN-16 (Compound 3344) is an anti-RAS small molecule derived from an intracellular antibody fragment with pan-RAS-effector protein-protein interaction inhibitor properties. pan-KRAS-IN-16 binds to a hydrophobic pocket near to the effector-binding switch regions of RAS. pan-KRAS-IN-16 prevents endogenous RAS-dependent signaling in tumor cell lines .

HY-P4037

HCV Core Protein (107-114)	HCV	Infection
HCV Core Protein (107-114) is a least immunogenic residue of the major linear HCV core regions. HCV Core Protein (107-114) is identified as the binding site within the region 101-118, which contains two residues differing between genotypes Ⅰ/Ⅱ and Ⅲ/Ⅵ. HCV Core Protein (107-114) might be a potential site for dissemination of HCV serotypes .

HY-107531

A 1070722	GSK-3	Neurological Disease Cancer
A 1070722 is a potent and selective glycogen synthase kinase 3 (GSK-3) inhibitor, with a K_i of 0.6 nM for both GSK-3α and GSK-3β. A 1070722 can penetrate the blood-brain barrier (BBB) and accumulates in brain regions, thus potential for PET radiotracer for the quantification of GSK-3 in brain. A 1070722 decreases spontaneous locomotion .

HY-174923

AZ12943203	Biochemical Assay Reagents GSK-3	Neurological Disease
AZ12943203 (Compound 13e) is a GSK-3 PET radioligand with a K_d of 2.94  nM. AZ12943203 has a significant inhibitory potency toward GSK-3β (IC₅₀: 4.44 nM), and can specifically bind to GSK-3-rich regions of the rodent brain. AZ12943203 can be used for neurodegenerative diseases imaging, particularly Alzheimer’s disease .

HY-P991534

PF-04382923	Amyloid-β	Neurological Disease
PF-04382923 is a humanized IgG2Δa monoclonal antibody. PF-04382923 binds with high affinity to the free C-terminal regions of the amyloid-β peptides Aβ1-40 and Aβ1-42. PF-04382923 is indicated for the study of geographic atrophy (GA) associated with dry age-related macular degeneration (ARMD) .

HY-RS16280

FAM-labeled P3H1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
FAM-labeled P3H1 Human Pre-designed siRNA Set A is a FAM-labeled P3H1 siRNA. FAM-labeled P3H1 Human Pre-designed siRNA Set A includes three pairs of siRNAs designed for different regions of the P3H1 (Human) gene, as well as a negative control, a FAM-labeled negative control, and a positive control .

FAM-labeled P3H1 Human Pre-designed siRNA Set A FAM-labeled P3H1 Human Pre-designed siRNA Set A

HY-164083

GR65630	5-HT Receptor	Neurological Disease
GR65630 is a potent and selective 5-hydroxytryptamine (5-HT) type 3 receptor antagonist. GR65630 can be used to study the expression patterns of 5-HT3 receptors in different brain regions and their possible functions in the central nervous system. GR65630 and its radiolabeled form [ ³H]GR65630 can be used to study the distribution, density and affinity of the receptors .

HY-171764

β-Ethoxy-α-ketobutyraldehyde	Fluorescent Dye	Others
β-Ethoxy-α-ketobutyraldehyde is a chemical probe. β-Ethoxy-α-ketobutyraldehyde specifically modifies the N1 and N2 positions of guanine. β-Ethoxy-α-ketobutyraldehyde is mainly used to study the steric protection of single-stranded/double-stranded regions of nucleic acids and protein binding sites. β-Ethoxy-α-ketobutyraldehyde can be used for nucleic acid structure analysis and footprint studies of protein-nucleic acid complexes .

HY-P991572

MM-151	EGFR	Cancer
MM-151 is a humanized IgG1 monoclonal antibody targeting EGFR. MM-151 binds multiple regions of the EGFR extracellular domain (ECD) and reduces its mutations in circulating cell-free tumor DNA with EGFR resistance. MM-151 significantly inhibits EGFR signaling and cell growth. MM-151 can be used for drug-resistant cancers research, such as colorectal, non-small cell lung and triple negative breast cancer .

Cat. No.	Product Name

HY-L191

Tibetan Medicine Compound Library

1,121 compounds

Tibetan medicine, as one of the treasures of traditional Chinese medicine, carries the profound cultural heritage of the Tibetan people and their unique understanding of health. Tibet is the birthplace of Tibetan medicine, and its plateau climate and unique ecological environment have nurtured its rich medicinal resources. Among them, cordyceps, saffron and snow lily are favored by people for their excellent medicinal value and unique growth characteristics. Tibetan medicine, with its profound heritage, plays a crucial role in the management of diseases that are unique to high-altitude regions, such as altitude stress. It facilitates a swifter adaptation to high-altitude conditions and mitigates the symptoms of altitude sickness by meticulously recalibrating the internal environment within the human body. For rheumatic diseases, cardiovascular diseases, etc., Tibetan medicine has also shown its remarkable effect.

MCE included 1,121 natural products from Tibetan medicine, including animal, plant and mineral sources.

HY-L082

Antiparasitic Compound library

557 compounds

A parasite is an organism that lives on or in a host organism and gets its food from or at the expense of its host. Parasites of humans include protozoans, helminths, and ecto-parasites (organisms that live on the external surface of a host). They are responsible for many diseases and are transmitted to their hosts most often through the ingestion of contaminated food, water or through the bite of an arthropod (e.g., a fly or tick), which can act as an intermediate host and as a vector. Parasitic diseases of humans are a major global health problem causing significant morbidity and mortality, especially in developing countries. Each year there are hundreds of millions of people infected with disease-causing parasites, particularly in tropical and subtropical regions of the world, resulting in an estimated one million deaths. Therefore, there is a dire need of novel anti-parasitic drugs.

MCE has a unique collection of 557 compounds with validated anti-parasitic activity which offer researchers an opportunity to screen novel anti-parasitic targets.

Cat. No.	Product Name	Type

HY-D1775

LysoTracker Blue DND-22	Fluorescent Dyes/Probes
LysoTracker blue DND-22 is a blue fluorescent dye (Ex/Em: 373/422 nm). LysoTracker blue DND-22 stains acidic regions in living cells. LysoTracker blue DND-22 is used in the researches of neurodegenerative diseases and leukemia .

HY-D1020

7-Aminoactinomycin D 5+ Cited Publications 7-AAD	DNA Stain
7-Aminoactinomycin D (7-AAD) a fluorescent DNA stain, is a potent RNA polymerase inhibitor. 7-Aminoactinomycin D selectively binds to GC regions of the DNA. 7-Aminoactinomycin D also has antibacterial effects .

HY-D0986

TMA-DPH 5+ Cited Publications	Fluorescent Dyes/Probes
TMA-DPH is a hydrophobic fluorescent membrane probe (Ex=355 nm; Em=430 nm). TMA-DPH is able to anchor on the cell surface and localize to different regions of the phospholipid bilayer. By analyzing the fluorescence polarization values of TMA-DPH in the plasma membrane and membrane substructures, the fluidity of the cell membrane can be determined .

HY-129763

Di-4-ANEPPS

Dyes

Di-4-ANEPPS is a voltage-sensitive dye that acts on voltage-gated ion channels (such as sodium channels) and inhibits sodium current, significantly reducing sodium current density, although specific values like IC₅₀ remain unclear. It mainly binds to the voltage-sensitive regions on the cell membrane, changing its fluorescence properties to reflect membrane potential changes and thus affecting the function of ion channels to exert its activity. This substance can be used in cardiovascular research, such as the electrophysiology of cardiomyocytes, myocardial ischemia, and the effects of drugs on cardiomyocytes. It is of great value in evaluating drug cardiotoxicity and exploring the mechanisms of arrhythmias .

Cat. No.	Product Name	Target	Research Area

HY-B0990

Thiostrepton 20+ Cited Publications	Bacterial Antibiotic YAP	Infection
Thiostrepton is a thiazole antibiotic which selectively inhibits FOXM1. FOXM1 binds to YAP/TEAD complex. YAP/TEAD/FOXM1 complex binding at regulatory regions of genes governing cell cycle may impact cell proliferation .

HY-103048A

PD-1/PD-L1-IN 3 TFA	PD-1/PD-L1	Cancer
PD-1/PD-L1-IN 3 TFA, a macrocyclic peptide, is a potent and selective inhibitor of the PD-1/PD-L1 and CD80/PD-L1 interactions extracted from patent WO2014151634A1, compound No.1. PD-1/PD-L1-IN 3 TFA interferes with PD-L1 binding to PD-1 and CD80 by binding to PD-L1, with IC₅₀s of 5.60 nM and 7.04 nM, respectively. PD-1/PD-L1-IN 3 TFA can be used for the research of various diseases, including cancer and infectious diseases .

HY-18678

Bremelanotide 1 Publications Verification PT-141	Melanocortin Receptor	Endocrinology
Bremelanotide (PT-141) is an analogue of α-melanocyte-stimulating hormone (α-MSH). Bremelanotide activates the mPOA and other hypothalamic and limbic regions of the brain involved in sexual behavior. Bremelanotide can be used for researching hypoactive sexual desire disorders .

HY-P10613

RERMS	Amyloid-β	Neurological Disease
RERMS are bioactive peptides produced from the active regions of amyloid-β and A4 protein precursors that promote fibroblast growth and can be used in the study of neurodegenerative diseases .

HY-120757

LP-130	Virus Protease	Others
LP-130 is a statin-based inhibitor that is a universal inhibitor with nanomolar inhibitory activity against all tested retroviral proteases. Crystal structure studies of its binding to different retroviral proteases have shown that it can adapt to different active site regions to achieve inhibition.

HY-P4027

HCV-1 e2 Protein (554-569)	HCV	Infection
HCV-1 e2 Protein (554-569) is one of the main antigenic regions of HCV envelope 2 (e2) protein. The HCV-1 e2 Protein (554-569) contains a putative n-glycosylation site, which was previously thought to influence the immune recognition of e2 .

HY-P4027A

HCV-1 e2 Protein (554-569) (TFA)	HCV	Infection
HCV-1 e2 Protein (554-569) TFA is one of the main antigenic regions of HCV envelope 2 (e2) protein. The HCV-1 e2 Protein (554-569) TFA contains a putative N-glycosylation site, which was previously thought to influence the immune recognition of e2 .

HY-P4037

HCV Core Protein (107-114)	HCV	Infection
HCV Core Protein (107-114) is a least immunogenic residue of the major linear HCV core regions. HCV Core Protein (107-114) is identified as the binding site within the region 101-118, which contains two residues differing between genotypes Ⅰ/Ⅱ and Ⅲ/Ⅵ. HCV Core Protein (107-114) might be a potential site for dissemination of HCV serotypes .

HY-P10744

BQ7859	Radionuclide-Drug Conjugates (RDCs) PSMA	Cancer
BQ7859 is a probe targeting PSMA that contains a NOTA chelator and demonstrates excellent imaging performance. BQ7859 can be labeled with various radionuclides, such as 68Ga, 18F, 55Co, and 111In. In a mouse prostate cancer xenograft model, BQ7859 (labeled with 111In) efficiently accumulates in tumor regions in a PSMA-dependent manner and provides high-contrast tumor imaging. BQ7859 shows potential for research in prostate cancer imaging, particularly in positron emission tomography (PET) and single-photon emission computed tomography (SPECT) . BQ7859 can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).

Cat. No.	Product Name	Target	Research Area

HY-P99293

Galiximab IDEC 114; Anti-Human CD80 Recombinant Antibody	CD28 Apoptosis	Cancer
Galiximab (IDEC-114) is a primatized monoclonal IgG1 antibody targeting CD80. Galiximab variable regions are primatized, and the constant regions are humanized. Galiximab induces antibody-dependent cellular cytotoxicity by blocking CD80-CD28 binding. Galiximab has antitumor activity and can induce apoptosis in tumor cells. Galiximab can be used in the research of relapsed Hodgkin lymphoma and solid tumors .

HY-P99830

Conbercept KH902	VEGFR	Cardiovascular Disease
Conbercept (KH902) is a recombinant fusion protein composed of VEGFR-1 (second domain) and VEGFR-2 (third and fourth domains) regions fused to human IgG1 Fc. Conbercept is a vascular endothelial growth factor (VEGF) inhibitor .

HY-P99008

Atibuclimab 1 Publications Verification IC14	Toll-like Receptor (TLR)	Infection Neurological Disease Inflammation/Immunology
Atibuclimab (IC14), is a chimeric monoclonal antibody directed against CD14 and is composed of murine variable and human IgG4 Fc regions. Atibuclimab attenuates Lipopolysaccharides (HY-D1056) (LPS)-induced symptoms and strongly inhibits LPS-induced proinflammatory cytokine release, while only delaying the release of the anti-inflammatory cytokines soluble TNF receptor type I and IL-1 receptor antagonist. Atibuclimab can be used for the research of amyotrophic lateral sclerosis, sepsis, community-acquired pneumonia, or acute lung injury .

HY-P990162

*Anti-Mouse T15 VH and T15 VL regions* of IgM Antibody (HB33)**	Inhibitory Antibodies	Others
Anti-Mouse T15 VH and T15 VL regions of IgM Antibody (HB33) is a mouse-derived IgG1, κ type antibody inhibitor, targeting to mouse T15 VH and T15 VL regions of IgM.

HY-P990693

Tarperprumig ALXN-1820	Inhibitory Antibodies	Inflammation/Immunology
Tarperprumig is an anti-ALB/CFP monoclonal antibody composed of 2 heavy chain variable regions linked together .

HY-P991512

SGN-30	Apoptosis	Cancer
SGN-30 is a chimeric antibody derived from a mouse antihuman CD30 antibody, AC10, with the variable regions of AC10 and human α 1 heavy chain and κ light chain constant regions. SGN-30 induces apoptosis and cell-cycle arrest in cancer cells. SGN-30 can be used for the study of Hodgkin lymphoma (HL) and anaplastic large cell lymphoma (ALCL) .

HY-P991132

Efclarofusp alfa	VEGFR	Cardiovascular Disease Cancer
Efclarofusp alfa is a CHO-expressed humanized antibody consisting of VEGFR-1 and VEGFR-2 regions fused to human IgG1 Fc. Efclarofusp alfa is an angiogenesis inhibitor .

HY-P991513

BI-655064	TNF Receptor	Inflammation/Immunology
BI-655064, a humanised anti-CD40 antibody with has fragment crystallisable (Fc) regions with two mutations that prevent Fc-mediated antibody-dependent or complement-mediated cellular cytotoxicity and platelet activation. BI-655064 can be used for the study of autoimmune disease, such as lupus nephritis and rheumatoid arthritis (RA) .

HY-P991534

PF-04382923	Amyloid-β	Neurological Disease
PF-04382923 is a humanized IgG2Δa monoclonal antibody. PF-04382923 binds with high affinity to the free C-terminal regions of the amyloid-β peptides Aβ1-40 and Aβ1-42. PF-04382923 is indicated for the study of geographic atrophy (GA) associated with dry age-related macular degeneration (ARMD) .

HY-P991572

MM-151	EGFR	Cancer
MM-151 is a humanized IgG1 monoclonal antibody targeting EGFR. MM-151 binds multiple regions of the EGFR extracellular domain (ECD) and reduces its mutations in circulating cell-free tumor DNA with EGFR resistance. MM-151 significantly inhibits EGFR signaling and cell growth. MM-151 can be used for drug-resistant cancers research, such as colorectal, non-small cell lung and triple negative breast cancer .

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HY-P86949

	Lambda Light Chain Antibody (YA6642) Constant region of lambda light chains antibody; Ig lambda chain C regions antibody; IGLC antibody; Immunoglobulin lambda constant 1 antibody; Mcg marker antibody	WB, ICC/IF, IHC-P, FC	Human

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HY-RS27429

Dpy30 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Dpy30 Rat Pre-designed siRNA Set A includes three pairs of siRNAs designed to target different regions of the Dpy30 (Rat) gene, as well as negative controls, FAM-labeled negative controls, and positive controls.

HY-RS14805

TNFRSF13C Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
TNFRSF13C Human Pre-designed siRNA Set A includes three pairs of siRNAs designed for different regions of the TNFRSF13C (Human) gene, as well as negative controls, FAM-labeled negative controls, and positive controls.

HY-RS15466

UNC13C Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
UNC13C Human Pre-designed siRNA Set A includes three pairs of siRNAs designed for different regions of the UNC13C (Human) gene, as well as negative controls, FAM-labeled negative controls, and positive controls.

HY-RS15674

VPS13C Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
VPS13C Human Pre-designed siRNA Set A includes three pairs of siRNAs designed for different regions of the VPS13C (Human) gene, as well as negative controls, FAM-labeled negative controls, and positive controls.

HY-RS16280

FAM-labeled P3H1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
FAM-labeled P3H1 Human Pre-designed siRNA Set A is a FAM-labeled P3H1 siRNA. FAM-labeled P3H1 Human Pre-designed siRNA Set A includes three pairs of siRNAs designed for different regions of the P3H1 (Human) gene, as well as a negative control, a FAM-labeled negative control, and a positive control .

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