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Results for "

pyrophosphatase

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By Targets:	DNA/RNA Synthesis (3) Endogenous Metabolite (1) Nucleoside Antimetabolite/Analog (3) Phosphatase (5) Phosphodiesterase (PDE) (17) SARS-CoV (1) STING (1)
By Research Areas:	Cancer (19) Infection (5) Inflammation/Immunology (1) Metabolic Disease (2)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P2992

*Inorganic pyrophosphatase, Saccharomyces cerevisiae* PPase	Endogenous Metabolite	Others
Inorganic pyrophosphatase, Saccharomyces cerevisiae (PPase) converts pyrophosphate (PPi) to phosphate. Inorganic pyrophosphatase is an essential component of in vitro transcription reactions for RNA preparation, is often used in biochemical studies. Inorganic pyrophosphatase is critical for driving cellular processes such as nucleic acid and protein synthesis .

HY-143256

Enpp-1-IN-12	Phosphodiesterase (PDE)	Cancer
Enpp-1-IN-12 (compound 43) is a potent and orally active *ecto-nucleotide pyrophosphatase/phosphodiesterases 1 (ENPP1)* inhibitor, with a Ki of 41 nM. Enpp-1-IN-12 exhibits anti-tumor activity .

HY-135909

TH1217 1 Publications Verification ZINC1775962367	SARS-CoV	Infection Cancer
TH1217 (ZINC1775962367) is a potent and selective *dCTPase pyrophosphatase* 1 (dCTPase) inhibitor, with an IC₅₀** of 47 nM. TH1217 enhances the cytotoxic effect of cytidine analogues in leukemia cells. TH1217 also could modulate SARS-Cov-2 interactors, so it shows activity of against COVID-19 .

HY-129490

Enpp-1-IN-1 2 Publications Verification	Phosphodiesterase (PDE)	Cancer
Enpp-1-IN-1 is an effective selective enpp-1 (nucleotide pyrophosphatase-phosphodiesterase 1) inhibitor .

HY-115736A

Xanthosine-5'-Triphosphate trisodium 5'-XTP trisodium	DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Phosphatase	Others
Xanthosine-5'-Triphosphate (5'-XTP) trisodium, a nucleotide, is produced by deamination of purine bases. Xanthosine-5'-Triphosphate trisodium is a substrate of inosine triphosphate pyrophosphatase (ITPase) .

HY-153334

Enpp-1-IN-15	Phosphodiesterase (PDE)	Others
Enpp-1-IN-15 (Compound 88a) is an Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 (Enpp-1) Inhibitor, with a K_i value of 0.00586 nM .

HY-163448

NPP1-IN-2	Phosphatase	Cancer
NPP1-IN-2 (compound 3h) is a potent and selective *Ectonucleotide pyrophosphatase/phosphodiesterase-1 (NPP1)* inhibitor with IC₅₀ values of 0.55, 3.73 µM for NPP1, NPP3, respectively .

HY-157522

NCI-14465	Phosphodiesterase (PDE)	Cancer
NCI-14465 is an ectonucleotide pyrophosphatase/phosphodiesterase (ENPP1) inhibitor with an IC 50 of 26.4 μM. NCI-14465 can be used in cancer research .

HY-115736

Xanthosine-5'-Triphosphate 5'-XTP	DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Phosphatase	Others
Xanthosine-5'-Triphosphate (5'-XTP), a nucleotide, is produced by deamination of purine bases. Xanthosine-5'-Triphosphate is a substrate of inosine triphosphate pyrophosphatase (ITPase) .

HY-115736B

Xanthosine-5'-triphosphate lithium 5'-XTP lithium	DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Phosphatase	Others
Xanthosine-5'-Triphosphate (5'-XTP) lithium, a nucleotide, is produced by deamination of purine bases. Xanthosine-5'-Triphosphate lithium is a substrate of inosine triphosphate pyrophosphatase (ITPase) .

HY-163449

NPP3-IN-1	Phosphatase	Metabolic Disease Cancer
NPP3-IN-1 (Compound 3e) is an inhibitor of phosphodiesterase/pyrophosphatase-3 (NPP3) (IC₅₀: 0.24 μM and 1.37 μM for NPP3 and NPP1 respectively .

HY-158791

Enpp-1-IN-21	Phosphodiesterase (PDE)	Metabolic Disease Cancer
Enpp-1-IN-21 (compound 4g) is an inhibitor of ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), with IC₅₀ values for ENPP1 and ENPP3 at 0.45 and 0.19 μM, respectively .

HY-143254

Enpp-1-IN-10	Phosphodiesterase (PDE)	Cancer
Enpp-1-IN-10 (compound 1) is a potent *Ecto-nucleotide pyrophosphatase/phosphodiesterases 1 (ENPP1)* inhibitor with an K_i value of 3.866 μM. Enpp-1-IN-10 can be used for researching anticancer .

HY-145062

Enpp-1-IN-4	Phosphodiesterase (PDE)	Cancer
Enpp-1-IN-4 is a potent inhibitor of ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1). Enpp-1-IN-4 has the potential for the research of cancer diseases (extracted from patent WO2019177971A1, compound 1) .

HY-147998

Enpp-1-IN-13	Phosphodiesterase (PDE)	Cancer
Enpp-1-IN-13 (Compound 1a) is an *ectonucleotide pyrophosphatase/phosphodiesterase (ENPP)* inhibitor with IC₅₀ values of 1.29 μM and 20.2 μM against ENPP1 and ENPP3, respectively. Enpp-1-IN-13 shows anticancer activity .

HY-147389

Enpp-1-IN-14	Phosphodiesterase (PDE)	Cancer
Enpp-1-IN-14 (Compound 015) is a potent *Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1)* inhibitor with an IC₅₀ value of 32.38 nM for recombinant human ENPP-1. Enpp-1-IN-14 has anti-tumor activity .

HY-139362

Enpp-1-IN-2	Phosphodiesterase (PDE)	Cancer
Enpp-1-IN-2 (Compound C) is a potent ENPP1 (ectonucleotide pyrophosphatase/phosphodiesterase 1) inhibitor with IC₅₀ values of 0.26, 0.48 and 2.0 μM evaluated by means of TG-mAMP, pNP-TMP, and ATP assays, respectively. TG (Tokyo Green)-mAMP: a newly synthesized sensitive ENPP1 fluorescence probe .

HY-143255

Enpp-1-IN-11	Phosphodiesterase (PDE)	Cancer
Enpp-1-IN-11 (compound 23) is a potent *Ecto-nucleotide pyrophosphatase/phosphodiesterases 1 (ENPP1)* inhibitor with an K_i value of 45 nM. Enpp-1-IN-11 exhibits low clearance in human and mouse liver microsomes, good plasma stability in human and mouse plasma. Enpp-1-IN-11 can be used for researching anticancer .

HY-145065

Enpp-1-IN-7	Phosphodiesterase (PDE)	Infection Cancer
Enpp-1-IN-7 is a potent inhibitor of ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1). The ENPP 1 has broad specificity and can cleave a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds nucleotides and nucleotide sugars. Enpp-1-IN-7 has the potential for the research of cancer and infectious diseases (extracted from patent WO2021203772A1, compound 51) .

HY-145064

Enpp-1-IN-6	Phosphodiesterase (PDE)	Infection Cancer
Enpp-1-IN-6 is a potent inhibitor of ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1). The ENPP 1 has broad specificity and can cleave a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds nucleotides and nucleotide sugars. Enpp-1-IN-6 has the potential for the research of cancer and infectious diseases (extracted from patent WO2021203772A1, compound 51) .

HY-145070

Enpp-1-IN-9	Phosphodiesterase (PDE)	Infection Cancer
Enpp-1-IN-9 is a potent inhibitor of ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1). The ENPP 1 has broad specificity and can cleave a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds nucleotides and nucleotide sugars. Enpp-1-IN-9 has the potential for the research of cancer and infectious diseases (extracted from patent WO2021203772A1, compound 51) .

HY-145069

Enpp-1-IN-8	Phosphodiesterase (PDE)	Cancer
Enpp-1-IN-8 is a potent inhibitor of ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1). The ENPP 1 has broad specificity and can cleave a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds nucleotides and nucleotide sugars. Enpp-1-IN-8 has the potential for the research of cancer and infectious diseases (extracted from patent WO2021203772A1, compound 51) .

HY-163343

Enpp-1-IN-20	Phosphodiesterase (PDE) STING	Cancer
Enpp-1-IN-20 (Compound 31) is an ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) inhibitor, with an IC₅₀ of 0.09 nM. Enpp-1-IN-20 has strongest inhibitory activity in the cell-based assay, with an IC₅₀ of 8.8 nM. Enpp-1-IN-20 has significant potency in both ENPP1 inhibition and STING pathway stimulation in vitro. Enpp-1-IN-20 can be used for the research of cancer .

HY-145063

Enpp-1-IN-5	Phosphodiesterase (PDE)	Infection Inflammation/Immunology Cancer
Enpp-1-IN-5 is a potent inhibitor of ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1). The ENPP 1 has broad specificity and can cleave a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds nucleotides and nucleotide sugars. Enpp-1-IN-5 has the potential for the research of cancer and infectious diseases (extracted from patent WO2019046778A1/WO2021203772A1, compound 1) .

Xanthosine-5'-Triphosphate 5'-XTP	Microorganisms Source classification	DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Phosphatase
Xanthosine-5'-Triphosphate (5'-XTP), a nucleotide, is produced by deamination of purine bases. Xanthosine-5'-Triphosphate is a substrate of inosine triphosphate pyrophosphatase (ITPase) .

Species:	Human (7) Rhesus Macaque (1) Mouse (2) Cynomolgus (1)
Tag:	His (11) Tag Free (2)
Source:	HEK293 (6) Sf9 insect cells (1) E. coli (5)

Cat. No.	Compare	Product Name	Species	Source

HY-P77508

	XTP3TPA Protein, Human (His) dCTP pyrophosphatase 1; dCTPase 1; RS21C6; DCTPP1; CDA03	Human	E. coli
	XTP3TPA protein crucially hydrolyzes deoxynucleoside triphosphates (dNTPs), particularly preferring dCTP and its analogs, like 5-iodo-dCTP and 5-methyl-dCTP. This selective hydrolysis, reflecting high efficiency, likely safeguards against the incorporation of genotoxic nucleotide analogs into DNA or RNA, contributing to genomic integrity and protecting cellular nucleotide pools. XTP3TPA Protein, Human (His) is the recombinant human-derived XTP3TPA protein, expressed by E. coli , with N-His labeled tag.

HY-P75734

	ENPP-5 Protein, Human (HEK293, His) Ectonucleotide pyrophosphatase/phosphodiesterase family member 5; NPP-5	Human	HEK293
	ENPP-5, also known as ectonucleotide pyrophosphatase/phosphodiesterase 5, has the ability to hydrolyze nicotinamide adenine dinucleotide (NAD) but does not have lysophospholipase D activity, indicating its inability to hydrolyze Nucleotide diphosphates and triphosphates. This enzymatic activity suggests that ENPP-5 may play a role in regulating NAD levels and possibly affecting cellular processes involved in NAD metabolism. ENPP-5 Protein, Human (HEK293, His) is the recombinant human-derived ENPP-5 protein, expressed by HEK293 , with C-His labeled tag.

HY-P79310

	PPA1 Protein, S. cerevisiae (His) Inorganic pyrophosphatase; IPP1; Pyrophosphate phospho-hydrolase; PPase; PPA; PPA1	Others	E. coli
	The PPA1 protein is an important member of the PPase family and plays an important role in cellular processes, especially dephosphorylation related to phosphate metabolism. PPA1 shares conserved features with related proteins and is involved in phosphatase activity. PPA1 Protein, S. cerevisiae (His) is the recombinant human-derived PPA1 protein, expressed by E. coli , with tag free.

HY-P70026

	dUTPase/DUT Protein, Human rHuDeoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial/DUT; Deoxyuridine 5'-Triphosphate Nucleotidohydrolase Mitochondrial; dUTPase; dUTP pyrophosphatase; DUT	Human	E. coli
	Deoxyuridine 5'-triphosphate nucleotidohydrolase (DUT) is an essential enzyme of nucleotide metabolism, as DUT hydrolyzes dUTP to dUMP and pyrophosphate, preventing uracil misincorporation into DNA efficiently and provides dUMP for thymidylate biosynthesis. DUT also prevents dimerization of PPAR and retinoid X receptor and is essential for embryonic development as well. dUTPase/DUT Protein, Human is the recombinant human-derived dUTPase/DUT protein, expressed by E. coli , with tag free.

HY-P76902

	ENPP-7 Protein, Mouse (HEK293, His) Ectonucleotide pyrophosphatase/phosphodiesterase family member 7; NPP-7; Alk-Smase	Mouse	HEK293
	The ENPP-7 protein acts as a choline-specific phosphodiesterase and is essential for sphingomyelin digestion, ceramide formation, and FA absorption in the gastrointestinal tract. It hydrolyzes sphingomyelin to release ceramide and phosphocholine. ENPP-7 Protein, Mouse (HEK293, His) is the recombinant mouse-derived ENPP-7 protein, expressed by HEK293 , with C-His labeled tag.

HY-P77358

	ENPP-7 Protein, Human (HEK293, His) Ectonucleotide pyrophosphatase/phosphodiesterase family member 7; NPP-7; Alk-Smase	Human	HEK293
	The ENPP-7 protein is a choline-specific phosphodiesterase that plays multiple roles in sphingomyelin digestion, ceramide formation, and fatty acid absorption in the gastrointestinal tract. It hydrolyzes sphingomyelin, releases ceramide and phosphocholine, and promotes the breakdown of sphingomyelin. ENPP-7 Protein, Human (HEK293, His) is the recombinant human-derived ENPP-7 protein, expressed by HEK293 , with C-His labeled tag.

HY-P76525

	NUDT5 Protein, Human (His) ADP-sugar pyrophosphatase; Nudix motif 5; hNUDT5; YSA1H; NUDIX5	Human	E. coli
	The NUDT5 protein acts as an ADP-glycopyrophosphatase or synthesizes ATP. NUDT5 Protein, Human (His) is the recombinant human-derived NUDT5 protein, expressed by E. coli , with N-His labeled tag.

HY-P75733

	ENPP-2 Protein, Mouse (HEK293, His) Ectonucleotide pyrophosphatase/phosphodiesterase family member 2; Autotaxin; LysoPLD; Npps2; Pdnp2	Mouse	HEK293
	The ENPP-2 protein catalyzes the hydrolysis of lysophospholipids (especially lysophosphatidylcholine) to produce the signaling molecule lysophosphatidic acid (LPA).It also acts on sphingosine phosphocholine to produce sphingosine 1-phosphate, which affects cell movement.ENPP-2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived ENPP-2 protein, expressed by HEK293 , with N-10*His labeled tag.

HY-P70904

	ITPase Protein, Human (His) Inosine Triphosphate pyrophosphatase; ITPase; Inosine Triphosphatase; Non-Canonical Purine NTP pyrophosphatase; Non-Standard Purine NTP pyrophosphatase; Nucleoside-Triphosphate Diphosphatase; Nucleoside-Triphosphate pyrophosphatase; NTPase; Putative Oncogene Prot	Human	E. coli
	ITPase protein is a pyrophosphatase that is essential in nucleotide metabolism and can hydrolyze non-classical purine nucleotides such as ITP, dITP, dHAPTP and XTP into their respective monophosphate derivatives. It lacks distinction between deoxy and ribose forms. ITPase Protein, Human (His) is the recombinant human-derived ITPase protein, expressed by E. coli , with C-6*His labeled tag.

HY-P703781

	ENPP-2 Protein, Cynomolgus (HEK293, His) Ectonucleotide pyrophosphatase/phosphodiesterase family member 2; Autotaxin; LysoPLD; Npps2; Pdnp2	Cynomolgus	HEK293
	ENPP-2 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived ENPP-2 protein, expressed by HEK293, with N-His tag.

HY-P77357

	ENPP-3 Protein, Rhesus Macaque (sf9, His) Ectonucleotide pyrophosphatase/phosphodiesterase family member 3; NPP3; PD-Ibeta; PDNP3	Rhesus Macaque	Sf9 insect cells
	ENPP-3 is a hydrolase that metabolizes extracellular nucleotides (ATP, GTP, UTP, CTP), which is critical for immune regulation of inflammation and chronic allergic reactions. By eliminating extracellular ATP, ENPP-3 inhibits basophil and mast cell activation and suppresses the release of inflammatory cytokines. ENPP-3 Protein, Rhesus Macaque (sf9, His) is the recombinant Rhesus Macaque-derived ENPP-3 protein, expressed by Sf9 insect cells , with N-His labeled tag.

HY-P70167

	ENPP-2 Protein, Human (HEK293, His) rHuEctonucleotide phosphodiesterase family member 2/ENPP-2, His ; ATX; ATXFLJ26803; ATX-X; Autotaxin; autotaxin-t; EC 3.1.4.39; ectonucleotide pyrophosphatase/phosphodiesterase 2; E-NPP 2; ENPP2; LysoPLD; NPP2; PD-IALPHA; PDNP2; PDNP2NPP2	Human	HEK293
	The ENPP-2 protein catalyzes the hydrolysis of lysophospholipids (especially lysophosphatidylcholine) to produce the signaling molecule lysophosphatidic acid (LPA). It also acts on sphingosine phosphocholine to produce sphingosine 1-phosphate, which affects cell movement. ENPP-2 Protein, Human (HEK293, His) is the recombinant human-derived ENPP-2 protein, expressed by HEK293 , with C-6*His labeled tag.

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HY-P87153

	dUTPase Antibody (YA6846) Deoxyuridine 5' triphosphate nucleotidohydrolase, nuclear isoform antibody; Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial antibody; Deoxyuridine triphosphatase antibody; dut antibody; DUT_HUMAN antibody; dUTP nucleotidohydrolase antibody; dUTP pyrophosphatase antibody; dUTPase antibody; FLJ20622 antibody	WB, IHC-P, ICC/IF, FC	Human

HY-P82041

	Pyrophosphatase 1 Antibody (YA1786) PP; PP1; IOPPP; HEL-S-66p; SID6-8061	WB, IP	Human, Mouse
	Pyrophosphatase 1 Antibody (YA1786) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1786), targeting Pyrophosphatase 1, with a predicted molecular weight of 33 kDa (observed band size: 33 kDa). Pyrophosphatase 1 Antibody (YA1786) can be used for WB, IP experiment in human, mouse background.

HY-P86861

	ENPP5 Antibody (YA6554) E-NPP 5 antibody; E-NPP5 antibody; ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative function) antibody; Ectonucleotide pyrophosphatase/phosphodiesterase 5 antibody; Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 antibody; ENPP5 antibody; ENPP5_HUMAN antibody; NPP-5 antibody; UNQ550/PRO1107 antibody	WB, ICC/IF, FC	Human, Mouse

HY-P86994

	NUDT5 Antibody (YA6687) ADP sugar pyrophosphatase antibody; ADP-sugar pyrophosphatase antibody; hYSAH 1 antibody; hYSAH1 antibody; Nucleoside diphosphate linked moiety X motif 5 antibody; Nucleoside diphosphate linked moiety X type motif 5 antibody; Nucleoside diphosphate-linked moiety X motif 5 antibody; Nudix (nucleoside diphosphate linked moiety X) type motif 5 antibody; Nudix motif 5 antibody; Nudix type motif 5 antibody; ADP sugar pyrophosphatase antibody; ADP-sugar pyrophosphatase antibody; hYSAH 1 antibody; hYSAH1 antibody; Nucleoside diphosphate linked moiety X motif 5 antibody; Nucleoside diphosphate linked moiety X type motif 5 antibody; Nucleoside diphosphate-linked moiety X motif 5 antibody; Nudix (nucleoside diphosphate linked moiety X) type motif 5 antibody; Nudix motif 5 antibody; Nudix type motif 5 antibody; NUDT 5 antibody; Nudt5 antibody; NUDT5_HUMAN antibody; YSA1 antibody; YSA1H antibody	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat

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pyrophosphatase

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