ENPP-3 Protein, Rhesus Macaque (sf9, His)

ENPP-3 is a hydrolase that metabolizes extracellular nucleotides (ATP, GTP, UTP, CTP), which is critical for immune regulation of inflammation and chronic allergic reactions. By eliminating extracellular ATP, ENPP-3 inhibits basophil and mast cell activation and suppresses the release of inflammatory cytokines. ENPP-3 Protein, Rhesus Macaque (sf9, His) is the recombinant Rhesus Macaque-derived ENPP-3 protein, expressed by Sf9 insect cells , with N-His labeled tag.

ENPP-3, a hydrolase, exhibits the ability to metabolize various extracellular nucleotides, including ATP, GTP, UTP, and CTP. This enzymatic activity plays a crucial role in modulating immune responses, particularly during inflammation and the chronic phases of allergic reactions. ENPP-3 acts by eliminating extracellular ATP, a signaling molecule that activates basophils and mast cells, leading to the release of inflammatory cytokines. Moreover, in the lumen of the small intestine, ENPP-3 metabolizes extracellular ATP, thereby preventing ATP-induced apoptosis of intestinal plasmacytoid dendritic cells. Besides its involvement in nucleotide metabolism, ENPP-3 also exhibits alkaline phosphodiesterase activity, adding to its multifaceted role in cellular processes.

Rhesus Macaque

Sf9 insect cells

N-His

XP_001103528 (R46-I874)

710232  [NCBI]

Approximately 97.2 kDa.

Greater than 95% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.