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pyrimidines

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288

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36

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-E70575

    DNA Glycosylase Others
    Endonuclease VIII is a DNA repair enzyme that excises oxidized pyrimidines from DNA. Endonuclease VIII is a bacterial DNA glycosylase/AP lyase that excises modified pyrimidines, including thymine glycol (Tg), uracil glycol, dihydrothymine, dihydrouracil (DHU) .
    Endonuclease VIII
  • HY-129046
    RNase A, Bovine pancreas
    1 Publications Verification

    Ribonuclease A; EC 4.6.1.18; RNase A

    DNA/RNA Synthesis Others
    RNase A, Bovine pancreas (Ribonuclease A) cleaves the 3' end of RNA to pyrimidine and actively cleaves RNA at each pyrimidine residue. RNase A, bovine pancreas catalyzes the hydrolysis of single-stranded RNA in the absence of metal ions or cofactors .
    RNase A, Bovine pancreas
  • HY-I0960
    Uracil
    4 Publications Verification

    Endogenous Metabolite Drug Derivative Cancer
    Uracil is a pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA. Uracil is a frequently occurring DNA base damage that results from the spontaneous or chemically induced deamination of cytosine and is mutagenic at the level of replication. Uracil could potentially alter transcriptional fidelity, resulting in production of mutant proteins .
    Uracil
  • HY-E70578

    DNA Glycosylase Others
    T4 Endonuclease V is a dual-activity DNA glycosylase that combines the activities of DNA N-glycosylase and AP lyase. T4 Endonuclease V can repair ultraviolet (UV)-induced cyclobutane pyrimidine dimers in DNA .
    T4 Endonuclease V
  • HY-W013046

    PRPP pentasodium

    Endogenous Metabolite Others
    Phosphoribosyl pyrophosphate (PRPP) pentasodium is an important metabolite required in the biosynthesis of purine and pyrimidine nucleotides, the amino acids histidine and tryptophan, and the cofactors NAD and NADP .
    Phosphoribosyl pyrophosphate pentasodium
  • HY-W751165

    β-Uridine-13C9,15N2

    Endogenous Metabolite Nucleoside Antimetabolite/Analog Isotope-Labeled Compounds Cancer
    Uridine-13C9,15N2 (β-Uridine-13C9,15N2) is 13C and 15N labeled Uridine (HY-B1449). Uridine is a glycosylated pyrimidine-analog containing uracil attached to a ribose ring (or more specifically, aribofuranose) via a β-N1-glycosidic bond .
    Uridine-13C9,15N2
  • HY-Y0519R

    Reference Standards Endogenous Metabolite Metabolic Disease
    Pyrimidine (Standard) is the analytical standard of Pyrimidine. This product is intended for research and analytical applications. Pyrimidine is a nitrogen-containing heterocyclic compound and endogenous metabolite. Pyrimidine derivatives can be used in pancreatic cancer, triple-negative breast cancer, colon carcinoma and neuron research .
    Pyrimidine (Standard)
  • HY-167828

    Ras Cancer
    ARN25062 (compound 27) is a CDC42/RHOJ inhibitor with antitumor activity. ARN25062 is a novel trisubstituted pyrimidine derivative .
    ARN25062
  • HY-B1449S12

    β-Uridine-d12

    Endogenous Metabolite Nucleoside Antimetabolite/Analog Isotope-Labeled Compounds Cancer
    Uridine-d12 (β-Uridine-d12) is the deuterium labeled Uridine (HY-B1449). Uridine is a glycosylated pyrimidine-analog containing uracil attached to a ribose ring (or more specifically, aribofuranose) via a β-N1-glycosidic bond .
    Uridine-d12
  • HY-161071

    Fungal Infection Cancer
    Antioxidant/anticancer agent 1 (compound 5) is a pyrimidine-derivatized Schiff base based on pyrimidine hydroxy-1-naphthaldehyde and has antibacterial, antioxidant, antifungal, and anticancer properties. Antioxidant/anticancer agent 1 .
    Antioxidant/anticancer agent 1
  • HY-135282

    Dihydroorotate Dehydrogenase DNA/RNA Synthesis Infection
    DHODH-IN-1 (compound 18d) is a potent Dihydroorotate Dehydrogenase (DHODH) inhibitor with an IC50 of 25 nM. DHODH-IN-1 is an inhibitor of pyrimidine biosynthesis pathway .
    DHODH-IN-1
  • HY-139974

    Cholinesterase (ChE) Neurological Disease
    BChE-IN-2 (compound 22) is a potent inhibitor of BChE with a Ki of 0.099 μM. BChE-IN-2 is a pyrimidine and pyridine derivative. BChE-IN-2 has the potential for the research of Alzheimer’s disease (AD) .
    BChE-IN-2
  • HY-158177

    EGFR Cancer
    EGFR T790M/L858R-IN-6 (compound 53), a pyrimidine compound, is a potent EGFR T790M/L858R inhibitor. EGFR T790M/L858R-IN-6 shows 90.88% enzyme activity inhibition with 0.05 μM .
    EGFR T790M/L858R-IN-6
  • HY-155761

    Fungal Infection
    Antifungal agent 71 (compound 6r) is a trifluoromethyl pyrimidine derivative with antifungal activity. Antifungal agent 71 exhibits good in vitro antifungal activity against F. oxysporum, with the EC50 value of 3.61 μg/mL .
    Antifungal agent 71
  • HY-176063

    TRP Channel Opioid Receptor Neurological Disease
    TRPV1 antagonist 11 (compound 2ac) is a potent TRPV1 antagonist with an IC50 of 29.3 nM. TRPV1 antagonist 11 is a potent μ-opioid receptor (MOR) agonist with a Ki of 60.3 nM. TRPV1 antagonist 11, a pyrimidine piperazine, exhibits pain relieving effects by antagonizing TRPV1 and stimulating MOR. TRPV1 antagonist 11 shows a potent, dose-dependent anti-nociceptive effect in a Formalin-induced pain model in mice .
    TRPV1 antagonist 11
  • HY-16182A
    Ecamsule disodium
    1 Publications Verification

    Biochemical Assay Reagents Others
    Ecamsule disodium is a broad-spectrum UVA filter that can be used in sunscreen product. Ecamsule reduces biological damage caused by solar radiation such as pyrimidine dimer formation, p53 protein accumula-tion, or collagenase 2 expression .
    Ecamsule disodium
  • HY-N0157
    Orotic acid
    3 Publications Verification

    6-Carboxyuracil; Vitamin B13

    Nucleoside Antimetabolite/Analog Endogenous Metabolite Metabolic Disease
    Orotic acid (6-Carboxyuracil), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Orotic acid is a marker for measurement in routine newborn screening for urea cycle disorders. Orotic acid can induce hepatic steatosis and hepatomegaly in rats .
    Orotic acid
  • HY-N0157A
    Orotic acid zinc
    3 Publications Verification

    6-Carboxyuracil zinc; Vitamin B13 zinc

    Nucleoside Antimetabolite/Analog Endogenous Metabolite Metabolic Disease
    Orotic acid (zinc), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Orotic acid (zinc) is a marker for measurement in routine newborn screening for urea cycle disorders. Orotic acid (zinc) can induce hepatic steatosis and hepatomegaly in rats .
    Orotic acid zinc
  • HY-130812

    Drug-Linker Conjugates for ADC Cancer
    Gemcitabine-O-Si(di-iso)-O-Mc is a agent-linker conjugate for ADC with potent antitumor activity by using Gemcitabine (a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent; HY-17026), linked via the ADC linker .
    Gemcitabine-O-Si(di-iso)-O-Mc
  • HY-N8060

    Orotidine monophosphate; Orotidylic acid

    Endogenous Metabolite Others
    Orotidine 5′-monophosphate is a pyrimidine ribonucleoside and plays a role as an endogenous metabolite of human, E. coli or mouse. Orotidine 5′-monophosphate is an intermediate in the biosynthesis of?uridine monophosphate (UMP). Orotidine 5′-monophosphate can be used for the study of mechanism of orotidine 5′-monophosphate decarboxylase .
    Orotidine 5′-monophosphate
  • HY-112732
    Sparfosic acid
    2 Publications Verification

    Apoptosis Metabolic Disease Cancer
    Sparfosic acid, a DNA antimetabolite agent, is a potent inhibitor of aspartate transcarbamoyl transferase, the enzyme catalyzing the second step of de novo pyrimidine biosynthesis. Sparfosic acid synergistically enhances the cytotoxicity of a combination of 5-fluorouracil (5-FU) and interferon-alpha (IFN) against human colon cancer cell lines .
    Sparfosic acid
  • HY-149877

    DNA/RNA Synthesis Dihydroorotate Dehydrogenase Cancer
    hDHODH-IN-12 is a potent DHODH inhibitor with an IC50 value of 0.421 μM. DHODH is the rate-limiting enzyme in the de novo synthesis of pyrimidine which is essential in DNA/RNA Synthesis. hDHODH-IN-12 is present in the inner membrane of human mitochondria.hDHODH-IN-12 can be used for the research of lung cancer .
    hDHODH-IN-12
  • HY-16182
    Ecamsule
    1 Publications Verification

    Biochemical Assay Reagents Others
    Ecamsule is a broad-spectrum UVA filter that can be used in sunscreen product. Ecamsule reduces biological damage caused by solar radiation such as pyrimidine dimer formation, p53 protein accumula-tion, or collagenase 2 expression. Ecamsule has the potential for the research of polymorphous light eruption (PMLE) .
    Ecamsule
  • HY-137602

    Up2U

    P2Y Receptor Others
    P1,P2-Diuridine-5’-diphosphate (Up2U) is a symmetrical dinucleoside polyphosphate containing two pyrimidine base moieties. P1,P2-Diuridine-5’-diphosphate is also an activator of purinergic P2Y receptor .
    P1,P2-Diuridine-5’-diphosphate
  • HY-112732B
    Sparfosic acid trisodium
    2 Publications Verification

    Apoptosis Metabolic Disease Cancer
    Sparfosic acid trisodium is a DNA antimetabolite agent and a potent inhibitor of aspartate transcarbamoyl transferase. Aspartate transcarbamoyl transferase catalyzes the second step of de novo pyrimidine biosynthesis. Sparfosic acid trisodium synergistically enhances the cytotoxicity of a combination of 5-fluorouracil (5-FU) and interferon-alpha (IFN) against human colon cancer cell lines .
    Sparfosic acid trisodium
  • HY-W043311

    Pyrimidine-4-carboxylicacidmethylester

    Drug Intermediate Others
    Methyl pyrimidine-4-carboxylate (Pyrimidine-4-carboxylicacidmethylester) is a synthetic intermediate useful for pharmaceutical synthesis.
    Methyl pyrimidine-4-carboxylate
  • HY-N0157AR

    Nucleoside Antimetabolite/Analog Endogenous Metabolite Metabolic Disease
    Orotic acid (zinc) (Standard) is the analytical standard of Orotic acid (zinc). This product is intended for research and analytical applications. Orotic acid (zinc), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Orotic acid (zinc) is a marker for measurement in routine newborn screening for urea cycle disorders. Orotic acid (zinc) can induce hepatic steatosis and hepatomegaly in rats .
    Orotic acid zinc (Standard)
  • HY-16182R

    Biochemical Assay Reagents Reference Standards Others
    Ecamsule (Standard) is the analytical standard of Ecamsule. This product is intended for research and analytical applications. Ecamsule is a broad-spectrum UVA filter that can be used in sunscreen product. Ecamsule reduces biological damage caused by solar radiation such as pyrimidine dimer formation, p53 protein accumula-tion, or collagenase 2 expression. Ecamsule has the potential for the research of polymorphous light eruption (PMLE) .
    Ecamsule (Standard)
  • HY-115528

    Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Cancer
    FF-10502, a structural analog of Gemcitabine, is a pyrimidine nucleoside antimetabolite. FF-10502 inhibits DNA polymerase α and β. FF-10502 shows beneficial anticancer activity via a mechanism of action on dormant cells .
    FF-10502
  • HY-123032

    BV-araU

    DNA/RNA Synthesis Infection
    Sorivudine (BV-araU) is an orally active synthetic pyrimidine nucleoside antimetabolite agent. Sorivudine derives its antiviral activity from selective conversion by a specific thymidine kinase present in certain DNA viruses to nucleotides, which can in turn interfere with viral DNA synthesis .
    Sorivudine
  • HY-W488088

    Biochemical Assay Reagents
    Pyrimidine-4-carboxylic acid (sodium) is a kind of biochemical reagent.
    Pyrimidine-4-carboxylic acid sodium
  • HY-12319

    β-catenin Wnt Cancer
    Cardiogenol C is a potent cell-permeable pyrimidine inducer which prompts the differentiation of ESCs into cardiomyocytes (EC50=100 nM) . Cardiogenol C also acts cardiomyogenic on already lineage-committed progenitor cell types with a limited degree of plasticity. Cardiogenol C is a useful cardiomyogenic agent and can be used as a tool to improve cardiac repair by cell transplantation therapy in animal models .
    Cardiogenol C
  • HY-12319A

    β-catenin Wnt Cardiovascular Disease
    Cardiogenol C hydrochloride is a potent cell-permeable pyrimidine inducer which prompts the differentiation of ESCs into cardiomyocytes (EC50=100 nM) . Cardiogenol C hydrochloride also acts cardiomyogenic on already lineage-committed progenitor cell types with a limited degree of plasticity. Cardiogenol C hydrochloride is a useful cardiomyogenic agent and can be used as a tool to improve cardiac repair by cell transplantation therapy in animal models .
    Cardiogenol C hydrochloride
  • HY-N8060A
    Orotidine 5′-monophosphate trisodium
    1 Publications Verification

    Orotidine monophosphate trisodium; Orotidylic acid trisodium

    Endogenous Metabolite DNA/RNA Synthesis Metabolic Disease
    Orotidine 5'-monophosphate trisodium is a pyrimidine nucleotide. Orotidine 5'-monophosphate trisodium is synthesized via the de novo synthesis pathway for DNA synthesis in a large number of microorganisms including M. tuberculosis, S. cerevisiae, S. typhimurium and P. falciparum to name a few. The synthesis of orotidine 5'-monophosphate trisodium uses phosphoribosyl pyrophosphate (PRPP) and orotic acid (OA) as the substrates catalyzed by orotate phosphoribosyltransferase (OPRT) .
    Orotidine 5′-monophosphate trisodium
  • HY-N6961
    Lapachol
    2 Publications Verification

    Dihydroorotate Dehydrogenase DNA/RNA Synthesis Parasite Infection Inflammation/Immunology Cancer
    Lapachol, a natural naphthoquinone, is an orally active, potent DHODH inhibitor. Lapachol has immunosuppressive activity on lymphocytes through its direct ability to block DHODH activity and inhibit pyrimidine synthesis. Lapachol is a vitamin K antagonist with antitumor activity and can inhibit DNA and RNA synthesis in neoplastic cells. Lapachol has anti-Leishmania activity .
    Lapachol
  • HY-17499

    EGFR Apoptosis Cancer
    EGFR-IN-12 is a 4,6-disubstituted pyrimidine and is a potent, ATP-competitive, irreversible and highly selective EGFR inhibitor with an IC50of 21 nM. EGFR-IN-12 also inhibits mutant EGFR L858R and EGFR L861Q with IC50s of 63 nM and 4 nM, respectively. EGFR-IN-12 displays strong selectivity for EGFR over HER4 (IC50 = 7640 nM) and a panel of 55 other kinases. EGFR-IN-12 induces cells apoptosis and has antitumor activity .
    EGFR-IN-12
  • HY-W017769

    Pyrimidin-4-ylmethanamine

    Drug Intermediate Others
    4-Pyrimidine methanamine (Pyrimidin-4-ylmethanamine) is a synthetic intermediate useful for pharmaceutical synthesis.
    4-Pyrimidine methanamine
  • HY-125818C

    Cytidine triphosphate disodium hydrate; 5'-CTP disodium hydrate

    DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Endogenous Metabolite Metabolic Disease
    Cytidine 5′-triphosphate is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). Cytidine 5′-triphosphate is an essential biomolecule in the de novo pyrimidine biosynthetic pathway in T. gondii .
    Cytidine-5'-triphosphate disodium hydrate
  • HY-W004464S

    Endogenous Metabolite Isotope-Labeled Compounds Others
    2-(1-Piperazinyl)pyrimidine-d8 is deuterium labeled 2-(1-Piperazinyl)pyrimidine.
    2-(1-Piperazinyl)pyrimidine-d8
  • HY-13434AR

    SQ23377 calcium (Standard)

    Reference Standards Calcium Channel PKC Bacterial Apoptosis Antibiotic Infection Cancer
    2-(1-Piperazinyl)pyrimidine (Standard) is the analytical standard of 2-(1-Piperazinyl)pyrimidine. This product is intended for research and analytical applications. 2-(1-Piperazinyl)pyrimidine is the major metabolite of Tandospirone (HY-14558) .
    Ionomycin calcium (Standard)
  • HY-W004464R

    Reference Standards Endogenous Metabolite Neurological Disease
    2-(1-Piperazinyl)pyrimidine (Standard) is the analytical standard of 2-(1-Piperazinyl)pyrimidine. This product is intended for research and analytical applications. 2-(1-Piperazinyl)pyrimidine is the major metabolite of Tandospirone (HY-14558) .
    2-(1-Piperazinyl)pyrimidine (Standard)
  • HY-W002404

    Biochemical Assay Reagents Others
    Pyrimidine-4-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    Pyrimidine-4-carboxylic acid
  • HY-N6961R

    Reference Standards Dihydroorotate Dehydrogenase DNA/RNA Synthesis Parasite Infection Inflammation/Immunology Cancer
    Lapachol (Standard) is the analytical standard of Lapachol. This product is intended for research and analytical applications. Lapachol, a natural naphthoquinone, is an orally active, potent DHODH inhibitor. Lapachol has immunosuppressive activity on lymphocytes through its direct ability to block DHODH activity and inhibit pyrimidine synthesis. Lapachol is a vitamin K antagonist with antitumor activity and can inhibit DNA and RNA synthesis in neoplastic cells. Lapachol has anti-Leishmania activity .
    Lapachol (Standard)
  • HY-125818
    Cytidine-5'-triphosphate
    2 Publications Verification

    Cytidine triphosphate; 5'-CTP

    DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Endogenous Metabolite Metabolic Disease
    Cytidine 5′-triphosphate (Cytidine triphosphate; 5'-CTP) is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). Cytidine 5′-triphosphate is an essential biomolecule in the de novo pyrimidine biosynthetic pathway in T. gondii .
    Cytidine-5'-triphosphate
  • HY-78337

    Biochemical Assay Reagents Others
    Methyl pyrimidine-2-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    Methyl pyrimidine-2-carboxylate
  • HY-17499R

    EGFR Apoptosis Cancer
    EGFR-IN-12 (Standard) is the analytical standard of EGFR-IN-12. This product is intended for research and analytical applications. EGFR-IN-12 is a 4,6-disubstituted pyrimidine and is a potent, ATP-competitive, irreversible and highly selective EGFR inhibitor with an IC50of 21 nM. EGFR-IN-12 also inhibits mutant EGFRL858R and EGFRL861Q with IC50s of 63 nM and 4 nM, respectively. EGFR-IN-12 displays strong selectivity for EGFR over HER4 (IC50 = 7640 nM) and a panel of 55 other kinases. EGFR-IN-12 induces cells apoptosis and has antitumor activity .
    EGFR-IN-12 (Standard)
  • HY-Y0519

    Endogenous Metabolite Neurological Disease Cancer
    Pyrimidine is a nitrogen-containing heterocyclic compound and endogenous metabolite. Pyrimidine derivatives can be used in pancreatic cancer, triple-negative breast cancer, colon carcinoma and neuron research .
    Pyrimidine
  • HY-159592

    PROTAC Linkers Cancer
    Piperazine-Pyrimidine-Cyclohexane-COOEt is a PROTAC linker. Piperazine-Pyrimidine-Cyclohexane-COOEt can be used in the synthesis of PROTAC SMARCA2/4-degrader-1 (HY-159452) .
    Piperazine-Pyrimidine-Cyclohexane-COOEt
  • HY-152980

    Nucleoside Antimetabolite/Analog Others
    4-Chloro-7-(2-deoxy-β-D-erythro-pentofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine is a pyrimidine nucleoside analog. Pyrimidine nucleoside analogs have a wide range of biochemical and anticancer activities. These include DNA synthesis inhibition, RNA synthesis inhibition, antiviral effects, and immunomodulatory effects .
    4-Chloro-7-(2-deoxy-β-D-erythro-pentofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine
  • HY-154046

    Nucleoside Antimetabolite/Analog Others
    4,6-Diamino-1-(2-deoxy-beta-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine is a pyrimidine nucleoside analog. Pyrimidine nucleoside analogs have a wide range of biochemical and anticancer activities. These include DNA synthesis inhibition, RNA synthesis inhibition, antiviral effects, and immunomodulatory effects .
    4,6-Diamino-1-(2-deoxy-beta-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine

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