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protein cross-link

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72

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3

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20

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2

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W009034

    Eukaryotic Initiation Factor (eIF) Others
    Fmoc-Suberol is a protein cross-linking agent.
    Fmoc-Suberol
  • HY-W017831

    Biochemical Assay Reagents Others
    2-Maleimido acetic acid is a protein cross-linking agent.
    2-Maleimido acetic acid
  • HY-W041994

    Biochemical Assay Reagents Others
    GMBS is a heterobifunctional cross-linker. GMBS can be used in chemical cross-linking of proteins coupled with mass spectrometry (CXMS) to study protein folding and to map the interfaces between interacting proteins .
    GMBS
  • HY-107783

    Others Cancer
    Sulfo-GMBS is a cross-linking agent widely used in chemical modification and coupling reactions of proteins and peptides. Among the amine-sulfhydryl cross-linkers, Sulfo-GMBS generated the largest number of cross-links and covered most of the cross-links that were identified with AMAS and GMBS .
    Sulfo-GMBS
  • HY-W040113

    Biochemical Assay Reagents Others
    6-(N-Boc)caproic acid NHS is a protein cross-linking agent.
    6-(N-Boc)caproic acid NHS
  • HY-W013538

    N,N'-Ethylenedimaleimide

    Biochemical Assay Reagents Others
    1,2-Bis(maleimido)ethane (N,N'-Ethylenedimaleimide) is a protein cross-linking agent.
    1,2-Bis(maleimido)ethane
  • HY-76214

    Dibenzyl hydrazine-1,2-dicarboxylate

    Others Others
    Dibenzyl hydrazodicarboxylate (Dibenzyl hydrazine-1,2-dicarboxylate) is a protein cross-linking agent.
    Dibenzyl hydrazodicarboxylate
  • HY-W012166

    NHS-Bromoacetate

    Biochemical Assay Reagents Others
    N-Succinimidyl bromoacetate is a heterobifunctional cross-linking reagent can be used to prepare peptide-protein immunogens .
    N-Succinimidyl bromoacetate
  • HY-122429

    LNL

    Biochemical Assay Reagents Others
    Lysinonorleucine (LNL) is a Schiff base-type protein cross-link. Lysinonorleucine could be used as a potential and specific biomarker to indicate the level of protein oxidation .
    Lysinonorleucine
  • HY-159008

    Biochemical Assay Reagents Others
    NHSF is a protein cross-linking agent .
    NHSF
  • HY-W008575

    Biochemical Assay Reagents Others
    N-Fmoc-N-methoxy-3-aminopropionic acid, a Weinreb amide linker, is a protein cross-linking agent .
    N-Fmoc-N-methoxy-3-aminopropionic acid
  • HY-W074785

    Biochemical Assay Reagents Others
    Carboxyl diazirine alkyne is a protein cross-linking compound. Carboxyl diazirine alkyne play crucial roles in the research on the inhibition and labeling of FTO protein by fluorescein derivatives .
    Carboxyl diazirine alkyne
  • HY-157414

    Biochemical Assay Reagents Others
    Azide-A-DSBSO crosslinker is a mass spectrometry (MS) cleavable, membrane permeable, homobifunctional, azide-labeled, acid-cleavable crosslinking peptide. Azide-A-DSBSO crosslinker crosslinks proteins via NHS ester reaction with lysine residues. Azide-A-DSBSO crosslinker can be used to study protein-protein interactions by cross-linking mass spectrometry (XL-MS) [1] .
    Azide-A-DSBSO crosslinker
  • HY-D0853A
    DiAzKs hydrochloride
    1 Publications Verification

    H-L-Photo-lysine hydrochloride

    Fluorescent Dye Others
    DiAzKs (H-L-Photo-lysine) hydrochloride is a diazirine-containing lysine amino acid and is a photo-cross-linker. DiAzKs hydrochloride can site-selective incorporated into proteins and is used to crosslink protein-protein interactions in vitro and in living cells. DiAzKs hydrochloride acts as a UV light-activated photo-crosslinking probe .
    DiAzKs hydrochloride
  • HY-D0853
    DiAzKs
    1 Publications Verification

    H-L-Photo-lysine

    Fluorescent Dye Others
    DiAzKs (H-L-Photo-lysine) is a diazirine-containing lysine amino acid and is a photo-cross-linker. DiAzKs can site-selective incorporated into proteins and is used to crosslink protein-protein interactions in vitro and in living cells. DiAzKs acts as a UV light-activated photo-crosslinking probe .
    DiAzKs
  • HY-137251

    Biochemical Assay Reagents Others
    Sulfo-MBS sodium is a heterobifunctional crosslinker with a maleimide group and an N-hydroxysuccinimide (NHS) ester group, which can react with cysteine residues and lysine residues on proteins. Sulfo-MBS sodium be used for protein cross-linking studies .
    Sulfo-MBS sodium
  • HY-129380A
    Fructosyl-lysine dihydrochloride
    1 Publications Verification

    Fructoselysine dihydrochloride

    Endogenous Metabolite Metabolic Disease
    Fructosyl-lysine (Fructoselysine) dihydrochloride is an amadori glycation product from the reaction of glucose and lysine by the Maillard reaction. Fructosyl-lysine dihydrochloride is the precursor to glucosepane, a lysine–arginine protein cross-link that can be an indicator in diabetes detection .
    Fructosyl-lysine dihydrochloride
  • HY-129380
    Fructosyl-lysine
    1 Publications Verification

    Fructoselysine

    Endogenous Metabolite Metabolic Disease
    Fructosyl-lysine (Fructoselysine) is an amadori glycation product from the reaction of glucose and lysine by the Maillard reaction. Fructosyl-lysine is the precursor to glucosepane, a lysine–arginine protein cross-link that can be an indicator in diabetes?detection .
    Fructosyl-lysine
  • HY-48999A

    Others Cancer
    FSK hydrochloride is fluorosulfonyloxybenzoyl-l-lysine, with a long and flexible aryl fluorosulfate-containing side chain that can reach protein sites that are difficult to reach by covalent linkage. FSK hydrochloride is a modified nanomolecule that targets the epidermal growth factor receptor (EGFR), creating a covalent binding that results in irreversible binding. FSK hydrochloride captures unknown enzyme-substrate interactions in living cells through genetically encoded chemical cross-linking, targeting residues beyond Cys, and cross-linking at the binding periphery. FSK hydrochloride enables the construction of bioreactive SuFEx systems for creating covalent bonds in different proteins in vitro and in vivo .
    FSK hydrochloride
  • HY-B0245
    Busulfan
    10+ Cited Publications

    DNA Alkylator/Crosslinker Apoptosis Inflammation/Immunology Cancer
    Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent .
    Busulfan
  • HY-B0245S

    DNA Alkylator/Crosslinker Apoptosis Inflammation/Immunology Cancer
    Busulfan-d8 is a deuterium labeled Busulfan. Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent .
    Busulfan-d8
  • HY-174358C

    Biochemical Assay Reagents Others
    HOOC-PEG-COOH (MW 5000) has two active carboxyl groups at both ends, which can selectively react with the amino groups in peptide coupling agents. HOOC-PEG-COOH (MW 5000) is a good cross-linking agent for PEGylation of proteins and peptides, nanoparticles and surface modification .
    HOOC-PEG-COOH (MW 5000)
  • HY-174358

    Biochemical Assay Reagents Others
    HOOC-PEG-COOH (MW 1000) has two active carboxyl groups at both ends, which can selectively react with the amino groups in peptide coupling agents. HOOC-PEG-COOH (MW 1000) is a good cross-linking agent for PEGylation of proteins and peptides, nanoparticles and surface modification .
    HOOC-PEG-COOH (MW 1000)
  • HY-174358D

    Biochemical Assay Reagents Others
    HOOC-PEG-COOH (MW 10000) has two active carboxyl groups at both ends, which can selectively react with the amino groups in peptide coupling agents. HOOC-PEG-COOH (MW 10000) is a good cross-linking agent for PEGylation of proteins and peptides, nanoparticles and surface modification .
    HOOC-PEG-COOH (MW 10000)
  • HY-174358E

    Biochemical Assay Reagents Others
    HOOC-PEG-COOH (MW 20000) has two active carboxyl groups at both ends, which can selectively react with the amino groups in peptide coupling agents. HOOC-PEG-COOH (MW 20000) is a good cross-linking agent for PEGylation of proteins and peptides, nanoparticles and surface modification .
    HOOC-PEG-COOH (MW 20000)
  • HY-174358H

    Biochemical Assay Reagents Others
    HOOC-PEG-COOH (MW 40000) has two active carboxyl groups at both ends, which can selectively react with the amino groups in peptide coupling agents. HOOC-PEG-COOH (MW 40000) is a good cross-linking agent for PEGylation of proteins and peptides, nanoparticles and surface modification .
    HOOC-PEG-COOH (MW 40000)
  • HY-174358A

    Biochemical Assay Reagents Others
    HOOC-PEG-COOH (MW 2000) has two active carboxyl groups at both ends, which can selectively react with the amino groups in peptide coupling agents. HOOC-PEG-COOH (MW 2000) is a good cross-linking agent for PEGylation of proteins and peptides, nanoparticles and surface modification .
    HOOC-PEG-COOH (MW 2000)
  • HY-174358B

    Biochemical Assay Reagents Others
    HOOC-PEG-COOH (MW 3400) has two active carboxyl groups at both ends, which can selectively react with the amino groups in peptide coupling agents. HOOC-PEG-COOH (MW 3400) is a good cross-linking agent for PEGylation of proteins and peptides, nanoparticles and surface modification .
    HOOC-PEG-COOH (MW 3400)
  • HY-W800818

    Biochemical Assay Reagents Others
    (Z)-Non-2-enyl 6-bromohexanoate is an analogue of Biotin and a protein cross-linking agent.(Z)-Non-2-enyl 6-bromohexanoate binds less tightly to biotin-binding proteins such as Avidin and is easily displaced by Biotin. It is used in the preparation of agarose matrices for affinity-based isolation of streptavidin-fluorophore conjugates.
    (Z)-Non-2-enyl 6-bromohexanoate
  • HY-129380AR

    Endogenous Metabolite Metabolic Disease
    Fructosyl-lysine (dihydrochloride) (Standard) is the analytical standard of Fructosyl-lysine (dihydrochloride). This product is intended for research and analytical applications. Fructosyl-lysine (Fructoselysine) dihydrochloride is an amadori glycation product from the reaction of glucose and lysine by the Maillard reaction. Fructosyl-lysine dihydrochloride is the precursor to glucosepane, a lysine-arginine protein cross-link that can be an indicator in diabetes detection .
    Fructosyl-lysine dihydrochloride (Standard)
  • HY-B0245R

    DNA Alkylator/Crosslinker Apoptosis Inflammation/Immunology Cancer
    Busulfan (Standard) is the analytical standard of Busulfan. This product is intended for research and analytical applications. Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent .
    Busulfan (Standard)
  • HY-148140
    Cross-linked dextran G 25
    1 Publications Verification

    Biochemical Assay Reagents Others
    Cross-linked dextran G 25 is a dextran chromatography medium. Cross-linked dextran G 25 separates from 1 to 5 kD (spherical proteins) and can be used for the separation of peptides as well as for the desalting and buffer replacement of large molecule proteins .
    Cross-linked dextran G 25
  • HY-137383

    Biochemical Assay Reagents Reactive Oxygen Species (ROS) Others
    Sulfo-SANPAH is a primary amine-nitrobenzene azide cross-linker. Sulfo-SANPAH is widely used to crosslink ECM proteins to various substrates, including acrylic-based hydrogels, such as polyacrylamide hydrogels. Sulfo-SANPAH facilitates covalent binding through its negatively charged sulfonate group on its N-hydroxysuccinimide ester ring and a photoactivated phenyl azide group that is highly reactive with nucleophiles and free radicals .
    Sulfo-SANPAH
  • HY-13588

    SCE-129 sodium

    Bacterial Antibiotic Infection
    Cefsulodin (SCE-129) sodium is a third generation β lactam antibiotic and member of the cephems subgroup of antibiotics. Cefsulodin sodium inhibits cell wall synthesis by competitively inhibiting penicillin binding protein (PBP) cross-linking and transpeptidation of peptidogly. Cefsulodin sodium is a potent tyrosine phosphatase inhibitor against mPTPB, a virulent phosphatase from Mycobacterium tuberculosis, with an IC50 value of 16 μM .
    Cefsulodin sodium
  • HY-13588B

    SCE-129 sodium hydrate

    Antibiotic Bacterial Infection
    Cefsulodin (SCE-129) sodium is a third generation β lactam antibiotic and member of the cephems subgroup of antibiotics. Cefsulodin sodium inhibits cell wall synthesis by competitively inhibiting penicillin binding protein (PBP) cross-linking and transpeptidation of peptidogly. Cefsulodin sodium is a potent tyrosine phosphatase inhibitor against mPTPB, a virulent phosphatase from Mycobacterium tuberculosis, with an IC50 value of 16 μM .
    Cefsulodin sodium hydrate
  • HY-W585874

    EAAT Neurological Disease
    Nε-(Carboxyethyl)lysine is an advanced glycation end product (AGE). Nε-(Carboxyethyl)lysine causes cross-linking between proteins, affects the structure and function of proteins, and leads to protein denaturation. Nε-(Carboxyethyl)lysine binds to RAGE receptors, affects cell signaling, regulates processes such as inflammatory response, cell proliferation and apoptosis. Nε-(Carboxyethyl)lysine affects glutamate transporter, reduces glutamate uptake and S100B protein secretion, affects neurotransmission in the nervous system, and exhibits diabetic-related neurotoxicity .
    Nε-(Carboxyethyl)lysine
  • HY-123740

    DSSO

    Biochemical Assay Reagents Others
    Disuccinimidyl sulfoxide (DSSO) is a mass spectrometry (MS)-cleavable cross-linker that is applicable for model peptides and proteins and a multisubunit protein complex. Disuccinimidyl sulfoxide contains two symmetric collision-induced dissociation (CID)-cleavable sites for identification of DSSO-cross-linked peptides based their distinct fragmentation patterns .
    Disuccinimidyl sulfoxide
  • HY-W035129

    Biochemical Assay Reagents Others
    endo-BCN-NHS carbonate is an elastin-like protein (ELP) modification reagent. endo-BCN-NHS carbonate can react with lysine residues in ELP to make ELP carry BCN groups, and then cross-link ELP through strain-promoted azide-alkyne cycloaddition (SPAAC) reaction. endo-BCN-NHS carbonate promotes hydrogel formation. endo-BCN-NHS carbonate is mainly used in cell encapsulation related research .
    endo-BCN-NHS carbonate
  • HY-156045C

    Biochemical Assay Reagents Others
    Cross-linked dextran G 200 is a hydrophilic gel based on molecular size exclusion and targeted macromolecular separation. Cross-linked dextran G 200 works through the gel permeation mechanism, and the cross-linked structure forms a three-dimensional network with a specific pore size, achieving separation based on the molecular hydrodynamic volume. Cross-linked dextran G 200 can be used to adjust the osmotic solute distribution coefficient and the ability to maintain osmotic equilibrium, such as in gel filtration chromatography for purification and analysis of biomacromolecules such as proteins and nucleic acids . Cross-linked dextran G 200 can also be used as a gel filtration filler (particle size range: 40-120 μm; globular protein separation range: 5-600 kDa) .
    Cross-linked dextran G 200
  • HY-13588R

    SCE-129 sodium (Standard)

    Reference Standards Bacterial Antibiotic Infection
    Cefsulodin (sodium) (Standard) is the analytical standard of Cefsulodin (sodium). This product is intended for research and analytical applications. Cefsulodin (SCE-129) sodium is a third generation β lactam antibiotic and member of the cephems subgroup of antibiotics. Cefsulodin sodium inhibits cell wall synthesis by competitively inhibiting penicillin binding protein (PBP) cross-linking and transpeptidation of peptidogly. Cefsulodin sodium is a potent tyrosine phosphatase inhibitor against mPTPB, a virulent phosphatase from Mycobacterium tuberculosis, with an IC50 value of 16 μM .
    Cefsulodin sodium (Standard)
  • HY-B1275A
    Cephalothin
    2 Publications Verification

    Cephalotin

    Beta-lactamase Bacterial Antibiotic Infection Cardiovascular Disease
    Cephalothin (Cephalotin) is a semi-synthetic cephalosporin antibiotic and beta-lactam antibiotic. Cephalothin inhibits class C β-lactamase AmpC, with an Ki of 0.32 µM. Cephalothin binds to penicillin-binding proteins, interfering with the cross-linking of peptidoglycan in the cell wall and thus hindering the normal synthesis of the bacterial cell wall. Cephalothin shows antibacterial activity against a variety of bacteria. Cephalothin can be used in hematological and nephrotoxicity studies .
    Cephalothin
  • HY-138560A

    Biochemical Assay Reagents Others
    Cross-linked dextran G 50, medium is a gel filtration medium. Cross-linked dextran G 50, medium can be used in gel permeation chromatography for fractionation of the glycopeptide mixture (Sphere protein separation range: 1.5K-30K Da; Polysaccharide separation range: 500-10K Da). Cross-linked dextran G 50, medium are microspheres with an average particle size of D50 = 220-250 μm .
    Cross-linked dextran G 50, medium
  • HY-138560B

    Biochemical Assay Reagents Others
    Cross-linked dextran G 50, fine is a gel filtration medium. Cross-linked dextran G 50, fine can be used in gel permeation chromatography for fractionation of the glycopeptide mixture (Sphere protein separation range: 1.5K-30K Da; Polysaccharide separation range: 500-10K Da). Cross-linked dextran G 50, fineThe average particle size is D50=110-130 μmof microspheres .
    Cross-linked dextran G 50, fine
  • HY-138560
    Cross-linked dextran G 50
    1 Publications Verification

    Biochemical Assay Reagents Others
    Cross-linked dextran G 50 is a gel filtration medium. Cross-linked dextran G 50 can be used in gel permeation chromatography for fractionation of the glycopeptide mixture (Sphere protein separation range: 1.5K-30K Da; Polysaccharide separation range: 500-10K Da) .
    Cross-linked dextran G 50
  • HY-W127719

    Biochemical Assay Reagents Others
    Photobiotin (acetate)It is a biological probe used to study biochemical processes such as protein interactions and enzymatic reactions. It is a molecule containing a photosensitive group, which can be combined with specific target molecules (such as proteins, nucleic acids, etc.) through photochemical cross-linking technology, so as to realize the labeling and detection of these molecules. During the photosensitive crosslinking process, Photobiotin (acetate)Can participate in the formation of covalent bonds and form stable compounds. In addition, the compound also has high biocompatibility and biological activity, so it is widely used in the field of biomedical research, such as enzymatic research, proteomics, western blotting and other aspects. Photobiotin (acetate) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Photobiotin acetate
  • HY-W096122

    Biochemical Assay Reagents Others
    DTSSP Crosslinker disodium is a protein cross-linker containing a disulfide bond. DTSSP Crosslinker disodium can react with sidechains of amino acids that are within close proximity .
    DTSSP Crosslinker disodium
  • HY-156045

    Biochemical Assay Reagents Others
    Cross-linked dextran G 15 is a hydrophilic gel that can be used as a gel filter filler (Sphere protein separation range: >1500 Da; Polysaccharide separation range: >1500 Da) .
    Cross-linked dextran G 15
  • HY-148139

    Biochemical Assay Reagents Others
    Cross-linked dextran G 75 is a Gel-filtration media. Cross-linked dextran G 75 also is a dextran-based matrix and used for Gel-filtration chromatography (Particle size range: 40-120 μm; Sphere protein separation range: 3K-80K Da; Polysaccharide separation range: 1K-50K Da) .
    Cross-linked dextran G 75
  • HY-B1275AR

    Cephalotin (Standard)

    Beta-lactamase Reference Standards Bacterial Antibiotic Infection Cardiovascular Disease
    Cephalothin (Standard) is the analytical standard of Cephalothin (HY-B1275A). This product is intended for research and analytical applications. Cephalothin (Cephalotin) is a semi-synthetic cephalosporin antibiotic and beta-lactam antibiotic. Cephalothin inhibits class C β-lactamase AmpC, with an Ki of 0.32 µM. Cephalothin binds to penicillin-binding proteins, interfering with the cross-linking of peptidoglycan in the cell wall and thus hindering the normal synthesis of the bacterial cell wall. Cephalothin shows antibacterial activity against a variety of bacteria. Cephalothin can be used in hematological and nephrotoxicity studies .
    Cephalothin (Standard)
  • HY-156045A

    Biochemical Assay Reagents Others
    Cross-linked dextran G 10 is a weak cation exchanger and a hydrophilic gel that can be used as a gel filter filler (Sphere protein separation range: >700 Da; Polysaccharide separation range: >700 Da) .
    Cross-linked dextran G 10

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