p63

By Targets:	AMPK (1) Apoptosis (2) Caspase (1) CDK (1) HDAC (1) MDM-2/p53 (1) Microtubule/Tubulin (1) p38 MAPK (1) Pim (1) Small Interfering RNA (siRNA) (7) Survivin (1)
By Research Areas:	Cancer (2)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (3) Human Pre-designed siRNA Sets (4) siRNAs (7)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N2424

Flavone 2-Phenyl-4-chromone	CDK Apoptosis Caspase	Cancer
Flavone is an anti-tumor compound that targets cell cycle regulatory proteins (such as cyclin B1) and apoptosis-related factors (such as p21_waf1, PIG3). Flavone selectively induces mitochondrial-mediated apoptosis pathways in tumor cells, inhibits cyclin B1 protein expression, upregulates p21_waf1, and activates p63/p73 proteins. Flavone has immunomodulatory functions that enhance natural killer cell (NK cell) activity and lymphocyte proliferation. Flavone is used in cancer research, especially for its inhibitory potential in solid tumor models such as esophageal cancer and liver cancer .

HY-174803

WMJ-J-09	p38 MAPK HDAC AMPK MDM-2/p53 Microtubule/Tubulin Pim Survivin Apoptosis	Cancer
WMJ-J-09 is an HDAC inhibitor with IC₅₀ values of 7.5 nM (HDAC1), 21.3 nM (HDAC2), 18.4 nM (HDAC3), 90.9 nM (HDAC8), 3.9 nM (HDAC6) and 8715.7 nM (HDAC4). WMJ-J-09 blocks the cell cycle and induces apoptosis in cancer cells. WMJ-J-09 induces cancer cell death through the LKB1-AMPK-p38MAPK-p63-survivin signaling cascade.WMJ-J-09 inhibits HDAC enzyme activity, leading to acetylation of key proteins and thereby regulating cancer cell death. WMJ-J-09 can be used in HCT116 cells and FaDu cells research^[1][2].

HY-RS19421

Ckap4 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ckap4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ckap4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ckap4 Mouse Pre-designed siRNA Set A Ckap4 Mouse Pre-designed siRNA Set A

HY-RS15588

UVRAG Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
UVRAG Human Pre-designed siRNA Set A contains three designed siRNAs for UVRAG gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

UVRAG Human Pre-designed siRNA Set A UVRAG Human Pre-designed siRNA Set A

HY-RS02734

CKAP4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CKAP4 Human Pre-designed siRNA Set A contains three designed siRNAs for CKAP4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CKAP4 Human Pre-designed siRNA Set A CKAP4 Human Pre-designed siRNA Set A

HY-RS22842

Taf1b Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Taf1b Mouse Pre-designed siRNA Set A contains three designed siRNAs for Taf1b gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Taf1b Mouse Pre-designed siRNA Set A Taf1b Mouse Pre-designed siRNA Set A

HY-RS12151

RPE65 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RPE65 Human Pre-designed siRNA Set A contains three designed siRNAs for RPE65 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RPE65 Human Pre-designed siRNA Set A RPE65 Human Pre-designed siRNA Set A

HY-RS19962

Tcp1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Tcp1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tcp1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Tcp1 Mouse Pre-designed siRNA Set A Tcp1 Mouse Pre-designed siRNA Set A

HY-RS14923

TP63 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TP63 Human Pre-designed siRNA Set A contains three designed siRNAs for TP63 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TP63 Human Pre-designed siRNA Set A TP63 Human Pre-designed siRNA Set A

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2424

Flavone 2-Phenyl-4-chromone	Structural Classification Flavonoids Classification of Application Fields Flavones Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	CDK Apoptosis Caspase
Flavone is an anti-tumor compound that targets cell cycle regulatory proteins (such as cyclin B1) and apoptosis-related factors (such as p21_waf1, PIG3). Flavone selectively induces mitochondrial-mediated apoptosis pathways in tumor cells, inhibits cyclin B1 protein expression, upregulates p21_waf1, and activates p63/p73 proteins. Flavone has immunomodulatory functions that enhance natural killer cell (NK cell) activity and lymphocyte proliferation. Flavone is used in cancer research, especially for its inhibitory potential in solid tumor models such as esophageal cancer and liver cancer .

Species:	Human (3)
Tag:	His (3) GST (2)
Source:	Sf9 insect cells (2) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P700976

	CKAP4 Protein, Human (His) Climp-63; p63; CLIMP-63; ERGIC-63;	Human	E. coli
	CKAP1/TBCB Protein plays a crucial role in cellular functions, anchoring the endoplasmic reticulum to microtubules for structural organization. Moreover, it serves as a high-affinity epithelial cell surface receptor for APF/antiproliferative factor, transmitting antiproliferative signals. This dual functionality underscores CKAP1/TBCB's significance in both intracellular structural dynamics and cellular signaling processes. CKAP4 Protein, Human (His) is the recombinant human-derived CKAP4 protein, expressed by E. coli, with N-His labeled tag.

HY-P73734

	p63/TP73L Protein, Human (sf9, His-GST) Tumor protein 63; p63; CUSP; Tp63; p73L	Human	Sf9 insect cells
	The p63/TP73L protein is a sequence-specific DNA-binding transcriptional regulator that exhibits diverse activities through its isoforms. Isoform 2 activates RIPK4 transcription, and binding of this protein to TP73/p73 initiates p53/TP53-dependent apoptosis in response to genotoxic stress. p63/TP73L Protein, Human (sf9, His-GST) is the recombinant human-derived p63/TP73L protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P701803

	MAPK4 Protein, Human (sf9, His, GST) MAPK4; Mitogen-activated protein kinase 4; MAP kinase 4; MAPK 4; Extracellular signal-regulated kinase 4; ERK-4; MAP kinase isoform p63; p63-MAPK	Human	Sf9 insect cells
	MAPK4, an atypical MAPK protein, phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5, forming a complex with intricate phosphorylation events. Interaction with MAPKAPK5 leads to ERK3/MAPK6 phosphorylation at Ser-189, activating MAPKAPK5, which reciprocally phosphorylates ERK3/MAPK6. The specific cellular role of this interplay, while unclear, suggests ERK3's potential involvement in promoting entry into the cell cycle. MAPK4 Protein, Human (sf9, His, GST) is the recombinant human-derived MAPK4 protein, expressed by sf9 insect cells , with N-8*His, N-GST labeled tag.

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Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81786

	p63 Antibody (YA1531) EEC3; KET; LMS; SHFM4; TA p63 alpha; Tp63; p51; p73H; p73L; tumor protein p63	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	p63 Antibody (YA1531) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to p63.

HY-P83565

	RPE65 Antibody (YA3310) LCA2; mRPE65; p63; rd12; Retinal pigment epithelium specific 61 kDa protein; RP20; RPE65; sRPE65	WB, IP	Human, Mouse, Rat
	RPE65 Antibody (YA3310) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RPE65.

HY-P86227

	p63 Antibody (YA5919)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	p63 Antibody (YA5919) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to p63.

HY-P84795

	p63 Antibody (YA4492) P51B; KET; p63α	WB, IHC-P, ELISA	Human, Mouse, Rat, Monkey
	p63 Antibody (YA4492) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to p63.

HY-P84796

	p63 Antibody (YA4493) Tp63,AIS; KET; LMS; NBP; RHS; p40; p51; p63; EEC3; OFC8; p73H; p73L; SHFM4; TP53L; TP73L; p53CP; TP53CP; B(p51A); B(p51B)	IHC-P, FC, ELISA	Human
	p63 Antibody (YA4493) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to p63.

HY-P84944

	CKAP4 Antibody p63; CLIMP-63; ERGIC-63	WB, IHC-P, ELISA	Human, Mouse
	CKAP4 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to CKAP4.

HY-P87494

	RPE65 Antibody (YA7182) LCA2; mRPE65; p63; rd12; Retinal pigment epithelium specific 61 kDa protein; RP20; RPE65; sRPE65	WB, IHC-P, IF-Tissue	Human, Mouse, Rat
	RPE65 Antibody (YA7182) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RPE65.