p63 Antibody (YA5919)

p63 Antibody (YA5919) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to p40/p63. It can be applicated for WB, IHC-P, ICC/IF, IP, ELISA assays, in the background of human, mouse, rat.

p40/p63 functions as a sequence-specific DNA-binding transcriptional activator or repressor. Its isoforms contain varying transactivation and auto-regulating transactivation-inhibiting domains, resulting in isoform-specific activities. Isoform 2 activates RIPK4 transcription. In response to genotoxic insults and activated oncogenes, p40/p63 may cooperate with TP73/p73 to initiate p53/TP53-dependent apoptosis. It participates in Notch signaling, likely by inducing JAG1 and JAG2 expression. p40/p63 plays a crucial role in regulating epithelial morphogenesis, where the ratio of DeltaN-type to TA*-type isoforms may govern epithelial stem cell compartment maintenance and initiation of epithelial stratification from undifferentiated embryonal ectoderm. This protein is also essential for limb formation from the apical ectodermal ridge and activates transcription of the p21 promoter.

Q9H3D4

Predicted band size: 77 kDa; Observed band size: 77 kDa

Protein A

Non-conjugated

Unmodified

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Monoclonal

Rabbit

Human, Mouse, Rat

IHC: 1:1000-1:4000; WB: 1:2000-1:10000; ICC/IF: 1:200-1:1000; ELISA: 1:5000-1:20000; IP: 1:50-1:200

WB, IHC-P, ICC/IF, IP, ELISA

Liquid

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG