CKAP4 Protein, Human (His)

CKAP1/TBCB Protein plays a crucial role in cellular functions, anchoring the endoplasmic reticulum to microtubules for structural organization. Moreover, it serves as a high-affinity epithelial cell surface receptor for APF/antiproliferative factor, transmitting antiproliferative signals. This dual functionality underscores CKAP1/TBCB's significance in both intracellular structural dynamics and cellular signaling processes. CKAP4 Protein, Human (His) is the recombinant human-derived CKAP4 protein, expressed by E. coli, with N-His labeled tag.

CKAP4 is a protein with multiple functions. Its core role includes mediating the anchoring of the endoplasmic reticulum and microtubules, thereby maintaining the stability of the intracellular structure. At the same time, as a high-affinity receptor on the surface of epithelial cells, it can bind to the FZD8-related low molecular weight sialic acid glycopeptide APF (anti-proliferation factor) and mediate the anti-proliferation signal transduction of APF in cells, playing an important role in maintaining cell structure and regulating proliferation.

Human

E. coli

N-6*His

Q07065 (H128-V602)

10970  [NCBI]

Extracellular Domain

53.66 kDa

Greater than 90 % as determined by SDS-PAGE.

Solution

Supplied as a 0.22μm filtered solution of PBS, 200mM NaCl, 10% glycerol, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.