RPE65 Antibody (YA7182)

RPE65 Antibody (YA7182) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RPE65.

The protein encoded by The related gene is a component of the vitamin A visual cycle of the retina which supplies the 11-cis retinal chromophore of the photoreceptors opsin visual pigments. It is a member of the carotenoid cleavage oxygenase superfamily. All members of The superfamily are non-heme iron oxygenases with a seven-bladed propeller fold and oxidatively cleave carotenoid carbon:carbon double bonds. However, the protein encoded by The related gene has acquired a divergent function that involves the concerted O-alkyl ester cleavage of its all-trans retinyl ester substrate and all-trans to 11-cis double bond isomerization of the retinyl moiety. As such, it performs the essential enzymatic isomerization step in the synthesis of 11-cis retinal. Mutations in The related gene are associated with early-onset severe blinding disorders such as Leber congenital.

Q16518

Predicted band size: 61 kDa; Observed band size: 61 kDa

affinity purified.

Unmodified

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Monoclonal, Recombinant

Rabbit

Human, Mouse, Rat

WB: 1:2,000; IHC-P: 1:1,000; IF-Tissue: 1:500

WB, IHC-P, IF-Tissue

Mouse eyeball tissue lysate, Rat eyeball tissue lysate, rat eyeball tissue, mouse eyeball tissue.

Liquid

Supplied in 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Synthetic peptide within Human RPE65 aa 441-484 / 533.