Search Result
Results for "
oligonucleotide synthesis
" in MedChemExpress (MCE) Product Catalog:
6
Biochemical Assay Reagents
5
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
- HY-112858
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Biochemical Assay Reagents
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Others
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dSPACER is a compound for the phosphoramidite synthesis of oligonucleotides and the creation of the abasic step in the oligonucleotide sequence.Abasic phosphoramidites are used in DNA and oligonucleotide synthesis.
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- HY-138584
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- HY-137576
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- HY-160642
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Others
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Others
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isoG Nucleoside-2 (compound 6) is an oligonucleotide. isoG Nucleoside-2 can be used to oligonucleotide synthesis research .
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- HY-W570893
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DNA/RNA Synthesis
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Others
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DMT-LNA-G phosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.
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- HY-W726091
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- HY-148947
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Fluorescent Dye
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Others
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Cy5 Phosphoramidite is a fluorescent dye that can be used in the synthesis of oligonucleotides .
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- HY-132272
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- HY-W570887
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- HY-114240
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DNA/RNA Synthesis
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Others
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5'-Cholesteryl-TEG phosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.
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- HY-139988
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DNA/RNA Synthesis
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Others
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2-O-DMT-Sulfonyldiethanol phosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.
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- HY-154585
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- HY-W570886
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- HY-24126
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Drug Intermediate
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Others
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Bis(2-cyanoethyl) diisopropylphosphoramidite is a phosphorite monomer that can be used in the synthesis of oligonucleotides.
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- HY-132273
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- HY-W608384
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- HY-21648
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DNA/RNA Synthesis
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Others
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2'-OMe-Ac-C Phosphoramidite is a modified phosphoramidite and can be used for the oligonucleotide synthesis.
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- HY-W036167
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DNA/RNA Synthesis
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Others
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DMT-2'-F-dA Phosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.
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- HY-W016041
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- HY-153249
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DNA/RNA Synthesis
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Others
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DMT-2'-F-Cytidine Phosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.
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- HY-151651
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Spacer Phosphoramidite 18
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Fluorescent Dye
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Others
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Hexaethylene glycol phosphoramidite (Spacer Phosphoramidite 18) is an amidite reagent for oligonucleotide synthesis. Hexaethylene glycol phosphoramidite can be used as a linker in synthesis of nucleotide chain and qPCR probes .
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- HY-W579407
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DNA/RNA Synthesis
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Others
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DMT-2'-OMe-dA(bz) phosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.
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- HY-W102322
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- HY-W881216
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- HY-W579408
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DNA/RNA Synthesis
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Others
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DMT-2'-F-dA(bz) phosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.
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- HY-138586
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- HY-138580
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- HY-W048491
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DNA/RNA Synthesis
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Others
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2′-O-(2-Methoxyethyl)adenosine is a compound can be used in the synthesis of oligonucleotides .
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- HY-21713
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DNA/RNA Synthesis
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Others
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DMT-2'O-Methyl-rC(tac) Phosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.
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- HY-138578
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- HY-W579410
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DNA/RNA Synthesis
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Others
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DMT-2'-F-6-chloro-dA phosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.
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- HY-23408
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PROTAC Linkers
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Cancer
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Tos-PEG3 is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Tos-PEG3 (structure 1) can be used for the synthesis of 3'-aminooxy oligonucleotides solid supports .
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- HY-W726201
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Nucleoside Antimetabolite/Analog
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Cancer
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2'-Deoxy-5'-O-DMT-5-fluorouridine 3'-CE phosphoramidite is a nucleoside phosphoramidite analogue employed in oligonucleotide synthesis. This compound contributes to crafting therapeutic oligonucleotides for drugs targeting cancers.
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- HY-173248
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Biochemical Assay Reagents
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Others
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GalNAc-NAG-15 phosphoramidite is a phosphoramidite derivative containing N-acetylgalactosamine (GalNAc) part linked to NAG, which can be used for the synthesis of oligonucleotides.
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- HY-21601
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- HY-173246
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Biochemical Assay Reagents
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Others
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GalNAc-NAG-25 phosphoramidite is a phosphoramidite derivative containing N-acetylgalactosamine (GalNAc) part linked to NAG, which can be used for the synthesis of oligonucleotides.
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- HY-153497
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IONIS ANGPT-L3Rx; ISIS 703802
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ANGPTL
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Metabolic Disease
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Vupanorsen is an N-acetyl galactosamine-conjugated antisense oligonucleotide that inhibits Angiopoietin-like 3 (ANGPTL3) protein synthesis. Vupanorsen lowers triglycerides and atherogenic lipoproteins.
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- HY-W1008621
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Biochemical Assay Reagents
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Others
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GalNAc-THA C6 phosphoramidite is a phosphoramidite derivative containing N-acetylgalactosamine (GalNAc) part linked to Trishexylamino (THA), which can be used for the synthesis of oligonucleotides.
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- HY-145624
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Acyltransferase
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Metabolic Disease
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Obeversen is an antisense oligonucleotide that inhibits the synthesis of diacylglycerol acyltransferase 2 (DGAT-2). Obeversen can be used in the research of nonalcoholic fatty liver disease .
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- HY-153497A
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IONIS ANGPT-L3Rx sodium; ISIS 703802 sodium
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ANGPTL
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Metabolic Disease
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Vupanorsen (sodium) is an N-acetyl galactosamine-conjugated antisense oligonucleotide that inhibits Angiopoietin-like 3 (ANGPTL3) protein synthesis. Vupanorsen (sodium) lowers triglycerides and atherogenic lipoproteins.
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- HY-154665
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DNA/RNA Synthesis
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Others
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N4-Benzoyl-N-DMTr- morpholino-5-methylcytosine-5’-O-phosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.
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- HY-164581
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DNA/RNA Synthesis
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Others
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DMTr-2'-O-C22-rG-3'-CE-Phosphoramidite (Compound 106) is a phosphoramidite, that can be used for synthesis of oligonucleotide .
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- HY-164582
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DNA/RNA Synthesis
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Others
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DMTr-2'-O-C22-rC-3'-CE-Phosphoramidite (Compound 114) is a phosphoramidite, that can be used for synthesis of oligonucleotide .
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- HY-164583
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DNA/RNA Synthesis
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Others
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DMTr-2'-O-C22-rA-3'-CE-Phosphoramidite (Compound 103) is a phosphoramidite, that can be used for synthesis of oligonucleotide .
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- HY-138579
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DMT-2'-O-Methyl-rG(ib) Phosphoramidite
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Nucleoside Antimetabolite/Analog
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Cancer
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2'-OMe-G(ibu) Phosphoramidite (DMT-2'-O-Methyl-rG(ib) Phosphoramidite) is a modified phosphoramidite monomer that can be used for the oligonucleotide synthesis .
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- HY-164623
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Biochemical Assay Reagents
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Others
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CUTAG CPG (pore size 1000 Å, 25-35 μmol/g) is a CUTAG-conjugated controlled pore glass (CPG), that can be used for solid phase oligonucleotides synthesis .
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- HY-145724
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Kyndrisa; GSK2402968A; PRO051
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DNA/RNA Synthesis
Dystrophin
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Others
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Drisapersen, a antisense oligonucleotide, induces exon 51 skipping during dystrophin pre-mRNA splicing and allows synthesis of partially functional dystrophin in Duchenne muscular dystrophy (DMD) patients with amenable mutations.
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- HY-147321
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Tau Protein
HBV
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Infection
Neurological Disease
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3'-DMTr-dG(iBu) is a nucleoside for the synthesis of nucleic acid, such as antiviral agents used in the research of viral infection (HBV, HDV), and oligonucleotides against Alzheimer’s disease and other tauopathies .
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- HY-W101391
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2'-O-Me-U Phosphoramidite
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DNA/RNA Synthesis
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Others
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DMT-2'O-Methyl-rU Phosphoramidite (2'-O-Me-U Phosphoramidite) is a 2'-O-Me derivative, and can be used for oligonucleotide synthesis .
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- HY-158825
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CIVI007 sodium
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PCSK9
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Metabolic Disease
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Cepadacursen sodium is a liver-targeting antisense oligonucleotide (ASO), inhibits proprotein convertase subtilisin/kexin type 9 (PCSK9) protein synthesis. Cepadacursen sodium can be used for hypercholesterolemia treatment and the prevention of atherosclerotic cardiovascular disease (ASCVD).
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- HY-132580A
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BIIB067 sodium; ISIS-SOD1Rx sodium
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DNA/RNA Synthesis
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Neurological Disease
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Tofersen sodium is an antisense oligonucleotide that mediates RNase H-dependent degradation of superoxide dismutase 1 (SOD1) mRNA to reduce the synthesis of SOD1 protein. Tofersen sodium can be used for the research of amyotrophic lateral sclerosis (ALS) .
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- HY-138577
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DNA/RNA Synthesis
Nucleoside Antimetabolite/Analog
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Others
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2'-F-Bz-dC Phosphoramidite can be used in the synthesis of oligoribonucleotide (such as DNA and RNA). 2'-F-Bz-dC Phosphoramidite also used for synthesis antiviral agent to inhibit the replication of virus. 2'-F-Bz-dC Phosphoramidite contains a phosphorothioate backbone, to synthesise antisense oligonucleotide analogs to induce apoptosis in cancer cells .
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- HY-104014
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DNA/RNA Synthesis
Nucleoside Antimetabolite/Analog
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Others
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DMT-2'O-MOE-rG(ib) Phosphoramidite (1g), belonging to the amide family of trivalent phosphate H3PO3, is a derivative of nucleotides and guanosine and can be used in the stereochemical synthesis of phosphorothioate oligonucleotides .
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- HY-132580
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BIIB067; ISIS-SOD1Rx
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DNA/RNA Synthesis
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Neurological Disease
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Tofersen (BIIB067) is an antisense oligonucleotide that mediates RNase H-dependent degradation of superoxide dismutase 1 (SOD1) mRNA to reduce the synthesis of SOD1 protein. Tofersen can be used for the research of amyotrophic lateral sclerosis (ALS) .
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- HY-150237
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DNA/RNA Synthesis
Dystrophin
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Others
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FITC-labeled Drisapersen (sodium) is Drisapersen labeled with FITC. Drisapersen, a antisense oligonucleotide, induces exon 51 skipping during dystrophin pre-mRNA splicing and allows synthesis of partially functional dystrophin in Duchenne muscular dystrophy (DMD) patients with amenable mutations.
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- HY-154211
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DNA/RNA Synthesis
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Others
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5’-O-DMTr-dU-methyl phosphonamidite; 5’-O-DMTr-2’-deoxyuridine-3’-O-(P-methyl-N,N-diisopropylamino)phosphonamidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.
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- HY-132274
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Biochemical Assay Reagents
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Others
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DMS(O)MT aminolink C6 for oligonucleotide synthesis. DMS(O)MT is a special protective group similar to traditional MMT, but designed as an improved alternative to it. DMS(O)MT aminolink is fully compatible with standard coupling, deblock, and purification protocols.
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- HY-15942
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5-TAMRA
2 Publications Verification
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Fluorescent Dye
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Others
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5-TAMRA can produce bright, pH-insensitive orange-red fluorescence (excitation and emission extremes of 546/579) and has good photostability. 5-TAMRA is mainly used as a fluorescent marker for the synthesis and study of specific oligonucleotide probes .
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- HY-172508
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Fluorescent Dye
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Others
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Perylene dU phosphoramidite is a bright and extremely photostable fluorescent polycyclic aromatic hydrocarbon (PAH) label with a quantum yield approaching quantitative. Due to the low lifetime of fluorescence, this probe does not form excimers.With this phosphoramidite, perylene can be introduced into DNA by automated oligonucleotide synthesis.
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- HY-W013059R
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DNA/RNA Synthesis
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Others
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DMT-dA(bz) Phosphoramidite (Standard) is the analytical standard of DMT-dA(bz) Phosphoramidite. This product is intended for research and analytical applications. DMT-dA(bz) Phosphoramidite is a phosphoramide monomer for the synthesis of oligonucleotides (ONs) through formation of DNA dimers and trimers via mechanochemistry .
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- HY-W800446
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Lna-g amidite
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Biochemical Assay Reagents
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Others
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LNA-Guanosine 3'-CE phosphoramidite (Lna-g amidite) is an essential building block to Locked Nucleic Acid (LNA) oligonucleotide synthesis, which includes a ribonucleoside linked by a methylene unit between the 2’-oxygen and 4’-carbon atoms, paralleling DNA polymer assembly.
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- HY-158827A
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PCSK9
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Metabolic Disease
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AZD8233 sodium, a liver-targeting antisense oligonucleotide (ASO), inhibits subtilisin/kexin type 9 (PCSK9) protein synthesis. AZD8233 sodium increases the available LDL receptors by reducing PCSK9 levels, thereby clearing LDL from the blood and decreasing LDL-C levels.
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- HY-154618
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DNA/RNA Synthesis
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Others
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N4-Benzoyl-5’-O-(4,4’-dimethoxytrityl)-3’-deoxy-3’-fluoro-beta-D-xylofuranosyl cytidine-2’-CED-phosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.
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- HY-154080
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DNA/RNA Synthesis
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Others
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5’-O-DMTr-2’-FU-methyl phosphonamidite, 5’-O-DMTr-2’-deoxy-2’-fluorouridine-3’-O-(P-methyl-N,N-diisopropylamino) phosphonamidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.
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- HY-D2737
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BHQ-2 DMT amidite
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Fluorescent Dye
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Others
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DMT-BH2 amidite (BHQ-2 DMT amidite) is a black quencher dye for the synthesis of dual-labeled oligonucleotide probes for qPCR bearing 5'-quencher. This quencher is ideal for HEX, JOE, ROX, Cyanine5, and other dyes with emissions in the orange and red parts of the spectrum.
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- HY-158827
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PCSK9
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Metabolic Disease
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AZD8233, a liver-targeting antisense oligonucleotide (ASO), inhibits proprotein convertase subtilisin/kexin type 9 (PCSK9) protein synthesis. AZD8233 increases the available LDL receptors by reducing PCSK9 levels, thereby clearing LDL from the blood and decreasing LDL-C levels.
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- HY-78574
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Nucleoside Antimetabolite/Analog
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Others
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N-Benzoylcytidine is a substrate for uracil-cytidine kinase 1 (UCK1) and UCK2. N-Benzoylcytidine can be used to synthesize 2-OH protective groups for solid-phase RNA synthesis，as well as synthetic oligonucleotides for UV induction and targeted gene silencing in zebrafish embryos .
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- HY-153485
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ISIS 766720; IONIS-GHR-LRx
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GHR
Small Interfering RNA (siRNA)
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Others
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Cimdelirsen is a novel, ligand-conjugated, hepatic-targeted investigative antisense oligonucleotide designed to reduce growth hormone receptor (GHr) synthesis, thereby inhibiting deleterious effects of growth hormone (GH) hypersecretion and reducing circulating insulin-like growth factor-1 (IGF-1) levels in acromegaly patients.
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- HY-153485A
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ISIS 766720 sodium; IONIS-GHR-LRx sodium
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GHR
Small Interfering RNA (siRNA)
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Others
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Cimdelirsen is a novel, ligand-conjugated, hepatic-targeted investigative antisense oligonucleotide designed to reduce growth hormone receptor (GHr) synthesis, thereby inhibiting deleterious effects of growth hormone (GH) hypersecretion and reducing circulating insulin-like growth factor-1 (IGF-1) levels in acromegaly patients.
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- HY-W784557
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Biochemical Assay Reagents
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Others
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O-DMT-2,2-di(ethoxycarbonyl)propan-1,3-diol is a chemical phosphorylation reagent used for the synthesis of 5'-phosphorylated oligonucleotides. It contains the chemical protective group DMT in its structure, which allows for purification through C18 columns or reversed-phase chromatography .
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- HY-160958
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Biochemical Assay Reagents
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Others
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Cap B (Acetonitrile/N-methylimidazole /pyridine, 50/20/30 v/v/v) is a biochemical reagent, which contains 50% Acetonitrile, 20 N-methylimidazole and 30% pyridine. Cap B (Acetonitrile/N-methylimidazole /pyridine, 50/20/30 v/v/v) is utilized as capping agent in oligonucleotide synthesis .
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- HY-D2742
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BHQ-1 DMT amidite
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Fluorescent Dye
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Others
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DMT-BH1 amidite (BHQ-1 DMT amidite) is a true dark quencher with broad absorption curve which covers the visible spectrum with maximum in green to yellow region. It is used for the synthesis of dual labeled oligonucleotide probes for qPCR bearing 5'-quencher DusQ 1 and other FRET applications for multiplexing assays.
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- HY-B0956
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Aminosidine sulfate
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Antibiotic
Parasite
Bacterial
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Infection
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Paromomycin (Aminosidine) sulfate, a neomycin (HY-B0470) derivative, is a broad spectrum aminoglycoside antibiotic with amebicidal and bactericidal effects. Paromomycin sulfate prematures termination of translation of mRNA and inhibits protein synthesis by specifically binds to the RNA oligonucleotide at the A site of bacterial 30S ribosomes. Paromomycin sulfate can be used for the research of bacterial and parasitic infections .
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- HY-172268
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Fluorescent Dye
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Others
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R6G phosphoramidite for oligonucleotide synthesis, pure 6-isomer. R6G (rhodamine 6G) is a xanthene dye of the rhodamine family with high fluorescence quantum yield and high molar extinction coefficient. Relative to those of fluorescein, the absorption (518 nm) and emission (542 nm) maxima of 6-R6G are shifted into the long-wave region.
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- HY-21997
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DNA/RNA Synthesis
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Others
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Dmt-2'fluoro-da(bz) amidite, an uniformly modified 2'-deoxy-2'-fluoro phosphorothioate oligonucleotide, is a nuclease-resistant antisense compound with high affinity and specificity for RNA targets. Dmt-2'fluoro-da(bz) amidite is also an intermediate for 5’-DMT-3’-phosphoramidite synthesis .
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- HY-148503
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Nucleoside Antimetabolite/Analog
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Others
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5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) is a nucleoside phosphoramidite monomer used to synthesize locked nucleic acid (LNA) analog oligonucleotides. It can be used as a building block of antisense oligonucleotides (ASOs) to target complementary RNA sequences. 5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) locks the furanose ring into an N-type conformation through 2',4'-constrained ethyl (cEt) modification, enhancing hybridization affinity and mismatch discrimination with RNA, while significantly improving the resistance of oligonucleotides to exonuclease digestion. 5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) mediates RNase H-dependent mRNA degradation or inhibits translation by forming a stable hybrid with RNA, thereby achieving gene expression regulation. 5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) is mainly used in the development of antisense drugs, gene function research and oligonucleotide synthesis related to disease treatment .
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- HY-159162A
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7CPT TFA
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Drug Derivative
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Others
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7-(2-Aminoethyl)camptothecin TFA (7CPT TFA) is the TFA salt form of Camptothecin (HY-16560) derivative 7-(2-Aminoethyl)camptothecin (HY-159162). 7-(2-Aminoethyl)camptothecin TFA can be used for synthesis of conjugate with triple helix-forming oligonucleotides (TFOs) and camptothecin (CPT). The TFO-CPT conjugate is used for DNA cleavage .
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- HY-N0677AR
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Antibiotic
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Infection
Inflammation/Immunology
Cancer
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Paromomycin (sulfate) (Standard) is the analytical standard of Paromomycin (sulfate). This product is intended for research and analytical applications. Paromomycin (Aminosidine) sulfate, a neomycin (HY-B0470) derivative, is a broad spectrum aminoglycoside antibiotic with amebicidal and bactericidal effects. Paromomycin sulfate prematures termination of translation of mRNA and inhibits protein synthesis?by specifically binds to the RNA oligonucleotide at the A site of bacterial 30S ribosomes. Paromomycin sulfate can be used for the research of bacterial and parasitic infections .
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- HY-B0956R
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Antibiotic
Parasite
Bacterial
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Infection
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Paromomycin (sulfate) (Standard) is the analytical standard of Paromomycin (sulfate). This product is intended for research and analytical applications. Paromomycin (Aminosidine) sulfate, a neomycin (HY-B0470) derivative, is a broad spectrum aminoglycoside antibiotic with amebicidal and bactericidal effects. Paromomycin sulfate prematures termination of translation of mRNA and inhibits protein synthesis?by specifically binds to the RNA oligonucleotide at the A site of bacterial 30S ribosomes. Paromomycin sulfate can be used for the research of bacterial and parasitic infections .
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- HY-W460666
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Drug Intermediate
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Cancer
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5'-O-DMT-N2-Ibu-2'-OMe-G is a crucial intermediate for the synthesis of antisense oligonucleotides. 5'-O-DMT-N2-Ibu-2'-OMe-G is involved in constructing antisense oligonucleotides with specific sequences, which can bind complementarily to the targeted mRNA. 5'-O-DMT-N2-Ibu-2'-OMe-G blocks the translation process of mRNA, thereby inhibiting the expression of specific proteins and playing a role in regulating gene expression. 5'-O-DMT-N2-Ibu-2'-OMe-G is promising for research of genetic diseases and tumors .
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- HY-W039442
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Nucleoside Antimetabolite/Analog
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Cancer
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2′-Deoxy-2′-fluoroadenosine can be used for the synthesis of 2′-Deoxy-2′-fluoro-modified oligonucleotides hybridized with RNA. 2′-Deoxy-2′-fluoroadenosine can be cleaved efficiently by E. coli purine nucleoside phosphorylase (PNP) to the toxic agent 2-fluoroadenine (FAde). 2′-Deoxy-2′-fluoroadenosine shows excellent in vivo activity against tumors expressing E. coli PNP .
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- HY-W570889
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DNA/RNA Synthesis
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Others
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(1R,3R,4R,7S)-3-(4-Amino-5-methyl-2-oxopyrimidin-1(2H)-yl)-1-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-2,5-dioxabicyclo[2.2.1]heptan-7-yl (2-cyanoethyl) diisopropylphosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.
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- HY-43066
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DNA/RNA Synthesis
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Others
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(2R,3R,4R,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2-(((E)-(dimethylamino)methylene)amino)-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.
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- HY-113138
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N3-Methyluridine
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Endogenous Metabolite
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Metabolic Disease
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3-Methyluridine (m 3U; N3-Methyluridine) is a methylated nucleotide present in ribosomal RNA (rRNA), mainly targeting specific base sites of RNA molecules such as 23S rRNA. 3-Methyluridine can introduce a methyl group at the N3 position of uracil, affecting the secondary structure stability and base pairing ability of RNA, and regulating ribosome function. For example, it affects ribosomal subunit binding and tRNA interaction. 3-Methyluridine is often used as a key raw material for the synthesis of modified nucleotides, and is used to construct RNA oligonucleotides containing methylation modifications to study the effects of RNA methylation on gene expression and drug resistance .
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| Cat. No. |
Product Name |
Type |
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- HY-15942
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5-TAMRA
2 Publications Verification
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Fluorescent Dyes/Probes
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5-TAMRA can produce bright, pH-insensitive orange-red fluorescence (excitation and emission extremes of 546/579) and has good photostability. 5-TAMRA is mainly used as a fluorescent marker for the synthesis and study of specific oligonucleotide probes .
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- HY-D2737
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BHQ-2 DMT amidite
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Fluorescent Dyes/Probes
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DMT-BH2 amidite (BHQ-2 DMT amidite) is a black quencher dye for the synthesis of dual-labeled oligonucleotide probes for qPCR bearing 5'-quencher. This quencher is ideal for HEX, JOE, ROX, Cyanine5, and other dyes with emissions in the orange and red parts of the spectrum.
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-
- HY-172268
-
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|
Fluorescent Dyes/Probes
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R6G phosphoramidite for oligonucleotide synthesis, pure 6-isomer. R6G (rhodamine 6G) is a xanthene dye of the rhodamine family with high fluorescence quantum yield and high molar extinction coefficient. Relative to those of fluorescein, the absorption (518 nm) and emission (542 nm) maxima of 6-R6G are shifted into the long-wave region.
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| Cat. No. |
Product Name |
Type |
-
- HY-21997
-
|
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Gene Sequencing and Synthesis
|
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Dmt-2'fluoro-da(bz) amidite, an uniformly modified 2'-deoxy-2'-fluoro phosphorothioate oligonucleotide, is a nuclease-resistant antisense compound with high affinity and specificity for RNA targets. Dmt-2'fluoro-da(bz) amidite is also an intermediate for 5’-DMT-3’-phosphoramidite synthesis .
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-
- HY-139099A
-
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Gp3G lithium
|
Gene Sequencing and Synthesis
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Diguanosine 5′-triphosphate (Gp3G) lithium is a dinucleoside triphosphates. Diguanosine 5′-triphosphate lithium also is a virus-specific oligonucleotide. Diguanosine 5′-triphosphate lithium is needed for the synthesis of RNA during the transcription process .
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-
- HY-173248
-
|
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Gene Sequencing and Synthesis
|
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GalNAc-NAG-15 phosphoramidite is a phosphoramidite derivative containing N-acetylgalactosamine (GalNAc) part linked to NAG, which can be used for the synthesis of oligonucleotides.
|
-
- HY-173246
-
|
|
Gene Sequencing and Synthesis
|
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GalNAc-NAG-25 phosphoramidite is a phosphoramidite derivative containing N-acetylgalactosamine (GalNAc) part linked to NAG, which can be used for the synthesis of oligonucleotides.
|
-
- HY-W1008621
-
|
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Gene Sequencing and Synthesis
|
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GalNAc-THA C6 phosphoramidite is a phosphoramidite derivative containing N-acetylgalactosamine (GalNAc) part linked to Trishexylamino (THA), which can be used for the synthesis of oligonucleotides.
|
-
- HY-W013059R
-
|
|
Gene Sequencing and Synthesis
|
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DMT-dA(bz) Phosphoramidite (Standard) is the analytical standard of DMT-dA(bz) Phosphoramidite. This product is intended for research and analytical applications. DMT-dA(bz) Phosphoramidite is a phosphoramide monomer for the synthesis of oligonucleotides (ONs) through formation of DNA dimers and trimers via mechanochemistry .
|
| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
| Cat. No. |
Product Name |
Chemical Structure |
-
- HY-W048482S4
-
|
|
|
rU Phosphoramidite- 15N (DMT-2'O-TBDMS-rU phosphoramidite- 15N) is 15N labeled rU Phosphoramidite (HY-W048482). rU Phosphoramidite is a phosphorite monomer that can be used in the synthesis of oligonucleotides.
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-
-
- HY-W048482S3
-
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|
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rU Phosphoramidite- 15N2 (DMT-2'O-TBDMS-rU phosphoramidite- 15N2) is 15N labeled rU Phosphoramidite (HY-W048482). rU Phosphoramidite is a phosphorite monomer that can be used in the synthesis of oligonucleotides.
|
-
-
- HY-W048482S2
-
|
|
|
rU Phosphoramidite- 13C9 (DMT-2'O-TBDMS-rU phosphoramidite- 13C9) is 13C-labeled rU Phosphoramidite (HY-W048482). rU Phosphoramidite is a phosphorite monomer that can be used in the synthesis of oligonucleotides.
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-
-
- HY-W048482S1
-
|
|
|
rU Phosphoramidite- 13C9, 15N2 (DMT-2'O-TBDMS-rU phosphoramidite- 13C9, 15N2) is 13C and 15N-labeled rU Phosphoramidite (HY-W048482). rU Phosphoramidite is a phosphorite monomer that can be used in the synthesis of oligonucleotides.
|
-
-
- HY-W048482S
-
|
|
|
rU Phosphoramidite- 13C2,d1 (DMT-2'O-TBDMS-rU phosphoramidite- 13C2,d1) is deuterium and 13C-labeled rU Phosphoramidite (HY-W048482). rU Phosphoramidite is a phosphorite monomer that can be used in the synthesis of oligonucleotides.
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-
| Cat. No. |
Product Name |
|
Classification |
-
- HY-W726091
-
|
|
|
Alkynes
|
|
5-ETHYNYL-DU CEP is a phosphoramidite monomer used in oligonucleotide synthesis.
|
| Cat. No. |
Product Name |
|
Classification |
- HY-W608384
-
|
|
|
Nucleoside Phosphoramidites
|
|
Bis(2-(trimethylsilyl)ethyl) diisopropylphosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.
|
- HY-21648
-
|
|
|
Nucleoside Phosphoramidites
|
|
2'-OMe-Ac-C Phosphoramidite is a modified phosphoramidite and can be used for the oligonucleotide synthesis.
|
- HY-W036167
-
- HY-W016041
-
- HY-153249
-
|
|
|
Nucleoside Phosphoramidites
|
|
DMT-2'-F-Cytidine Phosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.
|
- HY-W579407
-
|
|
|
Nucleoside Phosphoramidites
|
|
DMT-2'-OMe-dA(bz) phosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.
|
- HY-W102322
-
- HY-W579408
-
|
|
|
Nucleoside Phosphoramidites
|
|
DMT-2'-F-dA(bz) phosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.
|
- HY-138586
-
|
|
|
Nucleoside Phosphoramidites
|
|
DMT-dC(ac) Phosphoramidite (compound 30f) is a phosphoramidite derivative that can be used for the oligonucleotide synthesis .
|
- HY-138580
-
|
|
|
Nucleoside Phosphoramidites
|
|
2'-OMe-A(Bz) Phosphoramidite is a modified phosphoramidite monomer, which can be used for the oligonucleotide synthesis .
|
- HY-W048491
-
- HY-21713
-
|
|
|
Nucleoside Phosphoramidites
|
|
DMT-2'O-Methyl-rC(tac) Phosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.
|
- HY-153495A
-
|
BP1001 sodium
|
|
Antisense Oligonucleotides
|
|
Prexigebersen sodium is an antisense oligonucleotide designed to inhibit protein synthesis of Grb2 (growth factor receptor bound protein 2).
|
- HY-138578
-
|
|
|
Nucleoside Phosphoramidites
|
|
2'-O-Me-C(Bz) Phosphoramidite is a modified phosphoramidite monomer, which can be used for the oligonucleotide synthesis.
|
- HY-153495
-
|
BP1001
|
|
Antisense Oligonucleotides
|
|
Prexigebersen is an antisense oligonucleotide designed to inhibit protein synthesis of Grb2 (growth factor receptor bound protein 2).
|
- HY-W579410
-
|
|
|
Nucleoside Phosphoramidites
|
|
DMT-2'-F-6-chloro-dA phosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.
|
- HY-21601
-
|
|
|
Nucleoside Phosphoramidites
|
|
5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine is an adenosine derivative and can be used as an intermediate for oligonucleotides synthesis.
|
- HY-153497
-
|
IONIS ANGPT-L3Rx; ISIS 703802
|
|
Antisense Oligonucleotides
|
|
Vupanorsen is an N-acetyl galactosamine-conjugated antisense oligonucleotide that inhibits Angiopoietin-like 3 (ANGPTL3) protein synthesis. Vupanorsen lowers triglycerides and atherogenic lipoproteins.
|
- HY-145624
-
|
|
|
Antisense Oligonucleotides
|
|
Obeversen is an antisense oligonucleotide that inhibits the synthesis of diacylglycerol acyltransferase 2 (DGAT-2). Obeversen can be used in the research of nonalcoholic fatty liver disease .
|
- HY-153497A
-
|
IONIS ANGPT-L3Rx sodium; ISIS 703802 sodium
|
|
Antisense Oligonucleotides
|
|
Vupanorsen (sodium) is an N-acetyl galactosamine-conjugated antisense oligonucleotide that inhibits Angiopoietin-like 3 (ANGPTL3) protein synthesis. Vupanorsen (sodium) lowers triglycerides and atherogenic lipoproteins.
|
- HY-154665
-
|
|
|
Nucleoside Phosphoramidites
|
|
N4-Benzoyl-N-DMTr- morpholino-5-methylcytosine-5’-O-phosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.
|
- HY-138579
-
|
DMT-2'-O-Methyl-rG(ib) Phosphoramidite
|
|
Nucleoside Phosphoramidites
|
|
2'-OMe-G(ibu) Phosphoramidite (DMT-2'-O-Methyl-rG(ib) Phosphoramidite) is a modified phosphoramidite monomer that can be used for the oligonucleotide synthesis .
|
- HY-145724A
-
|
Kyndrisa sodium; GSK2402968A sodium; PRO051 sodium
|
|
Antisense Oligonucleotides
|
|
Drisapersen sodium, a antisense oligonucleotide, induces exon 51 skipping during dystrophin pre-mRNA splicing and allows synthesis of partially functional dystrophin in Duchenne muscular dystrophy (DMD) patients with amenable mutations.
|
- HY-145724
-
|
Kyndrisa; GSK2402968A; PRO051
|
|
Antisense Oligonucleotides
|
|
Drisapersen, a antisense oligonucleotide, induces exon 51 skipping during dystrophin pre-mRNA splicing and allows synthesis of partially functional dystrophin in Duchenne muscular dystrophy (DMD) patients with amenable mutations.
|
- HY-147321
-
|
|
|
Nucleosides and their Analogs
|
|
3'-DMTr-dG(iBu) is a nucleoside for the synthesis of nucleic acid, such as antiviral agents used in the research of viral infection (HBV, HDV), and oligonucleotides against Alzheimer’s disease and other tauopathies .
|
- HY-W101391
-
|
2'-O-Me-U Phosphoramidite
|
|
Nucleoside Phosphoramidites
|
|
DMT-2'O-Methyl-rU Phosphoramidite (2'-O-Me-U Phosphoramidite) is a 2'-O-Me derivative, and can be used for oligonucleotide synthesis .
|
- HY-158825
-
|
CIVI007 sodium
|
|
Antisense Oligonucleotides
|
|
Cepadacursen sodium is a liver-targeting antisense oligonucleotide (ASO), inhibits proprotein convertase subtilisin/kexin type 9 (PCSK9) protein synthesis. Cepadacursen sodium can be used for hypercholesterolemia treatment and the prevention of atherosclerotic cardiovascular disease (ASCVD).
|
- HY-132580A
-
|
BIIB067 sodium; ISIS-SOD1Rx sodium
|
|
Antisense Oligonucleotides
|
|
Tofersen sodium is an antisense oligonucleotide that mediates RNase H-dependent degradation of superoxide dismutase 1 (SOD1) mRNA to reduce the synthesis of SOD1 protein. Tofersen sodium can be used for the research of amyotrophic lateral sclerosis (ALS) .
|
- HY-138577
-
|
|
|
Nucleoside Phosphoramidites
|
|
2'-F-Bz-dC Phosphoramidite can be used in the synthesis of oligoribonucleotide (such as DNA and RNA). 2'-F-Bz-dC Phosphoramidite also used for synthesis antiviral agent to inhibit the replication of virus. 2'-F-Bz-dC Phosphoramidite contains a phosphorothioate backbone, to synthesise antisense oligonucleotide analogs to induce apoptosis in cancer cells .
|
- HY-104014
-
|
|
|
Nucleoside Phosphoramidites
|
|
DMT-2'O-MOE-rG(ib) Phosphoramidite (1g), belonging to the amide family of trivalent phosphate H3PO3, is a derivative of nucleotides and guanosine and can be used in the stereochemical synthesis of phosphorothioate oligonucleotides .
|
- HY-132580
-
|
BIIB067; ISIS-SOD1Rx
|
|
Antisense Oligonucleotides
|
|
Tofersen (BIIB067) is an antisense oligonucleotide that mediates RNase H-dependent degradation of superoxide dismutase 1 (SOD1) mRNA to reduce the synthesis of SOD1 protein. Tofersen can be used for the research of amyotrophic lateral sclerosis (ALS) .
|
- HY-150237
-
|
|
|
Antisense Oligonucleotides
|
|
FITC-labeled Drisapersen (sodium) is Drisapersen labeled with FITC. Drisapersen, a antisense oligonucleotide, induces exon 51 skipping during dystrophin pre-mRNA splicing and allows synthesis of partially functional dystrophin in Duchenne muscular dystrophy (DMD) patients with amenable mutations.
|
- HY-154211
-
|
|
|
Nucleoside Phosphoramidites
|
|
5’-O-DMTr-dU-methyl phosphonamidite; 5’-O-DMTr-2’-deoxyuridine-3’-O-(P-methyl-N,N-diisopropylamino)phosphonamidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.
|
- HY-158827A
-
|
|
|
Antisense Oligonucleotides
|
|
AZD8233 sodium, a liver-targeting antisense oligonucleotide (ASO), inhibits subtilisin/kexin type 9 (PCSK9) protein synthesis. AZD8233 sodium increases the available LDL receptors by reducing PCSK9 levels, thereby clearing LDL from the blood and decreasing LDL-C levels.
|
- HY-154618
-
|
|
|
Nucleoside Phosphoramidites
|
|
N4-Benzoyl-5’-O-(4,4’-dimethoxytrityl)-3’-deoxy-3’-fluoro-beta-D-xylofuranosyl cytidine-2’-CED-phosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.
|
- HY-154080
-
|
|
|
Nucleoside Phosphoramidites
|
|
5’-O-DMTr-2’-FU-methyl phosphonamidite, 5’-O-DMTr-2’-deoxy-2’-fluorouridine-3’-O-(P-methyl-N,N-diisopropylamino) phosphonamidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.
|
- HY-158827
-
|
|
|
Antisense Oligonucleotides
|
|
AZD8233, a liver-targeting antisense oligonucleotide (ASO), inhibits proprotein convertase subtilisin/kexin type 9 (PCSK9) protein synthesis. AZD8233 increases the available LDL receptors by reducing PCSK9 levels, thereby clearing LDL from the blood and decreasing LDL-C levels.
|
- HY-153485
-
|
ISIS 766720; IONIS-GHR-LRx
|
|
Antisense Oligonucleotides
|
|
Cimdelirsen is a novel, ligand-conjugated, hepatic-targeted investigative antisense oligonucleotide designed to reduce growth hormone receptor (GHr) synthesis, thereby inhibiting deleterious effects of growth hormone (GH) hypersecretion and reducing circulating insulin-like growth factor-1 (IGF-1) levels in acromegaly patients.
|
- HY-153485A
-
|
ISIS 766720 sodium; IONIS-GHR-LRx sodium
|
|
Antisense Oligonucleotides
|
|
Cimdelirsen is a novel, ligand-conjugated, hepatic-targeted investigative antisense oligonucleotide designed to reduce growth hormone receptor (GHr) synthesis, thereby inhibiting deleterious effects of growth hormone (GH) hypersecretion and reducing circulating insulin-like growth factor-1 (IGF-1) levels in acromegaly patients.
|
- HY-21997
-
|
|
|
Nucleoside Phosphoramidites
|
|
Dmt-2'fluoro-da(bz) amidite, an uniformly modified 2'-deoxy-2'-fluoro phosphorothioate oligonucleotide, is a nuclease-resistant antisense compound with high affinity and specificity for RNA targets. Dmt-2'fluoro-da(bz) amidite is also an intermediate for 5’-DMT-3’-phosphoramidite synthesis .
|
- HY-148503
-
|
|
|
Nucleoside Phosphoramidites
|
|
5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) is a nucleoside phosphoramidite monomer used to synthesize locked nucleic acid (LNA) analog oligonucleotides. It can be used as a building block of antisense oligonucleotides (ASOs) to target complementary RNA sequences. 5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) locks the furanose ring into an N-type conformation through 2',4'-constrained ethyl (cEt) modification, enhancing hybridization affinity and mismatch discrimination with RNA, while significantly improving the resistance of oligonucleotides to exonuclease digestion. 5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) mediates RNase H-dependent mRNA degradation or inhibits translation by forming a stable hybrid with RNA, thereby achieving gene expression regulation. 5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) is mainly used in the development of antisense drugs, gene function research and oligonucleotide synthesis related to disease treatment .
|
- HY-W039442
-
|
|
|
Nucleosides and their Analogs
|
|
2′-Deoxy-2′-fluoroadenosine can be used for the synthesis of 2′-Deoxy-2′-fluoro-modified oligonucleotides hybridized with RNA. 2′-Deoxy-2′-fluoroadenosine can be cleaved efficiently by E. coli purine nucleoside phosphorylase (PNP) to the toxic agent 2-fluoroadenine (FAde). 2′-Deoxy-2′-fluoroadenosine shows excellent in vivo activity against tumors expressing E. coli PNP .
|
- HY-W570889
-
|
|
|
Nucleoside Phosphoramidites
|
|
(1R,3R,4R,7S)-3-(4-Amino-5-methyl-2-oxopyrimidin-1(2H)-yl)-1-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-2,5-dioxabicyclo[2.2.1]heptan-7-yl (2-cyanoethyl) diisopropylphosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.
|
- HY-43066
-
|
|
|
Nucleoside Phosphoramidites
|
|
(2R,3R,4R,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2-(((E)-(dimethylamino)methylene)amino)-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.
|
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