Search Result
Results for "
nucleotide derivative
" in MedChemExpress (MCE) Product Catalog:
1
Biochemical Assay Reagents
6
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-W114328
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N-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methylcytidine
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Nucleoside Antimetabolite/Analog
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Others
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DMT-OMe-rC(Ac) (N-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methylcytidine) is a nucleotide derivative that can be used to synthesize oligoribonucleotides .
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- HY-113225S3
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- HY-113225S5
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- HY-N7517
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Nucleoside Antimetabolite/Analog
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Others
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Adenosine 5′-monophosphoramidate sodium is an adenosine derivative and can be used as an intermediate for nucleotide synthesis. Adenosine 5′-monophosphoramidate has a significant effect on the accumulation of cyclic AMP .
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- HY-104014
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DNA/RNA Synthesis
Nucleoside Antimetabolite/Analog
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Others
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DMT-2'O-MOE-rG(ib) Phosphoramidite belongs to cyanoethyl-protected nucleoside phosphoramidites. DMT-2'O-MOE-rG(ib) Phosphoramidite is a derivative of nucleotide and guanosine. DMT-2'O-MOE-rG(ib) Phosphoramidite can be used for the stereochemical synthesis of phosphorothioate oligonucleotides .
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- HY-W700549
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- HY-159849
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- HY-113225
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- HY-113225S2
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- HY-113225S4
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- HY-W131753
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N-Acetyl-2′-deoxy-2′-fluorocytidine
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Nucleoside Antimetabolite/Analog
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Others
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2'-F-Ac-C (N-Acetyl-2′-deoxy-2′-fluorocytidine) is a nucleoside analog that can be used to synthesize oligoribonucleotides .
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- HY-136647
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8-Br-ATP tetrasodium
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Drug Derivative
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Others
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8-Bromoadenosine 5'-triphosphate tetrasodium (8-Br-ATP tetrasodium) is an ATP analogue. ATP is a central component of energy storage and metabolism in vivo .
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- HY-143469
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- HY-171021
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- HY-138587
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- HY-138588
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- HY-171020
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Endogenous Metabolite
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Others
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8-Nitro-2'3'cGMP is a cyclic nucleotide derivative. 8-Nitro-2'3'cGMP is composed of 8-Nitro-GMP, ribose and phosphoric acid.
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- HY-B0128
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- HY-176023
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3'-O-Monosuccinyl dATP triethylammonium
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Drug Derivative
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Others
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2'-Deoxy-3'-O-monosuccinyladenosine-5'-O-triphosphate (3'-O-monosuccinyl dATP) triethylammonium is a derivative of the purine nucleotide 2'-deoxyadenosine-5'-O-triphosphate .
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- HY-113225S1
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- HY-16398
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DNA Alkylator/Crosslinker
DNA/RNA Synthesis
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Cancer
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Pipobroman is a bromide derivative of piperazine and acts as an alkylating agent. Pipobroman plays its role by inhibiting DNA and RNA polymerase or by reducing pyrimidine nucleotide incorporation into DNA. Pipobroman can be used for the cancer research, including polycythemia vera, myeloproliferative neoplasm, and AML et.al .
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- HY-150524
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Endogenous Metabolite
P2Y Receptor
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Metabolic Disease
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UDP-Galactose is a monosaccharide involved in nucleotide sugar metabolism. UDP-Galactose and its derivatives act as a natural agonist for Gi protein-conjugated P2Y14 receptors in the immune system (IC50=0.67 μM, hP2Y14) .
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- HY-176024
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2'-Deoxy-3'-IVal-dATP triethylammonium
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Drug Derivative
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Others
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2'-Deoxy-3'-O-isovaleryladenosine-5'-O-triphosphate (2'-Deoxy-3'-IVal-dATP) triethylammonium is a derivative of the purine nucleotide 2'-deoxyadenosine-5'-O-triphosphate (dATP; HY-136648) .
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- HY-134280
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Nicotinamide 8-Br-hypoxanthine dinucleotide
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Drug Derivative
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Others
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8-Br-NHD+ (Nicotinamide 8-Br-hypoxanthine dinucleotide) is a derivative of NAD+ (nicotinamide adenine dinucleotide) that acts as a potential substrate, competitive inhibitor or modulator of enzymes that interact with β-NAD+. 8-Br-NHD+ can be used to synthesize a cyclic ADP nucleotide (cADPR) analog .
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- HY-B0128R
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Adenosine Receptor
Phosphodiesterase (PDE)
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Cardiovascular Disease
Inflammation/Immunology
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Diphylline (Standard) is the analytical standard of Diphylline. This product is intended for research and analytical applications. Diphylline (Diprophylline) is a potent A1/A2 adenosine receptor antagonist and cyclic nucleotide phosphodiesterase inhibitor. Diphylline, a xanthine derivative, is a bronchodilator and vasodilator agent and has the potential for chronic bronchitis and emphysema .
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- HY-131776A
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2-Chloroadenosine 5′-diphosphate sodium
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Adenylate Cyclase
HSP
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Cardiovascular Disease
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2-Chloro-ADP (2-Chloroadenosine 5′-diphosphate) sodium is a Adenosine 5'-diphosphate (ADP; HY-W010918) derivative that induces human platelet aggregation and inhibits stimulated adenylate cyclase . 2-Chloro-ADP sodium inhibits mortalin nucleotide-binding domain (NBD) with a Ki of 45.05 μM .
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- HY-134245
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Tubercidin 5'-phosphate; 7-Deaza-AMP
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Nucleoside Antimetabolite/Analog
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Others
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7-Deazaadenosine 5'-phosphate (Tubercidin 5'-phosphate; 7-Deaza-AMP) is a potential substrate or competitive inhibitor of enzymes that interact with 5′-adenylic acid monophosphate. As a nucleotide derivative, 7-Deazaadenosine 5'-phosphate can regulate cellular functions by affecting intracellular signaling pathways, especially in signaling involving AMP .
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- HY-131776
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2-Chloroadenosine 5′-diphosphate
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Adenylate Cyclase
HSP
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Cardiovascular Disease
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2-Chloro-ADP (2-Chloroadenosine 5′-diphosphate) sis a Adenosine 5'-diphosphate (ADP; HY-W010918) derivative that induces human platelet aggregation and inhibits stimulated adenylate cyclase . 2-Chloro-ADP inhibits mortalin nucleotide-binding domain (NBD) with a Ki of 45.05 μM .
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- HY-15794
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Methoxymorpholinyl doxorubicin; FCE 23762; PNU 152243
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G-quadruplex
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Cancer
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Nemorubicin (Methoxymorpholinyl doxorubicin) is a Doxorubicin derivative with potent antitumor activity. Nemorubicin is highly cytotoxic to a variety of tumor cell lines presenting a multidrug-resistant phenotype. Nemorubicin not only intercalate into the duplex DNA, but also result in significant ligands for G-quadruplex DNA segments, stabilizing their structure. Nemorubicin requirs an intact nucleotide excision repair (NER) system to exert its activity .
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- HY-D2772
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Biochemical Assay Reagents
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Others
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5-TAMRA cadaverine can used to modify carboxylic acid group in the presence of activators (e.g. EDC, or DCC) or activated esters (e.g. NHS esters) through a stable amide bond. It also can be reversibly coupled to aldehydes and ketones to form a Schiff base – which can be reduced to a generate stable amine derivative by sodium borohydride (NaBH4) or sodium cyanoborohydride (NaCNH3).
Although the mixed isomers of 5(6)-TAMRA cadaverine is a preferred, routinely used orange-fluorescent dye for staining proteins, it is rearly used for labeling peptides and nucleotides. Purification of 5(6)-TAMRA labeled peptide and nucleotides might be troublesome due to significant signal broadening in HPLC purification. Peptides and nucleotides labeled with a single isomer TAMRA usually give better resolution in HPLC purification that is often required in the conjugation processes.
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- HY-15794G
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Methoxymorpholinyl doxorubicin; FCE 23762; PNU 152243
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G-quadruplex
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Cancer
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Nemorubicin (Methoxymorpholinyl doxorubicin) GMP is a GMP-class Nemorubicin (HY-15794). Nemorubicin is a Doxorubicin derivative with potent antitumor activity. Nemorubicin is highly cytotoxic to a variety of tumor cell lines presenting a multidrug-resistant phenotype. Nemorubicin not only intercalate into the duplex DNA, but also result in significant ligands for G-quadruplex DNA segments, stabilizing their structure. Nemorubicin requirs an intact nucleotide excision repair (NER) system to exert its activity .
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- HY-W013159
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5′-dGMP disodium
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Endogenous Metabolite
Nucleoside Antimetabolite/Analog
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Metabolic Disease
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2'-Deoxyguanosine 5'-monophosphate (5′-dGMP) disodium is a mononucleotide having guanine as the nucleobase. 2'-Deoxyguanosine 5'-monophosphate disodium is a reactant involved in analysis of self-assembling in solution and nucleation/growth of G-qudruplexes, nucleophilic trapping and reductive alkylation. 2'-Deoxyguanosine 5'-monophosphate disodium can be used as an oxidizable target. 2'-Deoxyguanosine 5'-monophosphate disodium is a nucleic acid guanosine triphosphate (GTP) derivative and is a nucleotide precursor used in DNA synthesis .
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- HY-13661
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UCN-01; KRX-0601
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Akt
PKC
CDK
Apoptosis
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Cancer
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7-Hydroxystaurosporine (UCN-01) is a synthetic derivative of Staurosporine (HY-15141) with antitumor activity. 7-hydroxystaurosporine inhibits serine/threonine kinase AKT and calcium-dependent protein kinase C activity. 7-hydroxystaurosporine also activates indirectly cyclin-dependent kinases (CDKs). 7-hydroxystaurosporine arrests tumor cells in the G1/S of the cell cycle and prevents nucleotide excision repair by inhibiting the G2 checkpoint kinase chk1, resulting in apoptosis .
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- HY-138844
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Eukaryotic Initiation Factor (eIF)
p38 MAPK
JNK
Apoptosis
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Cancer
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3-AP-Me is a dimethyl derivative of the nucleotide reductase inhibitor 3-AP (SML0568). 3-AP-Me can activate the endoplasmic reticulum (ER) stress pathway by promoting the phosphorylation of eIF2α and increasing the gene expression of transcription factors ATF4 and ATF6, leading to cell apoptosis. Additionally, 3-AP-Me can activate the stress kinases c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinases. 3-AP-Me also leads to the upregulation of the spliced mRNA variant XBP1, can be used in cancer research .
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- HY-W013159S
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dGMP-13C10,15N5
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Isotope-Labeled Compounds
Endogenous Metabolite
Nucleoside Antimetabolite/Analog
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Metabolic Disease
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2'-Deoxyguanosine 5'-monophosphate- 13C10, 15N5 (dGMP- 13C10, 15N5) disodium is the 13C and 15N labeled 2'-Deoxyguanosine 5'-monophosphate disodium (HY-W013159). 2'-Deoxyguanosine 5'-monophosphate (5′-dGMP) disodium is a mononucleotide having guanine as the nucleobase. 2'-Deoxyguanosine 5'-monophosphate disodium is a reactant involved in analysis of self-assembling in solution and nucleation/growth of G-qudruplexes, nucleophilic trapping and reductive alkylation. 2'-Deoxyguanosine 5'-monophosphate disodium can be used as an oxidizable target. 2'-Deoxyguanosine 5'-monophosphate disodium is a nucleic acid guanosine triphosphate (GTP) derivative and is a nucleotide precursor used in DNA synthesis .
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Cat. No. |
Product Name |
Type |
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- HY-D2772
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Fluorescent Dyes/Probes
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5-TAMRA cadaverine can used to modify carboxylic acid group in the presence of activators (e.g. EDC, or DCC) or activated esters (e.g. NHS esters) through a stable amide bond. It also can be reversibly coupled to aldehydes and ketones to form a Schiff base – which can be reduced to a generate stable amine derivative by sodium borohydride (NaBH4) or sodium cyanoborohydride (NaCNH3).
Although the mixed isomers of 5(6)-TAMRA cadaverine is a preferred, routinely used orange-fluorescent dye for staining proteins, it is rearly used for labeling peptides and nucleotides. Purification of 5(6)-TAMRA labeled peptide and nucleotides might be troublesome due to significant signal broadening in HPLC purification. Peptides and nucleotides labeled with a single isomer TAMRA usually give better resolution in HPLC purification that is often required in the conjugation processes.
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- HY-15794G
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Methoxymorpholinyl doxorubicin (GMP); FCE 23762 (GMP); PNU 152243 (GMP)
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Fluorescent Dye
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Nemorubicin (Methoxymorpholinyl doxorubicin) GMP is a GMP-class Nemorubicin (HY-15794). Nemorubicin is a Doxorubicin derivative with potent antitumor activity. Nemorubicin is highly cytotoxic to a variety of tumor cell lines presenting a multidrug-resistant phenotype. Nemorubicin not only intercalate into the duplex DNA, but also result in significant ligands for G-quadruplex DNA segments, stabilizing their structure. Nemorubicin requirs an intact nucleotide excision repair (NER) system to exert its activity .
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Cat. No. |
Product Name |
Type |
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- HY-15794G
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Methoxymorpholinyl doxorubicin (GMP); FCE 23762 (GMP); PNU 152243 (GMP)
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Biochemical Assay Reagents
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Nemorubicin (Methoxymorpholinyl doxorubicin) GMP is a GMP-class Nemorubicin (HY-15794). Nemorubicin is a Doxorubicin derivative with potent antitumor activity. Nemorubicin is highly cytotoxic to a variety of tumor cell lines presenting a multidrug-resistant phenotype. Nemorubicin not only intercalate into the duplex DNA, but also result in significant ligands for G-quadruplex DNA segments, stabilizing their structure. Nemorubicin requirs an intact nucleotide excision repair (NER) system to exert its activity .
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Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
Cat. No. |
Product Name |
Chemical Structure |
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- HY-113225S3
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Guanosine triphosphate- 15N5 (GTP- 15N5) dilithium is 15N labeled Guanosine triphosphate (HY-113225). Guanosine triphosphate is a native nucleotide. The derivatives of GTP may be used as specific inhibitors against COVID-19.
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- HY-113225S5
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Guanosine triphosphate- 13C10 (GTP- 13C10) dilithium is 13C-labeled Guanosine triphosphate (HY-113225). Guanosine triphosphate is a native nucleotide. The derivatives of GTP may be used as specific inhibitors against COVID-19.
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- HY-113225S2
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Guanosine triphosphate- 13C (GTP- 13C) dilithium is 13C-labeled Guanosine triphosphate (HY-113225). Guanosine triphosphate is a native nucleotide. The derivatives of GTP may be used as specific inhibitors against COVID-19.
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- HY-113225S4
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Guanosine triphosphate- 15N5,d14 (GTP- 15N5,d14) dilithium is deuterium and 15N labeled Guanosine triphosphate (HY-113225). Guanosine triphosphate is a native nucleotide. The derivatives of GTP may be used as specific inhibitors against COVID-19.
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- HY-113225S1
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Guanosine triphosphate- 13C10, 15N5 (tetraammonium) is the 13C and 15N labeled Guanosine triphosphate tetraammonium . Guanosine triphosphate is a native nucleotide. The derivatives of GTP may be used as specific inhibitors against COVID-19 .
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- HY-W013159S
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2'-Deoxyguanosine 5'-monophosphate- 13C10, 15N5 (dGMP- 13C10, 15N5) disodium is the 13C and 15N labeled 2'-Deoxyguanosine 5'-monophosphate disodium (HY-W013159). 2'-Deoxyguanosine 5'-monophosphate (5′-dGMP) disodium is a mononucleotide having guanine as the nucleobase. 2'-Deoxyguanosine 5'-monophosphate disodium is a reactant involved in analysis of self-assembling in solution and nucleation/growth of G-qudruplexes, nucleophilic trapping and reductive alkylation. 2'-Deoxyguanosine 5'-monophosphate disodium can be used as an oxidizable target. 2'-Deoxyguanosine 5'-monophosphate disodium is a nucleic acid guanosine triphosphate (GTP) derivative and is a nucleotide precursor used in DNA synthesis .
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Cat. No. |
Product Name |
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Classification |
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- HY-W114328
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N-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methylcytidine
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Nucleosides and their Analogs
C
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DMT-OMe-rC(Ac) (N-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methylcytidine) is a nucleotide derivative that can be used to synthesize oligoribonucleotides .
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- HY-N7517
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Nucleotides and their Analogs
A
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Adenosine 5′-monophosphoramidate sodium is an adenosine derivative and can be used as an intermediate for nucleotide synthesis. Adenosine 5′-monophosphoramidate has a significant effect on the accumulation of cyclic AMP .
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- HY-104014
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Nucleoside Phosphoramidites
G
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DMT-2'O-MOE-rG(ib) Phosphoramidite belongs to cyanoethyl-protected nucleoside phosphoramidites. DMT-2'O-MOE-rG(ib) Phosphoramidite is a derivative of nucleotide and guanosine. DMT-2'O-MOE-rG(ib) Phosphoramidite can be used for the stereochemical synthesis of phosphorothioate oligonucleotides .
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- HY-W131753
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N-Acetyl-2′-deoxy-2′-fluorocytidine
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Nucleosides and their Analogs
C
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2'-F-Ac-C (N-Acetyl-2′-deoxy-2′-fluorocytidine) is a nucleoside analog that can be used to synthesize oligoribonucleotides .
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- HY-136647
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8-Br-ATP tetrasodium
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Nucleotides and their Analogs
A
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8-Bromoadenosine 5'-triphosphate tetrasodium (8-Br-ATP tetrasodium) is an ATP analogue. ATP is a central component of energy storage and metabolism in vivo .
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- HY-W700549
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- HY-159849
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- HY-113225
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GTP
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Nucleotides and their Analogs
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Guanosine triphosphate is a native nucleotide. The derivatives of GTP may be used as specific inhibitors against COVID-19 .
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- HY-176023
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3'-O-Monosuccinyl dATP triethylammonium
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Nucleotides and their Analogs
A
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2'-Deoxy-3'-O-monosuccinyladenosine-5'-O-triphosphate (3'-O-monosuccinyl dATP) triethylammonium is a derivative of the purine nucleotide 2'-deoxyadenosine-5'-O-triphosphate .
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- HY-153846
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Aptamers
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RNA Aptamer Mango Ⅰ (sodium) consists of 39 nucleotides and has an exceptionally high affinity to TO1-biotin (a thiazole orange derivative fluorophore). RNA Aptamer Mango Ⅰ (sodium) can be used to visualize RNA expression or localization in live cells.
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- HY-176024
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2'-Deoxy-3'-IVal-dATP triethylammonium
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Nucleotides and their Analogs
A
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2'-Deoxy-3'-O-isovaleryladenosine-5'-O-triphosphate (2'-Deoxy-3'-IVal-dATP) triethylammonium is a derivative of the purine nucleotide 2'-deoxyadenosine-5'-O-triphosphate (dATP; HY-136648) .
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- HY-134245
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Tubercidin 5'-phosphate; 7-Deaza-AMP
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Nucleotides and their Analogs
A
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7-Deazaadenosine 5'-phosphate (Tubercidin 5'-phosphate; 7-Deaza-AMP) is a potential substrate or competitive inhibitor of enzymes that interact with 5′-adenylic acid monophosphate. As a nucleotide derivative, 7-Deazaadenosine 5'-phosphate can regulate cellular functions by affecting intracellular signaling pathways, especially in signaling involving AMP .
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- HY-W013159
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5′-dGMP disodium
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Nucleotides and their Analogs
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2'-Deoxyguanosine 5'-monophosphate (5′-dGMP) disodium is a mononucleotide having guanine as the nucleobase. 2'-Deoxyguanosine 5'-monophosphate disodium is a reactant involved in analysis of self-assembling in solution and nucleation/growth of G-qudruplexes, nucleophilic trapping and reductive alkylation. 2'-Deoxyguanosine 5'-monophosphate disodium can be used as an oxidizable target. 2'-Deoxyguanosine 5'-monophosphate disodium is a nucleic acid guanosine triphosphate (GTP) derivative and is a nucleotide precursor used in DNA synthesis .
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