Search Result
Results for "
mucins
" in MedChemExpress (MCE) Product Catalog:
6
Biochemical Assay Reagents
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-160060
-
|
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Mucin
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Cancer
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MA3 aptamer sodium is an 86-base long DNA aptamer targeting the mucin MUC1. MA3 aptamer sodium binds to the peptide epitope of mucin 1 (MUC1) with a Kd of 38.3 nM and has minimal cross-reactivity with albumin .
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- HY-D1542
-
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Fluorescent Dye
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Cancer
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Mucicarmine is used in the histological visualization of acid mucopolysaccharides in tissue sections. Mucicarmine can identify mucin (deep rose), which is useful in determining the mucin positive cancer (such as liver carcinoma) .
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-
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- HY-160109
-
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Mucin
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Inflammation/Immunology
Cancer
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Ac5GalNTGc is a potent, peracetylated C-2 thioglycolyl-substituted GalNAc analog that efficiently inhibits mucin-type O-glycan biosynthesis. Ac5GalNTGc reduces leukocyte sialyl-Lewis-X expression and inhibits L-/P-selectin mediated rolling under flow, as well as P-selectin dependent leukocyte-platelet adhesion. Ac5GalNTGc exhibits anti-inflammatory activity in a thioglycollate-induced acute peritonitis model. Ac5GalNTGc can be used for studies of O-glycan/mucin biology, inflammation, and related translational research .
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- HY-N2098
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NF-κB
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Cancer
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Obtusifolin, isolated from the seeds of Cassia obtusifolia, regulates the gene expression and production of MUC5AC mucin in airway epithelial cells via inhibiting NF-kB pathway . Obtusifolin suppresses phthalate esters-induced breast cancer bone metastasis by targeting parathyroid hormone-related protein .
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- HY-B2196
-
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Antibiotic
Bacterial
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Infection
Metabolic Disease
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Gastric mucin is a glycoprotein with natural antibiotic function. Gastric mucin against Helicobacter pylori infection. Gastric mucin effectively scavenges hydroxyl radical. Gastric mucin play a major role in the protection of the gastrointestinal tract from acid, proteases, pathogenic microorganisms, and mechanical trauma .
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- HY-P2508
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Mucin
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Cancer
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MUC1, mucin core is the region of the MUC1 mucin core. MUC1 is a type I transmembrane glycoprotein, and is overexpressed and aberrantly glycosylated in carcinoma cells. MUC1, mucin core protein binds to domain 1 of ICAM-1 .
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- HY-P991649
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SAR566658 antibody
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Mucin
ADC Antibody
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Cancer
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Anti-CA6 Antibody (huDS6) is a Mucin 1-associated sialoglycotope (CA6) targeting humanized monoclonal antibody. Anti-CA6 Antibody (huDS6) can be used for synthesis of ADCs .
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- HY-125396
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11-Deoxy-PGF2β
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Endogenous Metabolite
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Others
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11-Deoxyprostaglandin F2β (11-deoxy PGF2β) is an analog of PGF2β (HY-12956B). PGF2β is a metabolite produced by cyclooxygenase metabolism of arachidonic acid. PGF2β induces dose-dependent release of hexose containing mucin .
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- HY-N2098R
-
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Reference Standards
NF-κB
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Cancer
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Obtusifolin (Standard) is the analytical standard of Obtusifolin. This product is intended for research and analytical applications. Obtusifolin, isolated from the seeds of Cassia obtusifolia, regulates the gene expression and production of MUC5AC mucin in airway epithelial cells via inhibiting NF-kB pathway . Obtusifolin suppresses phthalate esters-induced breast cancer bone metastasis by targeting parathyroid hormone-related protein .
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- HY-160062
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Mucin
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Cancer
|
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S2.2 aptamer sodium is a nucleic acid aptamer targeting the mucin MUC1 and can be used for targeted imaging of MCF-7 cancer cells. S2.2 aptamer sodium was labeled with Cy5, and when fluorescent silicon nanodots (SiND) were present, the fluorescence was quenched; when MUC1 was also present, the fluorescence was restored. S2.2 aptamer sodium detects MUC1 with a linear range of 3.33-250 nM .
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- HY-D0220A
-
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Toluidine Blue O (purity 36%)
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Fluorescent Dye
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Others
Cancer
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Toluidine Blue (Toluidine Blue O) purity 36% is an alkaline quinonimine dye (vivo dye) with high affinity for acidic tissue components, staining nuclei blue and polysaccharides purple. Toluidine Blue purity 36% shows heterostaining properties for mast cells, mucins and chondrocytes. Toluidine Blue purity 36% can stain different components of plant tissues and cells in different colours. Toluidine Blue purity 36% is also used as a diagnostic aid to identify malignant lesions, such as cancer .
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- HY-E70562
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Biochemical Assay Reagents
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Infection
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Mucinase StcE is a metalloproteinase secreted by Enterohemorrhagic Escherichia coli (EHEC) and belongs to the serine protease family. Mucinase StcE plays an important role in pathogen infection by specifically cleaving the peptide backbone of glycosylated mucins (mucins).
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- HY-D1771
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- HY-P99634
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PankoMab; DS-3939a antibody
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Mucin
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Cancer
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Gatipotuzumab (PankoMab) is a humanized monoclonal antibody which recognizes the tumor-specific epitope of mucin-1 (TA-MUC1). Gatipotuzumab reveals a potent tumor-specific antibody-dependent cell cytotoxicity (ADCC) .
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- HY-W072147
-
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Fmoc-L-Ser-OMe
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Amino Acid Derivatives
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Others
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Fmoc-Ser-OMe (Fmoc-L-Ser-OMe) is a hydroxylated L-amino acid protected with a 9-fluorenylmethyloxycarbonyl (Fmoc) group. Fmoc-Ser-OMe involves in chlorophyll–amino acid conjugates synthesis, and acts as a chromo/fluorophores modified protein and emits visible to near-infrared lights efficiently. Fmoc-Ser-OMe glycosylates and produces small mucin-related Olinked glycopeptides, as an alcohol acceptor .
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-
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- HY-P0280
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-
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- HY-E70295
-
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GALNT14
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Endogenous Metabolite
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Cancer
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N-Acetylgalactosaminyltransferase 14 (GALNT14) is a mucin-type glycosylating enzyme polypeptide that promotes the migration of ovarian cancer by modifying mucin 13 (MUC13). GALNT14 can regulate the O-glycosylation and stability of MUC13, thereby mediating the malignant behavior of ovarian cancer cells .
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- HY-P3008
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-
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- HY-P99968
-
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Mucin
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Cancer
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Clivatuzumab is a humanized anti-mucin monoclonal antibody targeting an epitope in the MUC1 antigen expressed in most pancreatic cancers .
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- HY-P0179
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- HY-P0179A
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- HY-B0606
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INS365
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P2Y Receptor
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Inflammation/Immunology
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Diquafosol tetrasodium is a P2Y2 receptor agonist that stimulates fluid and mucin secretion on the ocular surface, as a topical treatment of dry eye disease.
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- HY-P99539
-
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REGN4018
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CD3
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Cancer
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Ubamatamab (REGN4018) is a humanized bispecific antibody targeted against Mucin 16 (MUC16) and CD3. Ubamatamab demonstrates potent antitumor activity .
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- HY-B0393
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- HY-P10218
-
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MARCKS
PKC
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Inflammation/Immunology
Cancer
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MANS peptide is an inhibitor for myristoylated alanine-rich C kinase substrate (MARCKS), which competes with MARCKS in cells for membrane binding, and thus inhibits the stimulation of mucin secretion and tumor metastasis .
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- HY-12956B
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Prostaglandin F2β; PGF2β
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Endogenous Metabolite
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Others
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(5R)-Dinoprost is a metabolite produced by cyclooxygenase metabolism of arachidonic acid. (5R)-Dinoprost (Prostaglandin F2β) induces dose-dependent release of hexose containing mucin .
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- HY-171270
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Antibody-Drug Conjugates (ADCs)
Mucin
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Cancer
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Clivatuzumab-MMAE is an antibody-drug conjugate (ADC) (Clivatuzumab antibody (HY-P99968), Linker: VC linker, Payload: MMAE (HY-15162)). Anetumab is a humanized anti-mucin monoclonal antibody.
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- HY-114850A
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Prostaglandin F2β tromethamine; PGF2β tromethamine
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Endogenous Metabolite
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Others
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(5R)-Dinoprost tromethamine (Prostaglandin F2β tromethamine) is a metabolite produced by the metabolism of arachidonic acid cyclooxygenase. (5R)-Dinoprost tromethamine induces dose-dependent release of hexosaccharide containing mucin .
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-
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- HY-E70164
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|
EC:2.8.2.-; CHST4; GlcNAc6ST2
|
Biochemical Assay Reagents
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Cancer
|
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Carbohydrate Sulfotransferase 4 (EC:2.8.2.-) can catalyze sulphate transfer to the hydroxyl group at C-6 position of the non-reducing GlcNAc residue within O-linked mucin-type glycans .
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- HY-160109A
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Mucin
|
Inflammation/Immunology
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Ac5GalNTGc epimer is an analogue of hexosamine and the racemate of Ac5GalNTGc (HY-160109). Ac5GalNTGc is a potent, peracetylated C-2 thioglycolyl-substituted GalNAc analog that efficiently inhibits mucin-type O-glycan biosynthesis. Ac5GalNTGc reduces leukocyte sialyl-Lewis-X expression and inhibits L-/P-selectin mediated rolling under flow, as well as P-selectin dependent leukocyte-platelet adhesion. Ac5GalNTGc exhibits anti-inflammatory activity in a thioglycollate-induced acute peritonitis model. Ac5GalNTGc can be used for studies of O-glycan/mucin biology, inflammation, and related translational research .
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- HY-E70290
-
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GALNT1
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Endogenous Metabolite
β-catenin
Wnt
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Cancer
|
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N-Acetylgalactosaminyltransferase 1 (GALNT1) is a glycosyltransferase that initiates mucin-type O-glycosylation by transferring α-GalNAc from UDP-GalNAc to serine (Ser) or threonine (Thr) residues in proteins. Overexpression of N-Acetylgalactosaminyltransferase 1 in gastric cancer can promote abnormal O-glycosylation of CD44, thereby activating the Wnt/β-catenin signaling pathway and regulating the malignant behavior of gastric cancer cells. Additionally, N-Acetylgalactosaminyltransferase 1 plays a crucial role in cancer growth and metastasis by modifying the O-glycosylation of various glycoproteins, such as mucin (MUC1), osteopontin (OPN), matrix metalloproteinase-14 (MMP14), and integrin α3 .
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- HY-P10218A
-
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MARCKS
PKC
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Inflammation/Immunology
Cancer
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MANS peptide TFA is the TFA salt form of MANS peptide (HY-P10218). MANS peptide TFA is an inhibitor for myristoylated alanine-rich C kinase substrate (MARCKS), which competes with MARCKS in cells for membrane binding, and thus inhibits the stimulation of mucin secretion and tumor metastasis .
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- HY-P99962
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BGB-A425
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Mucin
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Cancer
|
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Surzebiclimab (BGB-A425) is a humanized IgG1-variant monoclonal antibody against T-cell immunoglobulin and mucin-domain containing-3 (TIM-3). Surzebiclimab binds to the extracellular domain of human Tim-3 with high affinity (KD=0.36 nM) and specificity. Surzebiclimab can be used in research of cancer .
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- HY-D0220
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Toluidine Blue O
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Fluorescent Dye
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Cancer
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Toluidine Blue (Toluidine Blue O) is an alkaline quinonimine dye (vivo dye) with high affinity for acidic tissue components, staining nuclei blue and polysaccharides purple. Toluidine Blue shows heterostaining properties for mast cells, mucins and chondrocytes. Toluidine Blue can stain different components of plant tissues and cells in different colours. Toluidine Blue is also used as a diagnostic aid to identify malignant lesions, such as cancer .
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- HY-P5472
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Transmembrane Glycoprotein
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Others
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Tumour-associated MUC1 epitope is a biological active peptide. (This sequence is the hallmark of MUC1 mucin. MUC1 is a highly glycosylated type I transmembrane glycoprotein with a unique extracellular domain consisting of a variable number of tandem repeats (VNTR) of this 20 amino acid peptide. It is overexpressed on the cell surface of many human adenocarcinomas and hematological malignancies, including multiple myeloma and B-cell lymphoma, making MUC1 broadly applicable target for immunotherapeutic strategies.)
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- HY-177442
-
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DS-3939
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Antibody-Drug Conjugates (ADCs)
Mucin
Topoisomerase
Apoptosis
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Cancer
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DS-3939a (DS-3939) is an anti-TA-MUC1 (tumor-associated mucin-1) antibody-drug conjugate (ADC). DS-3939a consists of a humanized anti-TA-MUC1 IgG1 monoclonal antibody Gatipotuzumab ( HY-P99634), a stable and cleavable tetrapeptide-based linker (Gly-Gly-Phe-Gly), and a DNA topoisomerase I inhibitor payload (DXd) (HY-13631D), and the drug-linker conjugate for ADC is Deruxtecan (HY-13631E). DS-3939a inhibits the growth of TA-MUC1-positive cancer cells (CFPAC-1, NCI-H2110) by inducing DNA damage and apoptosis. DS-3939a exhibits significant antitumor activity in a variety of TA-MUC1-expressing advanced solid tumors. DS-3939a can be used for the study of TA-MUC1-expressing advanced cancers .
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- HY-E70565
-
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Endonuclease
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Inflammation/Immunology
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O-Glycoprotease is an O-glycoprotein-specific endoprotease that catalyzes the hydrolysis of peptide bonds directly adjacent to the O-polymer in native mucin-type O-glycosylated proteins. O-Glycoprotease sequence is from Akkermansia muciniphila, recombinantly expressed in E.coli, with a 6×His tag at the C-terminus.
The enzyme maintains high activity between pH 5.5-7.5 and is resistant to 1M NaCl, but is highly sensitive to EDTA (0.5 mM EDTA) and can be inhibited by Zn 2+.
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- HY-P990153
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Transmembrane Glycoprotein
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Inflammation/Immunology
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Anti-Mouse TIM-2 Antibody (RMT2-29) is a rat-derived Ig2a λ type antibody inhibitor, targeting to mouse TIM-2. Anti-Mouse TIM-2 Antibody (RMT2-29) reacts with mouse T cell immunoglobulin and mucin domain 2 (TIM-2) and blocks TIM-2 signaling. Anti-Mouse TIM-2 Antibody (RMT2-29) can be used for the research of immunology.
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- HY-158337
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CO-1177
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Histamine Receptor
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Inflammation/Immunology
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Nesosteine (CO-1177) is a bronchitis inhibitor that improves the rheology and production of airway bronchial mucus in rabbits. Nesosteine significantly reduced the viscosity of airway bronchial mucus in animals with sulfuric acid nebulized bronchitis and increased mucus production in healthy animals. Nesosteine is more active than mucus-regulating drugs such as Sobrerol, N-acetylcysteine, bromhexine, ambroxol, S-carboxymethylcysteine, and mercaptoalanine. Nesosteine also reduced the content of total proteins in airway bronchial mucus, such as albumin, α1, α2, β, and γ mucins .
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- HY-100958
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4-DAMP
4 Publications Verification
4-DAMP methiodide
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mAChR
Apoptosis
MMP
EGFR
Interleukin Related
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Inflammation/Immunology
Cancer
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4-DAMP (4-DAMP methiodide) is a potent and selective antagonist of M3 receptors and also has a high affinity for the closely-related M5 receptors. 4-DAMP combined with 5-Fluorouracil (5-Fu) (HY-90006) could significantly reduce the cell viability and enhance apoptosis in MKN45 and BGC823 gastric cancer cells. 4-DAMP inhibits lipopolysaccharide (LPS)- and tobacco-induced pulmonary inflammation and reduces mucin 5AC (MUC5AC), oligomeric mucus/gel-forming secretion .
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- HY-E70568
-
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Ser/Thr Protease
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Others
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Protease (O-glycan Cleaving) is recombinantly expressed from E.coli and contains a His tag. Protease (O-glycan Cleaving) is an O-glycan-dependent protease that digests proteins carrying mucin-type O-glycans, including sialylated substrates, glycosylated Ser and Thr residues at the N terminus. Protease (O-glycan Cleaving) digests a variety of O-glycan structures, including sialylated glycosylated core 1 and core 2 structures and Tn antigen. Protease (O-glycan Cleaving) does not digest terminally modified serine or threonine residues, nor does it digest N-glycosylation sites on glycoproteins.
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-
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- HY-P991198
-
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Tim3
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Cancer
|
|
M6903 is a humanized monoclonal IgG2 antibody targeting T cell immunoglobulin and mucin domain-3 (TIM-3) (KD for human TIM-3 is 2.3 nM). M6903 binds to TIM-3, blocking the binding of TIM-3 to phosphatidylserine (PtdSer), carcinoembryonic antigen cell adhesion-related molecule 1 (CEACAM1), and galectin 9 (Gal-9), thus relieving TIM-3-mediated T cell inhibition and exerting the activities of activating antigen-specific T cells and enhancing anti-tumor immunity. M6903 is promising for research of cancers .
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-
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- HY-P990152
-
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Transmembrane Glycoprotein
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Metabolic Disease
Inflammation/Immunology
|
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Anti-Mouse TIM-4 Antibody (RMT4-54) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse TIM-4. Anti-Mouse TIM-4 Antibody (RMT4-54) reacts with mouse T cell immunoglobulin and mucin domain 4 (TIM-4) and blocks TIM-4 signaling. Anti-Mouse TIM-4 Antibody (RMT4-54) inhibits phagocytosis of apoptotic cells. Anti-Mouse TIM-4 Antibody (RMT4-54) can be used for the researches of immunology and metabolic disease .
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-
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- HY-P990820
-
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Transmembrane Glycoprotein
|
Inflammation/Immunology
Cancer
|
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Anti-Mouse TIM-4 Antibody (RMT4-53) is a rat-derived IgG2b κ type antibody inhibitor, targeting to mouse TIM-4. Anti-Mouse TIM-4 Antibody (RMT4-53) can block T cell immunoglobulin and mucin domain 4 (TIM-4). Anti-Mouse TIM-4 Antibody (RMT4-53) can inhibit the engulfment of apoptotic cells and T cell proliferation. Anti-Mouse TIM-4 Antibody (RMT4-53) can be used for the researches of cancer, immunology and metabolic disease, such as MC38 tumor and graft .
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-
-
- HY-P990822
-
|
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Transmembrane Glycoprotein
|
Cardiovascular Disease
Inflammation/Immunology
|
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Anti-Mouse TIM-1/CD365 Antibody (3D10) is a rat-derived IgG1 κ type antibody inhibitor, targeting to mouse TIM-1/CD365. Anti-Mouse TIM-1/CD365 Antibody (3D10) can block mouse T cell immunoglobulin and mucin domain 1 (TIM-1) also known as CD365. Anti-Mouse TIM-1/CD365 Antibody (3D10) can be used for the researches of inflammation, immunology and cardiovascular disease, such as graft-versus-host disease (GVHD), airway inflammation and atherosclerosis .
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-
-
- HY-129389
-
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Glycosyltransferase
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Cancer
|
|
Benzyl-α-GalNAc is a potent O-glycosylation inhibitor. Benzyl-α-GalNAc effectively inhibits the proliferation and activation of LX-2 cells and suppresses the expression of collagen I/III, which has good potential for investigation in liver fibrosis. Benzyl-α-GalNAc also significantly enhances the anti-tumour activity of 5-Fluorouracil (HY-90006) (e.g. pancreatic cancer) by inhibiting O-glycosylation .
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-
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- HY-112624J
-
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Dextran 4; Dextran D4; Dextran T4(MW 3200-4800)
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Bacterial
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Others
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Dextran 4,000 is a mucus rheology modifier. The dextran molecules in Dextran 4,000 can reduce the cross-link density of mucus through osmotic effects and hydrogen bond substitution, and reduce viscoelasticity and improve the mucociliary/cough clearance index by destroying the DNA-mucin network structure in mucus. Dextran 4,000 has the ability to improve the rheological properties and clearance ability of cystic fibrosis (CF) sputum, and can be used in the study of inhalation therapy or aerosol delivery of mucostatic respiratory diseases. The Dextran series of compounds are also natural polysaccharide drug carriers that can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong the half-life of drugs, increase local concentrations, and reduce the activity of immune clearance .
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- HY-B0603
-
-
-
- HY-B0603R
-
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Reference Standards
Smo
Glucocorticoid Receptor
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Infection
Inflammation/Immunology
Endocrinology
|
|
Fluticasone (Standard) is the analytical standard of Fluticasone. This product is intended for research and analytical applications. Fluticasone is an inhaled corticosteroid used for respiratory research. Fluticasone is a Smo agonist with an IC50 value of 99 nM. Fluticasone activates Hedgehog signaling and promotes the proliferation of primary neuronal stem or precursor cells .
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| Cat. No. |
Product Name |
Type |
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- HY-D1542
-
|
|
Dyes
|
|
Mucicarmine is used in the histological visualization of acid mucopolysaccharides in tissue sections. Mucicarmine can identify mucin (deep rose), which is useful in determining the mucin positive cancer (such as liver carcinoma) .
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- HY-D0220A
-
|
Toluidine Blue O (purity 36%)
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Dyes
|
|
Toluidine Blue (Toluidine Blue O) purity 36% is an alkaline quinonimine dye (vivo dye) with high affinity for acidic tissue components, staining nuclei blue and polysaccharides purple. Toluidine Blue purity 36% shows heterostaining properties for mast cells, mucins and chondrocytes. Toluidine Blue purity 36% can stain different components of plant tissues and cells in different colours. Toluidine Blue purity 36% is also used as a diagnostic aid to identify malignant lesions, such as cancer .
|
-
- HY-D1771
-
-
- HY-177442
-
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DS-3939
|
Chromogenic Assays
|
|
DS-3939a (DS-3939) is an anti-TA-MUC1 (tumor-associated mucin-1) antibody-drug conjugate (ADC). DS-3939a consists of a humanized anti-TA-MUC1 IgG1 monoclonal antibody Gatipotuzumab ( HY-P99634), a stable and cleavable tetrapeptide-based linker (Gly-Gly-Phe-Gly), and a DNA topoisomerase I inhibitor payload (DXd) (HY-13631D), and the drug-linker conjugate for ADC is Deruxtecan (HY-13631E). DS-3939a inhibits the growth of TA-MUC1-positive cancer cells (CFPAC-1, NCI-H2110) by inducing DNA damage and apoptosis. DS-3939a exhibits significant antitumor activity in a variety of TA-MUC1-expressing advanced solid tumors. DS-3939a can be used for the study of TA-MUC1-expressing advanced cancers .
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| Cat. No. |
Product Name |
Type |
-
- HY-B2196
-
|
|
Native Proteins
|
|
Gastric mucin is a glycoprotein with natural antibiotic function. Gastric mucin against Helicobacter pylori infection. Gastric mucin effectively scavenges hydroxyl radical. Gastric mucin play a major role in the protection of the gastrointestinal tract from acid, proteases, pathogenic microorganisms, and mechanical trauma .
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- HY-P3008
-
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Native Proteins
|
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Submandibular mucin is a high molecular weight glycoprotein that is used as a substrate for the viral enzyme neuraminidase .
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- HY-112624J
-
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Dextran 4; Dextran D4; Dextran T4(MW 3200-4800)
|
Thickeners
|
|
Dextran 4,000 is a mucus rheology modifier. The dextran molecules in Dextran 4,000 can reduce the cross-link density of mucus through osmotic effects and hydrogen bond substitution, and reduce viscoelasticity and improve the mucociliary/cough clearance index by destroying the DNA-mucin network structure in mucus. Dextran 4,000 has the ability to improve the rheological properties and clearance ability of cystic fibrosis (CF) sputum, and can be used in the study of inhalation therapy or aerosol delivery of mucostatic respiratory diseases. The Dextran series of compounds are also natural polysaccharide drug carriers that can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong the half-life of drugs, increase local concentrations, and reduce the activity of immune clearance .
|
-
- HY-E70165
-
|
EC:2.8.2.-; CHST5; GST4-α
|
Enzyme Substrates
|
|
Carbohydrate Sulfotransferase 5 (EC:2.8.2.-) can catalyze sulphate transfer to position 6 of non- GlcNAc residues and O-linked sugars of mucin-type acceptors .
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-
- HY-E70164
-
|
EC:2.8.2.-; CHST4; GlcNAc6ST2
|
Enzyme Substrates
|
|
Carbohydrate Sulfotransferase 4 (EC:2.8.2.-) can catalyze sulphate transfer to the hydroxyl group at C-6 position of the non-reducing GlcNAc residue within O-linked mucin-type glycans .
|
-
- HY-E70162
-
|
EC:2.8.2.-; CHST; GlcNAc6ST-1
|
Enzyme Substrates
|
|
Carbohydrate Sulfotransferase 2 (EC:2.8.2.-) can catalyze sulphate transfer to position 6 of non-reducing GlcNAc residues within keratan-like structures on N-linked glycans and within mucin-associated glycans .
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| Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P2508
-
|
|
Mucin
|
Cancer
|
|
MUC1, mucin core is the region of the MUC1 mucin core. MUC1 is a type I transmembrane glycoprotein, and is overexpressed and aberrantly glycosylated in carcinoma cells. MUC1, mucin core protein binds to domain 1 of ICAM-1 .
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- HY-W072147
-
|
Fmoc-L-Ser-OMe
|
Amino Acid Derivatives
|
Others
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Fmoc-Ser-OMe (Fmoc-L-Ser-OMe) is a hydroxylated L-amino acid protected with a 9-fluorenylmethyloxycarbonyl (Fmoc) group. Fmoc-Ser-OMe involves in chlorophyll–amino acid conjugates synthesis, and acts as a chromo/fluorophores modified protein and emits visible to near-infrared lights efficiently. Fmoc-Ser-OMe glycosylates and produces small mucin-related Olinked glycopeptides, as an alcohol acceptor .
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- HY-P0280
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- HY-P3008
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- HY-P0179
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- HY-P10218
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MARCKS
PKC
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Inflammation/Immunology
Cancer
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MANS peptide is an inhibitor for myristoylated alanine-rich C kinase substrate (MARCKS), which competes with MARCKS in cells for membrane binding, and thus inhibits the stimulation of mucin secretion and tumor metastasis .
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- HY-P10218A
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MARCKS
PKC
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Inflammation/Immunology
Cancer
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MANS peptide TFA is the TFA salt form of MANS peptide (HY-P10218). MANS peptide TFA is an inhibitor for myristoylated alanine-rich C kinase substrate (MARCKS), which competes with MARCKS in cells for membrane binding, and thus inhibits the stimulation of mucin secretion and tumor metastasis .
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- HY-P0179A
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- HY-P5472
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Transmembrane Glycoprotein
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Others
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Tumour-associated MUC1 epitope is a biological active peptide. (This sequence is the hallmark of MUC1 mucin. MUC1 is a highly glycosylated type I transmembrane glycoprotein with a unique extracellular domain consisting of a variable number of tandem repeats (VNTR) of this 20 amino acid peptide. It is overexpressed on the cell surface of many human adenocarcinomas and hematological malignancies, including multiple myeloma and B-cell lymphoma, making MUC1 broadly applicable target for immunotherapeutic strategies.)
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- HY-P5508
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Peptides
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Others
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MUC5AC-13 is a biological active peptide. (This glycopeptide is an N-acetyl galactosamine (GalNAc)-modified MUC5AC mucin peptide containing the single site of threonine 13 labeled with GalNAc (T*). Polypeptide N-acetylgalactosaminyltransferase (ppGaNTase) catalyzes the transfer of GalNAc from the nucleotide sugar UDP-GalNAc to threonine. The MUC5AC gene is mainly expressed in gastric and tracheo-bronchial mucosae, and some tumors.)
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| Cat. No. |
Product Name |
Target |
Research Area |
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- HY-P99634
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PankoMab; DS-3939a antibody
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Mucin
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Cancer
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Gatipotuzumab (PankoMab) is a humanized monoclonal antibody which recognizes the tumor-specific epitope of mucin-1 (TA-MUC1). Gatipotuzumab reveals a potent tumor-specific antibody-dependent cell cytotoxicity (ADCC) .
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- HY-P99968
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Mucin
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Cancer
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Clivatuzumab is a humanized anti-mucin monoclonal antibody targeting an epitope in the MUC1 antigen expressed in most pancreatic cancers .
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- HY-P99539
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REGN4018
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CD3
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Cancer
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Ubamatamab (REGN4018) is a humanized bispecific antibody targeted against Mucin 16 (MUC16) and CD3. Ubamatamab demonstrates potent antitumor activity .
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- HY-P99962
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BGB-A425
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Mucin
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Cancer
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Surzebiclimab (BGB-A425) is a humanized IgG1-variant monoclonal antibody against T-cell immunoglobulin and mucin-domain containing-3 (TIM-3). Surzebiclimab binds to the extracellular domain of human Tim-3 with high affinity (KD=0.36 nM) and specificity. Surzebiclimab can be used in research of cancer .
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- HY-P991198
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Tim3
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Cancer
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M6903 is a humanized monoclonal IgG2 antibody targeting T cell immunoglobulin and mucin domain-3 (TIM-3) (KD for human TIM-3 is 2.3 nM). M6903 binds to TIM-3, blocking the binding of TIM-3 to phosphatidylserine (PtdSer), carcinoembryonic antigen cell adhesion-related molecule 1 (CEACAM1), and galectin 9 (Gal-9), thus relieving TIM-3-mediated T cell inhibition and exerting the activities of activating antigen-specific T cells and enhancing anti-tumor immunity. M6903 is promising for research of cancers .
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- HY-P990820
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Transmembrane Glycoprotein
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Inflammation/Immunology
Cancer
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Anti-Mouse TIM-4 Antibody (RMT4-53) is a rat-derived IgG2b κ type antibody inhibitor, targeting to mouse TIM-4. Anti-Mouse TIM-4 Antibody (RMT4-53) can block T cell immunoglobulin and mucin domain 4 (TIM-4). Anti-Mouse TIM-4 Antibody (RMT4-53) can inhibit the engulfment of apoptotic cells and T cell proliferation. Anti-Mouse TIM-4 Antibody (RMT4-53) can be used for the researches of cancer, immunology and metabolic disease, such as MC38 tumor and graft .
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- HY-P991649
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SAR566658 antibody
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Mucin
ADC Antibody
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Cancer
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Anti-CA6 Antibody (huDS6) is a Mucin 1-associated sialoglycotope (CA6) targeting humanized monoclonal antibody. Anti-CA6 Antibody (huDS6) can be used for synthesis of ADCs .
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- HY-P990153
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Transmembrane Glycoprotein
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Inflammation/Immunology
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Anti-Mouse TIM-2 Antibody (RMT2-29) is a rat-derived Ig2a λ type antibody inhibitor, targeting to mouse TIM-2. Anti-Mouse TIM-2 Antibody (RMT2-29) reacts with mouse T cell immunoglobulin and mucin domain 2 (TIM-2) and blocks TIM-2 signaling. Anti-Mouse TIM-2 Antibody (RMT2-29) can be used for the research of immunology.
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- HY-P990152
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Transmembrane Glycoprotein
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Metabolic Disease
Inflammation/Immunology
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Anti-Mouse TIM-4 Antibody (RMT4-54) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse TIM-4. Anti-Mouse TIM-4 Antibody (RMT4-54) reacts with mouse T cell immunoglobulin and mucin domain 4 (TIM-4) and blocks TIM-4 signaling. Anti-Mouse TIM-4 Antibody (RMT4-54) inhibits phagocytosis of apoptotic cells. Anti-Mouse TIM-4 Antibody (RMT4-54) can be used for the researches of immunology and metabolic disease .
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- HY-P990822
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Transmembrane Glycoprotein
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Cardiovascular Disease
Inflammation/Immunology
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Anti-Mouse TIM-1/CD365 Antibody (3D10) is a rat-derived IgG1 κ type antibody inhibitor, targeting to mouse TIM-1/CD365. Anti-Mouse TIM-1/CD365 Antibody (3D10) can block mouse T cell immunoglobulin and mucin domain 1 (TIM-1) also known as CD365. Anti-Mouse TIM-1/CD365 Antibody (3D10) can be used for the researches of inflammation, immunology and cardiovascular disease, such as graft-versus-host disease (GVHD), airway inflammation and atherosclerosis .
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| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
| Cat. No. |
Product Name |
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Classification |
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- HY-160060
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Aptamers
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MA3 aptamer sodium is an 86-base long DNA aptamer targeting the mucin MUC1. MA3 aptamer sodium binds to the peptide epitope of mucin 1 (MUC1) with a Kd of 38.3 nM and has minimal cross-reactivity with albumin .
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- HY-160062
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Aptamers
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S2.2 aptamer sodium is a nucleic acid aptamer targeting the mucin MUC1 and can be used for targeted imaging of MCF-7 cancer cells. S2.2 aptamer sodium was labeled with Cy5, and when fluorescent silicon nanodots (SiND) were present, the fluorescence was quenched; when MUC1 was also present, the fluorescence was restored. S2.2 aptamer sodium detects MUC1 with a linear range of 3.33-250 nM .
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