Search Result
Results for "
microbial inhibitor
" in MedChemExpress (MCE) Product Catalog:
4
Biochemical Assay Reagents
5
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-121291
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HIV
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Infection
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Aureothin, is a natural polyketide, is a HIV inhibitor with an IC50 of 5.3 nM. Aureothin is a microbial biolarvicide .
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- HY-126869
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Bacterial
Parasite
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Infection
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Pseudomonic acid D is a microbial inhibitor. Pseudomonic acid D potently inhibits mycoplasmas and bacterial pathogens. Pseudomonic acid D can be produced by fermentation with Pseudomonas fluorescens .
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- HY-N14938
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-
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- HY-N14914
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- HY-N14927
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- HY-N14928
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- HY-N14940
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- HY-N14929
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- HY-149450
-
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Fungal
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Infection
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Aflastatin A, a microbial metabolite, is an aflatoxin production inhibitor. Aflastatin A inhibits production of both aflatoxin B and G groups .
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-
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- HY-149851
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-
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- HY-16913
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-
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- HY-N14915
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Integrin
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Cancer
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Adxanthromycin A, a microbial metabolite, is a ICAM-1/LFA-1 mediated cell adhesion inhibitor .
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-
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- HY-N14907
-
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Glycosidase
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Infection
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Panosialin wA can inhibit α,β-glucosidase and mannose glycosidase. Panosialin wA does not inhibit the influenza virus, but it has weak anti-microbial effect .
|
-
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- HY-N14904
-
|
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Glycosidase
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Infection
|
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Panosialin D can inhibit α,β-glucosidase and mannose glycosidase. Panosialin D does not inhibit the influenza virus, but it has weak anti-microbial effect .
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-
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- HY-N14363
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-
-
- HY-N1322
-
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Bacterial
β-glucuronidase
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Others
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Sanggenol A acts as a dual inhibitor of nitrofuranone reduction mediated by the intestinal microbial nitrification reductases EcNfsA and EcNfsB. In addition, Sanggenol A is also an effective inhibitor of intestinal bacterial β-glucuronidase .
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-
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- HY-N0793A
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-
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- HY-N0793
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-
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- HY-N13886
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Endogenous Metabolite
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Cancer
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Anicequol, a microbial secondary metabolites, is an anchorage-independent growth of tumor cells inhibitor. Anicequol inhibits the anchorage-independent growth of human colon cancer DLD-1 cells with the IC50 of 1.2 μM .
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-
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- HY-N12260
-
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HIV
Bacterial
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Infection
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Benanomicin A is a microbial metabolite and can be isolated from Actinomycetes.Benanomicin has antifungal activitya and inhibits HIV-1 viral infection in MT-4 cells .
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-
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- HY-100599
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-
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- HY-N7107A
-
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1,3,3-Trimethyl-2-norbornanol
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Bacterial
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Infection
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(+)-Fenchyl alcohol is a monoterpene alcohol in the essential oils isolated from Douglas fir needles, acts as a fragrance. (+)-Fenchyl alcohol strongly inhibits the rumen microbial activity of both sheep and deer .
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-
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- HY-N16439
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Phoenicine
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HMG-CoA Reductase (HMGCR)
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Others
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Phenicin (Phoenicine), a microbial metabolite, is an irreversible HMG-CoA reductase (HMGCR) inhibitor. Phenicin can be isolated from cultures of Penicillium phoeniceum and Penicillium rubrum. Phenicin specifically inhibits the conversion of HMG-CoA to mevalonate catalyzed by HMGCR, effectively inhibiting cholesterol synthesis .
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- HY-P6442
-
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Biochemical Assay Reagents
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Inflammation/Immunology
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Chemerin15 is a chemerin peptide that enhances macrophage (MPhi) phagocytosis of microbial particles and apoptotic cells. Chemerin15 inhibits MΦ activation and suppress peritonitis induced by the yeast cell wall component zymosan .
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- HY-148968
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Carbathion
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Fungal
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Infection
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Metham sodium (Carbathion) is a broad-spectrum soil microbial suppressant. Metham sodium controls soil-borne pests and weeds. Metham sodium inhibits weed seeds, plant-parasitic nematodes, plant pathogenic fungi and soil insects .
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- HY-N8102
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Transmembrane Glycoprotein
Others
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Cardiovascular Disease
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Echinocystic acid 28-O-β-D-glucoside is a metabolite of Echinocystic acid by microbial oxidation and glucosidation. Echinocystic acid 28-O-β-D-glucoside is a tissue factor pathway inhibitor, with an IC50 of 10.61 nM .
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- HY-A0251
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Cefpodoxime acid; R 3763
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Antibiotic
Bacterial
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Infection
Cancer
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Cefpodoxime (Cefpodoxime acid) is a potent antibiotic active against gram-positive and gram-negative bacteria. Cefpodoxime inhibits the majority of cells in microbial populations. Cefpodoxime can be used for acute otitis media, sinusitis and tosillopharyngitis research .
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- HY-P5020
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Bacterial
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Infection
Cancer
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Crotalicidin is an antimicrobial peptide and anti-tumor peptide that can effectively inhibit the activity of Gram-negative bacteria and tumor cells. Crotalicidin can be obtained from rattlesnake venom. Crotalicidin can be used in the study of microbial infections and cancer .
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- HY-W141788
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Bacterial
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Infection
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N-Butyryl-DL-homocysteine thiolactone is an N-acyl homoserine lactone (AHL) analogue. AHLs are potent inhibitors of biofilm formation and virulence factors, and has been used for degrading microbial communities, reducing bacterial pathogenicity .
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- HY-138247
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EX-A4764; UUN51204
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Beta-lactamase
Bacterial
Antibiotic
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Infection
|
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β-Lactamase-IN-2 is a beta-lactamase inhibitor, extracted from patent WO 2019075084 A1, compound 1. β-Lactamase-IN-2 has anti-microbial and anti-bacterial effects .
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- HY-163111
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Bacterial
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Infection
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Antibacterial agent 170 (compound 6b) is a potent antibacterial agent which inhibits the formation of P. aeruginosa PAO1 biofilm. Antibacterial agent 170 exhibits quorum sensing inhibitor effect by the las system. Antibacterial agent 170 can used in study microbial resistance .
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- HY-125568
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MMP
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Others
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Pyridoxatin is a free radical scavenger of microbial origin. Pyridoxatin is isolated from a fungus culture identified as Acremonium sp. BX86. Pyridoxatin inhibits lipid peroxidation induced by free radicals in rat liver microsomes free from vitamin E .
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- HY-N2021
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-
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- HY-N0793R
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- HY-10234S
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AZD0530-d3
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Src
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Infection
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Saracatinib-d3 (AZD0530-d3) (ZG5129) is the deuterium-labeled analog of Saracatinib (HY-10234). Saracatinib-d3 is an inhibitor of the Src kinase, which can inhibit severe sepsis caused by bacterial or various microbial infections .
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- HY-N2021A
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- HY-B2171A
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Carminomycin hydrochloride; Carminomicin I hydrochloride
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Apoptosis
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Infection
Cancer
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Carubicin hydrochloride is a microbially-derived compound. Carubicin hydrochloride is an effective inhibitor of VHL-defective (VHL−/−) CCRCC cell proliferation. Carubicin hydrochloride also induces apoptosis by a mechanism independent of p53 or hypoxia-inducible factor HIF2. Carubicin hydrochloride has the potential for the research of cancer diseases .
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- HY-N7107R
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Fungal
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Infection
Metabolic Disease
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Fenchyl alcohol is a monoterpene alcohol that can be used as a fragrance. Fenchyl alcohol has antifungal activity and can inhibit the formation of biofilms and hyphae of Candida albicans. Fenchyl alcohol also has a strong inhibitory effect on the rumen microbial activity of sheep and deer .
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- HY-N7107
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Fungal
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Infection
Metabolic Disease
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Fenchyl alcohol is a monoterpene alcohol that can be used as a fragrance. Fenchyl alcohol has antifungal activity and can inhibit the formation of biofilms and hyphae of Candida albicans. Fenchyl alcohol also has a strong inhibitory effect on the rumen microbial activity of sheep and deer .
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- HY-W329071
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Bacterial
Fungal
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Infection
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Rose Bengal is a photosensitizer that acts on microbial cells. Rose Bengal inhibits yeast cells and other microorganisms growth and even causing death in the presence of light and oxygen. Rose Bengal can be used to inhibit bacterial growth, limit the colony size of filamentous fungi, and suppress the growth of "spreading fungi" like Rhizopus and Trichoderma .
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- HY-159080
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Parasite
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Infection
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HgCht2-IN-1 (compound 1516b) is a HgCht2 inhibitor that successfully inhibits the antagonism of cyst nematodes against nitrogen-fixing rhizobia and phosphate-absorbing arbuscular mycorrhizal symbionts. HgCht2-IN-1 can be used in the study of cyst nematode antagonism against microbial symbionts .
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- HY-P2124
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Antibiotic
Bacterial
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Infection
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Cyclo(L-Trp-L-Trp) is an antibiotic, and shows antimicrobial activity. Cyclo(L-Trp-L-Trp) can inhibit A. baumannii, as well as Candida albicans, Bacillus subtilis, Micrococcus luteus, Saccharomyces cerevisiae, Aspergillus niger, Staphylococcus aureus. Cyclo(L-Trp-L-Trp) can be used in microbial infection research .
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- HY-B2171
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Carminomycin; Carminomicin I
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Apoptosis
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Infection
Cancer
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Carubicin (Carminomycin) is a microbially-derived compound. Carubicin is an effective inhibitor of VHL-defective (VHL−/−) CCRCC cell proliferation. Carubicin also induces apoptosis by a mechanism independent of p53 or hypoxia-inducible factor HIF2. Carubicin has the potential for the research of cancer diseases .
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- HY-N15359
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Bacterial
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Infection
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Germicidin C is a microbial metabolite with antibacterial activity, which is found in the marine sponge-derived fungus Aspergillus niger. Germicidin C can inhibit the growth of various pathogenic bacteria such as Staphylococcus aureus, Escherichia coli, and Bacillus subtilis with MIC values ranging from 32 to 64 µg/mL .
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- HY-A0251R
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Cefpodoxime acid (Standard); R 3763 (Standard)
|
Reference Standards
Antibiotic
Bacterial
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Infection
|
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Cefpodoxime (Standard) is the analytical standard of Cefpodoxime. This product is intended for research and analytical applications. Cefpodoxime (Cefpodoxime acid) is a potent antibiotic active against gram-positive and gram-negative bacteria. Cefpodoxime inhibits the majority of cells in microbial populations. Cefpodoxime can be used for acute otitis media, sinusitis and tosillopharyngitis research .
|
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- HY-N0346A
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-
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- HY-125176
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G907
1 Publications Verification
|
Bacterial
|
Infection
|
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G907 is a selective antagonist of ATP-binding cassette (ABC) transporter MsbA with anti-microbial activity. G907 inhibits E. coli MsbA with an IC50 value of 18 nM. G907 traps MsbA in an inward-facing, lipopolysaccharide-bound conformation by wedging into an architecturally conserved transmembrane pocket .
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- HY-N6625
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Fungal
Estrogen Receptor/ERR
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Infection
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Chlorothalonil is a broad-spectrum foliar fungicide with oral activity. Chlorothalonil can be used to combat fungal diseases in vegetable and crop leaves. Chlorothalonil can alter the microbial community in the soil. Chlorothalonil inhibits spermatogenesis. Chlorothalonil can cause intestinal epithelial barrier dysfunction and fetal toxicity .
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- HY-115965
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Bacterial
Antibiotic
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Infection
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VP-4604 is a potent anti-methicillin-resistant Staphylococcus aureus (MRSA) agent. VP-4604 exhibits significant microbial growth inhibition toward Staphylococcus aureus (ATCC 43300) with MIC of 4-8 µg/mL. VP-4604 inhibits the growth of methicillin‐resistant Staphylococcus aureus with growth inhibition >95% .
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- HY-121636
-
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RvD2
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TRP Channel
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Infection
Neurological Disease
Inflammation/Immunology
|
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Resolvin D2 is a metabolite of docosahexaenoic acid (DHA), with anti-inflammatory, anti-infective activities. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Resolvin D2 is a remarkably potent inhibitor of TRPV1 (IC50 = 0.1 nM) and TRPA1 (IC50 = 2 nM) in primary sensory neurons .
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- HY-115964
-
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Bacterial
Antibiotic
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Infection
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VP-4556 is a potent anti-methicillin-resistant Staphylococcus aureus (MRSA) agent. VP-4556 exhibits significant microbial growth inhibition toward Staphylococcus aureus (ATCC 43300) with MIC of 8 µg/mL. VP-4556 inhibits the growth of methicillin‐resistant Staphylococcus aureus with growth inhibition >95% .
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- HY-Y0669S
-
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Isotope-Labeled Compounds
Endogenous Metabolite
Ferroptosis
YAP
Glutathione Peroxidase
|
Infection
|
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Pipecolic acid-d9 is the deuterium labeled Pipecolic acid. Pipecolic acid is a metabolite of lysine and an important precursor for many useful microbial secondary metabolites. Pipecolic acid slows ferroptosis in diabetic retinopathy by inhibiting the YAP-GPX4 signaling pathway. In addition, Pipecolic acid can be used as a diagnostic marker for pyridoxine-dependent epilepsy .
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- HY-W001940
-
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Amino Acid Derivatives
Bacterial
|
Infection
Cardiovascular Disease
|
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DL-m-Tyrosine is a non-protein amino acid. DL-m-Tyrosine inhibits microbial growth and spore formation. DL-m-Tyrosine also inhibits root growth in various plants, such as lettuce and Arabidopsis. DL-m-Tyrosine, when used in combination with Carbidopa (HY-B0311), has a potent antihypertensive effect. DL-m-Tyrosine can be used in research on biopesticide design .
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- HY-115959
-
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Bacterial
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Inflammation/Immunology
Cancer
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Anticancer agent 34 (compound 9), a sulfonylurea derivative, is a potent antimicrobial and anticancer agent. Anticancer agent 34 inhibits the microbial growth of B. mycoides, E. coli, and C. albicans with a MIC between 0.156 and 0.039 mg/ml. Anticancer agent 34 inhibits A549, PC3 cell growth with IC50s of 8.4 µg/ml, 7.8 µg/ml, respectively .
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- HY-115961
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Bacterial
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Inflammation/Immunology
Cancer
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Anticancer agent 36 (compound 11), a sulfonylurea derivative, is a potent antimicrobial and anticancer agent. Anticancer agent 36 inhibits the microbial growth of B. mycoides, E. coli, and C. albicans with a MIC between 0.156 and 0.039 mg/L. Anticancer agent 36 inhibits A549, PC3 cell growth with IC50s of 19.7 µg/mL, 11.9 µg/mL, respectively .
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- HY-N16445
-
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(-)-Strevertene A
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Endogenous Metabolite
Antibiotic
Fungal
|
Infection
|
|
Strevertene A ((-)-Strevertene A) (Compound 1), a pentaene macrolide, is a microbial secondary metabolite. Strevertene A is an antibiotic and has a potent antifungal activity. Strevertene A significantly inhibits the mycelial growth of phytopathogenic fungi (such as Alternaria mali, Aspergillus oryzae and Cylindrocarpon destructans) with IC50s of 4-16 μg/mL. Strevertenes A can strongly prevent Fusarium wilt development on tomato plants .
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- HY-P1116
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PBP10
1 Publications Verification
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Bacterial
|
Infection
Inflammation/Immunology
|
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PBP10 is a cell permeable and selective gelsolin-derived peptide inhibitor of formyl peptide receptor 2 (FPR2) over FPR1 . PBP10 is a 10-AA peptide with rhodamine conjugated at its N terminus, exerts bactericidal activity against gram-positive and gram-negative bacteria and limits microbial-induced inflammatory effects .
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- HY-Y0669R
-
-
- HY-P1116A
-
|
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Bacterial
|
Infection
Inflammation/Immunology
|
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PBP10 is a cell permeable and selective gelsolin-derived peptide inhibitor of formyl peptide receptor 2 (FPR2) over FPR1 . PBP10 is a 10-AA peptide with rhodamine conjugated at its N terminus, exerts bactericidal activity against gram-positive and gram-negative bacteria and limits microbial-induced inflammatory effects .
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- HY-N0108S
-
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Parietin-d3; Rheochrysidin-d3
|
Isotope-Labeled Compounds
Bacterial
|
Infection
Inflammation/Immunology
Cancer
|
|
Physcion-d3 (Parietin-d3) is the deuterium labeled Physcion (HY-N0108). Physcion acts as an inhibitor of 6-phosphogluconate dehydrogenase, with an IC50 and a Kd of 38.5 μM and 26.0 μM, respectively. Physcion exhibits laxative, hepatoprotective, anti-inflammatory, anti-microbial, anti-proliferative and anti-tumor effects .
|
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- HY-N7719
-
-
- HY-168705
-
|
|
Bacterial
|
Infection
|
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Anti-MRSA agent 20 (Compound a4) is an anti-microbial agent (MIC: < 0.03125 μg/mL) against MRSA). Anti-MRSA agent 20 binds to the ribosomal peptidyl transferase center and inhibits bacterial survival by inhibiting MRSA toxin synthesis and bacterial division. Anti-MRSA agent 20 significantly reduces the MRSA load in the lungs and attenuates lung injury in the MRSA-infected mice (ED50 = 6.48 mg/kg) .
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- HY-N12106
-
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Fumicycline
|
Endogenous Metabolite
Fungal
|
Infection
|
|
Neosartoricin (Fumicycline) (Compound 3), a prenylated anthracenone, is a microbial secondary metabolite. Neosartoricin can be isolated from Aspergillus fumigatus and Neosartorya fischeri. Neosartoricin has immunosuppressive activity, and significantly inhibits T-cell proliferative activity with an IC50 of 3 μM. Neosartoricin may be beneficial to fungal defense, facilitating infection through suppressing the host adaptive immunity without involvement of primary virulence .
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- HY-W014316
-
|
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Bacterial
Fungal
|
Infection
|
|
5-Bromo-5-nitro-1,3-dioxane, an antimicrobial compound, is effective against Gram-positive and Gram-negative bacteria and fungi, including yeast. 5-Bromo-5-nitro-1,3-dioxane inhibits enzyme activity and subsequent inhibition of microbial growth by the oxidation of essential protein thiol .
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- HY-N6625R
-
|
|
Reference Standards
Fungal
Estrogen Receptor/ERR
|
Infection
|
|
Chlorothalonil (Standard) is the analytical standard of Chlorothalonil. This product is intended for research and analytical applications. Chlorothalonil is a broad-spectrum foliar fungicide with oral activity. Chlorothalonil can be used to combat fungal diseases in vegetable and crop leaves. Chlorothalonil can alter the microbial community in the soil. Chlorothalonil inhibits spermatogenesis. Chlorothalonil can cause intestinal epithelial barrier dysfunction and fetal toxicity .
|
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- HY-14266A
-
|
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Apoptosis
Reverse Transcriptase
Autophagy
HIV
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Infection
|
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Dapivirine hydrochloride is a non-nucleoside reverse transcriptase inhibitor with antitumor activity. Dapivirine hydrochloride attenuates the proliferation of glioblastoma cells and induces apoptosis. Dapivirine hydrochloride modulates autophagy and activates Akt, Bad, and SAPK/JNK signaling pathways. Dapivirine hydrochloride has shown inhibitory effects on glioma cell growth both in vitro and in vivo. Dapivirine hydrochloride is also a promising drug candidate for topical microbial agents for the prevention of sexual transmission of HIV-1 .
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- HY-W001940S
-
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Isotope-Labeled Compounds
Amino Acid Derivatives
Bacterial
|
Infection
Cardiovascular Disease
|
|
DL-m-Tyrosine-d3 is the deuterium labeled DL-m-Tyrosine (HY-W001940). DL-m-Tyrosine is a non-protein amino acid. DL-m-Tyrosine inhibits microbial growth and spore formation. DL-m-Tyrosine also inhibits root growth in various plants, such as lettuce and Arabidopsis. DL-m-Tyrosine, when used in combination with Carbidopa (HY-B0311), has a potent antihypertensive effect. DL-m-Tyrosine can be used in research on biopesticide design.
|
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- HY-P5589
-
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PlnA
|
Bacterial
Reactive Oxygen Species (ROS)
|
Infection
Inflammation/Immunology
|
|
Plantaricin A is an antimicrobial peptide that can be derived from Lactobacillus plantarum. Plantaricin A has a synergistic effect with Ciprofloxacin. Plantaricin A shows anti-microbial activity. Plantaricin A increases the membrane potential of S. aureus and the level of intracellular ROS. Plantaricin A inhibits the function of the efflux pump by binding it and altering the structure of MepA, NorA, and LmrS. Plantaricin A significantly relieves inflammation, and promotes wound healing. Plantaricin A permeabilizes cancerous rat pituitary cells [1][2].
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- HY-N0108R
-
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Parietin (Standard); Rheochrysidin (Standard)
|
Reference Standards
Bacterial
|
Infection
Inflammation/Immunology
Cancer
|
|
Physcion (Standard) is the analytical standard of Physcion. This product is intended for research and analytical applications. Physcion (Parietin) is an anthraquinone isolated from traditional Chinese medicine Radix et Rhizoma Rhei, acts as an inhibitor of 6-phosphogluconate dehydrogenase, with an IC50 and a Kd of 38.5 μM and 26.0 μM, respectively . Physcion (Parietin) exhibits laxative, hepatoprotective, anti-inflammatory, anti-microbial, anti-proliferative and anti-tumor effects .
|
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- HY-121636S
-
|
RvD2-d5
|
TRP Channel
|
Infection
Neurological Disease
Inflammation/Immunology
|
|
Resolvin D2-d5 is the deuterium labeled Resolvin D2. Resolvin D2 is a metabolite of docosahexaenoic acid (DHA), with anti-inflammatory, anti-infective activities. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Resolvin D2 is a remarkably potent inhibitor of TRPV1 (IC50 = 0.1 nM) and TRPA1 (IC50 = 2 nM) in primary sensory neurons .
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- HY-115965R
-
|
|
Reference Standards
Bacterial
Antibiotic
|
Infection
|
|
VP-4604 (Standard) is the analytical standard of VP-4604. This product is intended for research and analytical applications. VP-4604 is a potent anti-methicillin-resistant Staphylococcus aureus (MRSA) agent. VP-4604 exhibits significant microbial growth inhibition toward Staphylococcus aureus (ATCC 43300) with MIC of 4-8 μg/mL. VP-4604 inhibits the growth of methicillin‐resistant Staphylococcus aureus with growth inhibition >95%[1].
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- HY-N0346AR
-
-
- HY-N7719R
-
|
|
Endogenous Metabolite
Reference Standards
Bacterial
Fungal
Parasite
Apoptosis
Reactive Oxygen Species (ROS)
Caspase
HSV
|
Infection
Inflammation/Immunology
Cancer
|
|
Oosporein (Standard) is the analytical standard of Oosporein (HY-N7719). This product is intended for research and analytical applications. Oosporein is a microbial metabolite and a red crystalline toxin produced by various fungi. Oosporein can promote the reproduction of fungi in host bodies by inhibiting insect immunity, and possesses multiple activities such as antibacterial, antiviral (HSV), and insecticidal effects. Oosporein can inhibit plant growth. In addition, Oosporein can also induce apoptosis, cell membrane damage, oxidative stress, and mitochondrial damage. Oosporein has certain antitumor activity .
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- HY-N7059
-
|
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Bacterial
Reactive Oxygen Species (ROS)
|
Infection
|
|
Lactobionic acid is a bionic acid that can be naturally found in the Caspian Sea yogurt and chemically constituted of a gluconic acid bonded to a galactose. Lactobionic acid has antioxidant, antimicrobial, chelating, stabilizer, acidulant, and moisturizing properties. Lactobionic acid can be obtained by electrolytic methods, microbial fermentation or biocatalytic approaches. Lactobionic acid can be used in foodstuffs, to produce new functional products and against food-borne pathogens. Lactobionic acid inhibits DNA repair and protein synthesis, induction of oxidative stress and inhibition of metabolic pathways against MRSA .
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- HY-P3161
-
|
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HSV
|
Infection
Inflammation/Immunology
Cancer
|
|
Lactoferrin from Bovine milk is a substance released by neutrophils. Lactoferrin from Bovine milk is an orally active multifunctional iron binding glycoprotein. Lactoferrin from Bovine milk prevents cell adhesion, growth and spreading of cell colonies. Lactoferrin from Bovine milk also has antiviral activity and inhibits microbial and viral adhesion and entry into host cells. Besides, Lactoferrin from Bovine milk has anti-inflammatory, immunomodulatory, and anti-cancer activities .
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- HY-N1377
-
-
- HY-162672
-
|
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Bacterial
|
Infection
|
|
Antibacterial agent 231 (derivative 8) is an antimicrobial agent against multidrug-resistant Helicobacter pylori (H. pylori) with a minimum inhibitory concentration of 0.25–0.5 μg/mL. Antibacterial agent 231 directly targets the protein transposase subunit SecA and the outer membrane protein assembly factor BamD to inhibit the trafficking and assembly of bacterial outer membrane proteins (OMPs). Antibacterial agent 231 can be used to study the effects of antibiotic treatment on intestinal microbial balance .
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- HY-134809A
-
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CADA hydrochloride
|
HIV
|
Infection
|
|
Cyclotriazadisulfonamide (CADA) hydrochloride is a specific CD4-targeted HIV entry inhibitor with activity against HIV-1 replication. Cyclotriazadisulfonamide hydrochloride can specifically downregulate the expression of CD4 receptors on the cell surface, effectively inhibiting HIV transmission. Cyclotriazadisulfonamide hydrochloride can inhibit HIV-1(NL4.3) and SIV(mac251), and has a synergistic effect when used in combination with cellulose acetate (CAP). Cyclotriazadisulfonamide hydrochloride can also be used as a microbial gel formulation to maintain CD4 downregulation and antiviral activity, and is a broad-spectrum anti-HIV agent.
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- HY-W016473
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Bacterial
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Infection
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Adamantane-carboxylic acid is a compound with inhibitory activity against microorganisms. Although its specific target has not been clearly defined, it can inhibit Gram-positive bacteria and some Gram-negative bacteria. It forms a 1-monoacylglycerol derivative through a direct reaction with glycidol, and exerts its antibacterial effect by mechanisms such as altering the permeability of the bacterial cell membrane. This compound can be used in the research of antibacterial agents in the food and cosmetic industries to reduce harmful microbial flora and extend the shelf life of products .
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- HY-122980
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(S)-Myxochelin A
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Lipoxygenase
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Infection
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Myxochelin A is a microbial metabolite that has been found in A. disciformis and has diverse biological activities. It is active against Gram-positive bacteria, including B. cereus, S. aureus, and M. luteus, but not Gram-negative bacteria or fungi in an agar diffusion assay when used at a concentration of 80 μg/disc. Myxochelin A inhibits 5-lipoxygenase (5-LO) activity with an IC50 value of 1.9 μM for the recombinant human enzyme. It is cytotoxic to 26-L5 colon cancer cells when used at a concentration of 3 μg/mL.
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- HY-N7059A
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Biochemical Assay Reagents
Bacterial
Reactive Oxygen Species (ROS)
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Infection
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Lactobionic acid calcium dihydrate is a biomimetic acid found in Caspian yogurt, chemically composed of gluconic acid bonded to galactose. Lactobionic acid calcium dihydrate has antioxidant, antimicrobial, chelating, stabilizer, acidulant and humectant properties. Lactobionic acid calcium dihydrate can be obtained by electrolytic methods, microbial fermentation or biocatalytic approaches. Lactobionic acid calcium dihydrate can be used in foodstuffs, to produce new functional products and against food-borne pathogens. Lactobionic acid calcium dihydrate inhibits DNA repair and protein synthesis, induction of oxidative stress and inhibition of metabolic pathways against MRSA .
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- HY-N7059R
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Reference Standards
Bacterial
Reactive Oxygen Species (ROS)
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Infection
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Lactobionic acid (Standard) is an analytical standard for lactobionic acid. This product is intended for use in research and analytical applications. Lactobionic acid is a bionic acid that can be naturally found in the Caspian Sea yogurt and chemically constituted of a gluconic acid bonded to a galactose. Lactobionic acid has antioxidant, antimicrobial, chelating, stabilizer, acidulant, and moisturizing properties. Lactobionic acid can be obtained by electrolytic methods, microbial fermentation or biocatalytic approaches. Lactobionic acid can be used in foodstuffs, to produce new functional products and against food-borne pathogens. Lactobionic acid inhibits DNA repair and protein synthesis, induction of oxidative stress and inhibition of metabolic pathways against MRSA .
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- HY-N1377R
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Lysionotin (Standard)
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Carboxylesterase (CES)
Reference Standards
DNA/RNA Synthesis
Apoptosis
Bacterial
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Infection
Metabolic Disease
Inflammation/Immunology
Endocrinology
Cancer
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Nevadensin (Standard) (Lysionotin (Standard)) is the analytical standard of Nevadensin (HY-N1377). This product is intended for research and analytical applications. Nevadensin, a natural flavonoid, is a selective human carboxylesterase 1 (hCE1) inhibitor with an IC50 of 2.64 μM. Nevadensin is more selective for hCE1 than hCE2 (IC50 of 132.8 μM). Nevadensin can induce apoptosis and DNA damage in cancer cells. Nevadensin has a variety of pharmacological effects such as anti-inflammatory, anti-tumour, anti-hypertensive, anti-tubercular, antitussive, antioxidant and anti-microbial activities.
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- HY-Y0079
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Endogenous Metabolite
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Infection
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D-Phenylalanine is an atypical D-amino acid and an inhibitor of bacterial biofilm formation. D-Phenylalanine mainly replaces D-alanine (D-Ala) by incorporating into the fourth and fifth positions of bacterial peptidoglycan (PG), changing the cell wall structure, enhancing bacterial acid resistance and affecting biofilm formation. D-Phenylalanine may promote the secretion of peptide tyrosine tyrosine (PYY) in mammals by activating the intestinal GPR109B receptor. D-Phenylalanine can inhibit the maturation of microbial biofilms and promote the release of specific hormones. It can be used for antibacterial preservation, improving the yield of probiotics in the food industry, and studying appetite regulation and blood sugar control in metabolic diseases such as diabetes .
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- HY-W014316R
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Reference Standards
Bacterial
Fungal
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Infection
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5-Bromo-5-nitro-1,3-dioxane (Standard) is the analytical standard of 5-Bromo-5-nitro-1,3-dioxane. This product is intended for research and analytical applications. 5-Bromo-5-nitro-1,3-dioxane, an antimicrobial compound, is effective against Gram-positive and Gram-negative bacteria and fungi, including yeast. 5-Bromo-5-nitro-1,3-dioxane inhibits enzyme activity and subsequent inhibition of microbial growth by the oxidation of essential protein thiol .
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- HY-N1916
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Glutathione S-transferase
P-glycoprotein
Apoptosis
iGluR
CaMK
p38 MAPK
Reactive Oxygen Species (ROS)
Bacterial
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Infection
Cardiovascular Disease
Neurological Disease
Inflammation/Immunology
Cancer
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|
Coniferyl ferulate is an orally active phenolic acid compound. Coniferyl ferulate is a potent inhibitor of glutathione S-transferase (GST) (IC50 = 0.3 μM), which downregulates P-gp expression, induces apoptosis in B-MD-C1 (ADR+/+) cells, and reverses multidrug resistance. Coniferyl ferulate blocks the NMDAR/NR2B-CaMKII-MAPKs signaling pathway, inhibits ROS production and mitochondrial apoptosis, while reshapes the intestinal microbiota and microbial metabolism, ameliorates colonic inflammation and alleviates depressive symptoms in mice. Coniferyl ferulate can alleviate the toxicity of xylene to hematopoietic stem and progenitor cells by targeting Mgst2. Coniferyl ferulate exhibits antibacterial activity against the Gram-positive Bacillus subtilis and Staphylococcus aureus .
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HY-L084
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893 compounds
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Nature has been a source of medicinal products for millennia, with many useful active substances developed from plant sources. In the 20th century, the discovery of the penicillin was the starting point for drug discovery from microbial sources. Microorganisms， which have been considered to be a rich source of unique bioactive compounds, play an important role in the development of the chemistry of natural products and medical therapy. Microbial metabolites have proved to be affective antimicrobial agents, anti-tumor agents, enzyme inhibitors, anti-inflammatory agents, etc. Today, many microbial-originated antibiotics are available in the mark, and a large number of bioactive metabolites are used in medicine.
MCE provides a unique collection of 893 microbial metabolites, which is an important source of lead compounds and can be used for drug discovery.
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| Cat. No. |
Product Name |
Type |
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- HY-Y0669R
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Cell Assay Reagents
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Pipecolic acid (Standard) is the analytical standard of Pipecolic acid. This product is intended for research and analytical applications. Pipecolic acid is a metabolite of lysine and an important precursor for many useful microbial secondary metabolites. Pipecolic acid slows ferroptosis in diabetic retinopathy by inhibiting the YAP-GPX4 signaling pathway. In addition, Pipecolic acid can be used as a diagnostic marker for pyridoxine-dependent epilepsy .
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- HY-P3161
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Native Proteins
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Lactoferrin from Bovine milk is a substance released by neutrophils. Lactoferrin from Bovine milk is an orally active multifunctional iron binding glycoprotein. Lactoferrin from Bovine milk prevents cell adhesion, growth and spreading of cell colonies. Lactoferrin from Bovine milk also has antiviral activity and inhibits microbial and viral adhesion and entry into host cells. Besides, Lactoferrin from Bovine milk has anti-inflammatory, immunomodulatory, and anti-cancer activities .
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- HY-W016473
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Biochemical Assay Reagents
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Adamantane-carboxylic acid is a compound with inhibitory activity against microorganisms. Although its specific target has not been clearly defined, it can inhibit Gram-positive bacteria and some Gram-negative bacteria. It forms a 1-monoacylglycerol derivative through a direct reaction with glycidol, and exerts its antibacterial effect by mechanisms such as altering the permeability of the bacterial cell membrane. This compound can be used in the research of antibacterial agents in the food and cosmetic industries to reduce harmful microbial flora and extend the shelf life of products .
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- HY-N7059A
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Cell Assay Reagents
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Lactobionic acid calcium dihydrate is a biomimetic acid found in Caspian yogurt, chemically composed of gluconic acid bonded to galactose. Lactobionic acid calcium dihydrate has antioxidant, antimicrobial, chelating, stabilizer, acidulant and humectant properties. Lactobionic acid calcium dihydrate can be obtained by electrolytic methods, microbial fermentation or biocatalytic approaches. Lactobionic acid calcium dihydrate can be used in foodstuffs, to produce new functional products and against food-borne pathogens. Lactobionic acid calcium dihydrate inhibits DNA repair and protein synthesis, induction of oxidative stress and inhibition of metabolic pathways against MRSA .
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| Cat. No. |
Product Name |
Target |
Research Area |
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- HY-P2124
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Antibiotic
Bacterial
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Infection
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Cyclo(L-Trp-L-Trp) is an antibiotic, and shows antimicrobial activity. Cyclo(L-Trp-L-Trp) can inhibit A. baumannii, as well as Candida albicans, Bacillus subtilis, Micrococcus luteus, Saccharomyces cerevisiae, Aspergillus niger, Staphylococcus aureus. Cyclo(L-Trp-L-Trp) can be used in microbial infection research .
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- HY-P1116
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PBP10
1 Publications Verification
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Bacterial
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Infection
Inflammation/Immunology
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PBP10 is a cell permeable and selective gelsolin-derived peptide inhibitor of formyl peptide receptor 2 (FPR2) over FPR1 . PBP10 is a 10-AA peptide with rhodamine conjugated at its N terminus, exerts bactericidal activity against gram-positive and gram-negative bacteria and limits microbial-induced inflammatory effects .
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- HY-P1116A
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Bacterial
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Infection
Inflammation/Immunology
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PBP10 is a cell permeable and selective gelsolin-derived peptide inhibitor of formyl peptide receptor 2 (FPR2) over FPR1 . PBP10 is a 10-AA peptide with rhodamine conjugated at its N terminus, exerts bactericidal activity against gram-positive and gram-negative bacteria and limits microbial-induced inflammatory effects .
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- HY-P5589
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PlnA
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Bacterial
Reactive Oxygen Species (ROS)
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Infection
Inflammation/Immunology
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Plantaricin A is an antimicrobial peptide that can be derived from Lactobacillus plantarum. Plantaricin A has a synergistic effect with Ciprofloxacin. Plantaricin A shows anti-microbial activity. Plantaricin A increases the membrane potential of S. aureus and the level of intracellular ROS. Plantaricin A inhibits the function of the efflux pump by binding it and altering the structure of MepA, NorA, and LmrS. Plantaricin A significantly relieves inflammation, and promotes wound healing. Plantaricin A permeabilizes cancerous rat pituitary cells [1][2].
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- HY-P6442
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Biochemical Assay Reagents
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Inflammation/Immunology
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Chemerin15 is a chemerin peptide that enhances macrophage (MPhi) phagocytosis of microbial particles and apoptotic cells. Chemerin15 inhibits MΦ activation and suppress peritonitis induced by the yeast cell wall component zymosan .
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- HY-P5020
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Bacterial
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Infection
Cancer
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Crotalicidin is an antimicrobial peptide and anti-tumor peptide that can effectively inhibit the activity of Gram-negative bacteria and tumor cells. Crotalicidin can be obtained from rattlesnake venom. Crotalicidin can be used in the study of microbial infections and cancer .
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- HY-W141788
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Bacterial
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Infection
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N-Butyryl-DL-homocysteine thiolactone is an N-acyl homoserine lactone (AHL) analogue. AHLs are potent inhibitors of biofilm formation and virulence factors, and has been used for degrading microbial communities, reducing bacterial pathogenicity .
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| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
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- HY-126869
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-
-
- HY-N14938
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-
-
- HY-N14914
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-
-
- HY-N14927
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-
-
- HY-N14928
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-
-
- HY-N14940
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-
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- HY-N14929
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-
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- HY-149450
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-
-
- HY-16913
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-
-
- HY-N14915
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-
-
- HY-N14907
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-
-
- HY-N14904
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-
-
- HY-N14363
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-
-
- HY-N1322
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-
-
- HY-N0793A
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-
-
- HY-N0793
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-
-
- HY-N13886
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-
-
- HY-N12260
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-
-
- HY-100599
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-
-
- HY-N16439
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Phoenicine
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Natural Products
Microorganisms
Source classification
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HMG-CoA Reductase (HMGCR)
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Phenicin (Phoenicine), a microbial metabolite, is an irreversible HMG-CoA reductase (HMGCR) inhibitor. Phenicin can be isolated from cultures of Penicillium phoeniceum and Penicillium rubrum. Phenicin specifically inhibits the conversion of HMG-CoA to mevalonate catalyzed by HMGCR, effectively inhibiting cholesterol synthesis .
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-
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- HY-N8102
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-
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- HY-125568
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-
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- HY-N2021
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-
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- HY-N0793R
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-
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- HY-N2021A
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-
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- HY-B2171A
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-
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- HY-N7107R
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-
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- HY-N7107
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-
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- HY-B2171
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-
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- HY-N15359
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Natural Products
Microorganisms
Source classification
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Bacterial
|
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Germicidin C is a microbial metabolite with antibacterial activity, which is found in the marine sponge-derived fungus Aspergillus niger. Germicidin C can inhibit the growth of various pathogenic bacteria such as Staphylococcus aureus, Escherichia coli, and Bacillus subtilis with MIC values ranging from 32 to 64 µg/mL .
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-
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- HY-N0346A
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-
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- HY-W001940
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-
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- HY-N16445
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(-)-Strevertene A
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Natural Products
Microorganisms
Source classification
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Endogenous Metabolite
Antibiotic
Fungal
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Strevertene A ((-)-Strevertene A) (Compound 1), a pentaene macrolide, is a microbial secondary metabolite. Strevertene A is an antibiotic and has a potent antifungal activity. Strevertene A significantly inhibits the mycelial growth of phytopathogenic fungi (such as Alternaria mali, Aspergillus oryzae and Cylindrocarpon destructans) with IC50s of 4-16 μg/mL. Strevertenes A can strongly prevent Fusarium wilt development on tomato plants .
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-
-
- HY-N7719
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-
-
- HY-N12106
-
|
Fumicycline
|
Microorganisms
Source classification
Phenols
Polyphenols
|
Endogenous Metabolite
Fungal
|
|
Neosartoricin (Fumicycline) (Compound 3), a prenylated anthracenone, is a microbial secondary metabolite. Neosartoricin can be isolated from Aspergillus fumigatus and Neosartorya fischeri. Neosartoricin has immunosuppressive activity, and significantly inhibits T-cell proliferative activity with an IC50 of 3 μM. Neosartoricin may be beneficial to fungal defense, facilitating infection through suppressing the host adaptive immunity without involvement of primary virulence .
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-
-
- HY-N0108R
-
|
Parietin (Standard); Rheochrysidin (Standard)
|
Quinones
Anthraquinones
Polygonaceae
Source classification
Rheum officinale Baill.
Phenols
Polyphenols
Plants
|
Reference Standards
Bacterial
|
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Physcion (Standard) is the analytical standard of Physcion. This product is intended for research and analytical applications. Physcion (Parietin) is an anthraquinone isolated from traditional Chinese medicine Radix et Rhizoma Rhei, acts as an inhibitor of 6-phosphogluconate dehydrogenase, with an IC50 and a Kd of 38.5 μM and 26.0 μM, respectively . Physcion (Parietin) exhibits laxative, hepatoprotective, anti-inflammatory, anti-microbial, anti-proliferative and anti-tumor effects .
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-
-
- HY-N0346AR
-
-
-
- HY-N7719R
-
-
-
- HY-N7059
-
|
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Infection
Microorganisms
Classification of Application Fields
Source classification
Disease Research Fields
Saccharides
|
Bacterial
Reactive Oxygen Species (ROS)
|
|
Lactobionic acid is a bionic acid that can be naturally found in the Caspian Sea yogurt and chemically constituted of a gluconic acid bonded to a galactose. Lactobionic acid has antioxidant, antimicrobial, chelating, stabilizer, acidulant, and moisturizing properties. Lactobionic acid can be obtained by electrolytic methods, microbial fermentation or biocatalytic approaches. Lactobionic acid can be used in foodstuffs, to produce new functional products and against food-borne pathogens. Lactobionic acid inhibits DNA repair and protein synthesis, induction of oxidative stress and inhibition of metabolic pathways against MRSA .
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-
-
- HY-N1377
-
-
-
- HY-N7059R
-
|
|
Microorganisms
Source classification
Saccharides
|
Reference Standards
Bacterial
Reactive Oxygen Species (ROS)
|
|
Lactobionic acid (Standard) is an analytical standard for lactobionic acid. This product is intended for use in research and analytical applications. Lactobionic acid is a bionic acid that can be naturally found in the Caspian Sea yogurt and chemically constituted of a gluconic acid bonded to a galactose. Lactobionic acid has antioxidant, antimicrobial, chelating, stabilizer, acidulant, and moisturizing properties. Lactobionic acid can be obtained by electrolytic methods, microbial fermentation or biocatalytic approaches. Lactobionic acid can be used in foodstuffs, to produce new functional products and against food-borne pathogens. Lactobionic acid inhibits DNA repair and protein synthesis, induction of oxidative stress and inhibition of metabolic pathways against MRSA .
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-
-
- HY-N1377R
-
|
Lysionotin (Standard)
|
Flavonoids
other families
Flavones
Source classification
Phenols
Polyphenols
Plants
|
Carboxylesterase (CES)
Reference Standards
DNA/RNA Synthesis
Apoptosis
Bacterial
|
|
Nevadensin (Standard) (Lysionotin (Standard)) is the analytical standard of Nevadensin (HY-N1377). This product is intended for research and analytical applications. Nevadensin, a natural flavonoid, is a selective human carboxylesterase 1 (hCE1) inhibitor with an IC50 of 2.64 μM. Nevadensin is more selective for hCE1 than hCE2 (IC50 of 132.8 μM). Nevadensin can induce apoptosis and DNA damage in cancer cells. Nevadensin has a variety of pharmacological effects such as anti-inflammatory, anti-tumour, anti-hypertensive, anti-tubercular, antitussive, antioxidant and anti-microbial activities.
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-
-
- HY-Y0079
-
|
|
Microorganisms
Classification of Application Fields
Ketones, Aldehydes, Acids
Source classification
Other Diseases
Endogenous metabolite
Disease Research Fields
|
Endogenous Metabolite
|
|
D-Phenylalanine is an atypical D-amino acid and an inhibitor of bacterial biofilm formation. D-Phenylalanine mainly replaces D-alanine (D-Ala) by incorporating into the fourth and fifth positions of bacterial peptidoglycan (PG), changing the cell wall structure, enhancing bacterial acid resistance and affecting biofilm formation. D-Phenylalanine may promote the secretion of peptide tyrosine tyrosine (PYY) in mammals by activating the intestinal GPR109B receptor. D-Phenylalanine can inhibit the maturation of microbial biofilms and promote the release of specific hormones. It can be used for antibacterial preservation, improving the yield of probiotics in the food industry, and studying appetite regulation and blood sugar control in metabolic diseases such as diabetes .
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-
-
- HY-N1916
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-
| Cat. No. |
Product Name |
Chemical Structure |
-
- HY-Y0669S
-
|
|
|
Pipecolic acid-d9 is the deuterium labeled Pipecolic acid. Pipecolic acid is a metabolite of lysine and an important precursor for many useful microbial secondary metabolites. Pipecolic acid slows ferroptosis in diabetic retinopathy by inhibiting the YAP-GPX4 signaling pathway. In addition, Pipecolic acid can be used as a diagnostic marker for pyridoxine-dependent epilepsy .
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-
-
- HY-N0108S
-
|
|
|
Physcion-d3 (Parietin-d3) is the deuterium labeled Physcion (HY-N0108). Physcion acts as an inhibitor of 6-phosphogluconate dehydrogenase, with an IC50 and a Kd of 38.5 μM and 26.0 μM, respectively. Physcion exhibits laxative, hepatoprotective, anti-inflammatory, anti-microbial, anti-proliferative and anti-tumor effects .
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-
-
- HY-121636S
-
|
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Resolvin D2-d5 is the deuterium labeled Resolvin D2. Resolvin D2 is a metabolite of docosahexaenoic acid (DHA), with anti-inflammatory, anti-infective activities. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Resolvin D2 is a remarkably potent inhibitor of TRPV1 (IC50 = 0.1 nM) and TRPA1 (IC50 = 2 nM) in primary sensory neurons .
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-
-
- HY-10234S
-
|
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Saracatinib-d3 (AZD0530-d3) (ZG5129) is the deuterium-labeled analog of Saracatinib (HY-10234). Saracatinib-d3 is an inhibitor of the Src kinase, which can inhibit severe sepsis caused by bacterial or various microbial infections .
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-
- HY-W001940S
-
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DL-m-Tyrosine-d3 is the deuterium labeled DL-m-Tyrosine (HY-W001940). DL-m-Tyrosine is a non-protein amino acid. DL-m-Tyrosine inhibits microbial growth and spore formation. DL-m-Tyrosine also inhibits root growth in various plants, such as lettuce and Arabidopsis. DL-m-Tyrosine, when used in combination with Carbidopa (HY-B0311), has a potent antihypertensive effect. DL-m-Tyrosine can be used in research on biopesticide design.
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-
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