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Results for "

melanocortin-4 receptor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Melanocortin Receptor (22) AP-1 (1) CRFR (2)
By Research Areas:	Cancer (2) Endocrinology (9) Inflammation/Immunology (5) Metabolic Disease (13) Neurological Disease (11)

Inhibitors & Agonists

Peptides

Antibodies

Targets Recommended: Melanocortin Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-148349

PF-07258669	Melanocortin Receptor	Neurological Disease Metabolic Disease
PF-07258669 is an orally active melanocortin-4 receptor (MC4R) antagonist that antagonizes MC4R with an IC₅₀ of 13 nM (K_i=0.46 nM). PF-07258669 can be used for the research of cachexia, anorexia, or anorexia nervosa .

HY-P3561A

Agouti-related Protein (AGRP) (83-132) Amide (human) (TFA)	Melanocortin Receptor	Neurological Disease
Agouti-related Protein (AGRP) (83-132) Amide (human) TFA is a fragment of agouti-related protein (AGRP) which is a protein found in abundance in the arcuate nucleus of the hypothalamus. AgRP primarily acts as an inverse agonist for the **melanocortin-4 receptor** (MC4R) to increase food intake .

HY-10622

PF-00446687 free base	Melanocortin Receptor	Endocrinology
PF-00446687 is a potent, selective **melanocortin-4 receptor (MC4R) agonist with EC50** of 12 ± 1 nM . Pf-446687 is brain penetrant .

HY-P1504

β-Melanocyte Stimulating Hormone (MSH), human Beta-MSH (1-22) (human)	Melanocortin Receptor	Neurological Disease Metabolic Disease Endocrinology
β-Melanocyte Stimulating Hormone (MSH), human, a 22-residue peptide, acts as an endogenous **melanocortin-4 receptor (MC4-R**) agonist .

HY-P1504A

β-Melanocyte Stimulating Hormone (MSH), human TFA Beta-MSH (1-22) (human) TFA	Melanocortin Receptor	Neurological Disease Metabolic Disease Endocrinology
β-Melanocyte Stimulating Hormone (MSH), human TFA, a 22-residue peptide, acts as an endogenous **melanocortin-4 receptor (MC4-R**) agonist .

HY-11030A

SNT-207858 free base	Melanocortin Receptor	Metabolic Disease Endocrinology Cancer
SNT207858 free base is a selective, blood brain barrier penetrating, potent and orally active *melanocortin-4* (MC-4) *receptor* antagonist. SNT207858 free base has an IC₅₀ of 22 nM (binding) and 11 nM (function) on the MC-4 receptor .

HY-P1216A

HS014 TFA 1 Publications Verification	Melanocortin Receptor	Neurological Disease
HS014 TFA is a potent and selective **melanocortin-4 (MC4) receptor antagonist, with K_i*s of 3.16, 108, 54.4 and 694 nM for human MC4, MC1, MC3 and MC5 receptors* respectively. HS014 TFA increases food intake in free-feeding rats .

HY-P3561

Agouti-related Protein (AGRP) (83-132) Amide (human)	Melanocortin Receptor	Neurological Disease
Agouti-related Protein (AGRP) (83-132) Amide (human) is a fragment of agouti-related protein (AGRP) which is a protein found in abundance in the arcuate nucleus of the hypothalamus. AgRP primarily acts as an inverse agonist for the **melanocortin-4 receptor** (MC4R) to increase food intake .

HY-U00396

MC-4R Agonist 1	Melanocortin Receptor	Metabolic Disease Endocrinology
MC-4R Agonist 1 is an agonist of *human melanocortin-4* receptor (MC-4R)**, used in the research of obesity, diabetes, and sexual dysfunction.

HY-11030

SNT-207858	Melanocortin Receptor	Metabolic Disease Endocrinology Cancer
SNT207858 is a selective, blood brain barrier penetrating, potent and orally active *melanocortin-4* (MC-4) *receptor* antagonist. SNT207858 has an IC₅₀ of 22 nM (binding) and 11 nM (function) on the MC-4 receptor .

HY-P1216

HS014	Melanocortin Receptor	Neurological Disease
HS014 is a potent and selective **melanocortin-4 (MC4) receptor antagonist, with K_i*s of 3.16, 108, 54.4 and 694 nM for human MC4, MC1, MC3 and MC5 receptors*, respectively. HS014 modulates the behavioral effects of morphine in mice. HS014 increases food intake in free-feeding rats .

HY-P0060

Tetracosactide Tetracosactrin; ACTH(1–24)	CRFR Melanocortin Receptor	Neurological Disease Inflammation/Immunology
Tetracosactide (Tetracosactrin) is an analogue of adrenocorticotrophic hormone (ACTH). Tetracosactide is the agonist for melanocortin-4 receptor (MC4R) that activates human MC4R with an EC₅₀ of 0.65 nM. Tetracosactide can stimulate the release of corticosteroids such as cortisol from the adrenal gland. Tetracosactide is currently used for the research of ulcerative colitis and Crohn's disease, juvenile/adult rheumatoid arthritis and osteoarthrosis .

HY-P0060A

Tetracosactide acetate Tetracosactrin acetate; ACTH(1–24) acetate	CRFR Melanocortin Receptor	Neurological Disease Inflammation/Immunology
Tetracosactide acetate (Tetracosactrin acetate ) is the acetate salt form of Tetracosactide (HY-P0060). Tetracosactide acetate is an analogue of adrenocorticotrophic hormone (ACTH). Tetracosactide acetate is the agonist for melanocortin-4 receptor (MC4R) that activates human MC4R with an EC₅₀ of 0.65 nM. Tetracosactide acetate can stimulate the release of corticosteroids such as cortisol from the adrenal gland. Tetracosactide acetate is currently used for the research of ulcerative colitis and Crohn's disease, juvenile/adult rheumatoid arthritis and osteoarthrosis .

HY-10624

THIQ 1 Publications Verification	Melanocortin Receptor	Metabolic Disease
THIQ is the first selective agonist of the melanocortin-4 receptor (MC4R), with high affinity and potency for hMC4R (IC₅₀=1.2 nM, EC₅₀=2.1 nM) and rMC4R (IC₅₀=0.6 nM, EC₅₀=2.9 nM). THIQ maintains low potency at MC1R, MC3R and MC5R. THIQ plays a role in eliciting erectile activity in rodents. THIQ acts as a pharmacoperone of the MC4R rescuing the cell surface expression and signaling of some intracellularly retained MC4R mutants .

HY-P1478

Adrenocorticotropic Hormone (ACTH) (4-10), human	Melanocortin Receptor	Metabolic Disease
Adrenocorticotropic Hormone (ACTH) (4-10), human is a melanocortin 4 (MC4R) receptor agonist.

HY-P10927

BRP BRINP2-related peptide	AP-1	Metabolic Disease
BRP, a BRINP2-related peptide, possesses anti-obesity activity via FOS activation. BRP central FOS activation and acts independently of leptin, GLP-1 receptor and melanocortin 4 receptor .

HY-19870C

Setmelanotide monoacetate Maximum Cited Publications 8 Publications Verification RM-493 monoacetate; BIM-22493 monoacetate; IRC-022493 monoacetate	Melanocortin Receptor	Metabolic Disease Endocrinology
Setmelanotide (monoacetate) is a melanocortin 4 receptor (MC4R) agonist that acts on human and rat MC4R with EC₅₀ values of 0.27 nM and 0.28 nM, respectively .

HY-19870

Setmelanotide Maximum Cited Publications 8 Publications Verification RM-493; BIM-22493; IRC-022493	Melanocortin Receptor	Metabolic Disease Endocrinology
Setmelanotide (RM-493) is a selective melanocortin 4 receptor (MC4R) agonist with EC₅₀s of 0.27 nM and 0.28 nM for human and rat MC4R, respectively .

HY-19870A

Setmelanotide TFA RM-493 TFA; BIM-22493 TFA; IRC-022493 TFA	Melanocortin Receptor	Metabolic Disease Endocrinology
Setmelanotide TFA (RM-493 TFA) is a selective melanocortin 4 receptor (MC4R) agonist with EC₅₀s of 0.27 nM and 0.28 nM for human and rat MC4R, respectively .

HY-148349A

(2R,2R)-PF-07258669	Melanocortin Receptor	Neurological Disease Metabolic Disease
(2R,2R)-PF-07258669 is a MC4R (melanocortin 4 receptor) antagonist. (2R,2R)-PF-07258669 can be used in the study of regulating appetite and energy expenditure .

HY-P1208

PG-931	Melanocortin Receptor	Inflammation/Immunology
PG-931, an analog of SHU 9119 (HY-P0227), is a potent **melanocortin 4 (MC4) receptor (IC₅₀=0.58 nM) agonist and is more selective than for the hMC3R (IC₅₀=55 nM) or the hMC5R (IC₅₀**=2.4 nM). PG-931 can reverse haemorrhagic shock and prevent multiple organ damage in vivo .

HY-P2242A

RO27-3225 TFA	Melanocortin Receptor	Neurological Disease Inflammation/Immunology
RO27-3225 TFA is potent and selective melanocortin 4 receptor (MC4R) agonist with an EC₅₀ of 1 nM and 8 nM for MC4R and MC1R, respectively. RO27-3225 TFA shows ~30-fold selectivity for MC4R over MC3R. RO27-3225 TFA has neuroprotective and anti-inflammatory effects .

HY-P1208A

PG-931 TFA	Melanocortin Receptor	Inflammation/Immunology
PG-931 TFA, an analog of SHU 9119 (HY-P0227), is a potent **melanocortin 4 (MC4) receptor (IC₅₀=0.58 nM) agonist and is more selective than for the hMC3R (IC₅₀=55 nM) or the hMC5R(IC₅₀**=2.4 nM). PG-931 TFA can reverse haemorrhagic shock and prevent multiple organ damage in vivo .

Cat. No.	Product Name	Target	Research Area

HY-P3561A

Agouti-related Protein (AGRP) (83-132) Amide (human) (TFA)	Melanocortin Receptor	Neurological Disease
Agouti-related Protein (AGRP) (83-132) Amide (human) TFA is a fragment of agouti-related protein (AGRP) which is a protein found in abundance in the arcuate nucleus of the hypothalamus. AgRP primarily acts as an inverse agonist for the **melanocortin-4 receptor** (MC4R) to increase food intake .

HY-P1504

β-Melanocyte Stimulating Hormone (MSH), human Beta-MSH (1-22) (human)	Melanocortin Receptor	Neurological Disease Metabolic Disease Endocrinology
β-Melanocyte Stimulating Hormone (MSH), human, a 22-residue peptide, acts as an endogenous **melanocortin-4 receptor (MC4-R**) agonist .

HY-P1504A

β-Melanocyte Stimulating Hormone (MSH), human TFA Beta-MSH (1-22) (human) TFA	Melanocortin Receptor	Neurological Disease Metabolic Disease Endocrinology
β-Melanocyte Stimulating Hormone (MSH), human TFA, a 22-residue peptide, acts as an endogenous **melanocortin-4 receptor (MC4-R**) agonist .

HY-P1216A

HS014 TFA 1 Publications Verification	Melanocortin Receptor	Neurological Disease
HS014 TFA is a potent and selective **melanocortin-4 (MC4) receptor antagonist, with K_i*s of 3.16, 108, 54.4 and 694 nM for human MC4, MC1, MC3 and MC5 receptors* respectively. HS014 TFA increases food intake in free-feeding rats .

HY-P0060

Tetracosactide Tetracosactrin; ACTH(1–24)	CRFR Melanocortin Receptor	Neurological Disease Inflammation/Immunology
Tetracosactide (Tetracosactrin) is an analogue of adrenocorticotrophic hormone (ACTH). Tetracosactide is the agonist for melanocortin-4 receptor (MC4R) that activates human MC4R with an EC₅₀ of 0.65 nM. Tetracosactide can stimulate the release of corticosteroids such as cortisol from the adrenal gland. Tetracosactide is currently used for the research of ulcerative colitis and Crohn's disease, juvenile/adult rheumatoid arthritis and osteoarthrosis .

HY-P0060A

Tetracosactide acetate Tetracosactrin acetate; ACTH(1–24) acetate	CRFR Melanocortin Receptor	Neurological Disease Inflammation/Immunology
Tetracosactide acetate (Tetracosactrin acetate ) is the acetate salt form of Tetracosactide (HY-P0060). Tetracosactide acetate is an analogue of adrenocorticotrophic hormone (ACTH). Tetracosactide acetate is the agonist for melanocortin-4 receptor (MC4R) that activates human MC4R with an EC₅₀ of 0.65 nM. Tetracosactide acetate can stimulate the release of corticosteroids such as cortisol from the adrenal gland. Tetracosactide acetate is currently used for the research of ulcerative colitis and Crohn's disease, juvenile/adult rheumatoid arthritis and osteoarthrosis .

HY-P1478

Adrenocorticotropic Hormone (ACTH) (4-10), human	Melanocortin Receptor	Metabolic Disease
Adrenocorticotropic Hormone (ACTH) (4-10), human is a melanocortin 4 (MC4R) receptor agonist.

HY-P3561

Agouti-related Protein (AGRP) (83-132) Amide (human)	Melanocortin Receptor	Neurological Disease
Agouti-related Protein (AGRP) (83-132) Amide (human) is a fragment of agouti-related protein (AGRP) which is a protein found in abundance in the arcuate nucleus of the hypothalamus. AgRP primarily acts as an inverse agonist for the **melanocortin-4 receptor** (MC4R) to increase food intake .

HY-P1216

HS014	Melanocortin Receptor	Neurological Disease
HS014 is a potent and selective **melanocortin-4 (MC4) receptor antagonist, with K_i*s of 3.16, 108, 54.4 and 694 nM for human MC4, MC1, MC3 and MC5 receptors*, respectively. HS014 modulates the behavioral effects of morphine in mice. HS014 increases food intake in free-feeding rats .

HY-P10927

BRP BRINP2-related peptide	AP-1	Metabolic Disease
BRP, a BRINP2-related peptide, possesses anti-obesity activity via FOS activation. BRP central FOS activation and acts independently of leptin, GLP-1 receptor and melanocortin 4 receptor .

HY-19870

Setmelanotide Maximum Cited Publications 8 Publications Verification RM-493; BIM-22493; IRC-022493	Melanocortin Receptor	Metabolic Disease Endocrinology
Setmelanotide (RM-493) is a selective melanocortin 4 receptor (MC4R) agonist with EC₅₀s of 0.27 nM and 0.28 nM for human and rat MC4R, respectively .

HY-19870A

Setmelanotide TFA RM-493 TFA; BIM-22493 TFA; IRC-022493 TFA	Melanocortin Receptor	Metabolic Disease Endocrinology
Setmelanotide TFA (RM-493 TFA) is a selective melanocortin 4 receptor (MC4R) agonist with EC₅₀s of 0.27 nM and 0.28 nM for human and rat MC4R, respectively .

HY-P1208

PG-931	Melanocortin Receptor	Inflammation/Immunology
PG-931, an analog of SHU 9119 (HY-P0227), is a potent **melanocortin 4 (MC4) receptor (IC₅₀=0.58 nM) agonist and is more selective than for the hMC3R (IC₅₀=55 nM) or the hMC5R (IC₅₀**=2.4 nM). PG-931 can reverse haemorrhagic shock and prevent multiple organ damage in vivo .

HY-P2242A

RO27-3225 TFA	Melanocortin Receptor	Neurological Disease Inflammation/Immunology
RO27-3225 TFA is potent and selective melanocortin 4 receptor (MC4R) agonist with an EC₅₀ of 1 nM and 8 nM for MC4R and MC1R, respectively. RO27-3225 TFA shows ~30-fold selectivity for MC4R over MC3R. RO27-3225 TFA has neuroprotective and anti-inflammatory effects .

HY-P1208A

PG-931 TFA	Melanocortin Receptor	Inflammation/Immunology
PG-931 TFA, an analog of SHU 9119 (HY-P0227), is a potent **melanocortin 4 (MC4) receptor (IC₅₀=0.58 nM) agonist and is more selective than for the hMC3R (IC₅₀=55 nM) or the hMC5R(IC₅₀**=2.4 nM). PG-931 TFA can reverse haemorrhagic shock and prevent multiple organ damage in vivo .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81900

	MC4R Antibody (YA1645) MC4R; melanocortin 4 receptor	WB	Human, Mouse, Rat
	MC4R Antibody (YA1645) is a non-conjugated IgG antibody, targeting MC4R, with a predicted molecular weight of 37 kDa (observed band size: 37 kDa). MC4R Antibody (YA1645) can be used for WB experiment in human, mouse, rat background.

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