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Results for "

ferritin

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amyloid-β (1) Apoptosis (3) Atg8/LC3 (1) Autophagy (3) Biochemical Assay Reagents (1) Caspase (3) Drug Metabolite (2) Ferroptosis (8) Glutathione Peroxidase (1) Keap1-Nrf2 (3) MDM-2/p53 (3) MMP (2) Monoamine Oxidase (1) PARP (2) PROTACs (2) Pyroptosis (1) Reactive Oxygen Species (ROS) (6) Reference Standards (1) Tau Protein (1) Transferrin Receptor (2)
By Research Areas:	Cancer (12) Inflammation/Immunology (3) Metabolic Disease (3) Neurological Disease (3)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-152093

YL-939	Ferroptosis	Cancer
YL-939 is a potent ferroptosis inhibitor. YL-939 inhibits ferroptosis by targeting the PHB2/ferritin/iron axis .

HY-108017

Ferric maltol	Others	Metabolic Disease Cancer
Ferric maltol is an orally active monovalent iron (Fe ³⁺) complex. Ferric maltol is used in the study of iron deficiency anemia in inflammatory bowel disease .

HY-N8210

Homoeriodictyol	Drug Metabolite Autophagy Apoptosis Reactive Oxygen Species (ROS) Keap1-Nrf2 MMP Caspase PARP MDM-2/p53	Neurological Disease Inflammation/Immunology Cancer
Homoeriodictyol is an orally active, bitter-tasting flavanone that can penetrate the blood-brain barrier. Homoeriodictyol enhances synaptic-related protein expression through NCOA4-mediated ferritin autophagy. Homoeriodictyol improves memory impairment in mice by inhibiting the NLRP3 inflammasome. Homoeriodictyol protects human endothelial cells from oxidative damage by activating Nrf2 and inhibiting mitochondrial dysfunction. Homoeriodictyol enhances ROS activity and induces apoptosis, exhibiting anticancer effects. Homoeriodictyol inhibits the survival and migration of androgen-resistant prostate cancer cells in vitro. Homoeriodictyol exerts antinociceptive activity in mice in vivo .

HY-108194

CGP 46700	Biochemical Assay Reagents	Others
CGP 46700 (Compound 49) is an orally active iron chelator, that exhibits high affinity for iron, removes iron from ferritin and human serum transferrin. CGP 46700 promotes iron excretion in a mouse iron overload model .

HY-175381

DeFer-2	PROTACs Pyroptosis Reactive Oxygen Species (ROS) Caspase	Cancer
DeFer-2 is a ferritin PROTAC degrader (K_d = 17.1 μM). DeFer-2 induces ferritin degradation, triggering caspase 3-GSDME-mediated pyroptosis in cancer cells through free iron accumulation and elevated ROS. DeFer-2 significantly inhibits tumor growth and prolongs survival in mice bearing B16F10 subcutaneous tumors. DeFer-2 can be used to study melanoma. (Pink: Oleic acid: HY-N1446, Blue: (S,R,S)-AHPC: HY-125845, Black: γ-Aminobutyric acid: HY-N0067, Blue + Black: (S,R,S)-AHPC-C3-NH2: HY-130711) .

HY-115832

Ap44mSe	Transferrin Receptor	Cancer
Ap44mSe is a selenosemicarbazone that effectively depletes cellular Fe, resulting in transferrin receptor-1 up-regulation, ferritin down-regulation, and increased expression of the potent metastasis suppressor, N-myc downstream regulated gene-1. Ap44mSe forms redox active Cu complexes that target the lysosome to induce lysosomal membrane permeabilization .

HY-108017R

Ferric maltol (Standard)	Others	Metabolic Disease Cancer
Ferric maltol (Standard) is the analytical standard of Ferric maltol. This product is intended for research and analytical applications. Ferric maltol is an orally active monovalent iron (Fe3+) complex. Ferric maltol is used in the study of iron deficiency anemia in inflammatory bowel disease .

HY-168894

CT-1	Ferroptosis	Cancer
CT-1 is a derivative of Cryptotanshinone (HY-N0174). CT-1 is a ferroptosis inducer. CT-1 promotes the interaction between NCOA4 and ferritin by targeting FTH1, triggering ferritinophagy-mediated ferroptosis. CT-1 has anticancer activity against triple-negative breast cancer (TNBC). CT-1 induces ferroptosis in both N2-type tumor-associated neutrophils (TANs) and TNBC cancer cells .

HY-P991381

JST-TfR09 PPMX-T003	Transferrin Receptor Reactive Oxygen Species (ROS) Ferroptosis	Cancer
TXB4 (PPMX-T003) is a human monoclonal antibody (mAb) targeting CD71. JST-TfR09 can induce ferroptosis by reducing ferritin levels in ATLL cell lines, increasing the generation of ferrous iron and reactive oxygen species (ROS), and inducing lipid peroxidation via malondialdehyde. JST-TfR09 can be used in leukemia research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-175209

Nrf2-IN-4	Keap1-Nrf2 Ferroptosis Reactive Oxygen Species (ROS) Atg8/LC3	Cancer
Nrf2-IN-4 is a Nrf2 inhibitor. Nrf2-IN-4 induces ferroptosis via NRF2 inhibition. Nrf2-IN-4 disrupts cellular iron homeostasis, facilitates ferritin degradation, and ultimately triggers ferroptosis. Nrf2-IN-4 induces lysosome activation by promoting iron-dependent ROS production and lysosomal acidification. Nrf2-IN-4 demonstrates significant antitumor efficacy. Nrf2-IN-4 can be used for the study of breast cancer .

HY-148409

MMRi62	Ferroptosis Apoptosis Autophagy MDM-2/p53	Cancer
MMRi62, a ferroptosis inducer targeting MDM2-MDM4 (negative regulators of tumor suppressor p53). MMRi62 shows a P53-independent pro-apoptotic activity against pancreatic ductal adenocarcinoma (PDAC) cells and induce autophagy. MMRi62 inducesferroptosis, resulting in a increase of reactive oxygen and lysosomal degradation of ferritin heavy chain (FTH1). MMRi62 also leads to proteasomal degradation of mutant p53, also inhibits orthotopic xenograft PDAC mouse model in vivo with high frequency mutation characteristics of KRAS and TP53.12 .

HY-176271

MAO-B-IN-45	Ferroptosis Monoamine Oxidase Glutathione Peroxidase Reactive Oxygen Species (ROS) Tau Protein Amyloid-β	Neurological Disease
MAO-B-IN-45 is a dual inhibitor of ferroptosis and MAO-B. MAO-B-IN-45 shows selectivity towards MAO-B with an IC₅₀ of 87.47 nM and selectivity exceeding 229-fold for MAO-B over MAO-A. MAO-B-IN-45 has excellent antiferroptosis activity through modulation of the iron metabolic pathway and GSH-GPX4 axis in vitro. MAO-B-IN-45 improves cognitive and behavioral impairments in 3×Tg (APP/Tau/Ps1) AD mouse and significantly reduced the levels of ferritin heavy chain 1 (FTH1), APP, and Tau phosphorylation (p-Tau) proteins in the brain.

HY-174867

AY-4	PROTACs Ferroptosis	Cancer
AY-4 (Compound AY-4) is an efficient PROTAC degrader targeting FTH1 (K_d = 3.17 nM). AY-4 effectively upregulates the levels of ferrous (Fe ²⁺) and ferric (Fe ³⁺) ions in cells. AY-4 is a potential anticancer candidate compound that regulates iron homeostasis through ferritin degradation and enhances the efficacy of existing drugs. AY-4 can effectively reduce the level of FTH1 in breast cancer cells (Pink: FTH1 ligand AY-2 (HY-174871); Blue: E3 ligand Pomalidomide (HY-10984); Black: Linker, Pomalidomide-PEG3-acid (HY-174872)) .

HY-N8210R

Homoeriodictyol (Standard)	Reference Standards Drug Metabolite Autophagy Apoptosis Reactive Oxygen Species (ROS) Keap1-Nrf2 MMP Caspase PARP MDM-2/p53	Neurological Disease Inflammation/Immunology Cancer
Homoeriodictyol (Standard) is the analytical standard of Homoeriodictyol (HY-N8210). This product is intended for research and analytical applications. Homoeriodictyol is an orally active, bitter-tasting flavanone that can penetrate the blood-brain barrier. Homoeriodictyol enhances synaptic-related protein expression through NCOA4-mediated ferritin autophagy. Homoeriodictyol improves memory impairment in mice by inhibiting the NLRP3 inflammasome. Homoeriodictyol protects human endothelial cells from oxidative damage by activating Nrf2 and inhibiting mitochondrial dysfunction. Homoeriodictyol enhances ROS activity and induces apoptosis, exhibiting anticancer effects. Homoeriodictyol inhibits the survival and migration of androgen-resistant prostate cancer cells in vitro. Homoeriodictyol exerts antinociceptive activity in mice in vivo .

HY-175869

Ferroptosis-IN-22	Ferroptosis	Metabolic Disease Inflammation/Immunology
Ferroptosis-IN-22 is a selective ferroptosis inhibitor by targeting NCOA4 and disrupting its interaction with ferritin with an EC₅₀ of 520 nM and a K_d of 0.78 μM. Ferroptosis-IN-22 has a strong inhibitory activity against ferroptosis induced by multiple ferroptosis inducers (RSL3 (HY-100218A), Erastin (HY-15763), ML210 (HY-100003), FIN56 (HY-103087)), but does not inhibit necrosis induced by H₂O₂ or apoptosis induced by STS (HY-15141). Ferroptosis-IN-22 effectively ameliorates Concanavalin A (HY-P2149)-induced acute liver injury. Ferroptosis-IN-22 can be used for the study of ferroptosis-related diseases .

Cat. No.	Product Name	Target	Research Area

HY-P991381

JST-TfR09 PPMX-T003	Transferrin Receptor Reactive Oxygen Species (ROS) Ferroptosis	Cancer
TXB4 (PPMX-T003) is a human monoclonal antibody (mAb) targeting CD71. JST-TfR09 can induce ferroptosis by reducing ferritin levels in ATLL cell lines, increasing the generation of ferrous iron and reactive oxygen species (ROS), and inducing lipid peroxidation via malondialdehyde. JST-TfR09 can be used in leukemia research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N8210

Homoeriodictyol	Structural Classification Flavonoids other families Classification of Application Fields Flavonones Source classification Other Diseases Phenols Polyphenols Plants Disease Research Fields	Drug Metabolite Autophagy Apoptosis Reactive Oxygen Species (ROS) Keap1-Nrf2 MMP Caspase PARP MDM-2/p53
Homoeriodictyol is an orally active, bitter-tasting flavanone that can penetrate the blood-brain barrier. Homoeriodictyol enhances synaptic-related protein expression through NCOA4-mediated ferritin autophagy. Homoeriodictyol improves memory impairment in mice by inhibiting the NLRP3 inflammasome. Homoeriodictyol protects human endothelial cells from oxidative damage by activating Nrf2 and inhibiting mitochondrial dysfunction. Homoeriodictyol enhances ROS activity and induces apoptosis, exhibiting anticancer effects. Homoeriodictyol inhibits the survival and migration of androgen-resistant prostate cancer cells in vitro. Homoeriodictyol exerts antinociceptive activity in mice in vivo .

HY-N8210R

Homoeriodictyol (Standard)	Structural Classification Flavonoids other families Flavonones Source classification Phenols Polyphenols Plants	Reference Standards Drug Metabolite Autophagy Apoptosis Reactive Oxygen Species (ROS) Keap1-Nrf2 MMP Caspase PARP MDM-2/p53
Homoeriodictyol (Standard) is the analytical standard of Homoeriodictyol (HY-N8210). This product is intended for research and analytical applications. Homoeriodictyol is an orally active, bitter-tasting flavanone that can penetrate the blood-brain barrier. Homoeriodictyol enhances synaptic-related protein expression through NCOA4-mediated ferritin autophagy. Homoeriodictyol improves memory impairment in mice by inhibiting the NLRP3 inflammasome. Homoeriodictyol protects human endothelial cells from oxidative damage by activating Nrf2 and inhibiting mitochondrial dysfunction. Homoeriodictyol enhances ROS activity and induces apoptosis, exhibiting anticancer effects. Homoeriodictyol inhibits the survival and migration of androgen-resistant prostate cancer cells in vitro. Homoeriodictyol exerts antinociceptive activity in mice in vivo .

Species:	Human (3)
Tag:	His (3) Tag Free (1)
Source:	HEK293 (1) E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P70245

	Ferritin light chain/FTL Protein, Human (His) rHuferritin light chain/FTL, His; ferritin L subunit; ferritin light chain; FTL	Human	E. coli
	Ferritin light chain/FTL protein is pivotal in iron homeostasis, storing iron in a soluble, non-toxic form and delivering it to cells. In kidney development, FTL mediates iron uptake in capsule cells, crucial for organogenesis. Structurally, FTL, an oligomer with light and heavy subunits forming a spherical shell, facilitates iron entry through pores. Mutations in the C-terminus disrupt pore formation, impacting iron accumulation. Ferritin light chain/FTL Protein, Human (His) is the recombinant human-derived Ferritin light chain/FTL protein, expressed by E. coli , with N-6*His labeled tag.

HY-P70246

	Ferritin heavy chain/FTH1 Protein, Human 1 Publications Verification rHuferritin heavy chain/FTH1; ferritin heavy chain; FTH1; FTH; FTHL6; ferritin H subunit; Cell proliferation-inducing gene 15 protein	Human	E. coli
	The ferritin heavy chain/FTH1 protein is critical for maintaining iron homeostasis, storing iron in soluble form through ferroxidase activity. It promotes the oxidation of ferrous iron so that it can be deposited in the form of iron hydroxide. Ferritin heavy chain/FTH1 Protein, Human is the recombinant human-derived Ferritin heavy chain/FTH1 protein, expressed by E. coli , with tag free.

HY-P703487

	Ferritin Protein, Penaeus japonicus (His) ferritin; Penaeus japonicus; Kuruma prawn; Oxidoreductase; 1.16.3.1	Others	E. coli
	Ferritin Protein, Penaeus japonicus (His) is the recombinant Ferritin, expressed by E. coli , with His labeled tag. ,

HY-P704455

	*CD24 Protein, Human (HEK293, His, Ferritin)* CD24; CD24 molecule; CD24 antigen (small cell lung carcinoma cluster 4 antigen); signal transducer CD24; CD24A; FLJ22950; FLJ43543; MGC75043;	Human	HEK293
	The CD24 protein plays a critical role in cellular differentiation in various cell types, and its signaling may be initiated by lectin-like ligands that bind to the CD24 carbohydrate and transduced by second messengers released from GPI anchors. CD24 also regulates B cell activation responses, promoting AG-dependent B cell proliferation and preventing terminal differentiation into antibody-forming cells. CD24 Protein, Human (HEK293, His, Ferritin) is the recombinant human-derived CD24 protein, expressed by HEK293, with N-His labeled tag.

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HY-P80670

	Ferritin Heavy Chain Antibody (YA443) 4 Publications Verification FTH1; FTH; FTHL6; OK/SW-cl.84; PIG15; ferritin heavy chain; ferritin H subunit; Cell proliferation-inducing gene 15 protein	WB, ICC/IF	Human, Mouse, Rat, Hamster
	Ferritin Heavy Chain Antibody (YA443) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Ferritin Heavy Chain.

HY-P86448

	Ferritin heavy chain Antibody (YA6140) FTH1; FTH; FTHL6; OK/SW-cl.84; PIG15; ferritin heavy chain; ferritin H subunit; Cell proliferation-inducing gene 15 protein	WB, IHC-P, ICC/IF, ELISA	Human, Mouse, Rat
	Ferritin heavy chain Antibody (YA6140) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Ferritin heavy chain.

HY-P83608

	*Mitochondrial Ferritin* Antibody (YA3353)** FerH; ferritin; ferritin H subunit; ferritin; mitochondrial; Fth3; FTMT; mitochondrial; Mitochondrial ferritin; MTF	WB	Human
	Mitochondrial Ferritin Antibody (YA3353) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Mitochondrial Ferritin.

HY-P83105

	Aconitase 1 Antibody (YA2850) ACO1; IREB1; Cytoplasmic aconitate hydratase; Aconitase; Citrate hydro-lyase; ferritin repressor protein; Iron regulatory protein 1; IRP1; Iron-responsive element-binding protein 1; IRE-BP 1	WB, ICC/IF	Human, Mouse, Rat
	Aconitase 1 Antibody (YA2850) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Aconitase 1.

HY-P81275

	Ferritin Light Chain Antibody (YA971) ferritin L chain; ferritin L subunit; ferritin light chain; ferritin light polypeptide; ferritin light polypeptide like 3; FRIL; FRIL_HUMAN; FTL; L apoferritin; LFTD; MGC71996; NBIA 3; NBIA3.	ELISA	Human
	Ferritin Light Chain Antibody (YA971) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to Ferritin Light Chain.

HY-P81275A

	Ferritin Light Chain Antibody (YA972) ferritin L chain; ferritin L subunit; ferritin light chain; ferritin light polypeptide; ferritin light polypeptide like 3; FRIL; FRIL_HUMAN; FTL; L apoferritin; LFTD; MGC71996; NBIA 3; NBIA3.	ELISA	Human
	Ferritin Light Chain Antibody (YA972) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to Ferritin Light Chain.

HY-P85608

	Ferritin Light Chain Antibody (YA5300) ferritin L chain; ferritin L subunit; ferritin light chain; ferritin light polypeptide; ferritin light polypeptide like 3; FRIL; FRIL_HUMAN; FTL; L apoferritin; LFTD; MGC71996; NBIA 3; NBIA3.	ELISA	Human
	Ferritin Light Chain Antibody (YA5300) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Ferritin Light Chain.

HY-P86406

	Ferritin Heavy Chain Antibody (YA6098) FTH1; FTH; FTHL6; OK/SW-cl.84; PIG15; ferritin heavy chain; ferritin H subunit; Cell proliferation-inducing gene 15 protein	WB, IHC-P, ICC/IF, IP, ELISA	Mouse, Rat
	Ferritin Heavy Chain Antibody (YA6098) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Ferritin Heavy Chain.

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ferritin

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