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excitatory

" in MedChemExpress (MCE) Product Catalog:

124

Inhibitors & Agonists

1

Screening Libraries

1

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18

Peptides

20

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Products

1

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26

Isotope-Labeled Compounds

4

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1

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Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B0649
    Propofol
    10+ Cited Publications

    2,6-Diisopropylphenol

    GABA Receptor Endogenous Metabolite Neurological Disease Cancer
    Propofol potently and directly activates GABAA receptor and inhibits glutamate receptor mediated excitatory synaptic transmission. Propofol has antinociceptive properties and is used for sedation and hypnotic .
    Propofol
  • HY-P1247

    Phosphatase Neurological Disease
    Calcineurin autoinhibitory peptide is a selective inhibitor of Ca 2+/calmodulin-dependent protein phosphatase (calcineurin), with an IC50 of ~10 μM. Calcineurin autoinhibitory peptide could protect neurons from excitatory neuronal death .
    Calcineurin autoinhibitory peptide
  • HY-12597

    L-Quisqualic acid

    iGluR mGluR Neurological Disease
    Quisqualic acid (L-Quisqualic acid), a natural analog of glutamate, is a potent and pan two subsets (iGluR and mGluR) of excitatory amino acid (EAA) agonist with an EC50 of 45 nM and a Ki of 10 nM for mGluR1R. Quisqualic acid is isolated from the fruits of Quisqualis indica .
    Quisqualic acid
  • HY-139692

    EAAT Neurological Disease
    EAAT2 activator 1 is the potent activator of excitatory amino acid transporter 2 (EAAT2). EAAT2 is the major glutamate transporter and functions to remove glutamate from synapses. EAAT2 activator 1 increases EAAT2 protein levels dose-dependently .
    EAAT2 activator 1
  • HY-101528

    iGluR Neurological Disease
    IDRA 21 is a positive and orally active modulator of the AMPA receptor. IDRA 21 facilitates excitatory neurotransmission via GluR1/2 receptors. IDRA 21 has the potential for the research of cognitive/memory disorders, including those associated with aging .
    IDRA 21
  • HY-100922

    iGluR Neurological Disease
    N-Acetylglycyl-D-glutamic acid is a peptide with excitatory effect. N-Acetylglycyl-D-glutamic acid induces seizures in mice .
    N-Acetylglycyl-D-glutamic acid
  • HY-P1716

    PKC Neurological Disease
    Neuropeptide DF2 is a DRNFLRFamide neuropeptide orignally isolated from crayfish. which enhances transmitter release and stimulates the amplitude of excitatory post-synaptic potentials (EPSP) through the calcium/calmodulin-dependent protein kinase .
    Neuropeptide DF2
  • HY-120989

    Endogenous Metabolite Metabolic Disease
    Methyl 7(Z)-hexadecenoate is a sex pheromone produced by Trogoderma glabrum. Methyl 7(Z)-hexadecenoate can elicit attractive and sexually excitatory responses in Trogoderma glabrum males .
    Methyl 7(Z)-hexadecenoate
  • HY-N12715

    Others Neurological Disease
    Valerena-4,7(11)-diene is a tranquilizer. Valerena-4,7(11)-diene suppresses stress-induced excitatory behaviors. Valerena-4,7(11)-diene is expressed via olfactory stimulation and pulmonary absorption .
    Valerena-4,7(11)-diene
  • HY-P1247A

    Phosphatase Neurological Disease
    Calcineurin autoinhibitory peptide TFA is a selective inhibitor of Ca 2+/calmodulin-dependent protein phosphatase (calcineurin), with an IC50 of ~10 μM. Calcineurin autoinhibitory peptide TFA could protect neurons from excitatory neuronal death .
    Calcineurin autoinhibitory peptide TFA
  • HY-B1789

    mAChR Neurological Disease
    Telenzepine is an antimuscarinic agent with Kis of 0.94 nM (M1 mAChR) and 17.8 nM (M2 mAChR) binding to muscarinic receptors. Telenzepine effectively blocks synaptic transmission promoted by muscarinic or M1 receptor agonists. Thus, Telenzepine can reduce the amplitude of extracellular slow excitatory postsynaptic potentials (EC50=38 nM) and slow inhibitory postsynaptic potentials (EC50=253 nM) .
    Telenzepine
  • HY-14563

    mAChR Neurological Disease
    VU10010 is a potent, highly selective and allosteric M4 mAChR potentiator with an EC50 of 400 nM. VU10010 binds to an allosteric site on M4 mAChR and increases affinity for acetylcholine and coupling to G proteins. VU10010 increases carbachol-induced depression of transmission at excitatory but not inhibitory synapses in the hippocampus .
    VU10010
  • HY-100781

    D-APB; D-2-Amino-4-phosphonobutyric acid

    iGluR Neurological Disease
    D-AP4 (D-APB; D-2-Amino-4-phosphonobutyric acid), a phosphono analogue of glutamate, is an NMDA broad spectrum excitatory amino acid receptor antagonist. D-AP4 also is an agonist for a quisqualate-sensitized AP6 site in hippocampus. D-AP4 inhibits AMPA receptor-stimulated 57Co 2+ influx in cultured cerebellar granule cells (IC50 ≥ 100 μM) .
    D-AP4
  • HY-W419700

    Endogenous Metabolite Neurological Disease
    L-Glutamic acid ammonium is an excitatory neurotransmitter .
    L-Glutamic acid ammonium
  • HY-P0275
    Proctolin
    1 Publications Verification

    Endogenous Metabolite Neurological Disease
    Proctolin is an endogenous pentapeptide that acts as an excitatory neuromodulator.
    Proctolin
  • HY-168771

    γDGG TFA; γ-D-Glutamylglycine TFA

    iGluR Neurological Disease
    gamma-DGG TFA is the antagonist for excitatory amino acid, that blocks NMDA-(HY-17551), Kainate-(HY-N2309) and Quisqualate-(HY-12597) induced depolarization, and antagonises the excitatory postsynaptic potential (e.p.s.p.) in rat hippocampal slices .
    gamma-DGG TFA
  • HY-110175
    CX614
    1 Publications Verification

    iGluR Neurological Disease
    CX614 is a positive variant modulator of AMPA receptors that enhances excitatory postsynaptic potentials (amplitude and duration) by blocking and slowing the inactivation of responses to glutamate and automatically evokes excitatory postsynaptic currents in neuronal cultures. CX614 can be used in the study of psychiatric disorders such as depression .
    CX614
  • HY-136980

    Asp-Glu

    Endogenous Metabolite Neurological Disease
    Aspartylglutamate (Asp-Glu) is a dipeptide that exhibits excitatory activity, as it has been shown to depolarize CA1 pyramidal neurons and increase conductance in response to stimulation. Aspartylglutamate selectively binds to certain glutamate receptors and demonstrates potent effects in specific regions of the hippocampus, particularly in the stratum radiatum where it enhances excitatory neurotransmission.
    Aspartylglutamate
  • HY-12741
    LDN-212320
    5+ Cited Publications

    LDN-0212320; OSU-0212320

    EAAT Neurological Disease
    LDN-212320 (LDN-0212320) is a glutamate transporter (GLT-1)/excitatory amino acid transporter 2 (EAAT2) activator (at translational level). LDN-212320 (LDN-0212320) prevents nociceptive pain by upregulating astroglial GLT-1 expression in the hippocampus and ACC [1]
    LDN-212320
  • HY-10914
    UCPH-101
    1 Publications Verification

    EAAT Neurological Disease
    UCPH-101 is an excitatory amino acid transporter subtype 1 (EAAT1) inhibitor with an IC50 of 0.66 μM.
    UCPH-101
  • HY-114381

    EAAT Neurological Disease
    GT 949 is a selective excitatory amino acid transporter-2 (EAAT2) positive allosteric modulator with an EC50 of 0.26 nM .
    GT 949
  • HY-103176

    Adenosine Receptor Others
    PSB11 hydrochloride is an antagonist with reverse excitatory activity for human A3 Adenosine Receptor with high affinity (Ki=2.3 nM) .
    PSB11 hydrochloride
  • HY-101352

    Cholecystokinin Receptor Neurological Disease
    LY 225910 is a selective antagonist for cholecystokinin receptor (CCK2 receptor), which affects the excitatory response to morphine, and leads to morphine sensitization .
    LY 225910
  • HY-N14867

    Complestatin A

    Others Neurological Disease
    Neuroprotectin A (Complestatin A) is a cyclopeptide. Neuroprotectin A has the function of protecting chicken brain neuron culture from excitatory toxicity induced by glutamate and red alginate .
    Neuroprotectin A
  • HY-N14868

    Others Neurological Disease
    Neuroprotectin B is a cyclopeptide. Neuroprotectin B has the function of protecting chicken brain neuron culture from excitatory toxicity induced by glutamate and red alginate .
    Neuroprotectin B
  • HY-B0649S1

    GABA Receptor Endogenous Metabolite Neurological Disease
    Propofol-d18 is the deuterium labeled Propofol. Propofol potently and directly activates GABAA receptor and inhibits glutamate receptor mediated excitatory synaptic transmission .
    Propofol-d18
  • HY-108576

    DuP 996 dihydrochloride

    TRP Channel Neurological Disease
    Linopirdine dihydrochloride is a agonist of capsaicin receptor TRPV1. Linopirdine increases the intracellular calcium concentration in HEK293 cells. Linopirdine dihydrochloride exerts an excitatory action on mammalian nociceptors .
    Linopirdine dihydrochloride
  • HY-100815B

    (±)-AMPA

    iGluR Neurological Disease
    (RS)-AMPA ((±)-AMPA) is a glutamate analogue and a potent and selective excitatory neurotransmitter L-glutamic acid agonist. (RS)-AMPA does not interfere with binding sites for kainic acid or NMDA receptors .
    (RS)-AMPA
  • HY-100815D

    (±)-AMPA monohydrate

    iGluR Neurological Disease
    (RS)-AMPA ((±)-AMPA) monohydrate is a glutamate analogue and a potent and selective excitatory neurotransmitter L-glutamic acid agonist. (RS)-AMPA monohydrate does not interfere with binding sites for kainic acid or NMDA receptors .
    (RS)-AMPA monohydrate
  • HY-100815E

    (±)-AMPA hydrochloride

    iGluR Neurological Disease
    (RS)-AMPA ((±)-AMPA) hydrochloride is a glutamate analogue and a potent and selective excitatory neurotransmitter L-glutamic acid agonist. (RS)-AMPA hydrobromide does not interfere with binding sites for kainic acid or NMDA receptors .
    (RS)-AMPA hydrochloride
  • HY-107498

    iGluR Neurological Disease
    GNE-8324 is a selective GluN2A positive allosteric modulator. GNE-8324 selectively enhances NMDA receptor (NMDAR)-mediated synaptic responses in inhibitory but not excitatory neurons .
    GNE-8324
  • HY-131039

    MDNI-glu

    Amino Acid Derivatives Others
    MDNI-caged-L-glutamate (MDNI-glu) is a biologically inert, photosensitive derivative of the major excitatory amino acid, L-glutamate. MDNI-caged-L-glutamate makes more efficient use of incident light .
    MDNI-caged-L-glutamate
  • HY-100785A

    γDGG acetate; γ-D-Glutamylglycine acetate

    iGluR Neurological Disease
    gamma-DGG acetate (γDGG acetate) is a competitive AMPA receptor blocker. gamma-DGG acetate is also a reversible Excitatory post-synaptic potentials (e.p.s.p.s) antagonist .
    gamma-DGG acetate
  • HY-B0649S

    GABA Receptor Endogenous Metabolite Neurological Disease
    Propofol-d17 is the deuterium labeled Propofol. Propofol potently and directly activates GABAA receptor and inhibits glutamate receptor mediated excitatory synaptic transmission. Propofol has antinociceptive properties .
    Propofol-d17
  • HY-100815C

    (±)-AMPA hydrobromide

    iGluR Neurological Disease
    (RS)-AMPA ((±)-AMPA) hydrobromide is a glutamate analogue and a potent and selective excitatory neurotransmitter L-glutamic acid agonist. (RS)-AMPA hydrobromide does not interfere with binding sites for kainic acid or NMDA receptors .
    (RS)-AMPA hydrobromide
  • HY-138903
    L-Homocysteic acid
    1 Publications Verification

    L-HCA

    iGluR Neurological Disease
    L-Homocysteic acid (L-HCA) is an endogenous excitatory amino acid that acts as a NMDA receptor agonist (EC50: 14 μM). L-Homocysteic acid is neurotoxic, and can be used in the research of neurological disorders .
    L-Homocysteic acid
  • HY-19465

    iGluR Neurological Disease
    Dasolampanel is a kainate receptor antagonist that helps regulate the excitability of the nervous system by blocking kainate receptors and reducing glutamate-mediated excitatory transmission. Dasolampanel can be used in the study of diseases such as overexcitement and sleep disorders .
    Dasolampanel
  • HY-162117

    mGluR Neurological Disease
    LBG30300 is a subtype-selective mGlu2 receptor agonist EC50 0.6 nM. LBG30300 is blood-brain barrier permeable .
    LBG30300
  • HY-Y0966S10

    Isotope-Labeled Compounds Endogenous Metabolite iGluR Cancer
    Glycine-d3 is the deuterium labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.
    Glycine-d3
  • HY-Y0966S8

    Endogenous Metabolite iGluR Neurological Disease
    Glycine-d5 is the deuterium labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.
    Glycine-d5
  • HY-Y0966S1

    Isotope-Labeled Compounds Endogenous Metabolite iGluR Neurological Disease
    Glycine-d2 is the deuterium labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.
    Glycine-d2
  • HY-Y0966S

    Endogenous Metabolite iGluR Neurological Disease
    Glycine- 15N is the 15N-labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors .
    Glycine-15N
  • HY-Y0966S3

    Isotope-Labeled Compounds Endogenous Metabolite iGluR Neurological Disease
    Glycine- 13C2 is the 13C-labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.
    Glycine-13C2
  • HY-107522
    DL-TBOA
    1 Publications Verification

    EAAT Neurological Disease
    DL-TBOA is a potent non-transportable inhibitor of excitatory amino acid transporters with IC50s of 70 μM, 6 μM and 6 μM for excitatory amino acid transporter-1 (EAAT1), EAAT2 and EAAT3, respectively. DL-TBOA inhibits the uptake of [ 14C]glutamate in COS-1 cells expressing the human EAAT1 and EAAT2 with Ki valuesof 42 μM and 5.7 μM, respectively. DL-TBOA blocks EAAT4 and EAAT5 in a competitive manner with Ki values of 4.4 μM and 3.2 μM, respectively .
    DL-TBOA
  • HY-Y0966S2

    Endogenous Metabolite iGluR Neurological Disease
    Glycine-2- 13C is the 13C-labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.
    Glycine-2-13C
  • HY-Y0966S4

    Endogenous Metabolite iGluR Neurological Disease
    Glycine-1- 13C is the 13C-labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.
    Glycine-1-13C
  • HY-P3280

    Endogenous Metabolite Metabolic Disease
    γ-Glu-Gly, a γ-glutamyl dipeptide, is a human lipid metabolite.γ-Glu-Gly has a similar structure to GABA (γ-aminobutyric acid) and can act as an antagonist of excitatory amino acids .
    γ-Glu-Gly
  • HY-B0649R

    2,6-Diisopropylphenol (Standard)

    Reference Standards GABA Receptor Endogenous Metabolite Neurological Disease Cancer
    Propofol (Standard) is the analytical standard of Propofol. This product is intended for research and analytical applications. Propofol potently and directly activates GABAA receptor and inhibits glutamate receptor mediated excitatory synaptic transmission. Propofol has antinociceptive properties and is used for sedation and hypnotic .
    Propofol (Standard)
  • HY-107522B

    EAAT Neurological Disease
    DL-TBOA ammonium is a potent non-transportable inhibitor of excitatory amino acid transporters with IC50s of 70 μM, 6 μM and 6 μM for excitatory amino acid transporter-1 (EAAT1), EAAT2 and EAAT3, respectively. DL-TBOA ammonium inhibits the uptake of [ 14C]glutamate in COS-1 cells expressing the human EAAT1 and EAAT2 with Ki valuesof 42 μM and 5.7 μM, respectively. DL-TBOA ammonium blocks EAAT4 and EAAT5 in a competitive manner with Ki values of 4.4 μM and 3.2 μM, respectively .
    DL-TBOA ammonium
  • HY-P3280A

    Endogenous Metabolite Metabolic Disease
    γ-Glu-Gly TFA, a γ-glutamyl dipeptide, is a human lipid metabolite.γ-Glu-Gly TFA has a similar structure to GABA (γ-aminobutyric acid) and can act as an antagonist of excitatory amino acids .
    γ-Glu-Gly TFA

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