Search Result
Results for "
cationic lipid
" in MedChemExpress (MCE) Product Catalog:
62
Biochemical Assay Reagents
3
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-134780
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Liposome
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Others
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L-369 is an ionizable cationic lipid that can be used to synthesize lipid nanoparticles and deliver mRNA .
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- HY-160908
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Liposome
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Others
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Lipid 88 is an ionizable cationic lipid. Lipid 88 can be used to synthesize lipid nanoparticles and deliver mRNA .
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-
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- HY-159709
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Liposome
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Others
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VL-422 is an ionizable cationic lipid that can be used for lipid nanoparticle (LNP) and drug delivery research .
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- HY-157252
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Liposome
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Cancer
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CL4F8-6 is an ionizable cationic lipid with a pKa of 6.14. CL4F8-6 can be used in lipid nanoparticles (LNPs)-based mRNA therapeutics .
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-
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- HY-159854
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Liposome
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Cancer
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C14-O2 is an ionizable cationic lipid that can be used to synthesize lipid nanoparticles (LNP) for delivering mRNA and other payloads .
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-
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- HY-168370
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-
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- HY-142999
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-
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- HY-168775
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Biochemical Assay Reagents
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Others
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Lipid 29d is an unsaturated ionizable cationic lipid that can be utilized in the formation of lipid nanoparticles and the delivery of mRNA .
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-
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- HY-159862
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Liposome
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Infection
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IM21.7c is a cationic lipid that can be used to synthesize lipid nanoparticles (LNP) for delivering mRNA and other payloads .
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-
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- HY-159853
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Liposome
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Inflammation/Immunology
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C14-A1 is an ionizable cationic lipid that can be used to synthesize lipid nanoparticles (LNP) for delivering mRNA and other payloads .
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-
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- HY-160553
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Liposome
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Others
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9322-O16B, an ionizable cationic lipid, is used for LNP generation .
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- HY-172344
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Biochemical Assay Reagents
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Others
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DB-lipidoid 11-10-8 is an ionizable cationic lipid (pKa = 6.22). DB-lipidoid 11-10-8 can be used in lipid nanoparticle (LNP) studies for in vivo delivery of mRNA .
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-
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- HY-112754A
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1,2-Dioleoyl-3-trimethylammonium-propane chloride
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Liposome
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Cancer
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DOTAP chloride is a useful and effective cationic lipid for transient and stable transfection DNA (plasmids, bacmids) and modified nucleic acids (antisense oligonucleotides) with out the use of helper lipid .
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-
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- HY-171114
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Liposome
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Others
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DMT7 is an ionizable cationic lipid (pKa = 6.5) that can be used to generate lipid nanoparticles (LNPs) for delivery of mRNA and anticancer drugs in the body .
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-
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- HY-W800776
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1,2-Dioleoyl-3-dimethyl-hydroxyethylammonium bromide
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Liposome
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Others
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DORI is a cationic lipid that can deliver plasmid DNA in vitro. DORI has lower cytotoxicity and high transfection efficiency .
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- HY-129990
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Liposome
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Cancer
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Dios-Arg diTFA, a cationic lipid with an arginine-bearing headgroup, shows obvious double bond proton signals at around 5.2-5.3 ppm. Dios-Arg diTFA is used, coupled to DOPE, to bind siRNA and plasmid to for cationic LNPs for intracellular transport .
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-
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- HY-154804
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Liposome
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Others
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DLin-M-C4-DMA (Compound MC4) is a cationic lipid. DLin-M-C4-DMA can be used for delivery of nucleic acids .
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-
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- HY-125734
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Liposome
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Others
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DMHAPC-Chol, a cationic lipid, contains a biodegradable carbamoyl linker and a hydroxyethyl group in the polar amino head moiety. DMHAPC-Chol can be used in both transfection experiments concerning plasmids or siRNA .
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- HY-W800782
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Liposome
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Others
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DC-6-14 is a cationic lipid with gene transfection activity, which can be used for the synthesis of liposomes .
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- HY-139305
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Liposome
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Cancer
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CL4H6 is a pH-sensitive cationic lipid. CL4H6 is the main component of lipid nanoparticles (LNPs), which can be used to target and deliver siRNA, and induces a potent gene-silencing response .
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- HY-165427
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Liposome
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Cancer
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Lipid 11 (Compound Lipid 1) is a cationic lipid for nucleic acid delivery. Lipid 11 forms lipid nanoparticles (LNPs) through electrostatic binding with nucleic acids (such as ceDNA). Lipid 11 forms complexes with negatively charged nucleic acids via cationic amine groups, which can be endocytosed by cells to release nucleic acids for activity. Lipid 11 is promising for research of gene therapy drug delivery systems .
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- HY-168776
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Biochemical Assay Reagents
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Others
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(S)-C12-200 is the (S)-isomer of C12-200 (HY-145405), an ionizable cationic lipid and helper lipid. (S)-C12-200 can be utilized in the formation of lipid nanoparticles and mRNA delivery .
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- HY-172535
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Lipase
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Inflammation/Immunology
Cancer
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Lipid OA2 dihydrochloride is an ionizable cationic lipid that can be used to prepare single-component lipid nanoparticles for siRNA delivery. Lipid OA2 dihydrochloride can effectively deliver SOCS1-siRNA to dendritic cells, silence the SOCS1 gene, and enhance their antigen-presenting ability and pro-inflammatory factor secretion capacity .
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- HY-143688
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Liposome
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Others
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EDMPC, a cationic lipid, has an enhanced ability to deliver DNA to pulmonary tissues. EDMPC mediates intralobar DNA delivery to rodents .
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- HY-171019
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Biochemical Assay Reagents
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Others
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Lipid 119-23 is an ionizable cationic lipid which can be utilized in the formation of lipid nanoparticles and the delivery of mRNA. Lipid 119-23 exhibits an enhanced capability to express functional mCre in several categories of immune cells, spanning the liver, spleen and lung .
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- HY-144014
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Liposome
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Cancer
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MVL5 is a non-degradable multivalent cationic lipid. MVL5 is a highly efficient vector for both DNA and siRNA. MVL5 can be used in breast cancer research .
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- HY-172328
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Liposome
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Cancer
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O12-D3-I3 is an ionizable cationic lipid. O12-D3-I3 can be used in the generation of lipid nanoparticles (LNPs) for siRNA delivery in vitro and in vivo. LNPs containing O12-D3-I3 enhances LNP endosomal escape for ferroptosis RNAi therapy of cancer .
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- HY-153125
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Liposome
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Others
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DLRIE is a cationic lipid that can be used for the synthesis of liposome GAP-DLRIE. GAP-DLRIE can be used to enhance the delivery and expression of plasmid DNA. DLRIE can be used for delivery of nucleic acids .
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- HY-138912
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Liposome
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Others
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Cho-Arg TFA is a steroid-based cationic lipid with an L-Arginine headgroup. Cho-Arg TFA shows a remarkably high optimized plasmid DNA transfection efficacy .
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- HY-W409806
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Liposome
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Inflammation/Immunology
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Cholesterylamine is a cationic lipid. Cholesterylamine can be added to the PLGA to prepare PLGA particle having surface charge. Cholesterylamine can be used for drug delivery. Cholesterylamine can be used for autoimmune diseases and allergy research .
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- HY-130751
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DODAP
1 Publications Verification
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Liposome
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Inflammation/Immunology
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DODAP is a cationic lipid utilized as the lipid component in liposomes (pKa = 5.59 in TNS binding tests). DODAP is employed for encapsulating siRNA and delivering immunostimulated chemotherapeutic agents both in vitro and in vivo. DODAP holds great promise for research in vaccines and inflammation .
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- HY-160275
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Liposome
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Others
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DOPE-PEG-Fluor 555,MW 2000 is a PEG-lipid-dye conjugate featuring a DOPE phospholipid and a Fluor 555 dye. DOPE (HY-112005) is a neutral helper lipid for cationic liposome. Fluor 555 is a fluorescent dye .
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- HY-143702
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NBD-DOTAP
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Fluorescent Dye
Liposome
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Inflammation/Immunology
Cancer
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Fluorescent DOTAP (NBD-DOTAP) is a cationic lipid which can be used for nucleic acid and protein delivery. Fluorescent DOTAP is labeled with a fluorophore NBD (maximum excitation/emission wavelength ∼463/536 nm). Fluorescent DOTAP can be used for gene delivery systems, drug delivery, as well as cell imaging and nanocarrier tracking. Fluorescent DOTAP is an ideal candidate for both biological and pharmaceutical formulation (e.g. co-delivery of vaccines) research .
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- HY-160852
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Liposome
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Inflammation/Immunology
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YSK 12C4 is an ionizable cationic lipid primarily used to enhance siRNA cellular delivery via multifunctional envelope-type nanodevices (MEND). YSK 12C4 promotes siRNA uptake and endosomal escape, effectively silencing genes in human immune cell lines .
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- HY-139200
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DOTMA
1 Publications Verification
|
Liposome
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Others
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DOTMA is a cationic lipid that has been used as a non-viral vector for gene therapy. DOTMA is used as a component of liposomes to encapsulate siRNA, microRNA, and oligonucleotides and for in vitro gene transfection. DOTMA promotes effective interaction between liposomes and cell membranes by inducing positive charge on the liposomes. DOTMA showed good gene transfection effect both in vitro and in vivo .
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- HY-W414069
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Endogenous Metabolite
Liposome
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Others
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Thiocholesterol is a member of the class of cholesteric liquid crystals (CLCs) that can be used to synthesis cationic lipid. Thiocholesterol is a stronger stabilizer of silver nanoparticles (SNPs). Thiocholesterol can be used for plasma membrane research and drug delivery .
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- HY-159861
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Liposome
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Others
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Ionizable Lipid 4 is an ionizable cationic lipid and a rearrangement product of the cationic lipid CA-lipid 5 induced by hydrogen peroxide .
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- HY-147087
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Liposome
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Cancer
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YSK 05 is a pH-sensitive cationic lipid. YSK 05 improves the intracellular trafficking of non-viral vectors. YSK 05-MEND shows significantly good gene silencing activity and hemolytic activity. YSK 05 overcomes the suppression of endosomal escape by PEGylation. YSK 05 effectively enhances siRNA delivery both in vitro and in vivo .
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- HY-168777
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Liposome
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Others
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Lipid 7-1 is an ionizable cationic lipid that can be used for the preparation of liposomes .
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- HY-112005
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DOPE
3 Publications Verification
Dioleoylphosphatidylethanolamine; 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine
|
Liposome
Endogenous Metabolite
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Inflammation/Immunology
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DOPE (Dioleoylphosphatidylethanolamine) is a neutral helper lipid for cationic liposome and combines with cationic phospholipids to improve transfection efficiency of naked siRNA .
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- HY-159735
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Liposome
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Others
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Lipid 23 is an ionizable cationic amino lipid that can be used to generate lipid nanoparticles (LNP). Lipid 23 can be used for mRNA delivery .
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- HY-46760
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Liposome
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Others
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CCD Lipid01 is a cationic lipid used in the delivery of biologically active agents to cells and tissues .
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- HY-145739
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- HY-149156
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Liposome
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Cancer
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Lipid C24 is a cationic ionizable lipid that can be used for synthesizing lipid nanoparticles. Lipid C24 can be used in the study of drug delivery .
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- HY-144025
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Liposome
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Others
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DOBAQ, a cationic lipid, is a pH-sensitive lipid. DOBAQ can be used for liposomes applied in drug delivery .
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- HY-112757
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DLinDMA
1 Publications Verification
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Liposome
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Others
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DLinDMA, a ionizable cationic lipid, is a key lipid component of stable nucleic acid lipid particles (SNALPs) as a benchmark. DLinDMA is used for siRNA delivery .
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- HY-112755
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Liposome
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Others
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DODMA is a cationic lipid that can be used to prepare lipid nanoparticles. DODMA can be used for drug delivery .
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- HY-W800783
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CDESA
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Liposome
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Others
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DSTAP chloride (CDESA) is a cationic lipid that used in the formation of lipid nanoparticles (LNPs). DORI chloride has high transfection efficiency .
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- HY-156985
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Isotope-Labeled Compounds
Liposome
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Others
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Lipid AX4 is an ionizable cationic lipid with the pKa of 6.89， and can be used the study for the formation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo .
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- HY-W590549
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DODAC
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Liposome
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Others
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Dioleyldimethylammonium chloride (DODAC) is a cationic lipid that can be used as transfection reagent .
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- HY-158796
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Liposome
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Others
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L202 is an ionizable cationic lipid (pKa=6.04) that can be used for the study of mRNA and lipid nanoparticles .
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- HY-156616
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Liposome
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Inflammation/Immunology
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VC1052 is a dialkoxypropylammonium-based material and is the core cationic lipid component of the cationic lipid adjuvant Vaxfectin (HY-142998). Vaxfectin consists of VC1052 and lipid DPyPE (HY-112766) in a 1:1 molar ratio. Vaxfectin can be used as a vaccine adjuvant for the preparation of plasmid DNA and protein vaccines .
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- HY-159725
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Liposome
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Others
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BAmP-O16B is an ionizable cationic amino lipid that can be used to generate lipid nanoparticles (LNPs) .
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- HY-153372
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Liposome
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Others
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93-O17S is a chalcogen-containing ionizable cationic lipid used for making lipid nanoparticles (LNPs).
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- HY-133952
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Liposome
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Cancer
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7-Oxotridecanedioic acid is a biodegradable cationic lipid intermediate compound for lipid nanoparticles formation. 7-Oxotridecanedioic acid can be incorporated into a lipid particle for delivering active agents .
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- HY-W590548
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Liposome
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Others
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ATX-001 is an ionizable cationic lipid. ATX-001 can be used in the formation of lipid nanoparticles (LNPs) for the delivery mRNA .
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- HY-W590532
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Liposome
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Others
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306-O12B is an ionizable cationic lipid used to prepare lipid nanoparticles (LNPs) for the delivery of mRNA .
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- HY-158867
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Liposome
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Infection
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DOSPA hydrochlorid is a frequently utilized cationic lipid in the generation of Lipid Nanoparticles (LNPs) for the development of mRNA vaccines, including the COVID-19 vaccine.
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- HY-145225
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Liposome
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Others
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DLin-K-C3-DMA, a cationic lipid, can be used in the synthesis of nucleic acid-lipid particle to delivery of nucleic acid .
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- HY-112523A
-
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Liposome
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Others
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DMTAP is a cationic lipid that can be used for delivery of DNA, RNAi and drugs .
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-
- HY-142996
-
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Liposome
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Cancer
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BGTC is a non-amino acid cationic lipid. BGTC can be used for delivery of nucleic acids .
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- HY-W590531
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- HY-176753
-
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Liposome
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Inflammation/Immunology
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Lipid 20b is a thiophene ionizable cationic lipid. Lipid 20 b can be used to generate lipid nanoparticles (LNPs) for the delivery of mRNA in vivo. Lipid 20b can be studied in research for enhancing mRNA vaccine delivery and transfection efficacy .
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- HY-151511
-
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Liposome
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Cancer
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A12-Iso5-2DC18, an ionizable cationic lipid, is a potent mRNA delivery lipid vehicle .
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- HY-144021
-
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Liposome
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Others
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14:0 EPC chloride is an acyl cationic lipid that can be used for liposomes applied in drug delivery .
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- HY-159726
-
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Liposome
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Others
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C10-200 is an ionizable cationic lipid that can be used to generate lipid nanoparticles (LNPs). C10-200 is used in the study of mRNA delivery .
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- HY-156448
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80-O14B
1 Publications Verification
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Liposome
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Cancer
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80-O14B is an cationic lipid-like compound for mRNA delivery .
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- HY-144022
-
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Liposome
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Others
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16:0 DAP is a cationic lipids that can be used for drug delivery, gene transfection and vaccine delivery .
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-
- HY-112251
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D-Lin-MC3-DMA
Maximum Cited Publications
96 Publications Verification
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Liposome
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Cancer
|
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D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle.
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- HY-148830
-
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Liposome
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Others
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Piperazine-bis(ethyl octadeca-9,12-dienoate) is a cationic lipid extracted from patent WO2023036148A1, and can be used for the generation of Lipid nanoparticles (LNPs).
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- HY-144023
-
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Liposome
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Others
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16:0-18:1 EPC chloride is a cationic lipid, which can be used for liposomes applied in drug delivery .
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- HY-112005GL
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Dioleoylphosphatidylethanolamine (GMP Like); 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (GMP Like)
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Liposome
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Inflammation/Immunology
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DOPE (GMP Like) is the GMP Like class DOPE (HY-112005), and can be used as pharmaceutical excipients. DOPE is a neutral helper lipid for cationic liposome and combines with cationic phospholipids to improve transfection efficiency of naked siRNA .
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- HY-143210
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Liposome
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Metabolic Disease
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Transfectam is a cationic lipid able to interact with DNA to form complexes that mediate efficient gene transfer into various eukaryotic cells .
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- HY-171113
-
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Liposome
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Cancer
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CP-LC-1143 is an ionizable cationic amino lipid efficient delivery of different kinds of RNA (mRNA, cRNA and saRNA).
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- HY-W800825
-
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Liposome
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Cancer
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Octadecanedioic Acid Mono-L-carnitine ester is a cationic lipid which may be used in combination with other lipids in the formation of lipid nanoparticles (LNPs). Its terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. HATU) to form a stable amide bond.
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- HY-172014
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Liposome
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Cancer
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CP-LC-0743 is an ionizable cationic amino lipid efficient delivery of different kinds of RNA (mRNA, cRNA and saRNA) .
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- HY-172016
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Liposome
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Cancer
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CP-LC-0867 is an ionizable cationic amino lipid efficient delivery of different kinds of RNA (mRNA, cRNA and saRNA) .
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- HY-172017
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Liposome
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Cancer
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CP-LC-1254 is an ionizable cationic amino lipid efficient delivery of different kinds of RNA (mRNA, cRNA and saRNA) .
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- HY-172015
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Liposome
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Cancer
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CP-LC-1143 is an ionizable cationic amino lipid efficient delivery of different kinds of RNA (mRNA, cRNA and saRNA) .
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- HY-172018
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Liposome
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Cancer
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CP-LC-0729 is an ionizable cationic amino lipid efficient delivery of different kinds of RNA (mRNA, cRNA and saRNA) .
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- HY-172329
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Liposome
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Others
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Q1-ALC-0315 iodide is a cationic quaternary ammonium lipid derivative of the ionizable cationic lipid ALC-0315 (HY-138170). Q1-ALC-0315-based LNPs can be used for lung-targeted mRNA delivery, which demonstrates high-performing firefly luciferase protein expression in the lungs .
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- HY-156936
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Liposome
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Others
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RCB-02-4-8 is an ionizable cationic lipid that is used to form lipid nanoparticles (LNPs) to deliver mRNA. RCB-02-4-8 can improve the efficiency of lung transfection in mice .
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- HY-134541
-
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Liposome
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Infection
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SM-102 is an amino cationic lipid useful in the formation of lipid nanoparticles (LNPs). SM-102 has higher transfection efficiency. SM-102 plays an important role in the effectiveness of lipid nanoparticles (LNPs) in delivering mRNA therapeutics and vaccines .
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- HY-153737
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Liposome
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Others
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113-N16B is an ionizable cationic lipid used for the generation of lipid nanoparticles (LNPs). 113-N16B delivers mRNA preferentially to pulmonary endothelial cells.
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- HY-W598178
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Liposome
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Others
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93-O17O is a chalcogen-containing ionizable cationic lipidoid that used in the formation of lipid nanoparticles (LNPs) .
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- HY-144020
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Liposome
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Others
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14:0 DAP (1,2-dimyristoyl-3-dimethylammonium-propane ) is a cationic lipid that can be used for drug delivery .
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- HY-112755A
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(R)-DODMA
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Liposome
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Metabolic Disease
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1,2(R)-Dioleyloxy-3-dimethylamino-propane ((R)-DODMA) is an ionizable cationic lipid and an isomer of DODMA (HY-112755).
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- HY-172336
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Liposome
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Inflammation/Immunology
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4-O10b1 is an ionizable cationic lipid. 4-O10b1 can be used to prepare lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo .
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- HY-112763
-
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Liposome
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Inflammation/Immunology
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CLinDMA, a cationic lipid, can cause inflammatory response. CLinDMA can be used for the synthesis LNP201. LNP201 is a liposome assembly for systemic delivery of siRNA .
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- HY-159869
-
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Liposome
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Others
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G0-C14 analog is a G0-C14 derivative. G0-C14 is an ionizable cationic lipid that can be used to synthesize lipid nanoparticles (LNP) .
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- HY-149037
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N4-Spermine cholesteryl carbamate
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Liposome
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Others
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GL67 (N4-Spermine cholesteryl carbamate) is a cationic lipid. GL67 can be used for nucleic acid agents and vaccines delivery, and gene transfection .
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- HY-149037A
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N4-Spermine cholesteryl carbamate pentahydrochloride
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Liposome
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Others
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GL67 (N4-Spermine cholesteryl carbamate) (pentahydrochloride) is a cationic lipid. GL67 can be used for nucleic acid agents and vaccines delivery, and gene transfection .
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- HY-158705
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Others
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Others
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SAINT-2 is a cationic lipid with gene transfection activity and is a pyridyl lipid analog. Molecular membranes prepared by SAINT-2 can interact with plasmids to form lipid complexes. After the complex is taken up by cells, the plasmid dissociates from the lipid complex under the action of DOPE and the plasmid translocates across the endosome and/or nuclear membrane. Thus, SAINT-2 effectively transfers small oligonucleotides into cells .
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- HY-172335
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Liposome
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Others
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C9-200 is an ionizable cationic lipid that has been used in the formation of lipid nanoparticles (LNPs). C9-200-based LNPs encapsulating mRNA encoding erythropoietin (EPO) can induced EPO production and stimulate red blood cell production in mice .
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- HY-159859
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Liposome
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Others
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IZ-Chol (IZ-Cholesterol) is an ionizable cationic lipid containing cholesterol. IZ-Chol-LNPs is highly potential to effectively complex with DNA, and endosome escape mechanisms mediated by proton sponge effect .
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- HY-142654
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Liposome
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Others
|
|
ATX-002 is an ionizable cationic lipid for RNA drug delivery. The calculated pKa (c-pKa) and measured pKa values for ATX-002 are 8.68 and 6.03, respectively .
|
-
- HY-W440681
-
|
|
Liposome
|
Others
|
|
C13-112-tri-tail is a cationic lipid-like compound containing a polar amino alcohol head group, three hydrophobic carbon-13 tails, and a PEG2 linker. C13-112-tri-tail can be formulated into a lipid nanoparticle (LNP).
|
-
- HY-W440684
-
|
|
Liposome
|
Others
|
|
C13-113-tetra tail is a cationic lipid-like compound containing a polar amino alcohol head group, four hydrophobic carbon-13 tails, and a tertiary amine linker. C13-113-tetra tail can be formulated into a lipid nanoparticle (LNP).
|
-
- HY-W440683
-
|
|
Liposome
|
Others
|
|
C13-112-tetra-tail is a cationic lipid-like compound containing a polar amino alcohol head group, four hydrophobic carbon-13 tails, and a PEG2 linker. C13-112-tetra-tail can be formulated into a lipid nanoparticle (LNP).
|
-
- HY-W440682
-
|
|
Liposome
|
Others
|
|
C13-113-tri tail is a cationic lipid-like compound containing a polar amino alcohol head group, three hydrophobic carbon-13 tails, and a tertiary amine linker. C13-113-tri tail can be formulated into a lipid nanoparticle (LNP).
|
-
- HY-138913
-
|
|
Liposome
|
Cancer
|
|
2H-Cho-Arg (TFA) is a steroid-based cationic lipid that contains a 2H-cholesterol skeleton coupled to an L-arginine head group and can be used to facilitate gene transfection.
|
-
- HY-158709
-
|
|
Biochemical Assay Reagents
Liposome
|
Others
|
|
Cho-es-Lys is a cationic lipid synthesized by coupling natural cholesterol and amino acids, which has high gene transfection efficiency. Cho-es-Lys can be used in drug delivery research .
|
-
- HY-112754AGL
-
|
1,2-Dioleoyl-3-trimethylammonium-propane chloride (GMP Like)
|
Liposome
|
Others
|
|
DOTAP chloride (GMP Like) is the GMP Like class DOTAP chloride (HY-112754A). DOTAP chloride is a cationic lipid with good membrane fusion ability and biocompatibility. DOTAP chloride (GMP Like) can be used as an excipient for transient and stable transfection DNA (plasmids, bacmids) and modified nucleic acids (antisense oligonucleotides) without the use of helper lipid .
|
-
- HY-159860
-
|
|
Liposome
|
Others
|
|
IR-117-17 is an ionizable cationic amino lipid, targeting the conducting airways. IR-117-17 could be degraded via esterase cleavage and thus be unlikely to accumulate upon repeated dosing .
|
-
- HY-171897
-
|
|
Liposome
|
Inflammation/Immunology
Cancer
|
|
E10i-494 is an ionizable cationic branched endosomal disruptor (BEND) lipid. E10i-494 can be used to generate lipid nanoparticles (LNPs) for mRNA delivery in vitro. E10i-494 can enhance transfection efficiency .
|
-
- HY-171900
-
|
|
Liposome
|
Inflammation/Immunology
|
|
Lipid 114 is an ionizable cationic lipid with a pKa of approximately 6.8. Lipid 114 can be used to generate lipid nanoparticles (LNP) to deliver siRNA in vitro as well as in vivo. Lipid 114 LNPs encapsulating siRNA that targets IL-1β can reduce IL-1β expression in macrophages. Lipid 114 LNPs encapsulating siRNA that targets IL-1β also reduces hepatic and renal expression of IL-1β, as well as decreasing hepatic inflammation in mouse model with LPS-induced acute liver failure .
|
-
- HY-W590681
-
|
|
Liposome
|
Others
|
|
113-O12B is a disulfide bond-containing ionizable cationic lipidoid. 113-O12B can be used in that generation of lipid nanoparticles (LNPs) for the delivery of mRNA .
|
-
- HY-W590679
-
|
|
Liposome
|
Others
|
|
113-O16B is a disulfide bond-containing ionizable cationic lipidoid. 113-O16B has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA .
|
-
- HY-134541A
-
|
|
Liposome
|
Infection
|
|
SM-102 (Excipient, GMP Like) is the GMP Like class SM-102 (HY-134541), and can be used as pharmaceutical excipients. SM-102 is an amino cationic lipid useful in the formation of lipid nanoparticles (LNPs). SM-102 (Excipient, GMP Like) has higher transfection efficiency. SM-102 (Excipient, GMP Like) plays an important role in the effectiveness of lipid nanoparticles (LNPs) in delivering mRNA therapeutics and vaccines .
|
-
- HY-160552
-
|
|
Liposome
|
Others
|
|
244cis, a piperazine-containing ionizable cationic lipid, has been used to generate lipid nanoparticles (LNPs). LNPs containing 244cis and coated with mRNA reporter gene were specifically accumulated in mouse lungs compared with LNPs containing SM-102. Induces a decrease in serum chemokine (C-C motif) ligand 2 (CCL2) levels .
|
-
- HY-144016
-
|
|
Liposome
|
Others
|
|
16:0 EPC chloride, a P-O-ethyl derivative, is a saturated cationic lipid. 16:0 EPC chloride can serve as a DNA and RNA transfecting agent. 16:0 EPC chloride can be used as a co-adjuvant for preparing vaccines and promote drug delivery .
|
-
- HY-145405
-
|
|
Liposome
|
Others
|
|
C12-200 is a type of ionizable cationic lipid and helper lipid commonly used for mRNA delivery. In the hemophilia B mouse model, mRNA encoding human erythropoietin (EPO) and coagulation factor IX (FIX) can be successfully delivered and expressed using C12-200. C12-200 is utilized in research related to hemophilia B .
|
-
- HY-169478
-
|
|
Liposome
|
Cancer
|
|
Lipid N2-3L is an ionizable cationic lipid (pKa = 8.99) that can be used to generate supramolecular lipid nanoparticles (SMLNPs) for mRNA delivery. Lipid nanoparticles formed by encapsulating a luciferase reporter gene with Lipid N2-3L were detected to accumulate in the lymph nodes of mice, indicating that they can effectively enter the mouse immune system. Lipid nanoparticles formed by encapsulating ovalbumin mRNA and the TLR7/8 agonist Resiquimod (HY-13740) with Lipid N2-3L were able to reduce tumor volume and increase survival in the MC-38-OVA mouse colon cancer model. Lipid N2-3L can be used in the research of drug delivery for cancer-related therapies .
|
-
- HY-171896
-
|
|
Liposome
|
Inflammation/Immunology
Cancer
|
|
A28-C6B2 is an ionizable cationic lipid with a pKa of 6.43, and can be used to generate lipid nanoparticles (LNPs) for mRNA delivery in vivo. A28-C6B2 can be studied in research for enhancing the selective delivery of mRNA to the spleen, particularly to antigen-presenting cells .
|
-
- HY-159700
-
|
|
Liposome
|
Infection
|
|
AA3-DLin is an ionizable cationic lipid with a pKa value of 5.8. AA3-DLin is used to delivery mRNA combined with lipid nanoparticles (LNPs). AA3-DLin LNP COVID-19 vaccines encapsulating SARS CoV-2 spike mRNAs successfully induces strong immunogenicity in a BALB/c mouse model .
|
-
- HY-112758
-
|
|
Liposome
|
Others
|
|
DLin-KC2-DMA is an ionisable cationic lipid (pKa≈6) that is virtually non-toxic to antigen presenting cells (APCs). DLin-KC2-DMA produces significant siRNA-mediated gene silencing of GAPDH, when binds to lipid nanoparticles (LNP). DLin-KC2-DMA can be used in siRNA delivery studies .
|
-
- HY-113217
-
|
|
Liposome
Endogenous Metabolite
|
Metabolic Disease
Cancer
|
|
Cholesteryl oleate is an ester compound formed from Cholesterol (HY-N0322) and Oleic acid (HY-N1446), which is involved in lipid transport, storage and cell membrane formation in living organisms. Cholesteryl oleate may serve as a potential biomarker for prostate cancer. Cholesteryl oleate can also prepare cationic solid lipid nanoparticles (SLNs) for efficient gene silencing .
|
-
- HY-112251S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
D-Lin-MC3-DMA- 13C3 is the 13C labeled D-Lin-MC3-DMA. D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle .
|
-
- HY-112251GL
-
|
|
Liposome
|
Cancer
|
|
D-Lin-MC3-DMA (GMP Like) is the GMP Like class D-Lin-MC3-DMA (HY-112251). D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle.
|
-
- HY-151512
-
-
- HY-142997
-
|
|
Liposome
|
Others
|
|
DOSPA is a cationicliposome. DOSPA can formulate with DNA to be a transfection system. DOSPA can be used for gene therapy research .
|
-
- HY-171904
-
|
|
Liposome
|
Others
|
|
BCP-NC2-C12 is an ionizable cationic lipid. BCP-NC2-C12 can be used to generate lipid nanoparticles (LNPs) for in vivo delivery of mRNA. BCP-NC2-C12 LNPs mediated an approximately 90% reduction in PCSK9 serum protein levels via CRISPR/Cas9 gene knockout .
|
-
- HY-152229
-
G0-C14
1 Publications Verification
|
Liposome
|
Cancer
|
|
G0-C14 is a cationic lipid-like compound alkyl-modified polyamidoamine (PAMAM) dendrimer. G0-C14 involves in the preparation of a series of macrophage-targeted nanoparticles (NPs). NPs can be used for agent and vaccine delivery .
|
-
- HY-113217S
-
|
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
|
Cholesteryl oleate-d7 is deuterium labeled Cholesteryl oleate. Cholesteryl oleate is an ester compound formed from Cholesterol (HY-N0322) and Oleic acid (HY-N1446), which is involved in lipid transport, storage and cell membrane formation in living organisms. Cholesteryl oleate may serve as a potential biomarker for prostate cancer. Cholesteryl oleate can also prepare cationic solid lipid nanoparticles (SLNs) for efficient gene silencing .
|
-
- HY-172332
-
|
|
Liposome
NF-κB
|
Cancer
|
|
H1L1A1B3 is an ionizable cationic lipid used in the formation of lipid nanoparticles (LNPs) for the delivery of circular RNA (circRNA). H1L1A1B3-LNPs demonstrates a fourfold increase in circRNA transfection efficiency in lung cancer cells over ALC-0315 (HY-138170). H1L1A1B3 can activate the NF-κB/IRF immune pathways .
|
-
- HY-113217S1
-
|
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
|
Cholesteryl oleate-d7-1 is deuterium labeled Cholesteryl oleate. Cholesteryl oleate is an ester compound formed from Cholesterol (HY-N0322) and Oleic acid (HY-N1446), which is involved in lipid transport, storage and cell membrane formation in living organisms. Cholesteryl oleate may serve as a potential biomarker for prostate cancer. Cholesteryl oleate can also prepare cationic solid lipid nanoparticles (SLNs) for efficient gene silencing .
|
-
- HY-112766
-
|
|
Liposome
|
Others
|
|
DPyPE is a neutral phosphatidylethanolamine lipid composed of a polyisoprene alkyl chain with two pyridine-containing phosphine ligands. DPyPE is mainly used in liposome formulations and to enhance the efficiency of gene delivery in vitro and in vivo. For example, DPyPE can be mixed with cationic lipids such as VC1052 (HY-156616) (in a 1:1 ratio) to form the vaccine adjuvant Vaxfectin (HY-142998). DPyPE assists VC1052 in binding to negatively charged pDNA to form a uniform liposome complex by regulating the fluidity and stability of the liposome membrane .
|
-
- HY-165604
-
|
|
Liposome
|
Others
|
C14-490, an ionizable cationic lipid (pKa = 5.94), is used for the synthesis of lipid nanoparticles (LNPs). C14-490 LNPs is used as the basis for subsequent study of in utero gene editing in HSCs. C14-490 LNPs are used to encapsulate SpCas9 mRNA and TTR sgRNA using optimized B5 formulation parameters and surface conjugation to CD45 antibody F(ab’)2 fragments-Systematically optimized Targeted Editing Machinery LNPs (STEM LNPs) .
|
-
- HY-131119
-
|
Dioctadecyldimethylammonium bromide; DODAB
|
Liposome
|
Others
|
|
Dimethyldioctadecylammonium bromide is a synthetic cationic lipid commonly used in gene delivery and vaccine development. Also known as DODAB or DDAB, it consists of a positively charged ammonium head group and two long hydrophobic tails. These properties make it useful for forming liposomes and other lipid-based nanoparticles that can efficiently deliver genetic material into cells. In addition to its applications in biotechnology, DDAB is also used in surfactants, emulsifiers and fabric softeners. However, due to its potential toxicity and irritation, extreme care should be taken when handling DDAB.
|
-
- HY-169480
-
|
|
Liposome
|
Infection
Cancer
|
|
Lipid C2 is an ionizable cationic lipid that has been used in the formation of lipid nanoparticles (LNP) for mRNA delivery in vivo. LNPs containing Lipid C2 and encapsulating an mRNA reporter selectively accumulate in the liver and spleen but not the heart, lungs, or kidneys in mice. LNP containing Lipid C2 and encapsulating mRNA encoding the Epstein-Barr virus (EBV) protein latent membrane protein 2 (LMP-2), in combination with an anti-programmed cell death protein 1 (PD-1) antibody, decrease tumor volume and reverse T cell exhaustion, as well as increase the percentage of CD3 +CD8 + central and CD3 +CD8 + effector memory T cells and decrease the percentage of CD3 + T cells expressing Pd-1, in the spleen in a CT26 murine EBV-infected colon cancer model .
|
-
- HY-W127378
-
|
1,2-Dioleoyl-3-trimethylammonium-propane methylsulfate
|
Liposome
|
Others
|
|
DOTAP methylsulfat is a cationic lipid reagent, a cationic derivative of trimethylammonium, linked to two 18-carbon fatty acid tails, each with a single olefin group. DOTAP methylsulfat can self-assemble with negatively charged ions (such as DNA) to form complexes, which can be adsorbed to the cell membrane surface and enter the cell by electrostatic interaction and endocytosis, respectively. DOTAP methylsulfat promotes endosomal membrane fusion with its own hydrophobic domain, releases DNA into the cytoplasm, and exerts gene delivery function. DOTAP methylsulfat can be widely used in research fields such as gene therapy, cell transfection, and non-viral vector design[1][2].
|
-
- HY-160726
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Polymethacrylate Copolymer N−C4−52−6.9 is a polymer that consists of hydrophobic butylmethacrylate and cationic methacroylcholine chloride monomers. Polymethacrylate Copolymer N−C4−52−6.9 is able to solubilise lipid bilayers into nanodiscs. Polymethacrylate Copolymer N−C4−52−6.9 can be utilized in structure and functional studies on membrane proteins .
|
-
- HY-138170
-
|
|
Liposome
SARS-CoV
|
Infection
|
|
ALC-0315 is an ionisable aminolipid that is responsible for mRNA compaction and aids mRNA cellular delivery and its cytoplasmic release through suspected endosomal destabilization. ALC-0315 can be used to form lipid nanoparticle (LNP) delivery vehicles. Lipid-Nanoparticles have been used in the research of mRNA COVID-19 vaccine .
|
-
- HY-138170A
-
|
|
Liposome
SARS-CoV
|
Infection
|
|
ALC-0315 (Excipient, GMP Like) is the GMP Like class ALC-0315 (HY-138170), and can be used as pharmaceutical excipients. ALC-0315 is an ionisable aminolipid that is responsible for mRNA compaction and aids mRNA cellular delivery and its cytoplasmic release through suspected endosomal destabilization. ALC-0315 (Excipient, GMP Like) can be used to form lipid nanoparticle (LNP) delivery vehicles. Lipid-Nanoparticles have been used in the research of mRNA COVID-19 vaccine .
|
-
- HY-142998
-
|
|
Liposome
Interleukin Related
IFNAR
|
Infection
Inflammation/Immunology
|
|
Vaxfectin is a second-generation cationic lipid-based suspension that adjuvants effectively both pDNA and protein-based vaccines. Vaxfectin can boost the immune response against a range of pDNA-expressed pathogenic antigens in vivo. Vaxfectin can increase IgG titers and give rise to an IL-6 dependent enhancement of the humoral immune response without altering the Th1 type immune response. Vaxfectin can be studied for vaccine formulation .
|
-
- HY-P10968
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
KT2 is a cationic amphipathic antibacterial peptide. KT2 can completely kill cells of E. coli O157:H7. KT2 has potent anti-biofilm activity and prevents biofilm formation of E. coli O157:H7. KT2 significantly binds to bacterial surface LPS and interacts with the lipids of liposomes with great penetration capability into bacterial cells, followed by bond to DNA and other cytoplasmic membrane .
|
-
- HY-137131
-
|
DC-Cholesterol hydrochloride
|
Amyloid-β
Liposome
IFNAR
Interleukin Related
|
Neurological Disease
Inflammation/Immunology
|
|
DC-Chol hydrochloride is a cationic lipid. DC-Chol hydrochloride could inhibit Aβ40 fibril formation under appropriate experimental conditions. DC-Chol hydrochloride strongly inhibits amyloidogenesis of oxidized hCT in a dose-dependent manner. DC-Chol hydrochloride induces the production of Th1 (IL-2 and IFN-γ) and Th2 (IL-5) cytokines. DC-Chol hydrochloride can enhance the body's immune response to antigens. DC-Chol hydrochloride is used as a gene delivery vector. DC-Chol hydrochloride can be used in research in areas such as hepatitis B vaccines to improve vaccine immunity .
|
-
- HY-P5712
-
|
Gramicidin soviet
|
Antibiotic
Bacterial
Na+/K+ ATPase
|
Infection
|
|
Gramicidin S (Gramicidin soviet) is a cationic cyclic peptide antibiotic that selectively targets bacterial cell membranes and has anticancer activity. Gramicidin S also exerts antibacterial activity by destroying membrane integrity and interfering with membrane protein function. Gramicidin S inserts into the phospholipid bilayer through hydrophobic amino acid residues, specifically binds to negatively charged membrane lipids and disrupts membrane structure, thereby inhibiting cell division and cell wall synthesis, and ultimately causing bacterial death. Gramicidin S also inhibits ion channels, with IC50s of 41 μM, 24 μM, and 3 μM for Na +/K +-ATPase, tobacco leaf plasma membrane Mg 2+/K +-ATPase, and rat heart plasma membrane Ca 2+-ATPase, respectively .
|
-
| Cat. No. |
Product Name |
Type |
-
- HY-112005GL
-
|
Dioleoylphosphatidylethanolamine (GMP Like); 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (GMP Like)
|
Fluorescent Dye
|
|
DOPE (GMP Like) is the GMP Like class DOPE (HY-112005), and can be used as pharmaceutical excipients. DOPE is a neutral helper lipid for cationic liposome and combines with cationic phospholipids to improve transfection efficiency of naked siRNA .
|
-
- HY-112754AGL
-
|
1,2-Dioleoyl-3-trimethylammonium-propane chloride (GMP Like)
|
Fluorescent Dye
|
|
DOTAP chloride (GMP Like) is the GMP Like class DOTAP chloride (HY-112754A). DOTAP chloride is a cationic lipid with good membrane fusion ability and biocompatibility. DOTAP chloride (GMP Like) can be used as an excipient for transient and stable transfection DNA (plasmids, bacmids) and modified nucleic acids (antisense oligonucleotides) without the use of helper lipid .
|
-
- HY-112251GL
-
|
|
Fluorescent Dye
|
|
D-Lin-MC3-DMA (GMP Like) is the GMP Like class D-Lin-MC3-DMA (HY-112251). D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle.
|
| Cat. No. |
Product Name |
Type |
-
- HY-157252
-
|
|
Drug Delivery
|
|
CL4F8-6 is an ionizable cationic lipid with a pKa of 6.14. CL4F8-6 can be used in lipid nanoparticles (LNPs)-based mRNA therapeutics .
|
-
- HY-112754A
-
|
1,2-Dioleoyl-3-trimethylammonium-propane chloride
|
Drug Delivery
|
|
DOTAP chloride is a useful and effective cationic lipid for transient and stable transfection DNA (plasmids, bacmids) and modified nucleic acids (antisense oligonucleotides) with out the use of helper lipid .
|
-
- HY-154804
-
|
|
Drug Delivery
|
|
DLin-M-C4-DMA (Compound MC4) is a cationic lipid. DLin-M-C4-DMA can be used for delivery of nucleic acids .
|
-
- HY-144014
-
|
|
Drug Delivery
|
|
MVL5 is a non-degradable multivalent cationic lipid. MVL5 is a highly efficient vector for both DNA and siRNA. MVL5 can be used in breast cancer research .
|
-
- HY-130751
-
DODAP
1 Publications Verification
|
Drug Delivery
|
|
DODAP is a cationic lipid utilized as the lipid component in liposomes (pKa = 5.59 in TNS binding tests). DODAP is employed for encapsulating siRNA and delivering immunostimulated chemotherapeutic agents both in vitro and in vivo. DODAP holds great promise for research in vaccines and inflammation .
|
-
- HY-143702
-
|
NBD-DOTAP
|
Drug Delivery
|
|
Fluorescent DOTAP (NBD-DOTAP) is a cationic lipid which can be used for nucleic acid and protein delivery. Fluorescent DOTAP is labeled with a fluorophore NBD (maximum excitation/emission wavelength ∼463/536 nm). Fluorescent DOTAP can be used for gene delivery systems, drug delivery, as well as cell imaging and nanocarrier tracking. Fluorescent DOTAP is an ideal candidate for both biological and pharmaceutical formulation (e.g. co-delivery of vaccines) research .
|
-
- HY-139200
-
DOTMA
1 Publications Verification
|
Drug Delivery
|
|
DOTMA is a cationic lipid that has been used as a non-viral vector for gene therapy. DOTMA is used as a component of liposomes to encapsulate siRNA, microRNA, and oligonucleotides and for in vitro gene transfection. DOTMA promotes effective interaction between liposomes and cell membranes by inducing positive charge on the liposomes. DOTMA showed good gene transfection effect both in vitro and in vivo .
|
-
- HY-142999
-
|
|
Drug Delivery
|
|
DOIC is a cationic lipid that can be used for RNA vaccines .
|
-
- HY-143688
-
|
|
Drug Delivery
|
|
EDMPC, a cationic lipid, has an enhanced ability to deliver DNA to pulmonary tissues. EDMPC mediates intralobar DNA delivery to rodents .
|
-
- HY-160275
-
|
|
Drug Delivery
|
|
DOPE-PEG-Fluor 555,MW 2000 is a PEG-lipid-dye conjugate featuring a DOPE phospholipid and a Fluor 555 dye. DOPE (HY-112005) is a neutral helper lipid for cationic liposome. Fluor 555 is a fluorescent dye .
|
-
- HY-W414069
-
|
|
Drug Delivery
|
|
Thiocholesterol is a member of the class of cholesteric liquid crystals (CLCs) that can be used to synthesis cationic lipid. Thiocholesterol is a stronger stabilizer of silver nanoparticles (SNPs). Thiocholesterol can be used for plasma membrane research and drug delivery .
|
-
- HY-147087
-
|
|
Drug Delivery
|
|
YSK 05 is a pH-sensitive cationic lipid. YSK 05 improves the intracellular trafficking of non-viral vectors. YSK 05-MEND shows significantly good gene silencing activity and hemolytic activity. YSK 05 overcomes the suppression of endosomal escape by PEGylation. YSK 05 effectively enhances siRNA delivery both in vitro and in vivo .
|
-
- HY-112005
-
DOPE
3 Publications Verification
Dioleoylphosphatidylethanolamine; 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine
|
Drug Delivery
|
|
DOPE (Dioleoylphosphatidylethanolamine) is a neutral helper lipid for cationic liposome and combines with cationic phospholipids to improve transfection efficiency of naked siRNA .
|
-
- HY-46760
-
|
|
Drug Delivery
|
|
CCD Lipid01 is a cationic lipid used in the delivery of biologically active agents to cells and tissues .
|
-
- HY-145739
-
-
- HY-149156
-
|
|
Drug Delivery
|
|
Lipid C24 is a cationic ionizable lipid that can be used for synthesizing lipid nanoparticles. Lipid C24 can be used in the study of drug delivery .
|
-
- HY-144025
-
|
|
Drug Delivery
|
|
DOBAQ, a cationic lipid, is a pH-sensitive lipid. DOBAQ can be used for liposomes applied in drug delivery .
|
-
- HY-112757
-
DLinDMA
1 Publications Verification
|
Drug Delivery
|
|
DLinDMA, a ionizable cationic lipid, is a key lipid component of stable nucleic acid lipid particles (SNALPs) as a benchmark. DLinDMA is used for siRNA delivery .
|
-
- HY-112755
-
|
|
Drug Delivery
|
|
DODMA is a cationic lipid that can be used to prepare lipid nanoparticles. DODMA can be used for drug delivery .
|
-
- HY-156616
-
|
|
Drug Delivery
|
|
VC1052 is a dialkoxypropylammonium-based material and is the core cationic lipid component of the cationic lipid adjuvant Vaxfectin (HY-142998). Vaxfectin consists of VC1052 and lipid DPyPE (HY-112766) in a 1:1 molar ratio. Vaxfectin can be used as a vaccine adjuvant for the preparation of plasmid DNA and protein vaccines .
|
-
- HY-153372
-
|
|
Drug Delivery
|
|
93-O17S is a chalcogen-containing ionizable cationic lipid used for making lipid nanoparticles (LNPs).
|
-
- HY-133952
-
|
|
Drug Delivery
|
|
7-Oxotridecanedioic acid is a biodegradable cationic lipid intermediate compound for lipid nanoparticles formation. 7-Oxotridecanedioic acid can be incorporated into a lipid particle for delivering active agents .
|
-
- HY-W590532
-
|
|
Drug Delivery
|
|
306-O12B is an ionizable cationic lipid used to prepare lipid nanoparticles (LNPs) for the delivery of mRNA .
|
-
- HY-145225
-
|
|
Drug Delivery
|
|
DLin-K-C3-DMA, a cationic lipid, can be used in the synthesis of nucleic acid-lipid particle to delivery of nucleic acid .
|
-
- HY-112523A
-
|
|
Drug Delivery
|
|
DMTAP is a cationic lipid that can be used for delivery of DNA, RNAi and drugs .
|
-
- HY-142996
-
|
|
Drug Delivery
|
|
BGTC is a non-amino acid cationic lipid. BGTC can be used for delivery of nucleic acids .
|
-
- HY-151511
-
|
|
Drug Delivery
|
|
A12-Iso5-2DC18, an ionizable cationic lipid, is a potent mRNA delivery lipid vehicle .
|
-
- HY-144021
-
|
|
Drug Delivery
|
|
14:0 EPC chloride is an acyl cationic lipid that can be used for liposomes applied in drug delivery .
|
-
- HY-156448
-
80-O14B
1 Publications Verification
|
Drug Delivery
|
|
80-O14B is an cationic lipid-like compound for mRNA delivery .
|
-
- HY-144022
-
|
|
Drug Delivery
|
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16:0 DAP is a cationic lipids that can be used for drug delivery, gene transfection and vaccine delivery .
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-
- HY-112251
-
D-Lin-MC3-DMA
Maximum Cited Publications
96 Publications Verification
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Drug Delivery
|
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D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle.
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-
- HY-148830
-
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Drug Delivery
|
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Piperazine-bis(ethyl octadeca-9,12-dienoate) is a cationic lipid extracted from patent WO2023036148A1, and can be used for the generation of Lipid nanoparticles (LNPs).
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- HY-144023
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Drug Delivery
|
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16:0-18:1 EPC chloride is a cationic lipid, which can be used for liposomes applied in drug delivery .
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-
- HY-112005GL
-
|
Dioleoylphosphatidylethanolamine (GMP Like); 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (GMP Like)
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Biochemical Assay Reagents
|
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DOPE (GMP Like) is the GMP Like class DOPE (HY-112005), and can be used as pharmaceutical excipients. DOPE is a neutral helper lipid for cationic liposome and combines with cationic phospholipids to improve transfection efficiency of naked siRNA .
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-
- HY-143210
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Drug Delivery
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Transfectam is a cationic lipid able to interact with DNA to form complexes that mediate efficient gene transfer into various eukaryotic cells .
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-
- HY-134541
-
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Drug Delivery
|
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SM-102 is an amino cationic lipid useful in the formation of lipid nanoparticles (LNPs). SM-102 has higher transfection efficiency. SM-102 plays an important role in the effectiveness of lipid nanoparticles (LNPs) in delivering mRNA therapeutics and vaccines .
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-
- HY-153737
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Drug Delivery
|
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113-N16B is an ionizable cationic lipid used for the generation of lipid nanoparticles (LNPs). 113-N16B delivers mRNA preferentially to pulmonary endothelial cells.
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-
- HY-144020
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Drug Delivery
|
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14:0 DAP (1,2-dimyristoyl-3-dimethylammonium-propane ) is a cationic lipid that can be used for drug delivery .
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- HY-112763
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Drug Delivery
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CLinDMA, a cationic lipid, can cause inflammatory response. CLinDMA can be used for the synthesis LNP201. LNP201 is a liposome assembly for systemic delivery of siRNA .
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- HY-149037
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N4-Spermine cholesteryl carbamate
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Drug Delivery
|
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GL67 (N4-Spermine cholesteryl carbamate) is a cationic lipid. GL67 can be used for nucleic acid agents and vaccines delivery, and gene transfection .
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- HY-149037A
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N4-Spermine cholesteryl carbamate pentahydrochloride
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Drug Delivery
|
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GL67 (N4-Spermine cholesteryl carbamate) (pentahydrochloride) is a cationic lipid. GL67 can be used for nucleic acid agents and vaccines delivery, and gene transfection .
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- HY-142654
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Drug Delivery
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ATX-002 is an ionizable cationic lipid for RNA drug delivery. The calculated pKa (c-pKa) and measured pKa values for ATX-002 are 8.68 and 6.03, respectively .
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- HY-W440681
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Drug Delivery
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C13-112-tri-tail is a cationic lipid-like compound containing a polar amino alcohol head group, three hydrophobic carbon-13 tails, and a PEG2 linker. C13-112-tri-tail can be formulated into a lipid nanoparticle (LNP).
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- HY-W440684
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Drug Delivery
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C13-113-tetra tail is a cationic lipid-like compound containing a polar amino alcohol head group, four hydrophobic carbon-13 tails, and a tertiary amine linker. C13-113-tetra tail can be formulated into a lipid nanoparticle (LNP).
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- HY-W440683
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Drug Delivery
|
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C13-112-tetra-tail is a cationic lipid-like compound containing a polar amino alcohol head group, four hydrophobic carbon-13 tails, and a PEG2 linker. C13-112-tetra-tail can be formulated into a lipid nanoparticle (LNP).
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- HY-W440682
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Drug Delivery
|
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C13-113-tri tail is a cationic lipid-like compound containing a polar amino alcohol head group, three hydrophobic carbon-13 tails, and a tertiary amine linker. C13-113-tri tail can be formulated into a lipid nanoparticle (LNP).
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- HY-158709
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Drug Delivery
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Cho-es-Lys is a cationic lipid synthesized by coupling natural cholesterol and amino acids, which has high gene transfection efficiency. Cho-es-Lys can be used in drug delivery research .
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- HY-112754AGL
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1,2-Dioleoyl-3-trimethylammonium-propane chloride (GMP Like)
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Biochemical Assay Reagents
|
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DOTAP chloride (GMP Like) is the GMP Like class DOTAP chloride (HY-112754A). DOTAP chloride is a cationic lipid with good membrane fusion ability and biocompatibility. DOTAP chloride (GMP Like) can be used as an excipient for transient and stable transfection DNA (plasmids, bacmids) and modified nucleic acids (antisense oligonucleotides) without the use of helper lipid .
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- HY-144016
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Drug Delivery
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16:0 EPC chloride, a P-O-ethyl derivative, is a saturated cationic lipid. 16:0 EPC chloride can serve as a DNA and RNA transfecting agent. 16:0 EPC chloride can be used as a co-adjuvant for preparing vaccines and promote drug delivery .
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- HY-145405
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Drug Delivery
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C12-200 is a type of ionizable cationic lipid and helper lipid commonly used for mRNA delivery. In the hemophilia B mouse model, mRNA encoding human erythropoietin (EPO) and coagulation factor IX (FIX) can be successfully delivered and expressed using C12-200. C12-200 is utilized in research related to hemophilia B .
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- HY-112758
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Drug Delivery
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DLin-KC2-DMA is an ionisable cationic lipid (pKa≈6) that is virtually non-toxic to antigen presenting cells (APCs). DLin-KC2-DMA produces significant siRNA-mediated gene silencing of GAPDH, when binds to lipid nanoparticles (LNP). DLin-KC2-DMA can be used in siRNA delivery studies .
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- HY-113217
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Drug Delivery
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Cholesteryl oleate is an ester compound formed from Cholesterol (HY-N0322) and Oleic acid (HY-N1446), which is involved in lipid transport, storage and cell membrane formation in living organisms. Cholesteryl oleate may serve as a potential biomarker for prostate cancer. Cholesteryl oleate can also prepare cationic solid lipid nanoparticles (SLNs) for efficient gene silencing .
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- HY-112251GL
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Biochemical Assay Reagents
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D-Lin-MC3-DMA (GMP Like) is the GMP Like class D-Lin-MC3-DMA (HY-112251). D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle.
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- HY-151512
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Drug Delivery
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A12-Iso5-4DC19 is an ionizable cationic lipid. A12-Iso5-4DC19 can facilitate mRNA delivery and be used for the research of RNA vaccines .
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- HY-142997
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Drug Delivery
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DOSPA is a cationicliposome. DOSPA can formulate with DNA to be a transfection system. DOSPA can be used for gene therapy research .
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- HY-152229
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G0-C14
1 Publications Verification
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Drug Delivery
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G0-C14 is a cationic lipid-like compound alkyl-modified polyamidoamine (PAMAM) dendrimer. G0-C14 involves in the preparation of a series of macrophage-targeted nanoparticles (NPs). NPs can be used for agent and vaccine delivery .
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- HY-131119
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Dioctadecyldimethylammonium bromide; DODAB
|
Drug Delivery
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Dimethyldioctadecylammonium bromide is a synthetic cationic lipid commonly used in gene delivery and vaccine development. Also known as DODAB or DDAB, it consists of a positively charged ammonium head group and two long hydrophobic tails. These properties make it useful for forming liposomes and other lipid-based nanoparticles that can efficiently deliver genetic material into cells. In addition to its applications in biotechnology, DDAB is also used in surfactants, emulsifiers and fabric softeners. However, due to its potential toxicity and irritation, extreme care should be taken when handling DDAB.
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- HY-W127378
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1,2-Dioleoyl-3-trimethylammonium-propane methylsulfate
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Drug Delivery
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DOTAP methylsulfat is a cationic lipid reagent, a cationic derivative of trimethylammonium, linked to two 18-carbon fatty acid tails, each with a single olefin group. DOTAP methylsulfat can self-assemble with negatively charged ions (such as DNA) to form complexes, which can be adsorbed to the cell membrane surface and enter the cell by electrostatic interaction and endocytosis, respectively. DOTAP methylsulfat promotes endosomal membrane fusion with its own hydrophobic domain, releases DNA into the cytoplasm, and exerts gene delivery function. DOTAP methylsulfat can be widely used in research fields such as gene therapy, cell transfection, and non-viral vector design[1][2].
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- HY-160726
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Drug Delivery
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Polymethacrylate Copolymer N−C4−52−6.9 is a polymer that consists of hydrophobic butylmethacrylate and cationic methacroylcholine chloride monomers. Polymethacrylate Copolymer N−C4−52−6.9 is able to solubilise lipid bilayers into nanodiscs. Polymethacrylate Copolymer N−C4−52−6.9 can be utilized in structure and functional studies on membrane proteins .
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- HY-138170
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Drug Delivery
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ALC-0315 is an ionisable aminolipid that is responsible for mRNA compaction and aids mRNA cellular delivery and its cytoplasmic release through suspected endosomal destabilization. ALC-0315 can be used to form lipid nanoparticle (LNP) delivery vehicles. Lipid-Nanoparticles have been used in the research of mRNA COVID-19 vaccine .
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- HY-142998
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Drug Delivery
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Vaxfectin is a second-generation cationic lipid-based suspension that adjuvants effectively both pDNA and protein-based vaccines. Vaxfectin can boost the immune response against a range of pDNA-expressed pathogenic antigens in vivo. Vaxfectin can increase IgG titers and give rise to an IL-6 dependent enhancement of the humoral immune response without altering the Th1 type immune response. Vaxfectin can be studied for vaccine formulation .
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- HY-137131
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DC-Cholesterol hydrochloride
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Drug Delivery
|
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DC-Chol hydrochloride is a cationic lipid. DC-Chol hydrochloride could inhibit Aβ40 fibril formation under appropriate experimental conditions. DC-Chol hydrochloride strongly inhibits amyloidogenesis of oxidized hCT in a dose-dependent manner. DC-Chol hydrochloride induces the production of Th1 (IL-2 and IFN-γ) and Th2 (IL-5) cytokines. DC-Chol hydrochloride can enhance the body's immune response to antigens. DC-Chol hydrochloride is used as a gene delivery vector. DC-Chol hydrochloride can be used in research in areas such as hepatitis B vaccines to improve vaccine immunity .
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| Cat. No. |
Product Name |
Target |
Research Area |
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- HY-P5712
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Gramicidin soviet
|
Antibiotic
Bacterial
Na+/K+ ATPase
|
Infection
|
|
Gramicidin S (Gramicidin soviet) is a cationic cyclic peptide antibiotic that selectively targets bacterial cell membranes and has anticancer activity. Gramicidin S also exerts antibacterial activity by destroying membrane integrity and interfering with membrane protein function. Gramicidin S inserts into the phospholipid bilayer through hydrophobic amino acid residues, specifically binds to negatively charged membrane lipids and disrupts membrane structure, thereby inhibiting cell division and cell wall synthesis, and ultimately causing bacterial death. Gramicidin S also inhibits ion channels, with IC50s of 41 μM, 24 μM, and 3 μM for Na +/K +-ATPase, tobacco leaf plasma membrane Mg 2+/K +-ATPase, and rat heart plasma membrane Ca 2+-ATPase, respectively .
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-
- HY-P10968
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|
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Bacterial
Antibiotic
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Infection
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KT2 is a cationic amphipathic antibacterial peptide. KT2 can completely kill cells of E. coli O157:H7. KT2 has potent anti-biofilm activity and prevents biofilm formation of E. coli O157:H7. KT2 significantly binds to bacterial surface LPS and interacts with the lipids of liposomes with great penetration capability into bacterial cells, followed by bond to DNA and other cytoplasmic membrane .
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-
- HY-K2016
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MCE Protein Transfection Reagent is a cationic lipid mixture for complexation with proteins, peptides, antibodies and other biologically active molecules to allow their direct intracellular delivery.
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| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
| Cat. No. |
Product Name |
Chemical Structure |
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- HY-113217S
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Cholesteryl oleate-d7 is deuterium labeled Cholesteryl oleate. Cholesteryl oleate is an ester compound formed from Cholesterol (HY-N0322) and Oleic acid (HY-N1446), which is involved in lipid transport, storage and cell membrane formation in living organisms. Cholesteryl oleate may serve as a potential biomarker for prostate cancer. Cholesteryl oleate can also prepare cationic solid lipid nanoparticles (SLNs) for efficient gene silencing .
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-
-
- HY-112251S
-
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|
|
D-Lin-MC3-DMA- 13C3 is the 13C labeled D-Lin-MC3-DMA. D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle .
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-
-
- HY-113217S1
-
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|
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Cholesteryl oleate-d7-1 is deuterium labeled Cholesteryl oleate. Cholesteryl oleate is an ester compound formed from Cholesterol (HY-N0322) and Oleic acid (HY-N1446), which is involved in lipid transport, storage and cell membrane formation in living organisms. Cholesteryl oleate may serve as a potential biomarker for prostate cancer. Cholesteryl oleate can also prepare cationic solid lipid nanoparticles (SLNs) for efficient gene silencing .
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-
| Cat. No. |
Product Name |
|
Classification |
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- HY-160908
-
|
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Cationic Lipids
|
Lipid 88 is an ionizable cationic lipid. Lipid 88 can be used to synthesize lipid nanoparticles and deliver mRNA .
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-
- HY-159709
-
|
|
|
Cationic Lipids
|
|
VL-422 is an ionizable cationic lipid that can be used for lipid nanoparticle (LNP) and drug delivery research .
|
-
- HY-157252
-
|
|
|
Cationic Lipids
|
|
CL4F8-6 is an ionizable cationic lipid with a pKa of 6.14. CL4F8-6 can be used in lipid nanoparticles (LNPs)-based mRNA therapeutics .
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-
- HY-160553
-
|
|
|
Cationic Lipids
|
9322-O16B, an ionizable cationic lipid, is used for LNP generation .
|
-
- HY-112754A
-
|
1,2-Dioleoyl-3-trimethylammonium-propane chloride
|
|
Cationic Lipids
|
|
DOTAP chloride is a useful and effective cationic lipid for transient and stable transfection DNA (plasmids, bacmids) and modified nucleic acids (antisense oligonucleotides) with out the use of helper lipid .
|
-
- HY-W800776
-
|
1,2-Dioleoyl-3-dimethyl-hydroxyethylammonium bromide
|
|
Cationic Lipids
|
|
DORI is a cationic lipid that can deliver plasmid DNA in vitro. DORI has lower cytotoxicity and high transfection efficiency .
|
-
- HY-154804
-
|
|
|
Pegylated Lipids
|
|
DLin-M-C4-DMA (Compound MC4) is a cationic lipid. DLin-M-C4-DMA can be used for delivery of nucleic acids .
|
-
- HY-142999
-
|
|
|
Cationic Lipids
|
|
DOIC is a cationic lipid that can be used for RNA vaccines .
|
-
- HY-129990
-
|
|
|
Cationic Lipids
|
|
Dios-Arg diTFA, a cationic lipid with an arginine-bearing headgroup, shows obvious double bond proton signals at around 5.2-5.3 ppm. Dios-Arg diTFA is used, coupled to DOPE, to bind siRNA and plasmid to for cationic LNPs for intracellular transport .
|
-
- HY-125734
-
|
|
|
Cationic Lipids
|
|
DMHAPC-Chol, a cationic lipid, contains a biodegradable carbamoyl linker and a hydroxyethyl group in the polar amino head moiety. DMHAPC-Chol can be used in both transfection experiments concerning plasmids or siRNA .
|
-
- HY-W800782
-
|
|
|
Cationic Lipids
|
|
DC-6-14 is a cationic lipid with gene transfection activity, which can be used for the synthesis of liposomes .
|
-
- HY-139305
-
|
|
|
Cationic Lipids
|
|
CL4H6 is a pH-sensitive cationic lipid. CL4H6 is the main component of lipid nanoparticles (LNPs), which can be used to target and deliver siRNA, and induces a potent gene-silencing response .
|
-
- HY-143688
-
|
|
|
Cationic Lipids
|
|
EDMPC, a cationic lipid, has an enhanced ability to deliver DNA to pulmonary tissues. EDMPC mediates intralobar DNA delivery to rodents .
|
-
- HY-144014
-
|
|
|
Cationic Lipids
|
|
MVL5 is a non-degradable multivalent cationic lipid. MVL5 is a highly efficient vector for both DNA and siRNA. MVL5 can be used in breast cancer research .
|
-
- HY-138912
-
|
|
|
Cholesterol
|
|
Cho-Arg TFA is a steroid-based cationic lipid with an L-Arginine headgroup. Cho-Arg TFA shows a remarkably high optimized plasmid DNA transfection efficacy .
|
-
- HY-W409806
-
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|
Cholesterol
|
|
Cholesterylamine is a cationic lipid. Cholesterylamine can be added to the PLGA to prepare PLGA particle having surface charge. Cholesterylamine can be used for drug delivery. Cholesterylamine can be used for autoimmune diseases and allergy research .
|
-
- HY-130751
-
DODAP
1 Publications Verification
|
|
Cationic Lipids
|
|
DODAP is a cationic lipid utilized as the lipid component in liposomes (pKa = 5.59 in TNS binding tests). DODAP is employed for encapsulating siRNA and delivering immunostimulated chemotherapeutic agents both in vitro and in vivo. DODAP holds great promise for research in vaccines and inflammation .
|
-
- HY-160275
-
|
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|
Pegylated Lipids
Fluorescent Lipids
|
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DOPE-PEG-Fluor 555,MW 2000 is a PEG-lipid-dye conjugate featuring a DOPE phospholipid and a Fluor 555 dye. DOPE (HY-112005) is a neutral helper lipid for cationic liposome. Fluor 555 is a fluorescent dye .
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-
- HY-143702
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|
NBD-DOTAP
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Cationic Lipids
|
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Fluorescent DOTAP (NBD-DOTAP) is a cationic lipid which can be used for nucleic acid and protein delivery. Fluorescent DOTAP is labeled with a fluorophore NBD (maximum excitation/emission wavelength ∼463/536 nm). Fluorescent DOTAP can be used for gene delivery systems, drug delivery, as well as cell imaging and nanocarrier tracking. Fluorescent DOTAP is an ideal candidate for both biological and pharmaceutical formulation (e.g. co-delivery of vaccines) research .
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-
- HY-139200
-
DOTMA
1 Publications Verification
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|
Cationic Lipids
|
|
DOTMA is a cationic lipid that has been used as a non-viral vector for gene therapy. DOTMA is used as a component of liposomes to encapsulate siRNA, microRNA, and oligonucleotides and for in vitro gene transfection. DOTMA promotes effective interaction between liposomes and cell membranes by inducing positive charge on the liposomes. DOTMA showed good gene transfection effect both in vitro and in vivo .
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-
- HY-W414069
-
|
|
|
Cholesterol
|
|
Thiocholesterol is a member of the class of cholesteric liquid crystals (CLCs) that can be used to synthesis cationic lipid. Thiocholesterol is a stronger stabilizer of silver nanoparticles (SNPs). Thiocholesterol can be used for plasma membrane research and drug delivery .
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-
- HY-147087
-
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Cationic Lipids
|
|
YSK 05 is a pH-sensitive cationic lipid. YSK 05 improves the intracellular trafficking of non-viral vectors. YSK 05-MEND shows significantly good gene silencing activity and hemolytic activity. YSK 05 overcomes the suppression of endosomal escape by PEGylation. YSK 05 effectively enhances siRNA delivery both in vitro and in vivo .
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-
- HY-112005
-
DOPE
3 Publications Verification
Dioleoylphosphatidylethanolamine; 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine
|
|
Phospholipids
|
|
DOPE (Dioleoylphosphatidylethanolamine) is a neutral helper lipid for cationic liposome and combines with cationic phospholipids to improve transfection efficiency of naked siRNA .
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-
- HY-46760
-
|
|
|
Cationic Lipids
|
|
CCD Lipid01 is a cationic lipid used in the delivery of biologically active agents to cells and tissues .
|
-
- HY-145739
-
-
- HY-149156
-
|
|
|
Cationic Lipids
|
|
Lipid C24 is a cationic ionizable lipid that can be used for synthesizing lipid nanoparticles. Lipid C24 can be used in the study of drug delivery .
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-
- HY-144025
-
|
|
|
Cationic Lipids
|
|
DOBAQ, a cationic lipid, is a pH-sensitive lipid. DOBAQ can be used for liposomes applied in drug delivery .
|
-
- HY-112757
-
DLinDMA
1 Publications Verification
|
|
Cationic Lipids
|
|
DLinDMA, a ionizable cationic lipid, is a key lipid component of stable nucleic acid lipid particles (SNALPs) as a benchmark. DLinDMA is used for siRNA delivery .
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-
- HY-112755
-
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Cationic Lipids
|
|
DODMA is a cationic lipid that can be used to prepare lipid nanoparticles. DODMA can be used for drug delivery .
|
-
- HY-W800783
-
|
CDESA
|
|
Cationic Lipids
|
|
DSTAP chloride (CDESA) is a cationic lipid that used in the formation of lipid nanoparticles (LNPs). DORI chloride has high transfection efficiency .
|
-
- HY-156985
-
|
|
|
Cationic Lipids
|
|
Lipid AX4 is an ionizable cationic lipid with the pKa of 6.89， and can be used the study for the formation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo .
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-
- HY-W590549
-
|
DODAC
|
|
Cationic Lipids
|
|
Dioleyldimethylammonium chloride (DODAC) is a cationic lipid that can be used as transfection reagent .
|
-
- HY-158796
-
|
|
|
Cationic Lipids
|
|
L202 is an ionizable cationic lipid (pKa=6.04) that can be used for the study of mRNA and lipid nanoparticles .
|
-
- HY-156616
-
|
|
|
Cationic Lipids
|
|
VC1052 is a dialkoxypropylammonium-based material and is the core cationic lipid component of the cationic lipid adjuvant Vaxfectin (HY-142998). Vaxfectin consists of VC1052 and lipid DPyPE (HY-112766) in a 1:1 molar ratio. Vaxfectin can be used as a vaccine adjuvant for the preparation of plasmid DNA and protein vaccines .
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-
- HY-159725
-
|
|
|
Cationic Lipids
|
|
BAmP-O16B is an ionizable cationic amino lipid that can be used to generate lipid nanoparticles (LNPs) .
|
-
- HY-153372
-
|
|
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Cationic Lipids
|
|
93-O17S is a chalcogen-containing ionizable cationic lipid used for making lipid nanoparticles (LNPs).
|
-
- HY-133952
-
|
|
|
Cationic Lipids
|
|
7-Oxotridecanedioic acid is a biodegradable cationic lipid intermediate compound for lipid nanoparticles formation. 7-Oxotridecanedioic acid can be incorporated into a lipid particle for delivering active agents .
|
-
- HY-W590548
-
|
|
|
Cationic Lipids
|
|
ATX-001 is an ionizable cationic lipid. ATX-001 can be used in the formation of lipid nanoparticles (LNPs) for the delivery mRNA .
|
-
- HY-W590532
-
|
|
|
Cationic Lipids
|
|
306-O12B is an ionizable cationic lipid used to prepare lipid nanoparticles (LNPs) for the delivery of mRNA .
|
-
- HY-158867
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|
|
|
Cationic Lipids
|
|
DOSPA hydrochlorid is a frequently utilized cationic lipid in the generation of Lipid Nanoparticles (LNPs) for the development of mRNA vaccines, including the COVID-19 vaccine.
|
-
- HY-145225
-
|
|
|
Cationic Lipids
|
|
DLin-K-C3-DMA, a cationic lipid, can be used in the synthesis of nucleic acid-lipid particle to delivery of nucleic acid .
|
-
- HY-112523A
-
|
|
|
Cationic Lipids
|
|
DMTAP is a cationic lipid that can be used for delivery of DNA, RNAi and drugs .
|
-
- HY-142996
-
|
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Cationic Lipids
|
|
BGTC is a non-amino acid cationic lipid. BGTC can be used for delivery of nucleic acids .
|
-
- HY-W590531
-
|
|
|
Cationic Lipids
|
|
80-O16B is an ionizable cationic lipid containing disulfide bonds that can be used to prepare lipid nanoparticles (LNP) .
|
-
- HY-176753
-
|
|
|
Cationic Lipids
|
|
Lipid 20b is a thiophene ionizable cationic lipid. Lipid 20 b can be used to generate lipid nanoparticles (LNPs) for the delivery of mRNA in vivo. Lipid 20b can be studied in research for enhancing mRNA vaccine delivery and transfection efficacy .
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-
- HY-151511
-
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Cationic Lipids
|
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A12-Iso5-2DC18, an ionizable cationic lipid, is a potent mRNA delivery lipid vehicle .
|
-
- HY-144021
-
|
|
|
Cationic Lipids
|
|
14:0 EPC chloride is an acyl cationic lipid that can be used for liposomes applied in drug delivery .
|
-
- HY-159726
-
|
|
|
Cationic Lipids
|
|
C10-200 is an ionizable cationic lipid that can be used to generate lipid nanoparticles (LNPs). C10-200 is used in the study of mRNA delivery .
|
-
- HY-156448
-
80-O14B
1 Publications Verification
|
|
Cationic Lipids
|
|
80-O14B is an cationic lipid-like compound for mRNA delivery .
|
-
- HY-144022
-
|
|
|
Cationic Lipids
|
|
16:0 DAP is a cationic lipids that can be used for drug delivery, gene transfection and vaccine delivery .
|
- HY-112251
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D-Lin-MC3-DMA
Maximum Cited Publications
96 Publications Verification
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Cationic Lipids
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D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle.
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- HY-148830
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Cationic Lipids
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Piperazine-bis(ethyl octadeca-9,12-dienoate) is a cationic lipid extracted from patent WO2023036148A1, and can be used for the generation of Lipid nanoparticles (LNPs).
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- HY-144023
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Cationic Lipids
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16:0-18:1 EPC chloride is a cationic lipid, which can be used for liposomes applied in drug delivery .
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- HY-143210
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Cationic Lipids
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Transfectam is a cationic lipid able to interact with DNA to form complexes that mediate efficient gene transfer into various eukaryotic cells .
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- HY-W800825
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Cationic Lipids
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Octadecanedioic Acid Mono-L-carnitine ester is a cationic lipid which may be used in combination with other lipids in the formation of lipid nanoparticles (LNPs). Its terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. HATU) to form a stable amide bond.
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- HY-156936
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Cationic Lipids
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RCB-02-4-8 is an ionizable cationic lipid that is used to form lipid nanoparticles (LNPs) to deliver mRNA. RCB-02-4-8 can improve the efficiency of lung transfection in mice .
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- HY-134541
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Cationic Lipids
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SM-102 is an amino cationic lipid useful in the formation of lipid nanoparticles (LNPs). SM-102 has higher transfection efficiency. SM-102 plays an important role in the effectiveness of lipid nanoparticles (LNPs) in delivering mRNA therapeutics and vaccines .
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- HY-153737
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Cationic Lipids
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113-N16B is an ionizable cationic lipid used for the generation of lipid nanoparticles (LNPs). 113-N16B delivers mRNA preferentially to pulmonary endothelial cells.
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- HY-W598178
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Cationic Lipids
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93-O17O is a chalcogen-containing ionizable cationic lipidoid that used in the formation of lipid nanoparticles (LNPs) .
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- HY-144020
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Cationic Lipids
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14:0 DAP (1,2-dimyristoyl-3-dimethylammonium-propane ) is a cationic lipid that can be used for drug delivery .
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- HY-154803
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DLin-M-C2-DMA
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Cationic Lipids
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DLin-M-K-DMA (DLin-M-C2-DMA) is a cationic lipid that can be used in the construction of biological delivery vectors .
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- HY-112763
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Cationic Lipids
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CLinDMA, a cationic lipid, can cause inflammatory response. CLinDMA can be used for the synthesis LNP201. LNP201 is a liposome assembly for systemic delivery of siRNA .
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- HY-149037
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N4-Spermine cholesteryl carbamate
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Cationic Lipids
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GL67 (N4-Spermine cholesteryl carbamate) is a cationic lipid. GL67 can be used for nucleic acid agents and vaccines delivery, and gene transfection .
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- HY-149037A
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N4-Spermine cholesteryl carbamate pentahydrochloride
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Cationic Lipids
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GL67 (N4-Spermine cholesteryl carbamate) (pentahydrochloride) is a cationic lipid. GL67 can be used for nucleic acid agents and vaccines delivery, and gene transfection .
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- HY-142654
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Cationic Lipids
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ATX-002 is an ionizable cationic lipid for RNA drug delivery. The calculated pKa (c-pKa) and measured pKa values for ATX-002 are 8.68 and 6.03, respectively .
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- HY-W440681
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Cationic Lipids
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C13-112-tri-tail is a cationic lipid-like compound containing a polar amino alcohol head group, three hydrophobic carbon-13 tails, and a PEG2 linker. C13-112-tri-tail can be formulated into a lipid nanoparticle (LNP).
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- HY-W440684
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Cationic Lipids
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C13-113-tetra tail is a cationic lipid-like compound containing a polar amino alcohol head group, four hydrophobic carbon-13 tails, and a tertiary amine linker. C13-113-tetra tail can be formulated into a lipid nanoparticle (LNP).
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- HY-W440683
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Cationic Lipids
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C13-112-tetra-tail is a cationic lipid-like compound containing a polar amino alcohol head group, four hydrophobic carbon-13 tails, and a PEG2 linker. C13-112-tetra-tail can be formulated into a lipid nanoparticle (LNP).
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- HY-W440682
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Cationic Lipids
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C13-113-tri tail is a cationic lipid-like compound containing a polar amino alcohol head group, three hydrophobic carbon-13 tails, and a tertiary amine linker. C13-113-tri tail can be formulated into a lipid nanoparticle (LNP).
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- HY-138913
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Cholesterol
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2H-Cho-Arg (TFA) is a steroid-based cationic lipid that contains a 2H-cholesterol skeleton coupled to an L-arginine head group and can be used to facilitate gene transfection.
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- HY-158709
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Cholesterol
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Cho-es-Lys is a cationic lipid synthesized by coupling natural cholesterol and amino acids, which has high gene transfection efficiency. Cho-es-Lys can be used in drug delivery research .
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- HY-W590681
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Cationic Lipids
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113-O12B is a disulfide bond-containing ionizable cationic lipidoid. 113-O12B can be used in that generation of lipid nanoparticles (LNPs) for the delivery of mRNA .
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- HY-W590679
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Cationic Lipids
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113-O16B is a disulfide bond-containing ionizable cationic lipidoid. 113-O16B has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA .
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- HY-134541A
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Emulsifiers
Liposomal Film-forming Agents
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SM-102 (Excipient, GMP Like) is the GMP Like class SM-102 (HY-134541), and can be used as pharmaceutical excipients. SM-102 is an amino cationic lipid useful in the formation of lipid nanoparticles (LNPs). SM-102 (Excipient, GMP Like) has higher transfection efficiency. SM-102 (Excipient, GMP Like) plays an important role in the effectiveness of lipid nanoparticles (LNPs) in delivering mRNA therapeutics and vaccines .
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- HY-160552
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Cationic Lipids
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244cis, a piperazine-containing ionizable cationic lipid, has been used to generate lipid nanoparticles (LNPs). LNPs containing 244cis and coated with mRNA reporter gene were specifically accumulated in mouse lungs compared with LNPs containing SM-102. Induces a decrease in serum chemokine (C-C motif) ligand 2 (CCL2) levels .
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- HY-144016
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Cationic Lipids
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16:0 EPC chloride, a P-O-ethyl derivative, is a saturated cationic lipid. 16:0 EPC chloride can serve as a DNA and RNA transfecting agent. 16:0 EPC chloride can be used as a co-adjuvant for preparing vaccines and promote drug delivery .
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- HY-145405
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Cationic Lipids
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C12-200 is a type of ionizable cationic lipid and helper lipid commonly used for mRNA delivery. In the hemophilia B mouse model, mRNA encoding human erythropoietin (EPO) and coagulation factor IX (FIX) can be successfully delivered and expressed using C12-200. C12-200 is utilized in research related to hemophilia B .
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- HY-159700
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Cationic Lipids
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AA3-DLin is an ionizable cationic lipid with a pKa value of 5.8. AA3-DLin is used to delivery mRNA combined with lipid nanoparticles (LNPs). AA3-DLin LNP COVID-19 vaccines encapsulating SARS CoV-2 spike mRNAs successfully induces strong immunogenicity in a BALB/c mouse model .
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- HY-112758
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Cationic Lipids
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DLin-KC2-DMA is an ionisable cationic lipid (pKa≈6) that is virtually non-toxic to antigen presenting cells (APCs). DLin-KC2-DMA produces significant siRNA-mediated gene silencing of GAPDH, when binds to lipid nanoparticles (LNP). DLin-KC2-DMA can be used in siRNA delivery studies .
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- HY-113217
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Cholesterol
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Cholesteryl oleate is an ester compound formed from Cholesterol (HY-N0322) and Oleic acid (HY-N1446), which is involved in lipid transport, storage and cell membrane formation in living organisms. Cholesteryl oleate may serve as a potential biomarker for prostate cancer. Cholesteryl oleate can also prepare cationic solid lipid nanoparticles (SLNs) for efficient gene silencing .
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- HY-151512
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Cationic Lipids
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A12-Iso5-4DC19 is an ionizable cationic lipid. A12-Iso5-4DC19 can facilitate mRNA delivery and be used for the research of RNA vaccines .
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- HY-142997
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Cationic Lipids
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DOSPA is a cationicliposome. DOSPA can formulate with DNA to be a transfection system. DOSPA can be used for gene therapy research .
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- HY-152229
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G0-C14
1 Publications Verification
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Cationic Lipids
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G0-C14 is a cationic lipid-like compound alkyl-modified polyamidoamine (PAMAM) dendrimer. G0-C14 involves in the preparation of a series of macrophage-targeted nanoparticles (NPs). NPs can be used for agent and vaccine delivery .
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- HY-112766
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Phospholipids
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DPyPE is a neutral phosphatidylethanolamine lipid composed of a polyisoprene alkyl chain with two pyridine-containing phosphine ligands. DPyPE is mainly used in liposome formulations and to enhance the efficiency of gene delivery in vitro and in vivo. For example, DPyPE can be mixed with cationic lipids such as VC1052 (HY-156616) (in a 1:1 ratio) to form the vaccine adjuvant Vaxfectin (HY-142998). DPyPE assists VC1052 in binding to negatively charged pDNA to form a uniform liposome complex by regulating the fluidity and stability of the liposome membrane .
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- HY-131119
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Dioctadecyldimethylammonium bromide; DODAB
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Cationic Lipids
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Dimethyldioctadecylammonium bromide is a synthetic cationic lipid commonly used in gene delivery and vaccine development. Also known as DODAB or DDAB, it consists of a positively charged ammonium head group and two long hydrophobic tails. These properties make it useful for forming liposomes and other lipid-based nanoparticles that can efficiently deliver genetic material into cells. In addition to its applications in biotechnology, DDAB is also used in surfactants, emulsifiers and fabric softeners. However, due to its potential toxicity and irritation, extreme care should be taken when handling DDAB.
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- HY-W127378
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1,2-Dioleoyl-3-trimethylammonium-propane methylsulfate
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Cationic Lipids
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DOTAP methylsulfat is a cationic lipid reagent, a cationic derivative of trimethylammonium, linked to two 18-carbon fatty acid tails, each with a single olefin group. DOTAP methylsulfat can self-assemble with negatively charged ions (such as DNA) to form complexes, which can be adsorbed to the cell membrane surface and enter the cell by electrostatic interaction and endocytosis, respectively. DOTAP methylsulfat promotes endosomal membrane fusion with its own hydrophobic domain, releases DNA into the cytoplasm, and exerts gene delivery function. DOTAP methylsulfat can be widely used in research fields such as gene therapy, cell transfection, and non-viral vector design[1][2].
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- HY-138170
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Cationic Lipids
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ALC-0315 is an ionisable aminolipid that is responsible for mRNA compaction and aids mRNA cellular delivery and its cytoplasmic release through suspected endosomal destabilization. ALC-0315 can be used to form lipid nanoparticle (LNP) delivery vehicles. Lipid-Nanoparticles have been used in the research of mRNA COVID-19 vaccine .
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- HY-138170A
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Emulsifiers
Liposomal Film-forming Agents
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ALC-0315 (Excipient, GMP Like) is the GMP Like class ALC-0315 (HY-138170), and can be used as pharmaceutical excipients. ALC-0315 is an ionisable aminolipid that is responsible for mRNA compaction and aids mRNA cellular delivery and its cytoplasmic release through suspected endosomal destabilization. ALC-0315 (Excipient, GMP Like) can be used to form lipid nanoparticle (LNP) delivery vehicles. Lipid-Nanoparticles have been used in the research of mRNA COVID-19 vaccine .
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- HY-142998
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Cationic Lipids
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Vaxfectin is a second-generation cationic lipid-based suspension that adjuvants effectively both pDNA and protein-based vaccines. Vaxfectin can boost the immune response against a range of pDNA-expressed pathogenic antigens in vivo. Vaxfectin can increase IgG titers and give rise to an IL-6 dependent enhancement of the humoral immune response without altering the Th1 type immune response. Vaxfectin can be studied for vaccine formulation .
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- HY-137131
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DC-Cholesterol hydrochloride
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Cholesterol
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DC-Chol hydrochloride is a cationic lipid. DC-Chol hydrochloride could inhibit Aβ40 fibril formation under appropriate experimental conditions. DC-Chol hydrochloride strongly inhibits amyloidogenesis of oxidized hCT in a dose-dependent manner. DC-Chol hydrochloride induces the production of Th1 (IL-2 and IFN-γ) and Th2 (IL-5) cytokines. DC-Chol hydrochloride can enhance the body's immune response to antigens. DC-Chol hydrochloride is used as a gene delivery vector. DC-Chol hydrochloride can be used in research in areas such as hepatitis B vaccines to improve vaccine immunity .
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