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  4. VC1052

VC1052 is a dialkoxypropylammonium-based material and is the core cationic lipid component of the cationic lipid adjuvant Vaxfectin (HY-142998). Vaxfectin consists of VC1052 and lipid DPyPE (HY-112766) in a 1:1 molar ratio. Vaxfectin can be used as a vaccine adjuvant for the preparation of plasmid DNA and protein vaccines.

For research use only. We do not sell to patients.

VC1052

VC1052 Chemical Structure

CAS No. : 370108-98-8

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Based on 1 publication(s) in Google Scholar

VC1052 Related Antibodies

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Description

VC1052 is a dialkoxypropylammonium-based material and is the core cationic lipid component of the cationic lipid adjuvant Vaxfectin (HY-142998). Vaxfectin consists of VC1052 and lipid DPyPE (HY-112766) in a 1:1 molar ratio. Vaxfectin can be used as a vaccine adjuvant for the preparation of plasmid DNA and protein vaccines[1].

In Vitro

VC1052 has a similar structure to GAP-DLRIE and DMRIE, and is a member of the dialkoxypropylamine cationic lipid class[1].
GAP-DLRIE is primarily used to enhance gene transfection efficiency in local tissues (e.g., lungs), but VC1052 does not enhance pDNA transfection in muscle tissue when it forms a complex with the neutral lipid DPyPE at a 1:1 molar ratio. However, it significantly enhances humoral immune responses (antibody titers increased by 20-50 times) by promoting pDNA uptake by antigen presenting cells (APCs) and inducing cytokine secretion (e.g., IL-6) [1].
GAP-DLRIE significantly enhances the delivery efficiency and gene expression level of pDNA in specific tissues (e.g., mouse lungs) by forming a lipoplex with plasmid DNA (pDNA). GAP-DLRIE relies on cationic lipids to bind to the negatively charged phosphate backbone of DNA to form a stable complex that promotes cellular uptake of DNA and protects DNA from nuclease degradation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

VC1052 Related Antibodies
Molecular Weight

645.88

Formula

C36H73BrN2O2
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

CCCC/C=C\CCCCCCCCOCC(C[N+](C)(C)CCCN)OCCCCCCCC/C=C\CCCC.[Br-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (154.83 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5483 mL 7.7414 mL 15.4828 mL
5 mM 0.3097 mL 1.5483 mL 3.0966 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.72%

SDS (252 KB)

COA (238 KB) HNMR (274 KB) RP-HPLC (201 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5483 mL 7.7414 mL 15.4828 mL 38.7069 mL
5 mM 0.3097 mL 1.5483 mL 3.0966 mL 7.7414 mL
10 mM 0.1548 mL 0.7741 mL 1.5483 mL 3.8707 mL
15 mM 0.1032 mL 0.5161 mL 1.0322 mL 2.5805 mL
20 mM 0.0774 mL 0.3871 mL 0.7741 mL 1.9353 mL
25 mM 0.0619 mL 0.3097 mL 0.6193 mL 1.5483 mL
30 mM 0.0516 mL 0.2580 mL 0.5161 mL 1.2902 mL
40 mM 0.0387 mL 0.1935 mL 0.3871 mL 0.9677 mL
50 mM 0.0310 mL 0.1548 mL 0.3097 mL 0.7741 mL
60 mM 0.0258 mL 0.1290 mL 0.2580 mL 0.6451 mL
80 mM 0.0194 mL 0.0968 mL 0.1935 mL 0.4838 mL
100 mM 0.0155 mL 0.0774 mL 0.1548 mL 0.3871 mL
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VC1052 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VC1052370108-98-8VC 1052VC-1052LiposomeVaxfectinplasmid DNAprotein-based vaccinesInhibitorinhibitorinhibit

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