VC1052 

VC1052 is a dialkoxypropylammonium-based material and is the core cationic lipid component of the cationic lipid adjuvant Vaxfectin (HY-142998). Vaxfectin consists of VC1052 and lipid DPyPE (HY-112766) in a 1:1 molar ratio. Vaxfectin can be used as a vaccine adjuvant for the preparation of plasmid DNA and protein vaccines^[1].

VC1052 has a similar structure to GAP-DLRIE and DMRIE, and is a member of the dialkoxypropylamine cationic lipid class^[1].
GAP-DLRIE is primarily used to enhance gene transfection efficiency in local tissues (e.g., lungs), but VC1052 does not enhance pDNA transfection in muscle tissue when it forms a complex with the neutral lipid DPyPE at a 1:1 molar ratio. However, it significantly enhances humoral immune responses (antibody titers increased by 20-50 times) by promoting pDNA uptake by antigen presenting cells (APCs) and inducing cytokine secretion (e.g., IL-6) ^[1].
GAP-DLRIE significantly enhances the delivery efficiency and gene expression level of pDNA in specific tissues (e.g., mouse lungs) by forming a lipoplex with plasmid DNA (pDNA). GAP-DLRIE relies on cationic lipids to bind to the negatively charged phosphate backbone of DNA to form a stable complex that promotes cellular uptake of DNA and protects DNA from nuclease degradation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

645.88

C₃₆H₇₃BrN₂O₂

370108-98-8

Solid

White to off-white

CCCC/C=C\CCCCCCCCOCC(C[N+](C)(C)CCCN)OCCCCCCCC/C=C\CCCC.[Br-]

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Hartikka J, et al. Vaxfectin enhances the humoral immune response to plasmid DNA-encoded antigens. Vaccine. 2001 Feb 28;19(15-16):1911-23.  [Content Brief]