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Isoforms Recommended:	cIAP-2

Results for "

cIAP2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (9) Autophagy (1) Bcr-Abl (1) Caspase (2) Epigenetic Reader Domain (1) HIV (1) IAP (13) Interleukin Related (1) PROTACs (3) RIP kinase (1) Small Interfering RNA (siRNA) (3) SNIPERs (2)
By Research Areas:	Cancer (15) Inflammation/Immunology (1) Metabolic Disease (1)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (2) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

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Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W269593

Perfluorodecanoic acid PFDA	Caspase Interleukin Related	Metabolic Disease
Perfluorodecanoic acid (PFDA) is a perfluoroalkyl substance (PFAS). Perfluorodecanoic acid induces weight loss and increases liver weight and lipid content in mice. Perfluorodecanoic acid also reduces mRNA expression of the genes encoding IL-1β, IL-18, and cellular inhibitor of apoptosis 2 (cIAP2), as well as caspase-1, -3, and -7 in mouse liver ^[2].

HY-13638

GDC-0152 10+ Cited Publications	IAP	Cancer
GDC-0152 is a potent IAPs inhibitor, and binds to the BIR3 domains of XIAP, *cIAP1, cIAP2* and the BIR domain of ML-IAP with K_i values of 28 nM, 17 nM, 43 nM and 14 nM, respectively.

HY-15454

Xevinapant 5+ Cited Publications AT-406; Debio 1143; SM-406	IAP Apoptosis	Cancer
Xevinapant (AT-406) is a potent and orally bioavailable Smac mimetic and an antagonist of IAPs, and it binds to XIAP, cIAP1, and cIAP2 proteins with K_i of 66.4, 1.9, and 5.1 nM, respectively.

HY-110346

AZD5582 dihydrochloride 10+ Cited Publications	IAP Apoptosis	Cancer
AZD5582 dihydrochloride is an antagonist of the inhibitor of apoptosis proteins (IAPs), which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC₅₀s of 15, 21, and 15 nM, respectively. AZD5582 induces apoptosis .

HY-12600

AZD5582 10+ Cited Publications	IAP Apoptosis	Cancer
AZD5582 is an antagonist of the inhibitor of apoptosis proteins (IAPs), which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC₅₀s of 15, 21, and 15 nM, respectively. AZD5582 induces apoptosis .

HY-149924

CST626	PROTACs IAP	Cancer
CST626 (Compound 9) is a pan-IAP degrader PROTAC. CST626 degrades XIAP, cIAP1 and cIAP2 with DC₅₀s of 0.7, 2.4, and 6.2 nM in MM.1S cells, respectively .

HY-N6064

Polygalacin D 1 Publications Verification	Apoptosis IAP	Cancer
Polygalacin D (PGD) is a bioactive compound isolated from Platycodon grandiflorum with anticancer and anti-proliferative properties. PGD suppresses the expression of the IAP family of proteins including survivin, cIAP-1 and cIAP-2 and blocks the PI3K/Akt pathway by inhibiting the phosphorylation of GSK3β, Akt and the expression of PI3K. Polygalacin D induces apoptosis

HY-155019

Anticancer agent 128	IAP	Cancer
Anticancer agent 128 (compound 1) is an IAP inhibitor that covalently targets the BIR3 domains of XIAP, cIAP1, and cIAP2. Anticancer agent 128 targets the BIR3 domains of XIAP, cIAP1, and cIAP2 with IC₅₀s of 24.9 nM, 19.3 nM, and 10.3 nM, respectively .

HY-155018

Anticancer agent 127	IAP	Cancer
Anticancer agent 127 (142D6) is an IAP inhibitor that covalently targets the BIR3 domains of XIAP, cIAP1, and cIAP2. Anticancer agent 127 targets the BIR3 domains of XIAP, cIAP1, and cIAP2 with IC₅₀s of 12 nM, 14 nM, and 9 nM, respectively. Anticancer agent 127 has anticancer effects .

HY-111874

SNIPER(ABL)-039	SNIPERs Bcr-Abl	Cancer
SNIPER(ABL)-039, conjugating Dasatinib (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC₅₀ of 10 nM. IC₅₀s are 0.54 nM, 10 nM, 12 nM, and 50 nM for ABL, cIAP1, cIAP2, XIAP, respectively .

HY-125593

Dasminapant APG-1387	IAP Apoptosis	Cancer
Dasminapant (APG-1387), a bivalent SMAC mimetic and an IAP antagonist, blocks the activity of IAPs family proteins (XIAP, cIAP-1, cIAP-2, and ML-IAP). Dasminapant induces degradation of cIAP-1 and XIAP proteins, as well as caspase-3 activation and PARP cleavage, which leads to apoptosis. Dasminapant can be used for the research of hepatocellular carcinoma, ovarian cancer, and nasopharyngeal carcinoma ^[2] .

HY-151966

TD1092	PROTACs IAP Caspase	Cancer
TD1092 is a pan-IAP degrader, degrades *cIAP1, cIAP2, and XIAP. TD1092 activates Caspase* 3/7, and promotes cancer cells apoptosis via IAP degradation. TD1092 inhibits TNFα mediated NF-κB pathway and reduces the phosphorylation of IKK, IkBα, p65, and p38. TD1092 can act as PROTAC, and is used for cancer research .

HY-111875

SNIPER(BRD)-1	SNIPERs PROTACs Epigenetic Reader Domain	Cancer
SNIPER(BRD)-1 is a SNIPER degrader of BRD4, *cIAP1* and XIAP. SNIPER(BRD)-1 has IC₅₀ values of 6.8 nM, 17 nM and 49 nM for *cIAP1, cIAP2* and XIAP, respectively. SNIPER(BRD)-1 can be used for cancer research . (Blue: LCL161 (HY-15518); Black: linker (HY-W008005); Pink: (+)-JQ-1 (HY-13030))

HY-16591

Birinapant Maximum Cited Publications 37 Publications Verification TL32711	IAP Apoptosis HIV	Cancer
Birinapant (TL32711), a bivalent Smac mimetic, is a potent antagonist for XIAP and *cIAP1* with K_ds of 45 nM and less than 1 nM, respectively. Birinapant (TL32711) induces the autoubiquitylation and proteasomal degradation of cIAP1 and cIAP2 in intact cells, which results in formation of a RIPK1: caspase-8 complex, caspase-8 activation, and induction of tumor cell death. Birinapant (TL32711) targets TRAF2-associated cIAPs and abrogates TNF-induced NF-κB activation.

HY-13208

Xevinapant hydrochloride 5+ Cited Publications AT-406 hydrochloride; Debio 1143 hydrochloride; SM-406 hydrochloride	IAP Apoptosis	Cancer
Xevinapant (AT-406) hydrochloride is a potent and orally bioavailable Smac mimetic and an antagonist of the inhibitor of apoptosis proteins (IAPs). Xevinapant hydrochloride binds to XIAP, cIAP1, and cIAP2 proteins with K_is of 66.4, 1.9, and 5.1 nM, respectively. Xevinapant hydrochloride effectively antagonizes XIAP BIR3 protein in a cell-free functional assay, induces rapid degradation of cellular cIAP1 protein, and inhibits cancer cell growth in various human cancer cell lines. Xevinapant hydrochloride is highly effective in induction of apoptosis in xenograft tumors ^[2].

HY-124181

SM-1295	IAP Apoptosis	Cancer
SM-1295 is an inhibitor of apoptosis protein (IAP) antagonist, with K_d values of 3077 nM, 3.2 nM and 9.5 nM for XIAP-BIR3, c-IAP1-BIR3 and c-IAP2-BIR3, respectively ^[2].

HY-RS01511

Birc3 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Birc3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Birc3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Birc3 Mouse Pre-designed siRNA Set A Birc3 Mouse Pre-designed siRNA Set A

HY-RS01510

BIRC3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
BIRC3 Human Pre-designed siRNA Set A contains three designed siRNAs for BIRC3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

BIRC3 Human Pre-designed siRNA Set A BIRC3 Human Pre-designed siRNA Set A

HY-138779

ICCB-19 hydrochloride 1 Publications Verification	Autophagy RIP kinase Apoptosis	Inflammation/Immunology
ICCB-19 hydrochloride is a TRADD (TNFRSF1A associated via death domain) inhibitor. ICCB-19 hydrochloride binds with N-terminal domain of TRADD (TRADD-N), disrupting its binding to both TRADD-C and TRAF2. ICCB-19 hydrochloride is indirect inhibitor of RIPK1 kinase activity. ICCB-19 hydrochloride effectively induces autophagy and the degradation of long-lived proteins .

HY-RS01508

Birc2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Birc2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Birc2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Birc2 Mouse Pre-designed siRNA Set A Birc2 Mouse Pre-designed siRNA Set A

Polygalacin D 1 Publications Verification	Triterpenes Classification of Application Fields Terpenoids Source classification Platycodon grandiflorus (Jacq.) A. DC. Campanulaceae Plants Disease Research Fields Cancer	Apoptosis IAP
Polygalacin D (PGD) is a bioactive compound isolated from Platycodon grandiflorum with anticancer and anti-proliferative properties. PGD suppresses the expression of the IAP family of proteins including survivin, cIAP-1 and cIAP-2 and blocks the PI3K/Akt pathway by inhibiting the phosphorylation of GSK3β, Akt and the expression of PI3K. Polygalacin D induces apoptosis

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80618

	cIAP2 Antibody (YA795) cIAP2; AIP1; API2; BIRC3; cIAP2; HAIP1; IAP homolog C; RNF49; MIHC; MALT2; Apoptosis inhibitor 2; IAP2	WB	Human, Monkey
	cIAP2 Antibody (YA795) is a non-conjugated and Mouse origined monoclonal antibody about 68 kDa, targeting to cIAP2 (1F12). It can be used for WB assays with tag free, in the background of Human, Monkey.

HY-P85568

	cIAP2 Antibody (YA5260) AIP 1; AIP1; API 2; API2; API2; Apoptosis inhibitor 2; Baculoviral IAP repeat containing 3; Baculoviral IAP repeat containing protein 3; Baculoviral IAP repeat-containing protein 3; BIRC 3; BIRC3; BIRC3; BIRC3_HUMAN; C IAP2; C-IAP2; cIAP 2; cIAP 2; cIAP2; HAIP 1; HAIP1; HAIP1; HIAP 1; HIAP-1; HIAP1; IAP homolog C; IAP-1; Inhibitor of apoptosis protein 1; Inhibitor of apoptosis protein 1; MALT 2; MALT2; Mammalian IAP homolog C; MIHC; MIHC; RING finger protein 49; RNF49; TNFR2 TRAF signaling complex protein 1; TNFR2 TRAF signalling complex protein; TNFR2-TRAF-signaling complex protein 1.	WB	Human, Monkey
	cIAP2 Antibody (YA5260) is a mouse-derived and non-conjugated monoclonal antibody, targeting to cIAP2. It can be applicated for WB assays, in the background of human, monkey.

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Birc3 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Birc3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Birc3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

BIRC3 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
BIRC3 Human Pre-designed siRNA Set A contains three designed siRNAs for BIRC3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Birc2 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Birc2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Birc2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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