Search Result

Results for "

broad-spectrum anticancer

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Payload (1) Akt (2) Aminopeptidase (3) AMPK (1) Antibiotic (17) Apoptosis (18) Aurora Kinase (1) Autophagy (13) Bacterial (21) Bcl-2 Family (6) c-Fms (1) c-Kit (1) Calcium Channel (1) Carbonic Anhydrase (3) Caspase (2) CDK (5) DNA Alkylator/Crosslinker (2) DNA/RNA Synthesis (1) Drug Derivative (1) EGFR (3) Endogenous Metabolite (1) ERK (1) Ferroptosis (4) Fungal (8) HBV (1) HDAC (2) HIV (8) HIV Protease (6) Interleukin Related (1) Isotope-Labeled Compounds (6) JNK (2) MASTL (1) MDM-2/p53 (1) MEK (1) Microtubule/Tubulin (4) Mitophagy (1) MMP (9) mTOR (1) Mucin (1) Necroptosis (1) NF-κB (4) p38 MAPK (5) Parasite (14) PARP (2) PI3K (5) PKD (1) Polo-like Kinase (PLK) (1) Reactive Oxygen Species (ROS) (5) Reference Standards (10) SARS-CoV (1) Ser/Thr Protease (1) Src (1) STAT (2) TNF Receptor (1) Topoisomerase (8) VEGFR (2) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (80) Endocrinology (2) Infection (31) Inflammation/Immunology (4) Metabolic Disease (1) Neurological Disease (3)

By Targets:

ADC Payload (1)

Akt (2)

Aminopeptidase (3)

AMPK (1)

Antibiotic (17)

Apoptosis (18)

Aurora Kinase (1)

Autophagy (13)

Bacterial (21)

Bcl-2 Family (6)

c-Fms (1)

c-Kit (1)

Calcium Channel (1)

Carbonic Anhydrase (3)

Caspase (2)

CDK (5)

DNA Alkylator/Crosslinker (2)

DNA/RNA Synthesis (1)

Drug Derivative (1)

EGFR (3)

Endogenous Metabolite (1)

ERK (1)

Ferroptosis (4)

Fungal (8)

HBV (1)

HDAC (2)

HIV (8)

HIV Protease (6)

Interleukin Related (1)

Isotope-Labeled Compounds (6)

JNK (2)

MASTL (1)

MDM-2/p53 (1)

MEK (1)

Microtubule/Tubulin (4)

Mitophagy (1)

MMP (9)

mTOR (1)

Mucin (1)

Necroptosis (1)

NF-κB (4)

p38 MAPK (5)

Parasite (14)

PARP (2)

PI3K (5)

PKD (1)

Polo-like Kinase (PLK) (1)

Reactive Oxygen Species (ROS) (5)

Reference Standards (10)

SARS-CoV (1)

Ser/Thr Protease (1)

Src (1)

STAT (2)

TNF Receptor (1)

Topoisomerase (8)

VEGFR (2)

Wnt (1)

β-catenin (1)

By Research Areas:

Cancer (80)

Endocrinology (2)

Infection (31)

Inflammation/Immunology (4)

Metabolic Disease (1)

Neurological Disease (3)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0134

Bestatin 5+ Cited Publications Ubenimex	Aminopeptidase Bacterial Antibiotic	Infection Cancer
Bestatin is a natural, broad-spectrum, and competitive CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase inhibitor. Bestatin has anticancer effects .

HY-156777

Antiproliferative agent-36	Others	Cancer
Antiproliferative agent-36 (compound 8i) is a benzothiazolyl hydrazones derived compound with antiproliferative activity. Antiproliferative agent-36 has a broad-spectrum anticancer activity .

HY-N0565

Doxycycline 135+ Cited Publications	MMP Bacterial Antibiotic Parasite	Infection Cancer
Doxycycline, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor . Doxycycline shows antibacterial activity and anti-cancer cell proliferation activity .

HY-15287

Nelfinavir 10+ Cited Publications AG1341	HIV Protease HIV	Infection Cancer
Nelfinavir (AG-1341) is a potent and orally bioavailable HIV-1 protease inhibitor (K_i=2 nM) for HIV infection. Nelfinavir is a broad-spectrum, anticancer agent .

HY-15287A

Nelfinavir Mesylate 10+ Cited Publications AG 1343 Mesylate	HIV Protease HIV	Infection Cancer
Nelfinavir Mesylate (AG 1343 Mesylate) is a potent and orally bioavailable HIV-1 protease inhibitor (K_i=2 nM) for HIV infection. Nelfinavir Mesylate (AG 1343 Mesylate) is a broad-spectrum, anticancer agent .

HY-158061A

Topoisomerase II inhibitor 20 TFA	Topoisomerase Apoptosis	Cancer
Topoisomerase II inhibitor 20 TFA is a potent topoisomerase II inhibitor with IC₅₀ of 0.98 µM. Topoisomerase II inhibitor 20 TFA can induce apoptosis and has broad-spectrum anticancer activity .

HY-139635

Anticancer agent 11	DNA Alkylator/Crosslinker	Cancer
Anticancer agent 11 is a broad-spectrum anticancer agent that inhibits angiogenesis and induces DNA cross-links.

HY-151630

hCAIX-IN-16	Carbonic Anhydrase	Cancer
hCAIX-IN-16 (Compound 12d) is hCA IX inhibitor, with K_{i values of 190.0 and 187.9 nM for hCA IX and hCA XII, respectively. hCAIX-IN-16 can arrest the cell cycle of breast cancer MDA-MB-468 in G0-G1 and S phase and induce apoptosis. hCAIX-IN-16 shows good broad-spectrum anticancer activity and can be used for cancer research .}

HY-147822

Apoptosis inducer 6	Apoptosis	Cancer
Apoptosis inducer 6 (compound 4e) is an anticancer agent with a broad-spectrum anticancer activity. Apoptosis inducer 6 triggers cell death through the induction of apoptosis .

HY-151632

hCAIX-IN-15	Carbonic Anhydrase	Cancer
hCAIX-IN-15 is a potent hCA IX inhibitor with a K_i value of 38.8 nM. hCAIX-IN-15 shows good broad-spectrum anticancer activity and can be used for cancer research .

HY-158061

Topoisomerase II inhibitor 20	Topoisomerase Apoptosis	Cancer
Topoisomerase II inhibitor 20 (Compound 3e) is a potent topoisomerase II (Topoisomerase II) inhibitor with an IC₅₀ of 0.98 µM. Topoisomerase II inhibitor 20 induces apoptosis and has broad-spectrum anticancer activity .

HY-155570

Anticancer agent 137	PI3K Apoptosis Caspase PARP	Cancer
Anticancer agent 137 (8q) is a potent PI3k inhibitor. Anticancer agent 137 has broad-spectrum anticancer activity. Anticancer agent 137 induces G2/M cell cycle arrest and apoptosis. Anticancer agent 137 increases cleaved PARP, caspase 3, and 7. Anticancer agent 137 can be used in research of cancer .

HY-B0134R

Bestatin (Standard) Ubenimex (Standard)	Reference Standards Aminopeptidase Bacterial Antibiotic	Infection Cancer
Bestatin (Standard) is the analytical standard of Bestatin. This product is intended for research and analytical applications. Bestatin is a natural, broad-spectrum, and competitive CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase inhibitor. Bestatin has anticancer effects .

HY-N0565A

Doxycycline hydrochloride 135+ Cited Publications	MMP Bacterial Antibiotic Parasite	Infection Cancer
Doxycycline hydrochloride, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor . Doxycycline hydrochloride shows antibacterial activity and anti-cancer cell proliferation activity. Doxycycline hydrochloride can be used to construct gene expression regulation models .

HY-B0134S1

Bestatin-d10 Ubenimex-d₁₀	Isotope-Labeled Compounds Bacterial Antibiotic Aminopeptidase	Infection Cancer
Bestatin-d₁₀ (Ubenimex-d₁₀) is deuterium labeled Bestatin. Bestatin is a natural, broad-spectrum, and competitive CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase inhibitor. Bestatin has anticancer effects .

HY-N0565AS

Doxycycline-d3 hydrochloride	Isotope-Labeled Compounds Bacterial Antibiotic MMP Parasite	Infection Cancer
Doxycycline-d₃ hydrochloride is deuterium labeled Doxycycline (hydrochloride). Doxycycline hydrochloride, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor . Doxycycline hydrochloride shows antibacterial activity and anti-cancer cell proliferation activity .

HY-163114

2-Stearoxyphenethyl phosphocholin	p38 MAPK	Metabolic Disease
2-Stearoxyphenethyl phosphocholin (compound 1a) is a p38 MAPK inhibitor with anticancer activity. 2-Stearoxyphenethyl phosphocholin may bind to the p38 MAPK lipid-binding pocket and has broad-spectrum anti-tumor and lipid-modulating activities .

HY-113064

Selenocystine	Endogenous Metabolite	Cancer
Selenocystine is a broad-spectrum *anti-cancer* agent. Selenocystine induces DNA damage in HepG2 cells, particularly in the form of DNA double strand breaks (DSBs). Selenocystine exhibits great promise as a therapeutic or adjuvant agent targeting DNA repair for cancer treatment .

HY-N0565B

Doxycycline hyclate 135+ Cited Publications Doxycycline hydrochloride hemiethanolate hemihydrate; WC2031	Antibiotic MMP Bacterial Parasite	Infection Cancer
Doxycycline hyclate, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor. Doxycycline hyclate shows antibacterial activity and anti-cancer cell proliferation activity. Doxycycline hyclate can be used to construct gene expression regulation models .

HY-163115

2-Oleoxyphenethyl phosphocholin	p38 MAPK	Cancer
2-Oleoxyphenethyl phosphocholin (compound 1b) is a p38 MAPK inhibitor with anticancer activity. 2-Oleoxyphenethyl phosphocholin may bind to the p38 MAPK lipid-binding pocket and has broad-spectrum anti-tumor and lipid-modulating activities .

HY-N0565AR

Doxycycline hydrochloride (Standard)	Reference Standards MMP Bacterial Antibiotic Parasite	Infection Cancer
Doxycycline (hydrochloride) (Standard) is the analytical standard of Doxycycline (hydrochloride). This product is intended for research and analytical applications. Doxycycline hydrochloride, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor . Doxycycline hydrochloride shows antibacterial activity and anti-cancer cell proliferation activity [4] .

HY-N0565R

Doxycycline (Standard)	Reference Standards MMP Bacterial Antibiotic Parasite	Infection Cancer
Doxycycline (Standard) is the analytical standard of Doxycycline. This product is intended for research and analytical applications. Doxycycline, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor . Doxycycline shows antibacterial activity and anti-cancer cell proliferation activity [4] .

HY-N0565C

Doxycycline calcium	MMP Bacterial Antibiotic Parasite	Infection Cancer
Doxycycline calcium, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor . Doxycycline calcium shows antibacterial activity and anti-cancer cell proliferation activity. Doxycycline calcium can be used to construct gene expression regulation models .

HY-15287R

Nelfinavir (Standard) AG1341 (Standard)	Reference Standards HIV Protease HIV	Infection Cancer
Nelfinavir (Standard) is the analytical standard of Nelfinavir. This product is intended for research and analytical applications. Nelfinavir (AG-1341) is a potent and orally bioavailable HIV-1 protease inhibitor (K_i=2 nM) for HIV infection. Nelfinavir is a broad-spectrum, anticancer agent .

HY-15287S1

Nelfinavir-d4	HIV HIV Protease Isotope-Labeled Compounds	Infection Cancer
Nelfinavir-d₄ is deuterated labeled Nelfinavir (HY-15287). Nelfinavir (AG-1341) is a potent and orally bioavailable HIV-1 protease inhibitor (K_i=2 nM) for HIV infection. Nelfinavir is a broad-spectrum, anticancer agent .

HY-15287AR

Nelfinavir Mesylate (Standard)	HIV Protease HIV	Infection Cancer
Nelfinavir (Mesylate) (Standard) is the analytical standard of Nelfinavir (Mesylate). This product is intended for research and analytical applications. Nelfinavir Mesylate (AG 1343 Mesylate) is a potent and orally bioavailable HIV-1 protease inhibitor (Ki=2 nM) for HIV infection. Nelfinavir Mesylate (AG 1343 Mesylate) is a broad-spectrum, anticancer agent .

HY-157990

Wnt/β-catenin-IN-1	Wnt β-catenin	Cancer
Wnt/β-catenin-in-1 (compounds 17) is a Wnt/β-catenin signaling pathway inhibitor. Wnt/β-catenin-IN-1 can induce apoptosis of colon cancer cells, has broad-spectrum anticancer activity, and can be used for the reseach of a variety of solid tumors .

HY-117782

Anticancer agent 236	Others	Cancer
Anticancer agent 236 (compound JP-8g) is a broad-spectrum anticancer agent that has toxic effects on several cancer cell lines with IC₅₀ values of 6.925 μM (MDA), 6.296 μM (U937), 6.548 μM (Jurkat), 6.373 μM (Hela), and 10.381 μM (EJ) .

HY-N0565S3

Doxycycline-13C,d3	Isotope-Labeled Compounds MMP Parasite Bacterial Antibiotic	Infection Cancer
Doxycycline- ¹³C,d₃ is ¹³C and deuterium labeled Doxycycline. Doxycycline, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor . Doxycycline shows antibacterial activity and anti-cancer cell proliferation activity .

HY-161144

AKT-IN-21	Akt Apoptosis	Cancer
AKT-IN-21 (compound C36) is a potent AKT inhibitor with broad-spectrum cytotoxicity and anticancer activity. AKT-IN-21 also blocks the cell cycle and induces apoptosis of cancer cells by down-regulating the PI3K/AKT pathway .

HY-N0565BR

Doxycycline hyclate (Standard) Doxycycline hydrochloride hemiethanolate hemihydrate (Standard); WC2031 (Standard)	Reference Standards Antibiotic MMP Bacterial Parasite	Infection Cancer
Doxycycline hyclate (Standard) is the analytical standard of Doxycycline hyclate. This product is intended for research and analytical applications. Doxycycline hyclate, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor . Doxycycline hyclate shows antibacterial activity and anti-cancer cell proliferation activity .

HY-108016

Peruvoside Encordin	Src PI3K JNK STAT EGFR Apoptosis Autophagy	Cancer
Peruvoside is a potent inhibitor of Src, PI3K, JNK, STAT, and EGFR. Peruvoside induces apoptosis and autophagy and possesses a broad spectrum of anticancer activity in breast, lung, liver cancers and leukemia. Peruvoside is a broad-spectrum and potent antiviral activity against positive-sense RNA viruses. Peruvoside sensitizes Gefitinib (HY-50895)-resistant tumour cells (A549, PC9/gef and H1975) to Gefitinib .

HY-15287S

Nelfinavir-d3	Isotope-Labeled Compounds HIV Protease HIV	Infection Cancer
Nelfinavir-d₃ (AG1341-d3) is the deuterium labeled Nelfinavir. Nelfinavir (AG-1341) is a potent and orally bioavailable HIV-1 protease inhibitor (Ki=2 nM) for HIV infection. Nelfinavir is a broad-spectrum, anticancer agent .

HY-N2949

Bonducellpin D	SARS-CoV	Infection Cancer
Bonducellpin D is a furanoditerpenoid lactone isolated from Caesalpinia minax. Bonducellpin D exhibits broad-spectrum inhibition potential against SARS-CoV M ^pro and MERS-CoV M ^pro, with an K_i of 467.11 and 284.86 nM, respectively. Bonducellpin D also exhibits moderate anti-cancer activity in vitro .

HY-10969

Obatoclax Mesylate 10+ Cited Publications GX15-070 Mesylate	Bcl-2 Family Autophagy Parasite	Infection Cancer
Obatoclax Mesylate (GX15-070 Mesylate), a BH3 mimetic, is a pan-BCL-2 family proteins inhibitor with a K_i of 220 nM for BCL-2 . Obatoclax Mesylate induces autophagy-dependent cell death and targets cyclin D1 for proteasomal degradation. Obatoclax Mesylate has anti-cancer and broad-spectrum antiparasitic activity .

HY-147864

c-Fms-IN-12	c-Fms c-Kit Apoptosis	Cancer
c-Fms-IN-12 (Compound 4g) is an FMS kinase inhibitor. c-Fms-IN-12 can also inhibits c-KIT. c-Fms-IN-12 is a potential broad-spectrum anticancer agent against multiple cancer types. c-Fms-IN-12 induces A549 cell apoptosis .

HY-10969A

Obatoclax GX15-070	Bcl-2 Family Autophagy Parasite	Infection Cancer
Obatoclax (GX15-070), a BH3 mimetic, is a pan-BCL-2 family proteins inhibitor with a K_i of 220 nM for BCL-2 . Obatoclax induces autophagy-dependent cell death and targets cyclin D1 for proteasomal degradation. Obatoclax has anti-cancer and broad-spectrum antiparasitic activity .

HY-176347S

Alpha Feto Protein, Arg-13C6,15N4, Lys-13C6,15N2	Isotope-Labeled Compounds	Cancer
Alpha Feto Protein, Arg- ¹³C₃₆, ¹⁵N₄, Lys- ¹³C₆, ¹⁵N₂ is the ¹³C- and ¹⁵N-labeled Alpha Feto Protein.

HY-N0275

(±)-10-Hydroxycamptothecin (±)-10-HCPT	Topoisomerase	Cancer
(±)-10-Hydroxycamptothecin is an indole alkaloid that inhibits the activity of topoisomerase I and has a broad spectrum of anticancer activity.

HY-12098

Verubulin hydrochloride MPC-6827 hydrochloride	Microtubule/Tubulin	Cancer
Verubulin hydrochloride (MPC-6827 hydrochloride) is a blood brain barrier permeable microtubule-disrupting agent, with potent and broad-spectrum in vitro and in vivo cytotoxic activities. Verubulin hydrochloride (MPC-6827 hydrochloride) exhibits potent anticancer activity in human MX-1 breast and other mouse xenograft cancer models. Verubulin hydrochloride (MPC 6827 hydrochloride) is a promising candidate for the treatment of multiple cancer types .

HY-146358

Anticancer agent 49	Microtubule/Tubulin	Cancer
Anticancer agent 49 (compound 69) is a broad spectrum anticancer agent. Anticancer agent 49 inhibits tubulin polymerization. Anticancer agent 49 shows antiproliferative activity. Anticancer agent 49 has the potential for the research of solid and hematological tumors .

HY-N0372

Licochalcone A 15+ Cited Publications	Autophagy	Cancer
Licochalcone A (LCA), a flavonoid isolated, presents obvious anti-cancer effects, displays broad-spectrum inhibition against UDP-glucuronosyltransferases (UGTs) . Licochalcone A (LCA) exhibits strong inhibitory effects against UGT1A1, 1A3, 1A4, 1A6, 1A7, 1A9, and 2B7 (both IC₅₀ and K_i values lower than 5 μM) .

HY-175269

MGB1Y	DNA Alkylator/Crosslinker DNA/RNA Synthesis Topoisomerase	Cancer
MGB1Y is a noncovalent DNA minor groove binder (MGB). MGB1Y potently inhibits cancer cells proliferation and topoisomerase I activity. MGB1Y downregulates their breast cancer-related genes in MCF7 and MDA-MB-231 cells. MGB1Y has a broad-spectrum anticancer activity, such as breast cancer, colon cancer, and leukemia .

HY-B0319

Tioconazole 3 Publications Verification UK-20349	Fungal Antibiotic Parasite Akt PI3K mTOR Autophagy	Infection Cancer
Tioconazole (UK-20349) is a broad-spectrum antifungal imidazole derivative. Tioconazole inhibits several dermatophytes and yeasts, with MIC₅₀ values of less than 3.12 mg/L and 9 mg/L, respectively. Additionally, Tioconazole exhibits anti-parasitic activity. Tioconazole exerts anticancer activity by inhibiting the PI3K/AKT/mTOR signaling pathway and blocking autophagy. Tioconazole is applicable for research in the fields of anti-infection and anticancer therapy .

HY-176282

CDK8-IN-19	CDK PI3K	Cancer
CDK8-IN-19 (Compound 3d) is a CDK8 inhibitor with an IC₅₀ of 25.08 nM. CDK8-IN-19 has a broad-spectrum anticancer activity, such as leukemia, melanoma and breast cancer, without significant cytotoxic effect on the normal Vero cells (mean IC₅₀s of 2.87, 3.65, 3.79 and 45.48 μM, respectively) .

HY-146357

Anticancer agent 48	Microtubule/Tubulin	Cancer
Anticancer agent 48 (compound 48) is a broad spectrum anticancer agent. Anticancer agent 48 inhibits tubulin polymerization. Anticancer agent 48 shows antiproliferative activity. Anticancer agent 48 shows antitumor activity in vivo. Anticancer agent 48 has the potential for the research of solid and hematological tumors .

HY-175245

hCA-IN-1	Carbonic Anhydrase	Cancer
hCA-IN-1 (Compound 5u) is an hCA inhibitor with K_i values of 159.2, 4.8, 15.5, and 2 nM against hCA I, hCA II, hCA IX, and hCA XII, respectively. hCA-IN-1 exhibits broad-spectrum anticancer activity against melanoma, breast, and colon cancer cells. ADME predictions indicate that hCA-IN-1 has good solubility and oral bioavailability. hCA-IN-1 can be used in tumor research .

HY-176281

PI3Kα-IN-26	PI3K CDK	Cancer
PI3Kα-IN-26 (Compound 11e) is a PI3Kα inhibitor with an IC₅₀ of 75.31 nM. PI3Kα-IN-26 has a broad-spectrum anticancer activity, such as leukemia, colon and breast cancer, without significant cytotoxic effect on the normal Vero cells (mean IC₅₀s of 2.74, 3.50, 3.34 and 85.29 μM, respectively) .

HY-155458

HYDAMTIQ	PARP	Inflammation/Immunology Cancer
HYDAMTIQ is a PARP-1/2 inhibitor (IC₅₀: 29-38 nM) with anticancer, anti-inflammatory, and ischemic protective effects. HYDAMTIQ inhibits pulmonary PARP activity, is effective against allergen-induced cough and dyspnea, and inhibits bronchial hyperresponsiveness to methacholine. HYDAMTIQ has broad-spectrum tumor suppressor effects, including ovarian and breast cancers, prostate and pancreatic tumors, and glioblastoma multiforme. HYDAMTIQ has demonstrated in vivo efficacy in animal models of cerebral ischemia, asthma, cancer, and more .

HY-12098R

Verubulin hydrochloride (Standard)	Microtubule/Tubulin	Cancer
Verubulin (hydrochloride) (Standard) is the analytical standard of Verubulin (hydrochloride). This product is intended for research and analytical applications. Verubulin hydrochloride (MPC-6827 hydrochloride) is a blood brain barrier permeable microtubule-disrupting agent, with potent and broad-spectrum in vitro and in vivo cytotoxic activities. Verubulin hydrochloride (MPC-6827 hydrochloride) exhibits potent anticancer activity in human MX-1 breast and other mouse xenograft cancer models. Verubulin hydrochloride (MPC 6827 hydrochloride) is a promising candidate for the treatment of multiple cancer types .

Cat. No.	Product Name	Target	Research Area

HY-113064

Selenocystine	Endogenous Metabolite	Cancer
Selenocystine is a broad-spectrum *anti-cancer* agent. Selenocystine induces DNA damage in HepG2 cells, particularly in the form of DNA double strand breaks (DSBs). Selenocystine exhibits great promise as a therapeutic or adjuvant agent targeting DNA repair for cancer treatment .

HY-P11102

Temporin-SHa	Bacterial Fungal HIV Parasite	Infection Cancer
Temporin-Sha is an antibacterial peptide with extensive biological activity. Temporin-Sha exhibits broad-spectrum antibacterial activity (e.g., against L. ivanovii, MIC = 6.25 μM), and is effective against Gram-negative bacteria (such as Escherichia coli, MIC = 10 μM), including drug-resistant strains (such as Methicillin (HY-121544)-resistant Staphylococcus aureus). Temporin-Sha also has inhibitory effects on Candida albicans (MIC = 25 μM), Saccharomyces cerevisiae (MIC = 12 μM), the pre-flagellated and non-flagellated forms of Leishmania infantum (IC₅₀ = 5-20 μM), and Trypanosoma cruzi (IC₅₀ = 17 μM). Temporin-Sha exhibits antiviral activity against HSV-1 and has anti-cancer effects (cytotoxicity against breast cancer cells MCF-7 and lung cancer cells H460, etc.) .

Cat. No.	Product Name	Target	Research Area

HY-P991608

CTM01 7F11C7	Mucin	Cancer
CTM01 is a murine IgG1 (or humanized IgG4) monoclonal antibody inhibitor targeting MUC1. CTM01 has a broad spectrum anticancer activity against solid tumors of epithelial origin, such as breast, lung and ovarian cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0134

Bestatin 5+ Cited Publications Ubenimex	Infection Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields	Aminopeptidase Bacterial Antibiotic
Bestatin is a natural, broad-spectrum, and competitive CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase inhibitor. Bestatin has anticancer effects .

HY-108016

Peruvoside Encordin	Apocynaceae Triterpenes Structural Classification Terpenoids Source classification Thevetia peruviana (Pers.) K. Schum. Plants	Src PI3K JNK STAT EGFR Apoptosis Autophagy
Peruvoside is a potent inhibitor of Src, PI3K, JNK, STAT, and EGFR. Peruvoside induces apoptosis and autophagy and possesses a broad spectrum of anticancer activity in breast, lung, liver cancers and leukemia. Peruvoside is a broad-spectrum and potent antiviral activity against positive-sense RNA viruses. Peruvoside sensitizes Gefitinib (HY-50895)-resistant tumour cells (A549, PC9/gef and H1975) to Gefitinib .

HY-N2949

Bonducellpin D	Other Terpenoids Infection Caesalpinia minax Hance Classification of Application Fields Leguminosae Terpenoids Source classification Plants Disease Research Fields	SARS-CoV
Bonducellpin D is a furanoditerpenoid lactone isolated from Caesalpinia minax. Bonducellpin D exhibits broad-spectrum inhibition potential against SARS-CoV M ^pro and MERS-CoV M ^pro, with an K_i of 467.11 and 284.86 nM, respectively. Bonducellpin D also exhibits moderate anti-cancer activity in vitro .

HY-N0275

(±)-10-Hydroxycamptothecin (±)-10-HCPT	Structural Classification Pyrrole Alkaloids Classification of Application Fields Source classification Quinoline Alkaloids Camptotheca acuminata Decne. Nyssaceae Plants Alkaloids Monophenols Phenols Disease Research Fields Cancer	Topoisomerase
(±)-10-Hydroxycamptothecin is an indole alkaloid that inhibits the activity of topoisomerase I and has a broad spectrum of anticancer activity.

HY-N0372

Licochalcone A 15+ Cited Publications	Structural Classification Chalcones Flavonoids Classification of Application Fields Leguminosae Source classification Plants Glycyrrhiza uralensis Fisch. Disease Research Fields Cancer	Autophagy
Licochalcone A (LCA), a flavonoid isolated, presents obvious anti-cancer effects, displays broad-spectrum inhibition against UDP-glucuronosyltransferases (UGTs) . Licochalcone A (LCA) exhibits strong inhibitory effects against UGT1A1, 1A3, 1A4, 1A6, 1A7, 1A9, and 2B7 (both IC₅₀ and K_i values lower than 5 μM) .

HY-N0168

Hesperetin 20+ Cited Publications	Structural Classification Flavonoids other families Neurological Disease Classification of Application Fields Sunscreen Flavonones Source classification Cosmetic Research Plants Disease Research Fields Cancer	p38 MAPK Autophagy Apoptosis Reactive Oxygen Species (ROS) NF-κB Bcl-2 Family
Hesperetin is a natural flavanone that can be found in citrus, and acts as a potent and orally active broad-spectrum inhibitor against human UGT activity. Hesperetin induces apoptosis via p38 MAPK activation. Hesperetin displays a range of bioactivities including antioxidant, anti-inflammatory, and anti-cancer. Hesperetin is found to induce cell-cycle arrest at G2/M phase. Hesperetin can reduce Bcl-2 and enhance BaxM. Hesperetin induces apoptosis through inhibiting NF-κB receptor .

HY-B0134R

Bestatin (Standard) Ubenimex (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Reference Standards Aminopeptidase Bacterial Antibiotic
Bestatin (Standard) is the analytical standard of Bestatin. This product is intended for research and analytical applications. Bestatin is a natural, broad-spectrum, and competitive CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase inhibitor. Bestatin has anticancer effects .

HY-113064

Selenocystine	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
Selenocystine is a broad-spectrum *anti-cancer* agent. Selenocystine induces DNA damage in HepG2 cells, particularly in the form of DNA double strand breaks (DSBs). Selenocystine exhibits great promise as a therapeutic or adjuvant agent targeting DNA repair for cancer treatment .

HY-15142A

Doxorubicin Hydroxydaunorubicin	Infection Quinones Structural Classification Microorganisms Classification of Application Fields Anthraquinones Source classification Phenols Polyphenols Disease Research Fields	ADC Payload Antibiotic Bacterial Topoisomerase AMPK HIV Autophagy Mitophagy Apoptosis HBV
Doxorubicin (Hydroxydaunorubicin), a broad-spectrum anthracycline antibiotic with cytotoxic properties, is an anti-cancer chemotherapy agent. Doxorubicin has fluorescence properties. Doxorubicin inhibits topoisomerase II with an IC₅₀ of 2.67 μM, thus stopping DNA replication. Doxorubicin reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin induces apoptosis and autophagy . Doxorubicin inhibits human DNA topoisomerase I with an IC₅₀ of 0.8 μM .

HY-N0372R

Licochalcone A (Standard)	Structural Classification Chalcones Flavonoids Leguminosae Source classification Plants Glycyrrhiza uralensis Fisch.	Reference Standards Autophagy
Licochalcone A (Standard) is the analytical standard of Licochalcone A. This product is intended for research and analytical applications. Licochalcone A (LCA), a flavonoid isolated, presents obvious anti-cancer effects, displays broad-spectrum inhibition against UDP-glucuronosyltransferases (UGTs) . Licochalcone A (LCA) exhibits strong inhibitory effects against UGT1A1, 1A3, 1A4, 1A6, 1A7, 1A9, and 2B7 (both IC₅₀ and Ki values lower than 5 μM) .

HY-N0275R

(±)-10-Hydroxycamptothecin (Standard)	Alkaloids Structural Classification Monophenols Pyrrole Alkaloids Source classification Phenols Quinoline Alkaloids Camptotheca acuminata Decne. Nyssaceae Plants	Topoisomerase
(±)-10-Hydroxycamptothecin (Standard) is the analytical standard of (±)-10-Hydroxycamptothecin. This product is intended for research and analytical applications. (±)-10-Hydroxycamptothecin is an indole alkaloid that inhibits the activity of topoisomerase I and has a broad spectrum of anticancer activity.

HY-N0168A

(Rac)-Hesperetin	Structural Classification Flavonoids other families Flavonones Source classification Phenols Polyphenols Plants	p38 MAPK Apoptosis Autophagy Reactive Oxygen Species (ROS) NF-κB Bcl-2 Family
(Rac)-Hesperetin is the racemate of Hesperetin. Hesperetin is a natural flavanone that can be found in citrus, and acts as a potent and orally active broad-spectrum inhibitor against human UGT activity. Hesperetin induces apoptosis via p38 MAPK activation. Hesperetin displays a range of bioactivities including antioxidant, anti-inflammatory, and anti-cancer. Hesperetin is found to induce cell-cycle arrest at G2/M phase. Hesperetin can reduce Bcl-2 and enhance BaxM. Hesperetin induces apoptosis through inhibiting NF-κB receptor .

HY-N2491

Deoxyelephantopin 1 Publications Verification	Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Source classification Amorpha fruticosaL. Plants Compositae Disease Research Fields Cancer	NF-κB
Deoxyelephantopin, a natural bioactive sesquiterpene lactone from Elephantopus scaber, has shown promising anticancer effects against a broad spectrum of cancers. Deoxyelephantopin inhibits NF-κB, MAPK, PI3K/Akt, and β-catenin signaling .

HY-N0168AR

(Rac)-Hesperetin (Standard)	Structural Classification Flavonoids other families Flavonones Source classification Phenols Polyphenols Plants	Reference Standards p38 MAPK Apoptosis Autophagy Reactive Oxygen Species (ROS) Bcl-2 Family NF-κB
(Rac)-Hesperetin (Standard) is the analytical standard of (Rac)-Hesperetin. This product is intended for research and analytical applications. (Rac)-Hesperetin is the racemate of Hesperetin. Hesperetin is a natural flavanone that can be found in citrus, and acts as a potent and orally active broad-spectrum inhibitor against human UGT activity. Hesperetin induces apoptosis via p38 MAPK activation. Hesperetin displays a range of bioactivities including antioxidant, anti-inflammatory, and anti-cancer. Hesperetin is found to induce cell-cycle arrest at G2/M phase. Hesperetin can reduce Bcl-2 and enhance BaxM. Hesperetin induces apoptosis through inhibiting NF-κB receptor .

Cat. No.	Product Name	Chemical Structure

HY-B0134S1

Bestatin-d10
Bestatin-d₁₀ (Ubenimex-d₁₀) is deuterium labeled Bestatin. Bestatin is a natural, broad-spectrum, and competitive CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase inhibitor. Bestatin has anticancer effects .

HY-N0565AS

Doxycycline-d3 hydrochloride
Doxycycline-d₃ hydrochloride is deuterium labeled Doxycycline (hydrochloride). Doxycycline hydrochloride, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor . Doxycycline hydrochloride shows antibacterial activity and anti-cancer cell proliferation activity .

HY-15287S1

Nelfinavir-d4
Nelfinavir-d₄ is deuterated labeled Nelfinavir (HY-15287). Nelfinavir (AG-1341) is a potent and orally bioavailable HIV-1 protease inhibitor (K_i=2 nM) for HIV infection. Nelfinavir is a broad-spectrum, anticancer agent .

HY-N0565S3

Doxycycline-13C,d3
Doxycycline- ¹³C,d₃ is ¹³C and deuterium labeled Doxycycline. Doxycycline, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor . Doxycycline shows antibacterial activity and anti-cancer cell proliferation activity .

HY-15287S

Nelfinavir-d3
Nelfinavir-d₃ (AG1341-d3) is the deuterium labeled Nelfinavir. Nelfinavir (AG-1341) is a potent and orally bioavailable HIV-1 protease inhibitor (Ki=2 nM) for HIV infection. Nelfinavir is a broad-spectrum, anticancer agent .

HY-176347S

Alpha Feto Protein, Arg-13C6,15N4, Lys-13C6,15N2
Alpha Feto Protein, Arg- ¹³C₃₆, ¹⁵N₄, Lys- ¹³C₆, ¹⁵N₂ is the ¹³C- and ¹⁵N-labeled Alpha Feto Protein.

HY-175318S

p53 Activator 15

p53 Activator 15 (Compound 2) is an orally active p53 activator. p53 Activator 15 enhances the bind ability of p53 Y220C to DNA and significantly suppresses cancer cells proliferation (IC₅₀: 58  nM for NUGC-3 cells), without inhibitory activity against CYP enzyme. p53 Activator 15 potently inhibits tumor growth in NUGC-3 xenograft mice model. p53 Activator 15 has a broad-spectrum anti-cancer activity, such as breast, stomach and lung cancer .

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broad-spectrum anticancer

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