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Results for "

amide linker

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Linker (25) Drug-Linker Conjugates for ADC (6) E3 Ligase Ligand-Linker Conjugates (25) Target Protein Ligand-Linker Conjugates (1) Androgen Receptor (2) Apoptosis (2) Autophagy (2) Bacterial (2) Biochemical Assay Reagents (49) DNA Alkylator/Crosslinker (1) Drug Intermediate (3) Endogenous Metabolite (2) Epigenetic Reader Domain (1) Ferroptosis (1) Fluorescent Dye (5) Glutathione Peroxidase (1) Influenza Virus (1) Isotope-Labeled Compounds (1) Liposome (1) LXR (1) MAGL (1) N-myristoyltransferase (1) PROTAC Linkers (45) PROTACs (3) Reactive Oxygen Species (ROS) (1) SNIPERs (1) Toll-like Receptor (TLR) (4) Topoisomerase (2)
By Research Areas:	Cancer (96) Cardiovascular Disease (1) Infection (2) Inflammation/Immunology (5) Metabolic Disease (2) Neurological Disease (1)
Click Chemistry:	ADC Synthesis (2) TCO (1) DBCO (5) PROTAC Synthesis (7) Azide (6) Tetrazine (1) Alkynes (4)
Oligonucleotides:	Phospholipids (1) Polymers (1)

172

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Targets Recommended: FAAH ADC Linker Target Protein Ligand-Linker Conjugates PROTAC-Linker Conjugates for PAC Drug-Linker Conjugates for ADC E3 Ligase Ligand-Linker Conjugates

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W008575

N-Fmoc-N-methoxy-3-aminopropionic acid	Biochemical Assay Reagents	Others
N-Fmoc-N-methoxy-3-aminopropionic acid, a Weinreb amide linker, is a protein cross-linking agent .

HY-49484

EGGGG-PEG8-amide-bis(deoxyglucitol)	ADC Linker	Cancer
EGGGG-PEG8-amide-bis(deoxyglucitol) is a cleavable ADC linker.

HY-48692

Mal-EGGGG-PEG8-amide-bis(deoxyglucitol)	ADC Linker	Cancer
Mal-EGGGG-PEG8-amide-bis(deoxyglucitol) is a cleavable ADC linker.

HY-159165

Pomalidomide-cyclopentane-amide-Alkyne	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide-cyclopentane-amide-Alkyne is an *E3 ligase ligand-linker* conjugate** that incorporates the Pomalidomide (HY-10984) and the linker cyclopentane-amide-Alkyne. Pomalidomide-cyclopentane-amide-Alkyne is used to form PROTACs, such as RGB110 (HY-159087) .

HY-171814

Mal-PEG2-amide-C2-amide-Phenyl(β-D-glucuronide)-NMT-IN-7	Drug-Linker Conjugates for ADC N-myristoyltransferase	Cancer
Mal-PEG2-amide-C2-amide-Phenyl(β-D-glucuronide)-NMT-IN-7 (Compound DC-2) is a *drug-linker* conjugate for ADC*. Mal-PEG2-amide-C2-amide-Phenyl(β-D-glucuronide)-NMT-IN-7 consists of a NMT* inhibitor (HY-160945) and a stable and cleavable linker (Mal-PEG2-amide-C2-amide-Phenyl(β-D-glucuronide)). Mal-PEG2-amide-C2-amide-Phenyl(β-D-glucuronide)-NMT-IN-7 can be used for synthesis of ADCs .

HY-W800648

Mal-PEG2-amide	Biochemical Assay Reagents	Others
Mal-PEG2-Amide is a PEG linker with a maleimide group which can react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.

HY-W800791

16:0 Caproylamine PE	Liposome	Cancer
16:0 Caproylamine PE is an amide-functionalized lipid with a phosphoethanolamine linked to two palmitic acid tails.

HY-176430

Lenalidomide-amide-pimelic acid	E3 Ligase Ligand-Linker Conjugates	Cancer
Lenalidomide-amide-pimelic acid is an *E3 ligase ligand-linker* conjugate** that incorporates the Lenalidomide (HY-A0003) based CRBN ligand and Linker (HY-Y1139). Lenalidomide-amide-pimelic acid can be used for synthesis of PROTAC MNK1 degrader-1 (HY-176428) .

HY-171507

Mal-Val-Ala-amide-(3)PEA-PNU-159682	Drug-Linker Conjugates for ADC	Cancer
Mal-Val-Ala-amide-(3)PEA-PNU-159682 is a *Drug-Linker* Conjugates for ADC*, composes of ADC linker* (Mal-Val-Ala-amide-(3)PEA) and ADC cytotoxin PNU-159682 (HY-16700), and has anti-tumor activity .

HY-136272

A 410099.1 amide-PEG3-amine-Boc	E3 Ligase Ligand-Linker Conjugates	Cancer
A 410099.1 amide-PEG3-amine-Boc is a functionalized IAP ligand for PROTACs that incorporates an IAP ligand and an amide-PEG3 linker with terminal amine. A 410099.1 amide-PEG3-amine-Boc can conjugates with target protein ligands.

HY-136273

A 410099.1 amide-PEG2-amine-Boc	E3 Ligase Ligand-Linker Conjugates	Cancer
A 410099.1 amide-PEG2-amine-Boc is a functionalized IAP ligand for PROTACs that incorporates an IAP ligand and an amide-PEG3 linker with terminal amine. A 410099.1 amide-PEG2-amine-Boc can conjugates with target protein ligands.

HY-136274

Boc-A 410099.1 amide-alkylC4-amine	E3 Ligase Ligand-Linker Conjugates	Cancer
Boc-A 410099.1 amide-alkylC4-amine is a functionalized IAP ligand for PROTACs that incorporates an IAP ligand and an amide-alkylC4 linker with terminal amine. Boc-A 410099.1 amide-alkylC4-amine can conjugates with target protein ligands.

HY-164391

Pomalidomide-C2-amide-C4-Br	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide-C2-amide-C4-Br is an E3 ligase ligand-linker conjugate containing a Pomalidomide (HY-10984) based cereblon (CRBN) ligand and a linker. Pomalidomide-C2-amide-C4-Br can be used in the synthesis of PROTACs .

HY-148471A

C3-Amide-C4-NH2	ADC Linker	Others
C3-Amide-C4-NH2 is a potent linker .

HY-148472A

C2-Amide-C4-NH2	ADC Linker	Others
C2-Amide-C4-NH2 is a potent linker .

HY-157921

Amino-EG6-undecanethiol hydrochloride 20-(9-Mercaptononyl)-3,6,9,12,15,18-hexaoxaeicosane-1-amine, hydrochloride	Biochemical Assay Reagents	Others
Amino-EG6-undecanethiol hydrochloride is a biochemical assay reagent, and can be used as a linker through amide coupling .

HY-163208

VH 032 amide-alkylC9-amine hydrochloride (S,R,S)-AHPC-C9-NH2 hydrochloride	PROTAC Linkers	Others
VH 032 amide-alkylC9-amine hydrochloride (Linker 33) is TRK ligand conjugated to the degradation tag .

HY-133507

Mal-amide-PEG2-oxyamine	PROTAC Linkers	Cancer
Mal-amide-PEG2-oxyamine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-130908

11-Maleimidoundecanoic acid	Biochemical Assay Reagents	Others
11-Maleimidoundecanoic acid is an intermediate for ester and amide linked maleimide monomers. 11-Maleimidoundecanoic acid can be used to generate copolymers .

HY-133503

Mal-amide-PEG2-oxyamine-Boc	PROTAC Linkers	Cancer
Mal-amide-PEG2-oxyamineBoc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-148080

Indole-C2-amide-C2-NH2	ADC Linker	Others
Indole-C2-amide-C2-NH2 is a potent linker .

HY-161974

Adamantan-C-amide-PEG2-C-Br	E3 Ligase Ligand-Linker Conjugates	Cancer
Adamantan-C-amide-PEG2-C-Br is a conjugate of a Hyt hydrophobic group and a linker. Adamantan-C-amide-PEG2-C-Br can be used to synthesize ZX782 (HY-161972) .

HY-140249

Tri(Amino-PEG3-amide)-amine	PROTAC Linkers	Cancer
Tri(Amino-PEG3-amide)-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-138522

NHS-bis-PEG2-amide-Mal	PROTAC Linkers	Cancer
NHS-bis-PEG2-amide-Mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-141008

Tri(Mal-PEG2-amide)-amine	PROTAC Linkers	Cancer
Tri(Mal-PEG2-amide)-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-140251

Tri(Amino-PEG5-amide)-amine	PROTAC Linkers	Cancer
Tri(Amino-PEG5-amide)-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-160714

Fmoc-Ala-Ala-Ala-amide-C-O-C-COOH	ADC Linker	Cancer
Fmoc-Ala-Ala-Ala-amide-C-O-C-COOH (Compound IM-3) is a cleavable ADC linker .

HY-140250

Tri(Amino-PEG4-amide)-amine	PROTAC Linkers	Cancer
Tri(Amino-PEG4-amide)-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-138533

Thiol-C10-amide-PEG8	PROTAC Linkers	Cancer
Thiol-C10-amide-PEG8 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-138530

Thiol-PEG4-amide-NH2	PROTAC Linkers	Cancer
Thiol-PEG4-amide-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-145367

Ala-CO-amide-C4-Boc	ADC Linker	Cancer
Ala-CO-amide-C4-Boc is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-140250A

Tri(Amino-PEG4-amide)-amine TFA	PROTAC Linkers	Cancer
Tri(Amino-PEG4-amide)-amine TFA is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-140249A

Tri(Amino-PEG3-amide)-amine TFA	PROTAC Linkers	Cancer
Tri(Amino-PEG3-amide)-amine TFA is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-141423

Thalidomide-O-amide-C5-NH2	E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis	Cancer
Thalidomide-O-amide-C5-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology .

HY-139085A

XL388-C2-amide-PEG9-NH2 hydrochloride	Drug Intermediate	Cancer
XL388-C2-amide-PEG9-NH2 hydrochloride is an intermediate used in the synthesis of C26-linked Rapamycin analog .

HY-141423A

Thalidomide-O-amide-C5-NH2 TFA	E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis	Cancer
Thalidomide-O-amide-C5-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology .

HY-139085B

XL388-C2-amide-PEG9-NH2 TFA	Drug Intermediate	Cancer
XL388-C2-amide-PEG9-NH2 TFA is an intermediate used in the synthesis of C26-linked Rapamycin analog .

HY-176038

MS1262-C3-amide-C10-amine	Target Protein Ligand-Linker Conjugates MAGL	Others
MS1262-C3-amide-C10-amine is a *E3 Ligase Ligand-Linker* Conjugates*. MS1262-C3-amide-C10-amine incorporates a GLP ligand for the E3 ligase SPOP* (HY-176036), and a PROTAC linker (HY-176037). MS1262-C3-amide-C10-amine can be used to design PROTACs such as MS479 (HY-176035) .

HY-W800847

Mal-Amide-PEG4-Val-Cit-PAB-PNP	ADC Linker	Cancer
Mal-Amide-PEG4-Val-Cit-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-141185

TCO-PEG3-amide-C3-triethoxysilane	PROTAC Linkers	Cancer
TCO-PEG3-amide-C3-triethoxysilane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-148425

Mal-amide-PEG8-Val-Ala-PAB-PNP	ADC Linker	Cancer
Mal-amide-PEG8-Val-Ala-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-138532

m-PEG8-amide-C10-Thiol	PROTAC Linkers	Cancer
m-PEG8-amide-C10-Thiol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-168318

Bestatin-amide-PEG3-CH2-acid	E3 Ligase Ligand-Linker Conjugates	Cancer
Bestatin-amide-PEG3-CH2-acid is an *E3 ligase ligand-linker* conjugate*. Bestatin-amide*-PEG3-CH2-acid can be used to synthesize PROTAC RAR Degrader-1 (HY-111844) .

HY-125541

DBCO-NHCO-PEG4-acid	ADC Linker PROTAC Linkers	Cancer
DBCO-Amide-PEG5-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-Amide-PEG5-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . DBCO-NHCO-PEG4-acid is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-49206

CbzNH-PEG8-amide-bis(pentayl-5OBz)	ADC Linker	Cancer
CbzNH-PEG8-amide-bis(pentayl-5OBz) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-172625

VH 101-amide-piperidine-Pip-alkyne	E3 Ligase Ligand-Linker Conjugates	Cancer
VH 101-amide-piperidine-Pip-alkyne is an *E3 Ligase Ligand-Linker* Conjugates** that can be used to synthesize PROTAC degrader. The linker part of VH 101-amide-piperidine-Pip-alkyne is tert-Butyl 4-ethynyl-[1,4'-bipiperidine]-1'-carboxylate (HY-W442074), and the VHL-type E3 ubiquitinase ligand is VH 101, acid (HY-47070) .

HY-160235

Pomalidomide-C2-amide-C5-azide	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide-C2-amide-C5-azidea is an E3 linker conjugate, pomalidomide, that can be used to synthesize highly effective PROTAC molecules towards CDK9. Pomalidomide-C2-amide-C5-azidea has antiproliferative activity .

HY-140923

Biotin-PEG4-amide-Alkyne	PROTAC Linkers	Cancer
Biotin-PEG4-amide-Alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Biotin-PEG4-amide-Alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-176188

Lenalidomide-5-Br-amide-C2-Br	E3 Ligase Ligand-Linker Conjugates	Cancer
Lenalidomide-5-Br-amide-C2-Br is an *E3 ligase ligand-linker* conjugate*. Lenalidomide-5-Br-amide*-C2-Br can be used to synthesize PROTAC DDR1 degrader-1 (HY-176184) .

HY-140656H

Biotin-PEG-Biotin(MW 40000)	Biochemical Assay Reagents	Others
Biotin-PEG-Biotin (MW 40000) can be used for crosslinking PEGylation by binding to two streptavidin and avidin. Biotin is conjugated to a linear PEG through a stable amide linker .

Cat. No.	Product Name	Type

HY-D1734

FITC-GW3965	Fluorescent Dyes/Probes
FITC-GW3965 is a fluorescence-labelled liver X receptor β (LXRβ) agonist GW3965 (HY-10627). FITC-GW3965 is a tracer, that can be designed by replacing the trifluoromethyl of GW3965 with an amide to link the FITC. FITC-GW3965 can be used to study the function of LXRβ .

HY-W585390

BDP 581/591 hydrazide hydrochloride	Fluorescent Dyes/Probes
BDP 581/591 hydrazide hydrochloride is a BDP linker containing a hydrazide. The BDP 581/591 is very photostable. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

HY-W585383

BDP TR hydrazide hydrochloride	Fluorescent Dyes/Probes
BDP TR hydrazide is a BDP TR linker with a hydrazide group. The BDP dye is popular for the microscopy and fluorescence polarization assays. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

HY-W585384

BDP 558/568 carboxylic acid	Fluorescent Dyes/Probes
BDP 558/568 carboxylic acid is a BDP linker containing a carboxylic acid. The BDP 558/568 has similar excitation and emission wavelengths to Cy3. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

HY-133540G

Maleimide-DOTA (GMP) Maleimido-mono-amide-DOTA (GMP)	Fluorescent Dye
Maleimide-DOTA (Maleimido-mono-amide-DOTA) (GMP) is Maleimide-DOTA (HY-133540) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Maleimide-DOTA is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-D1650

BDP 630/650 carboxylic acid	Fluorescent Dyes/Probes
BDP 630/650 carboxylic acid is a bright far-red fluorophore based on a borondipyrromethene scaffold. BDP 630/650 carboxylic acid is a BDP linker containing carboxylic acid. BDP 630/650 carboxylic acid can react with primary amine groups to form a stable amide bond. (λ_ex=630 nm, λ_em=650 nm) .

Cat. No.	Product Name	Type

HY-157921

Amino-EG6-undecanethiol hydrochloride 20-(9-Mercaptononyl)-3,6,9,12,15,18-hexaoxaeicosane-1-amine, hydrochloride	Biochemical Assay Reagents
Amino-EG6-undecanethiol hydrochloride is a biochemical assay reagent, and can be used as a linker through amide coupling .

HY-140656H

Biotin-PEG-Biotin(MW 40000)	Drug Delivery
Biotin-PEG-Biotin (MW 40000) can be used for crosslinking PEGylation by binding to two streptavidin and avidin. Biotin is conjugated to a linear PEG through a stable amide linker .

HY-137425

N-Biotinyl-12-aminododecanoic acid	Biochemical Assay Reagents
N-Biotinyl-12-aminododecanoic acid is a compound formed by linking biotin and 12-aminododecanoic acid through an amide bond. N-Biotinyl-12-aminododecanoic acid is used as a biotinylation reagent to test the ligation activity of SimL .

HY-174264

DMG-PEG-NHS, MW 2000 DMG-PEG2000-NHS	Drug Delivery
DMG-PEG-NHS, MW 2000 is a compound composed of Myristic acid (HY-N2041) and PEG linked by an amide bond, with NHS as an active ester group attached to the end of the PEG chain. DMG-PEG-NHS, MW 2000 can be used for protein/biomolecule modification, gene delivery and biosensor applications.

HY-133540G

Maleimide-DOTA (GMP) Maleimido-mono-amide-DOTA (GMP)	Biochemical Assay Reagents
Maleimide-DOTA (Maleimido-mono-amide-DOTA) (GMP) is Maleimide-DOTA (HY-133540) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Maleimide-DOTA is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-140895B

Biotin-PEG-Amine (MW 10000) Biotin-PEG-NH2 (MW 10000)	Drug Delivery
Biotin-PEG-Amine (MW 10000) (Biotin-PEG-NH2 (MW 10000)) is a biotin PEG polymer containing a free amine group (-NH2). The amine group is reactive with an activated NHS ester via formation of an amide bond. Biotin-labeled compounds can then be linked to avidin or streptavidin for further purification or detection .

HY-140895C

Biotin-PEG-Amine (MW 20000) Biotin-PEG-NH2 (MW 20000)	Drug Delivery
Biotin-PEG-Amine (MW 20000) (Biotin-PEG-NH2 (MW 20000)) is a biotin PEG polymer containing a free amine group (-NH2). The amine group is reactive with an activated NHS ester via formation of an amide bond. Biotin-labeled compounds can then be linked to avidin or streptavidin for further purification or detection .

HY-140895D

Biotin-PEG-Amine (MW 40000) Biotin-PEG-NH2 (MW 40000)	Drug Delivery
Biotin-PEG-Amine (MW 40000) (Biotin-PEG-NH2 (MW 40000)) is a biotin PEG polymer containing a free amine group (-NH2). The amine group is reactive with an activated NHS ester via formation of an amide bond. Biotin-labeled compounds can then be linked to avidin or streptavidin for further purification or detection .

HY-140895A

Biotin-PEG-Amine (MW 5000) Biotin-PEG-NH2 (MW 5000)	Drug Delivery
Biotin-PEG-Amine (MW 5000) (Biotin-PEG-NH2 (MW 5000)) is a biotin PEG polymer containing a free amine group (-NH2). The amine group is reactive with an activated NHS ester via formation of an amide bond. Biotin-labeled compounds can then be linked to avidin or streptavidin for further purification or detection .

HY-W1048549E

HOOC-PEG-SH (MW 20000) HOOC-PEG-Thiol (MW 20000)	Drug Delivery
HOOC-PEG-SH (MW 20000) (HOOC-PEG-Thiol (MW 20000)) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .

HY-W1048549A

HOOC-PEG-SH (MW 2000) HOOC-PEG-Thiol (MW 2000)	Drug Delivery
HOOC-PEG-SH (MW 2000) (HOOC-PEG-Thiol (MW 2000)) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .

HY-W1048549B

HOOC-PEG-SH (MW 3400) HOOC-PEG-Thiol (MW 3400)	Drug Delivery
HOOC-PEG-SH (MW 3400) (HOOC-PEG-Thiol (MW 3400)) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .

HY-W1048549C

HOOC-PEG-SH (MW 5000) HOOC-PEG-Thiol (MW 5000)	Drug Delivery
HOOC-PEG-SH (MW 5000) (HOOC-PEG-Thiol (MW 5000)) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .

HY-W1048549D

HOOC-PEG-SH (MW 10000) HOOC-PEG-Thiol (MW 10000)	Drug Delivery
HOOC-PEG-SH (MW 10000) (HOOC-PEG-Thiol (MW 10000)) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .

HY-W1048549J

HOOC-PEG-SH (MW 40000)

HOOC-PEG-Thiol (MW 40000)

Drug Delivery

HOOC-PEG-SH (MW 40000) (HOOC-PEG-Thiol (MW 40000)) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The reaction of the carboxyl group allows the amine or hydroxyl group to be converted into a free thiol with a linear PEG linkage. The generated thiol group can be used to modify the surface of gold nanoparticles or participate in other PEGylation reactions. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .

HY-W1048549H

HOOC-PEG-SH (MW 1000)

HOOC-PEG-Thiol (MW 1000)

Drug Delivery

HOOC-PEG-SH (MW 1000) (HOOC-PEG-Thiol (MW 1000)) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The reaction of the carboxyl group allows the amine or hydroxyl group to be converted into a free thiol with a linear PEG linkage. The generated thiol group can be used to modify the surface of gold nanoparticles or participate in other PEGylation reactions. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .

HY-112624J

Dextran T4 (MW 4,000)

Dextran 4; Dextran D4; Dextran T4(MW 3200-4800)

Thickeners

Dextran 4,000 is a mucus rheology modifier. The dextran molecules in Dextran 4,000 can reduce the cross-link density of mucus through osmotic effects and hydrogen bond substitution, and reduce viscoelasticity and improve the mucociliary/cough clearance index by destroying the DNA-mucin network structure in mucus. Dextran 4,000 has the ability to improve the rheological properties and clearance ability of cystic fibrosis (CF) sputum, and can be used in the study of inhalation therapy or aerosol delivery of mucostatic respiratory diseases. The Dextran series of compounds are also natural polysaccharide drug carriers that can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong the half-life of drugs, increase local concentrations, and reduce the activity of immune clearance .

HY-112624B

Dextran T70 (MW 70,000)

Dextran 70; Dextran D70; Dextran T70(MW 64000-76000)

Drug Delivery Thickeners

Dextran 70,000 is a high molecular weight polysaccharide formed by glucose linked by α-(1→6) glycosidic bonds. Dextran 70,000 can expand blood volume through colloidal osmotic pressure effect and inhibit cell adhesion and platelet aggregation through steric hindrance. At the same time, Dextran 70,000 can be used as a drug carrier to achieve targeted delivery through endocytosis. Dextran 70,000 is biologically inert and has low immunogenicity. It can be used for clinical blood volume expansion, anti-thrombotic research, and evaluation of vascular permeability in in vitro experiments. It can also be combined with fluorescent dyes for cell tracking and drug delivery research. The Dextran series of compounds are also natural polysaccharide drug carriers that can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong the half-life of drugs, increase local concentrations, and reduce the activity of immune clearance.

Cat. No.	Product Name	Target	Research Area

HY-126584

H-Val-Val-OH Val-val	Drug Intermediate	Others
H-VAL-VAL-OH (Val-val) is a dipeptide in which two valine (Val) residues are linked by an amide bond. H-VAL-VAL-OH can be used for the synthesis of some important compounds such as Poststatin (HY-125432) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W001959

D-Allothreonine	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
D-Allothreonine is the D type stereoisomer of Allothreonine. D-Allothreonine is a peptido-lipid derived from bacteria. D-Allothreonine, amide-linked to the D-galacturonic acid, is also a constituent in the polysaccharide .

Cat. No.	Product Name	Chemical Structure

HY-161022S1

FL118-C3-O-C-amide-C-NH2-d5 formate
FL118-C3-O-C-amide-C-NH2-d5 formate is a deuterium labeled FL118-C3-O-C-amide-C-NH2 formate. FL118-C3-O-C-amide-C-NH2 formate is an ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

Cat. No.	Product Name		Classification

HY-140923

Biotin-PEG4-amide-Alkyne		Alkynes PROTAC Synthesis
Biotin-PEG4-amide-Alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Biotin-PEG4-amide-Alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-133436

Boc-aminooxy-amide-PEG4-propargyl		Alkynes ADC Synthesis
Boc-aminooxy-amide-PEG4-propargyl is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Boc-aminooxy-amide-PEG4-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-163167

VH 032 amide-alkylC5-azide		Azide
VH 032 amide-alkylC5-amine is a functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC research and development; incorporates an E3 ligase ligand plus an alkyl linker with terminal amine ready for conjugation to a target protein ligand .

HY-140914

Biotin-PEG4-Amide-C6-Azide		PROTAC Synthesis Azide
Biotin-PEG4-Amide-C6-Azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Biotin-PEG4-Amide-C6-Azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-159165

Pomalidomide-cyclopentane-amide-Alkyne		Alkynes
Pomalidomide-cyclopentane-amide-Alkyne is an *E3 ligase ligand-linker* conjugate** that incorporates the Pomalidomide (HY-10984) and the linker cyclopentane-amide-Alkyne. Pomalidomide-cyclopentane-amide-Alkyne is used to form PROTACs, such as RGB110 (HY-159087) .

HY-141185

TCO-PEG3-amide-C3-triethoxysilane		TCO
TCO-PEG3-amide-C3-triethoxysilane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-125541

DBCO-NHCO-PEG4-acid		PROTAC Synthesis ADC Synthesis DBCO
DBCO-Amide-PEG5-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-Amide-PEG5-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . DBCO-NHCO-PEG4-acid is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-138318

DBCO-PEG3-amide-N-Fmoc		PROTAC Synthesis DBCO
DBCO-PEG3-amide-N-Fmoc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . DBCO-PEG3-amide-N-Fmoc is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-161832

(S,R,S)-Me-AHPC-amide-C3-alkyne		Alkynes
(S,R,S)-Me-AHPC-amide-C3-alkyne is an E3 ligase ligand-linker conjugate used for the synthesis of JWZ-5-13 (HY-161828) .

HY-140019

Azido-PEG3-amide-C3-triethoxysilane		Azide PROTAC Synthesis
Azido-PEG3-amide-C3-triethoxysilane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG3-amide-C3-triethoxysilane is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-176536

(S,R,S)-AHPC-amide-PEG5-C2-azide VH032-CO-(CH2)2-(O-CH2-CH2)5-azide		Azide
(S,R,S)-AHPC-amide-PEG5-C2-azide (VH032-CO-(CH2)2-(O-CH2-CH2)5-azide) is a PROTAC linker that can be used to design PROTACs .

HY-141065

N-(azide-PEG3)-N'-(Amine-C3-Amide-PEG4)-Cy5		Azide PROTAC Synthesis
N-(azide-PEG3)-N'-(Amine-C3-Amide-PEG4)-Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . N-(azide-PEG3)-N'-(Amine-C3-Amide-PEG4)-Cy5 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-151820

DBCO-PEG24-acid		DBCO
DBCO-PEG24-acid is a click chemistry reagent. DBCO-PEG24-acid is an analog of DBCO-Acid with PEG linker and a DBCO group. The DBCO groups is commonly used for copper-free Click Chemistry reactions due to its strain promoted high energy. The hydrophilic PEG chain allows for increased water solubility. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. Reagent grade, for research use only .

HY-151821

Sulfo DBCO-PEG3-acid		DBCO
Sulfo DBCO-PEG3-acid is a click chemistry reagent containing an azide group. Sulfo DBCO-PEG3-acid is an analog of DBCO-Acid with PEG linker and a DBCO group. The DBCO groups is commonly used for copper-free Click Chemistry reactions due to its strain promoted high energy. The hydrophilic PEG chain and sulfo group increase water solubility. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. Reagent grade, for research use only .

HY-148840

Sulfo DBCO-PEG3-NHS ester		DBCO
Sulfo DBCO-PEG3-NHS ester is a click chemistry reagent containing an azide group. Sulfo DBCO-PEG3-NHS ester is an analog of DBCO-Acid with PEG linker and a DBCO group. The DBCO group is commonly used for copper-free Click Chemistry reactions due to its strain promoted high energy. The hydrophilic PEG chain and sulfo group increase water solubility. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. Reagent grade, for research use only .

HY-151647

3-Azidopropanoic acid-PFP ester		Azide
3-Azidopropanoic acid-PFP ester is an azidopropanoic acid linker that contains an activated PFP ester. The azide group can undergo copper-catalyzed Click Chemistry reactions with alkynes, DBCO and BCN to form triazole linkages. The activated PFP ester can react with amine groups to form stable amide bonds . 3-Azidopropanoic acid-PFP ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-114402

ARD-69		PROTAC Synthesis
ARD-69 is a PROTAC degrader based on the E3 ubiquitin ligase VHL and targeting the androgen receptor, which can induce androgen receptor (AR) protein degradation in AR-positive prostate cancer cells. ARD-69 inhibits AR-regulated gene expression, binds to the AR ligand binding domain at one end and binds to VHL at the other end, prompting AR to be recruited to the E3 ubiquitin ligase complex, triggering proteasome degradation, thereby inhibiting AR signaling pathways and downstream gene expression (such as PSA, TMPRSS2). ARD-69 can be used to study the treatment of castration-resistant prostate cancer (mCRPC) . ARD-69 is composed of a target protein ligand (pink part) AR antagonist 14 (HY-172624), a PROTAC linker (black part) tert-Butyl 4-ethynyl-[1,4'-bipiperidine]-1'-carboxylate (HY-W442074), and a VHL-type E3 ubiquitinase ligand (blue part) VH 101, acid (HY-47070); among them, the VHL ligand and the linker can form a conjugate VH 101-amide-piperidine-Pip-alkyne (HY-172625).

HY-151833

Methyltetrazine-amido-N-bis(PEG4-acid)		Tetrazine
Methyltetrazine-amido-N-bis(PEG4-acid) is a click chemistry reagent containing an azide group. Methyltetrazine-amido-N-bis(PEG4-acid) is a PEG derivative that contains a methyltetrazine group and two acid groups. This reagent can react with TCO-containing compounds to form a stable covalent bond without the catalysis of Cu or elevated temperatures. The inverse-electron demand Diels-Alder cycloaddition reaction of TCO with tetrazines is the fastest bioorthogonal reaction with exceptional selectivity. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. PEG linker increases the water solubility of the compound. Reagent grade, for research use only . Methyltetrazine-amido-N-bis(PEG4-acid) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

Cat. No.	Product Name		Classification