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Pathways Recommended:	Antibody-drug Conjugate/ADC Related

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Target protein ligand-linker conjugate

" in MedChemExpress (MCE) Product Catalog:

By Targets:	E3 Ligase Ligand-Linker Conjugates (2) Ligands for Target Protein for PROTAC (2) Target Protein Ligand-Linker Conjugates (27) 17β-HSD (1) Androgen Receptor (1) Apoptosis (3) AUTACs (1) Btk (1) c-Met/HGFR (3) Casein Kinase (1) CDK (1) CRM1 (1) Deubiquitinase (1) EGFR (1) Epigenetic Reader Domain (8) Estrogen Receptor/ERR (1) FGFR (1) FKBP (1) FLT3 (1) HDAC (1) Isotope-Labeled Compounds (1) MAP4K (2) Mitophagy (1) Molecular Glues (1) NF-κB (1) PROTACs (17) Ras (1) RET (1) RIP kinase (1) Src (1) SWI/SNF Complex (1)
By Research Areas:	Cancer (46) Metabolic Disease (1) Neurological Disease (1)
Click Chemistry:	Azide (1)

Inhibitors & Agonists

Isotope-Labeled Compounds

Click Chemistry

Targets Recommended: Target Protein Ligand-Linker Conjugates E3 Ligase Ligand-Linker Conjugates ADC Linker PROTAC-Linker Conjugates for PAC Drug-Linker Conjugates for ADC PD-1/PD-L1 Ligands for Target Protein for PROTAC

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-168693

Target Protein Ligand-Linker Conjugates 2	Target Protein Ligand-Linker Conjugates
Target Protein Ligand-Linker Conjugates 2 is a conjugate of the Target Protein Ligand and Linker, consisting of Desmethyl-QCA276 (HY-44103) and the corresponding Linker. Target Protein Ligand-Linker Conjugates 2 can be used to synthesize PROTAC BD-9136 (HY-149878) .

HY-176788

EGFR Ligand-Linker Conjugates 1	Target Protein Ligand-Linker Conjugates EGFR	Cancer
EGFR Ligand-Linker Conjugates 1 is an **Target Protein Ligand-Linker Conjugate** that incorporates a ligand for EGFR (HY-150905) and a PROTAC linker, which recruits E3 ligases. EGFR Ligand-Linker Conjugates 1 can be used for synthesis of PROTAC EGFR degrader 3 (HY-144605) .

HY-175374

RIPK1 ligand-Linker Conjugate-1	Target Protein Ligand-Linker Conjugates RIP kinase	Cancer
RIPK1 ligand-Linker Conjugate-1 is a **Target Protein Ligand-Linker Conjugate** that incorporates a ligand for RIPK1 (HY-175371) and a PROTAC linker (HY-175373), which recruits E3 ligases. RIPK1 ligand-Linker Conjugate-1 can be used for synthesis of PROTAC RIPK1 Degrader-1 (HY-175370) .

HY-175360

USP7 Ligand-Linker Conjugates 1	Target Protein Ligand-Linker Conjugates Deubiquitinase	Others
USP7 Ligand-Linker Conjugates 1 is an **Target Protein Ligand-Linker Conjugate** that incorporates a ligand for USP7 (HY-175359) and a PROTAC linker, which recruits E3 ligases. USP7 Ligand-Linker Conjugates 1 can be used for synthesis of PROTAC USP7 Degrader-1 (HY-175358) .

HY-175333

c-Met ligand-Linker Conjugate 1	Target Protein Ligand-Linker Conjugates c-Met/HGFR	Cancer
c-Met ligand-Linker Conjugate 1 is an **Target Protein Ligand-Linker Conjugate** that incorporates a ligand for c-Met (HY-W425461) and a PROTAC linker (HY-151862), which recruits E3 ligases. c-Met ligand-Linker Conjugate 1 can be used for synthesis of PROTAC c-Met degrader-5 (HY-175320) .

HY-176791

CDK12-Cyclin K Ligand-Linker Conjugates 1	Target Protein Ligand-Linker Conjugates CDK	Cancer
CDK12-Cyclin K Ligand-Linker Conjugates 1 is an **Target Protein Ligand-Linker Conjugate** that incorporates a ligand for CDK12-Cyclin K (HY-176790) and a PROTAC linker (HY-W244922), which recruits E3 ligases. CDK12-Cyclin K Ligand-Linker Conjugates 1 can be used for synthesis of PROTAC PP-C8 (HY-144691) .

HY-175551

HPK1 ligand-Linker Conjugate 1	Target Protein Ligand-Linker Conjugates MAP4K	Cancer
HPK1 ligand-Linker Conjugate 1 is a synthesized target protein ligand-linker conjugate that can be used for synthesis of PROTACs, such as PROTAC HPK1 Degrader-5 (HY-175547). PROTAC HPK1 Degrader-5 is a potent and orally active HPK1 PROTAC degrader with anti-tumor activity .

HY-174995

JQ-1-Azidopropylamine	Target Protein Ligand-Linker Conjugates Epigenetic Reader Domain	Cancer
JQ-1-Azidopropylamine is an **Target Protein Ligand-Linker Conjugate** that incorporates a ligand for BRD4 (HY-78695) and a PROTAC linker (HY-151862), which recruits E3 ligases. JQ-1-Azidopropylamine can be used for synthesis of PROTAC JY-21 (HY-174975) .

HY-169488

SMARCA2 ligand-12-3-methylazetidine	Epigenetic Reader Domain Target Protein Ligand-Linker Conjugates	Cancer
SMARCA2 ligand-12-3-methylazetidin is a **target protein ligand-linker conjugate** that incorporates a ligand for SMARCA2 (HY-169487), and a PROTAC linker (HY-W052601), which recruit E3 ligases. SMARCA2 ligand-12-3-methylazetidin can be used to synthesize PROTAC SMARCA2 degrader-25 (HY-169276) .

HY-175193

N-Deshydroxyethyl Dasatinib-C3-NH2 N-Deshydroxyethyl BMS-354825-C3-NH2	Target Protein Ligand-Linker Conjugates Src	Cancer
N-Deshydroxyethyl Dasatinib-C3-NH2 is an **Target Protein Ligand-Linker Conjugate** that incorporates a ligand for LCK (HY-107447) and a PROTAC linker (HY-76667), which recruits E3 ligases. N-Deshydroxyethyl Dasatinib-C3-NH2 can be used for synthesis of PROTAC SJ11646 (HY-175281) .

HY-176391

Ad-JQ1	Target Protein Ligand-Linker Conjugates Epigenetic Reader Domain	Cancer
Ad-JQ1 (Compound 16) is an **Target Protein Ligand-Linker Conjugate** that incorporates a ligand for BRD4 (HY-78695) and a PROTAC linker (HY-176390), which recruits E3 ligases. Ad-JQ1 can be used for synthesis of PROTAC β-NF-JQ1 (HY-130256) .

HY-176802

Oxide-DFHBI-demethyl-C6-NH2	Target Protein Ligand-Linker Conjugates	Cancer
Oxide-DFHBI-demethyl-C6-NH2 is a **Target Protein Ligand-Linker Conjugate** that incorporates a target aptamer ligand (HY-176801) and a PROTAC linker (HY-79577), which recruits E3 ligases. Oxide-DFHBI-demethyl-C6-NH2 can be used for synthesis of RNA aptamer-based PROTAC Dth (HY-175397) .

HY-153424

PROTAC SMARCA2 degrader-1	Target Protein Ligand-Linker Conjugates	Cancer
PROTAC SMARCA2 degrader-1 (compound ex7) is a BRM2 (SMARCA2) degrader (DC₅₀<0.1 μM). PROTAC SMARCA2 degrader-1 is also an E3 ubiquitin ligase binding linker useful in research of cancers. PROTAC SMARCA2 degrader-1 is a **target protein ligand-linker conjugate** .

HY-132943

BRD4 ligand-Linker Conjugate 1	Target Protein Ligand-Linker Conjugates	Cancer
BRD4 ligand-Linker Conjugate 1 is a target protein ligand-linker conjugate that can be used in the synthesis of PROTACs.

HY-176347S

Alpha Feto Protein, Arg-13C6,15N4, Lys-13C6,15N2	Isotope-Labeled Compounds	Cancer
Alpha Feto Protein, Arg- ¹³C₃₆, ¹⁵N₄, Lys- ¹³C₆, ¹⁵N₂ is the ¹³C- and ¹⁵N-labeled Alpha Feto Protein.

HY-175726

BRAF ligand-Linker Conjugate 1	Target Protein Ligand-Linker Conjugates	Cancer
BRAF ligand-Linker Conjugate 1 is a target protein ligand-linker conjugate that can be used to synthesize PROTAC CST905(HY-175435) .

HY-132943A

BRD4 ligand-Linker Conjugate 1 TFA	Target Protein Ligand-Linker Conjugates	Cancer
BRD4 ligand-Linker Conjugate 1 TFA (compound 106-1) is a target protein ligand-linker conjugate that can be used in the synthesis of PROTACs .

HY-176797

SMARCA2/4 Ligand-Linker Conjugate 2	Target Protein Ligand-Linker Conjugates	Cancer
SMARCA2/4 Ligand-Linker Conjugate 2 is a target protein ligand-linker conjugate that can be used to synthesize PROTAC AU-15330 (HY-145388) .

HY-170987

FKBP12 Ligand-Linker Conjugate 1	Target Protein Ligand-Linker Conjugates FKBP	Cancer
FKBP12 Ligand-Linker Conjugate 1 is the conjugate composed of a target protein ligand for FKBP12 and a linker. FKBP12 Ligand-Linker Conjugate 1 can be used for synthesis of PROTAC degrader MC-25B (HY-170983) .

HY-175337

c-Met ligand-Linker Conjugate 2	Target Protein Ligand-Linker Conjugates c-Met/HGFR	Cancer
c-Met ligand-Linker Conjugate 2 is a synthesized target protein ligand-linker conjugate that can be used for synthesis of PROTACs, such as PROTAC c-Met degrader-6 (HY-175321). PROTAC c-Met degrader-6 is a c-Met PROTAC degrader with anti-tumor activity ^{[1] ^.}

HY-147225

TSPO Ligand-Linker Conjugates 1	AUTACs Mitophagy	Neurological Disease Metabolic Disease Cancer
TSPO Ligand-Linker Conjugates 1 contains a ligand for translocator protein (TSPO) and a linker, which is used for the synthesis of mitochondria-targeting autophagy-targeting chimera (AUTAC). AUTAC can bind the TSPO on the outer mitochondrial membrane (OMM) of mitochondria and degrades impaired mitochondria and proteins via mitophagy, and improves mitochondrial activity. TSPO Ligand-Linker Conjugates 1 can be used in mitochondrial dysfunction related research, including neurodegenerative diseases, cancer, and diabetes .

HY-169357

Acepromazine-1-Piperazinepropanamine	E3 Ligase Ligand-Linker Conjugates	Cancer
Acepromazine-1-Piperazinepropanamine (compound 10) is a synthesized E3 ligase ligand-linker conjugate (E3 Ligase Ligand-Linker Conjugate) that incorporates a TRIM21 ligand and a linker. Acepromazine-1-Piperazinepropanamine can be connected to the target protein ligand to form a PROTAC molecule, TrimTAC1 (HY-169355) .

HY-172266

FKBP12 Ligand-Linker Conjugate 2	Target Protein Ligand-Linker Conjugates	Others
FKBP12 Ligand-Linker Conjugate 2 is a conjugate of the FKBP12 target protein ligand and a linker, and it can be used for the synthesis of FKBP12 PROTAC FM4 (HY-172265) .

HY-173137

KDM4 Ligand-Linker Conjugate 1	Target Protein Ligand-Linker Conjugates	Others
KDM4 Ligand-Linker Conjugate 1 is a conjugate of a KDM4 target protein ligand and a linker, and can be used for the synthesis of PROTAC KDM4 degrader-1 (HY-173135) .

HY-170769

FLT3 Ligand-Linker Conjugate 1	Target Protein Ligand-Linker Conjugates FLT3	Cancer
FLT3 Ligand-Linker Conjugate 1 (compound 7) contains the FLT3 ligand and a PROTAC linker, which can recruit the E3 ligase VHL. FLT3 Ligand-Linker Conjugate 1 can be used to synthesize the PROTAC RSS0680 (HY-148062). PROTAC RSS0680 is a bifunctional compound that targets protein degradation of kinases .

HY-174357

HPK1 ligand 3-dimethylph tetrahydropyridine	Target Protein Ligand-Linker Conjugates	Cancer
HPK1 ligand 3-dimethylph tetrahydropyridine is a **Target Protein Ligand-Linker Conjugate*. HPK1 ligand* 3-dimethylph tetrahydropyridine can be used to synthesize PROTAC HPK1 Degrader-4 (HY-174135) .

HY-174409

HDAC6 ligand-Linker Conjugate 1	Target Protein Ligand-Linker Conjugates HDAC	Cancer
HDAC6 ligand-linker conjugate 1 is a conjugate of HDAC6 ligand and linker, which can be used to synthesize PROTACs such as PROTAC HDAC6 degrader 5 (HY-174401) .

HY-176263

TH10184-octanedioic acid	Target Protein Ligand-Linker Conjugates	Cancer
TH10184-octanedioic acid is a conjugate of the NUDT5 ligand (HY-176262) and the linker (HY-W001958). TH10184-octanedioic acid can be used for synthesizing PROTAC NUDT5 degrader DDD2 (HY-176261) .

HY-176124

CDK2 ligand-2	Ligands for Target Protein for PROTAC	Cancer
CDK2 ligand-2 is a PROTAC target protein ligand (Ligands *for Target* Protein for PROTAC*). CDK2 ligand-2 combined with E3 Ligase Ligand-linker* Conjugate 184 (HY-176125) can be used to synthesize PROTAC degrader (CDK2 degrader 2 (HY-163815)) .

HY-175255

EGFR-IN-47-C6-COOMe	Target Protein Ligand-Linker Conjugates	Cancer
EGFR-IN-47-C6-COOMe is a synthesized target protein ligand-linker conjugate that can be used for synthesis of PROTACs, such as PROTAC EGFR degrader 14 (HY-175252). PROTAC EGFR degrader 14 is a EGFR PROTAC degrader with anti-tumor activity .

HY-131886

Pomalidomide 4'-alkylC4-acid	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide 4'-alkylC4-acid (linker 16) is a E3 ligase ligand-linker conjugate. Pomalidomide 4'-alkylC4-acid contains a cereblon ligand, an alkylC4 chain, and a terminal acid. Pomalidomide 4'-alkylC4-acid can be used to couple with target protein ligands to synthesize PROTAC .

HY-170332

PROTAC ER Degrader-15	PROTACs Estrogen Receptor/ERR	Cancer
PROTAC ER Degrader-15 (Compound 40) is an orally active degrader of the estrogen receptor (ER) with anticancer activity，which can be used in breast cancer research (Pink: Target Protein Ligand (HY-170334); Black: Linker (HY-30756); Blue: E3 Ligase Ligand (HY-138793); E3 Ligase Ligand-Linker Conjugate (HY-169979)) .

HY-170808

PROTAC BRD4 Degrader-28	PROTACs Epigenetic Reader Domain	Cancer
PROTAC BRD4 Degrader-28 (Compound 4) is a PROTAC degrader targeting BRD4. PROTAC BRD4 Degrader-28 is promising for research of cancers (Pink: target protein ligand JQ-1 (carboxylic acid) (HY-78695); Black+ Blue: E3 ubiquitin ligase ligand-Linker conjugate Thalidomide-O-amido-C3-NH2 (HY-115560)) .

HY-170828

SMD-1087	PROTACs SWI/SNF Complex	Others
SMD-1087 is a PROTAC that selectively targets SMARCA2 (DC₅₀=8 nM, D_max=89%) and SMARCA4 with a DC₅₀ of 1 μM. SMD-1087 consists of the E3 ligase ligand (S,R,S)-AHPC-Me (blue part) (HY-112078), the target protein ligand SMI-1074 (red part) (HY-170817), and the PROTAC linker (1r,4r)-tert-Butyl 4-(bromomethyl)cyclohexanecarboxylate (black part) (HY-W890392). Among them, its target protein ligand + Linker part corresponds to SMARCA2 Ligand-Linker Conjugate-1 (HY-170829) .

HY-172265

FKBP12 PROTAC FM4	PROTACs	Cancer
FKBP12 PROTAC FM4 is a PROTAC degrader of MTH1, with a DC₅₀ values of 0.09–0.22 nM. FKBP12 PROTAC FM4 is composed of PROTAC target protein ligand AP1867-3-(aminoethoxy) (HY-129363) (red part), E3 ligase ligand MTH1 ligand 1 (HY-134724) (blue part) and PROTAC Linker t-Boc-N-amido-PEG5-acetic acid (HY-W190962) (black part), among which the conjugate of PROTAC target protein ligand + Linker is FKBP12 Ligand-Linker Conjugate 2 (HY-172266) .

HY-176385

3-Fluoro-desmethyl-cabozantinib-C3-O-C3-PEG-acid	Target Protein Ligand-Linker Conjugates c-Met/HGFR	Cancer
3-Fluoro-desmethyl-cabozantinib-C3-O-C3-PEG-acid is a **target protein ligand-linker conjugate** that incorporates a ligand for c-Met (HY-451241) and a PROTAC linker (HY-W442078), which recruits E3 ligases. 3-Fluoro-desmethyl-cabozantinib-C3-O-C3-PEG-acid can be used in the synthesis of PROTACs, such as SJF-8240 (HY-123961) .

HY-170852

QZ2135	PROTACs RET	Cancer
QZ2135 (compound 20) is a *RET*-targeted PROTAC degrader with in vivo antitumor properties in a Ba/F3-KIF5B-RET-G810C xenograft mouse model. The degradation activities of QZ2135 targeting KIF5B-RET have DC₅₀ values of 4.7 nM (WT), 17.2 nM (V804M), and 73.8 nM (G810C), respectively. QZ2135 is composed of a target protein ligand (red part) RET ligand-3 (HY-170853), an E3 ligase ligand (blue part) Lenalidomide-F (HY-W039233), and a PROTAC Linker (black part) 7-Iodohept-1-yne (HY-W587352), in which the target protein ligand + linker form a conjugate RET Ligand-Linker Conjugate-1 (HY-170854) .

HY-170859

AH078	Casein Kinase	Others
AH078 (compound 37) is a PROTAC degrader that selectively targets CK1δ and CK1ε, and has low targeting for CK1α. AH078 consists of PROTAC linker (black part) Monomethyl octanoate (HY-W001958), target protein ligand (red part) (HY-170860) CK1δ/CK1ε liagnd-1 and E3 ligase ligand (blue part) E3 ligase Ligand 58 (HY-170861). Among them, E3 ligase ligand + linker can form a conjugate E3 Ligase Ligand-linker Conjugate 163 (HY-170862) .

HY-160221

PROTAC AR Degrader-7	PROTACs Androgen Receptor	Cancer
PROTAC AR Degrader-7 (compound 99) is a PROTAC targeting androgen receptor with an IC₅₀ value of 3 nM. PROTAC AR Degrader-7 is composed of PROTAC target protein ligand AR ligand-32 (HY-170303) (red part), E3 ligase ligand E3 ligase Ligand 44 (HY-170304) (blue part) and PROTAC Linker N-Boc-piperazine (HY-30105) (black part), among which the conjugate of E3 ubiquitin ligase ligand + Linker is E3 Ligase Ligand-linker Conjugate 145 (HY-170305) .

HY-142621

BCPyr	PROTACs Btk	Cancer
BCPyr is a PROTAC-class BTK degrader (DC₅₀ = 800 nM) . BCPyr consists of a PROTAC target protein ligand (red part) BTK ligand 11 (HY-168314), an E3 ubiquitin ligase ligand (blue part) E3 ligase Ligand 20 (HY-135997), and a PROTAC linker (black part) (5-(Bromomethyl)pyrazin-2-yl)methanol (HY-168315). E3 ubiquitin ligase+linker can form E3 Ligase Ligand-linker Conjugate 146 (HY-168316).

HY-168274

PROTAC TRIB2 degrader-1	PROTACs Apoptosis	Cancer
PROTAC TRIB2 degrader-1 (Compound 5k) is an effective TRIB2 degrader that selectively induces TRIB2 degradation through the CRBN-dependent ubiquitin-proteasome pathway. PROTAC TRIB2 degrader-1 can inhibit cell proliferation and induce cell apoptosis, and can be used in cancer research. (Target protein ligand (Pink): HY-168275; linker (black): HY-168276; E3 Ligase Ligand-Linker Conjugates: HY-168277; E3 ligase (Blue): HY-W023573) .

HY-174135

PROTAC HPK1 Degrader-4	PROTACs MAP4K	Cancer
PROTAC HPK1 Degrader-4 (compound E3) is a selective and orally active PROTAC HPK1 degrader with a DC₅₀ of 3.16 nM. PROTAC HPK1 Degrader-4 demonstrates >1000-fold selectivity over GLK. PROTAC HPK1 Degrader-4 promotes immune activation. PROTAC HPK1 Degrader-4 can be used for the study of colon cancer and lymphoma (Pink: ligand for target protein (HY-174355); Blue: ligand for E3 ligase CRBN (HY-45808); Black: Linker (HY-174356); Target protein ligand-linker Conjugate (HY-174357)) .

HY-170869

PROTAC FGFR1 degrader-1	PROTACs FGFR	Cancer
PROTAC FGFR1 degrader-1 (compound S2H) is a PROTAC degrader targeting FGFR1, with IC₅₀=26.81 nM and DC₅₀=39.78 nM in KG1a cells. PROTAC FGFR1 degrader-1 is composed of CRBN-type E3 ligase ligand (blue part) Pomalidomide (HY-10984), target protein ligand (red part) FGFR1 ligand-1 (HY-170871), and PROTAC linker (black part) 9-Bromononanoic acid (HY-W007587), in which the E3 ligase ligand and linker form a conjugate E3 Ligase Ligand-linker Conjugate 164 (HY-170870) .

HY-157228

ACBI3	PROTACs Ras	Cancer
ACBI3 (compound 7) is a PROTAC targeting KRAS. ACBI3 is composed of PROTAC target protein ligand pan-KRAS degrader 1 (HY-162960) (red part), E3 ligase ligand E3 ligase Ligand 43 (HY-401613) (blue part) and PROTAC Linker 1-Bromo-4-(ethynyloxy)butane (HY-169992) (black part), among which the conjugate of E3 ubiquitin ligase ligand + Linker is E3 Ligase Ligand-linker Conjugate 143 (HY-169995). ACBI3 achieves in vivo degradation of oncogenic KRAS, resulting in durable pathway modulation and tumor regressions in KRAS mutant xenograft mouse models .

HY-159651

PTOTAC HSD17B13 degrader 1	PROTACs 17β-HSD	Cancer
PTOTAC HSD17B13 degrader 1 (compound 1) is a PROTAC targeting 17β-HSD 13 (HSD17B13). PTOTAC HSD17B13 degrader 1 is composed of PROTAC target protein ligand HSD17B13 degrader 2 (HY-159662) (red part), PROTAC Linker tert-Butyl 5-bromoisoindoline-2-carboxylate (HY-W003696) (black part) and E3 ubiquitin ligase ligand E3 ligase Ligand 31 (HY-159660) (blue part), among which the conjugate of E3 ubiquitin ligase ligand + Linker is E3 Ligase Ligand-linker Conjugate 114 (HY-159661) ^{[1] ^.}

HY-176167

mTOR ligand 1-C6-amino	Ligands for Target Protein for PROTAC	Cancer
mTOR ligand 1-C6-amino is a conjugate of a target protein ligand (HY-B0795) and a linker (HY-W008296). mTOR ligand 1-C6-amino can be used to synthesize PROTAC PD-M6 (HY-176166) .

HY-170347

PROTAC SMARCA2/4 degrader-36	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4 degrader-36 (Compound 29) is an effective dual degrader of SMARCA2/4,with DC₅₀ values of 0.22 nM and 0.85 nM for SMARCA2 and SMARCA4, respectively. PROTAC SMARCA2/4 degrader-36 has anti-cell proliferation activity (Pink: Target Protein Ligand (HY-170354); Black: Linker (HY-W895794); Blue: E3 Ligase Ligand (HY-170353); E3 Ligase Ligand-Linker Conjugate (HY-170356)) .

HY-170669

PROTAC XPO1 degrader-1	PROTACs CRM1 Apoptosis NF-κB	Cancer
PROTAC XPO1 degrader-1 (Compound 2c) is an XPO1 degrader. PROTAC XPO1 degrader-1 exhibits anti-proliferative effects, can induce cell apoptosis, inhibit NF-κB activity, and cause cell cycle arrest in the G1 phase. PROTAC XPO1 degrader-1 can be used in research on hematological malignancies (Pink: Target Protein Ligand (HY-170672); Black: Linker (HY-W010525); Blue: E3 Ligase Ligand (HY-170671); E3 Ligase Ligand-Linker Conjugate (HY-170673)) .

HY-145925C

(S,R)-CFT8634	PROTACs Epigenetic Reader Domain	Cancer
(S,R)-CFT8634 (compound 176) is a selective and orally active PROTAC-class BRD9 protein degrader. (S,R)-CFT8634 has the potential to study BRD9-mediated diseases, including but not limited to abnormal cell proliferation. (S,R)-CFT8634 consists of a target protein ligand (red part) BRD9 ligand-5 (HY-169988), an E3 ligase ligand (blue part) CRBN ligand-11 (HY-169989), and a PROTAC linker (black part) 1-(3,3-Difluoro-4-piperidinyl)piperazine (HY-169991). E3 ligase ligand and linker can form E3 Ligase Ligand-linker Conjugate 142 (HY-169990) .

HY-173333

PROTAC SMARCA2/4 degrader-38	PROTACs Epigenetic Reader Domain Apoptosis	Cancer
PROTAC SMARCA2/4 degrader-38 is a degrader SMARCA2/4 PROTAC (DC₅₀: 3.0 nM and 4.0 nM respectively). PROTAC SMARCA2/4 degrader-38 promotes the ubiquitination and degradation of SMARCA2/4. PROTAC SMARCA2/4 degrader-38 blocks the G0/G1 cell cycle and induces apoptosis. PROTAC SMARCA2/4 degrader-38 can be used in acute myeloid leukemia (AML) research. (Pink: SMARCA2/4 ligand; Blue: VHL ligand (HY-112078); Black: linker; Target Protein Ligand-Linker Conjugates (HY-173343)) .

Cat. No.	Product Name		Classification

HY-174995

JQ-1-Azidopropylamine		Azide
JQ-1-Azidopropylamine is an **Target Protein Ligand-Linker Conjugate** that incorporates a ligand for BRD4 (HY-78695) and a PROTAC linker (HY-151862), which recruits E3 ligases. JQ-1-Azidopropylamine can be used for synthesis of PROTAC JY-21 (HY-174975) .

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