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Results for "

TA

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acyltransferase (1) Adrenergic Receptor (1) Amino Acid Derivatives (1) Angiotensin Receptor (1) Angiotensin-converting Enzyme (ACE) (7) Antibiotic (4) Antibody-Drug Conjugates (ADCs) (1) Apoptosis (5) Autophagy (2) Bacterial (13) Casein Kinase (1) CETP (1) Cyclin G-associated Kinase (GAK) (2) Cytochrome P450 (2) Dipeptidyl Peptidase (1) DNA Alkylator/Crosslinker (1) DNA/RNA Synthesis (2) Drug Derivative (2) Drug Metabolite (1) Endogenous Metabolite (7) FGFR (1) Fluorescent Dye (1) Isotope-Labeled Compounds (9) Lipoxygenase (1) MMP (4) mRNA (1) Mucin (2) NO Synthase (6) p38 MAPK (2) Parasite (2) Phosphodiesterase (PDE) (8) PROTAC Linkers (1) Radionuclide-Drug Conjugates (RDCs) (2) Reactive Oxygen Species (ROS) (4) Reference Standards (5) SGLT (1) Small Interfering RNA (siRNA) (2) Thyroid Hormone Receptor (4) TNF Receptor (2) Topoisomerase (1) Tyrosinase (1)
By Research Areas:	Cancer (14) Cardiovascular Disease (20) Endocrinology (10) Infection (15) Inflammation/Immunology (6) Metabolic Disease (10) Neurological Disease (5)
Oligonucleotides:	mRNA (1) Mouse Pre-designed siRNA Sets (2) siRNAs (2)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-117178

TA 0910 acid-type	Thyroid Hormone Receptor	Metabolic Disease
TA 0910 acid-type is a metabolite of TA 0910. TA-0910 is a metabolically stable analogue of thyrotropin releasing hormone (TRH) .

HY-100115

TA-02 2 Publications Verification	p38 MAPK Autophagy	Cardiovascular Disease Inflammation/Immunology Cancer
TA-02, an analog of SB 203580 (HY-10256), is a p38 MAPK inhibitor with an IC₅₀ of 20 nM. TA-02 especially inhibits TGFBR-2. TA-02 exhibits similar cardiogenic properties as SB 203580 and SB 202190 (HY-10295) .

HY-100114

TA-01	Casein Kinase p38 MAPK Autophagy	Cardiovascular Disease
TA-01 is a potent CK1 and p38 MAPK inhibitor, with IC₅₀s of 6.4 nM, 6.8 nM, 6.7 nM for CK1ε, CK1δ and p38 MAPK, respectively. TA-01 acts as a cardiogenic inhibitor.

HY-176913

TA	Fluorescent Dye	Others
TA is an anthracene derivative with ultrasound-activated luminescence properties. TA can be activated by ultrasound and emit fluorescence. TA is generally not used directly but can be used to construct TA-NP nanoparticles. The ultrasound-activated luminescence of TA-NPs is mainly concentrated in the wavelength range of 600~650 nm, exhibiting good penetration ability into biological tissues, making it suitable for in vivo imaging .

HY-123226

TA-606	Angiotensin Receptor	Cardiovascular Disease
TA-606 is a potent and orally active angiotensin II-receptor antagonist. TA-606 shows antihypertensive efficacy. TA-606 can be used for hypertension research .

HY-105060

TA 077	Drug Derivative	Cancer
TA 077 is a nitrosourea derivative with antitumor activity. TA 077 can be used for the research of cancer, such as lung cancer and leukemia .

HY-19030

TA-1801	Others	Metabolic Disease
TA-1801 is a hypolipidemic agent.

HY-100253

TA-7552	Acyltransferase	Cardiovascular Disease
TA-7552 is a potent cholesterol-lowering agent.

HY-126467

TA-270	Lipoxygenase	Inflammation/Immunology
TA-270, a novel quinolinone derivative, is a potent inhibitor of 5-lipoxygenase that plays an important role in asthma research .

HY-12608

TA-1887 JNJ-39933673	SGLT	Metabolic Disease
TA-1887 (JNJ-39933673) is a highly potent, selective and orally active SGLT2 inhibitor (IC₅₀: 1.4 nM) with antihyperglycemic effects. TA-1887 can be used in the research of diabetes .

HY-18778

Obicetrapib TA-8995; DEZ-001	CETP	Metabolic Disease
TA-8995 is a new and selective cholesteryl ester transfer protein (CETP) inhibitor.

HY-B0691A

Ecabet sodium TA-2711	Reactive Oxygen Species (ROS) Bacterial Apoptosis	Infection
Ecabet sodium (TA-2711) is currently applied to some gastrointestinal disease by inhibiting the ROS production and improving Helicobacter pylori eradication . Ecabet sodium reduces apoptosis .

HY-125347

TA-993	Drug Derivative	Others
TA-993 is a compound that increases limb blood flow. Its effect of increasing limb blood flow is mediated through the sympathetic nervous system, but not through adrenergic receptors, and its mechanism of action on heart rate may be different.

HY-112486G

TA-316 (GMP) Megakaryocytes/platelets inducing agent (GMP)	Cyclin G-associated Kinase (GAK)	Cardiovascular Disease
TA-316 (GMP) is TA-316 (HY-112486) produced by using GMP guidelines. GMP grade small molecules can be used as auxiliary agents in cell therapy. TA-316 is a c-MPL agonist and a thrombopoietin (TPO) receptor agonist .

HY-B0596A

Taltirelin acetate 1 Publications Verification TA-0910 aceTAte	Thyroid Hormone Receptor Apoptosis	Neurological Disease Endocrinology
Taltirelin acetate (TA-0910) is an acetate form of Taltirelin (TA-0910). Taltirelin (TA-0910) is an orally effective analogue of thyrotropin releasing hormone (TRH) and a TRH receptor (TRH-R) superagonist (IC₅₀ at 910 nM). Taltirelin can cross the blood-brain barrier. Taltirelin stimulates an increase in cytosolic Ca ²⁺ concentration (Ca ²⁺ release) with an EC₅₀ value of 36 nM. Taltirelin increases cell viability and reduces apoptosis in SH-SY5Y cells and primary rat mesencephalic neurons treated with MPP+ (HY-W008719) or Rotenone (HY-B1756). Taltirelin has neuroprotective effects in both cellular and animal models of Parkinson's disease. Taltirelin alleviates fatigue-like behavior in mouse models of cancer-related fatigue .

HY-112486

TA-316 Megakaryocytes/platelets inducing agent	Cyclin G-associated Kinase (GAK)	Cardiovascular Disease
TA-3166 (Megakaryocytes/platelets inducing agent) is a novel chemically synthesized c-MPL agonist (CMA) and thrombopoietin (TPO) receptor agonist. TA-316 enhances ex vivo platelet generation from human-induced pluripotent stem (iPS) cells .

HY-B1451

Imidapril hydrochloride TA-6366	Angiotensin-converting Enzyme (ACE) MMP	Cardiovascular Disease Metabolic Disease
Imidapril hydrochloride (TA-6366) is an orally active angiotensin-converting enzyme (ACE) and MMP-9 inhibitor. Imidapril hydrochloride suppresses the conversion of angiotensin I to angiotensin II and thereby reduces total peripheral resistance and systemic blood pressure. Imidapril hydrochloride can be used for hypertension, type 1 diabetic, nephropathy and chronic heart failure research .

HY-164599

TA-DOTA	Radionuclide-Drug Conjugates (RDCs)	Cancer
TA-DOTA is a radionuclide conjugate (RDC), which is capable of binding to a radionuclide. RDC has the ability to specifically target biomolecules and can be used in medical imaging or therapy .

HY-18252S2

Avanafil-d4 TA1790-d₄	NO Synthase Endogenous Metabolite Phosphodiesterase (PDE) Isotope-Labeled Compounds	Endocrinology
Avanafil-d₄ (TA1790-d₄) is deuterium-labeled Avanafil (HY-18252) .

HY-P99823

Recifercept TA-46; sFGFR3	FGFR	Others
Recifercept (TA-46) is a soluble, recombinant fibroblast growth factor receptor 3 (FGFR3) molecule. Recifercept can be used as a decoy/ligand trap to decrease the amount of fibroblast growth factors that can bind to mutant FGFR3 receptors. Recifercept can be used for the research of achondroplasia .

HY-164594

TA-DOTA-GA	Radionuclide-Drug Conjugates (RDCs)	Cancer
TA-DOTA-GA is a radionuclide conjugate (RDC), which is capable of binding to a radionuclide. RDC has the ability to specifically target biomolecules and can be used in medical imaging or therapy .

HY-B1451A

Imidapril TA-6366 free base	Angiotensin-converting Enzyme (ACE) MMP	Cardiovascular Disease Metabolic Disease
Imidapril (TA-6366 free base) is an orally active angiotensin-converting enzyme (ACE) and MMP-9 inhibitor. Imidapril suppresses the conversion of angiotensin I to angiotensin II and thereby reduces total peripheral resistance and systemic blood pressure. Imidapril can be used for hypertension, type 1 diabetic, nephropathy and chronic heart failure research .

HY-18252

Avanafil 1 Publications Verification TA1790	Phosphodiesterase (PDE) NO Synthase Endogenous Metabolite	Cardiovascular Disease Endocrinology
Avanafil (TA-1790) is a potent and selective phosphodiesterase-5 (PDE-5) inhibitor with IC₅₀ values of 5.2 nM, 630 nM, 5700 nM, 6200 nM, 12000 nM, 27000 nM, 51000 nM and 53000 nM for PDE-5, PDE-6, PDE-4, PDE-10, PDE-8, PDE-7, PDE-2 and PDE-1, respectively. Avanafil activates NO/cGMP/PKG signaling-pathway to decrease loss in BMD, bone atrophy, and oxidative stress. Avanafil inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels. Avanafil can be used for the research of erectile dysfunction and osteoporosis .

HY-B0596

Taltirelin 1 Publications Verification TA-0910	Thyroid Hormone Receptor Apoptosis	Neurological Disease Endocrinology
Taltirelin (TA-0910) is an orally effective analogue of thyrotropin releasing hormone (TRH) and a TRH receptor (TRH-R) superagonist (IC₅₀ at 910 nM). Taltirelin can cross the blood-brain barrier. Taltirelin stimulates an increase in cytosolic Ca ²⁺ concentration (Ca ²⁺ release) with an EC₅₀ value of 36 nM. Taltirelin increases cell viability and reduces apoptosis in SH-SY5Y cells and primary rat mesencephalic neurons treated with MPP+ (HY-W008719) or Rotenone (HY-B1756). Taltirelin has neuroprotective effects in both cellular and animal models of Parkinson's disease. Taltirelin alleviates fatigue-like behavior in mouse models of cancer-related fatigue .

HY-B0596S

Taltirelin-13C,d3 TA-0910-¹³C,d₃	Isotope-Labeled Compounds Thyroid Hormone Receptor Apoptosis	Neurological Disease Endocrinology
Taltirelin- ¹³C,d₃ (TA-0910- ¹³C,d₃) is ¹³C and deuterated labeled Taltirelin (HY-B0596). Taltirelin (TA0910) is a superagonist at thyrotropin-releasing hormone receptor (TRH-R) with an IC₅₀ of 910 nM and EC₅₀ of 36 nM for stimulating an increase in cytosolic Ca ²⁺ concentration (Ca ²⁺ release).

HY-18252R

Avanafil (Standard) TA1790 (STAndard)	Reference Standards Phosphodiesterase (PDE) NO Synthase Endogenous Metabolite	Cardiovascular Disease Endocrinology
Avanafil (Standard) is the analytical standard of Avanafil. This product is intended for research and analytical applications. Avanafil (TA-1790) is a potent and selective phosphodiesterase-5 (PDE-5) inhibitor with IC50 values of 5.2 nM, 630 nM, 5700 nM, 6200 nM, 12000 nM, 27000 nM, 51000 nM and 53000 nM for PDE-5, PDE-6, PDE-4, PDE-10, PDE-8, PDE-7, PDE-2 and PDE-1, respectively. Avanafil activates NO/cGMP/PKG signaling-pathway to decrease loss in BMD, bone atrophy, and oxidative stress. Avanafil inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels. Avanafil can be used for the research of erectile dysfunction and osteoporosis .

HY-18252A

Avanafil dibenzenesulfonate TA1790 dibenzenesulfonate	Phosphodiesterase (PDE) NO Synthase Endogenous Metabolite	Cardiovascular Disease Endocrinology
Avanafil (TA-1790) dibenzenesulfonate is a potent and selective phosphodiesterase-5 (PDE-5) inhibitor with IC₅₀ values of 5.2 nM, 630 nM, 5700 nM, 6200 nM, 12000 nM, 27000 nM, 51000 nM and 53000 nM for PDE-5, PDE-6, PDE-4, PDE-10, PDE-8, PDE-7, PDE-2 and PDE-1, respectively. Avanafil dibenzenesulfonate activates NO/cGMP/PKG signaling-pathway to decrease loss in BMD, bone atrophy, and oxidative stress. Avanafil dibenzenesulfonate inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels. Avanafil dibenzenesulfonate can be used for the research of erectile dysfunction and osteoporosis .

HY-18252S3

Avanafil-13C5 TA1790-¹³C₅	Isotope-Labeled Compounds Endogenous Metabolite Phosphodiesterase (PDE) NO Synthase	Cardiovascular Disease Endocrinology
Avanafil- ¹³C₅ (TA1790- ¹³C₅) is ¹³C labeled Avanafil. Avanafil (TA-1790) is a potent and selective phosphodiesterase-5 (PDE-5) inhibitor with IC₅₀ values of 5.2 nM, 630 nM, 5700 nM, 6200 nM, 12000 nM, 27000 nM, 51000 nM and 53000 nM for PDE-5, PDE-6, PDE-4, PDE-10, PDE-8, PDE-7, PDE-2 and PDE-1, respectively. Avanafil activates NO/cGMP/PKG signaling-pathway to decrease loss in BMD, bone atrophy, and oxidative stress. Avanafil inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels. Avanafil can be used for the research of erectile dysfunction and osteoporosis .

HY-105981

Cefempidone GR 50692; TA 5901	Antibiotic Bacterial	Infection
Cefempidone (GR 50692) is a third-generation cephalosporin antibiotic. Cefempidone exerts antibacterial activity by inhibiting penicillin-binding proteins in bacterial cell wall synthesis .

HY-12169

Marimastat 15+ Cited Publications BB2516; TA2516	MMP	Cancer
Marimastat (BB2516) is a broad spectrum and orally bioavailable inhibitor of MMPs, with potent activity against MMP-9 (IC₅₀=3 nM), MMP-1 (IC₅₀=5 nM), MMP-2 (IC₅₀=6 nM), MMP-14 (IC₅₀=9 nM) and MMP-7 (IC₅₀=13 nM), used in the treatment of cancer. Marimastat (BB2516) is an angiogenesis and metastasis inhibitor, which limits the growth and production of blood vessels. As an antimetatstatic agent it prevents malignant cells from breaching the basement membranes .

HY-119515

Denopamine (R)-(-)-Denopamine; TA-064	Adrenergic Receptor	Cardiovascular Disease Cancer
Denopamine ((R)-(-)-Denopamine) is an orally active, selective β1-adrenergic agonist. Denopamine prolongs survival in a murine model of congestive heart failure induced by viral myocarditis: suppression of tumor necrosis factor-α production in the heart. Cardiovascular effects .

HY-113595

Temafloxacin hydrochloride TMFX hydrochloride; TA-167; A-62254	Antibiotic Bacterial	Infection
Temafloxacin (TMFX) hydrochloride is an orally active quinolone broad-spectrum antibacterial agent. Temafloxacin hydrochloride is well tolerated in lower respiratory and genitourinary tract infections .

HY-16487

Temafloxacin TMFX; TA-167 free acid; A-62254 free acid	Bacterial Antibiotic	Infection
Temafloxacin (TMFX) is an orally active quinolone broad-spectrum antibacterial agent. Temafloxacin is well tolerated in lower respiratory and genitourinary tract infections .

HY-P9970

Infliximab Maximum Cited Publications 22 Publications Verification Avakine; CT-P13; SB2; TA-650	TNF Receptor	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Infliximab (Avakine) is a chimeric monoclonal IgG1 antibody that specifically binds to TNF-α. Infliximab prevents the interaction of TNF-α with TNF-α receptor (TNFR1 and TNFR2). Infliximab has the potential for autoimmune, chronic inflammatory diseases and diabetic neuropathy research . The component ratio of this product is Active ingredient : Excipients = 9 : 47.

HY-16487R

Temafloxacin (Standard) TMFX (STAndard); TA-167 free acid (STAndard); A-62254 free acid (STAndard)	Reference Standards Bacterial Antibiotic	Infection
Temafloxacin (Standard) is the analytical standard of Temafloxacin. This product is intended for research and analytical applications. Temafloxacin (TMFX) is an orally active quinolone broad-spectrum antibacterial agent. Temafloxacin is well tolerated in lower respiratory and genitourinary tract infections .

HY-18252S

Avanafil-13C,d3 TA1790-¹³C,d₃	Isotope-Labeled Compounds Phosphodiesterase (PDE)	Cardiovascular Disease
Avanafil- ¹³C,d₃ is the ¹³C- and deuterium labeled Avanafil.

HY-P990149

Anti-Mouse/Human TYRP1 Antibody (TA99)	Tyrosinase	Cancer
Anti-Mouse/Human TYRP1 Antibody (TA99) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse/human TYRP1. Anti-Mouse/Human TYRP1 Antibody (TA99) binds to Tyrp1 (tyrosinase related protein-1) on tumor. Anti-Mouse/Human TYRP1 Antibody (TA99) enhances infiltration of the tumor by CD8+ T cells. Anti-Mouse/Human TYRP1 Antibody (TA99) can be used for the research of melanoma .

HY-18252B

(R)-Avanafil (R)-TA1790	Phosphodiesterase (PDE)	Endocrinology
(R)-Avanafil ((R)-TA1790) is a selective PDE5 inhibitor (IC₅₀: 5.2 nM). (R)-Avanafil can be used for research of erectile dysfunction .

HY-B1451S

Imidapril-d3 hydrochloride	Isotope-Labeled Compounds Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Imidapril-d₃ hydrochloride (TA-6366-d₃) is the deuterium labeled Imidapril hydrochloride. Imidapril hydrochloride (TA-6366) is the hydrochloride salt of Imidapril, an angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity .

HY-N12695

Altertoxin III	Bacterial	Infection
Altertoxin III is a mutagen that is mutagenic to Salmonella typhimurium TA98, TA100, and TA1537. Altertoxin III can be obtained from the extract of the A. alternata isolate that shows a mutagenic response in the Ames Salmonella typhimurium assay .

HY-N14989A

Fluostatin A sodium	Dipeptidyl Peptidase	Others
Fluostatin A sodium is a dipeptidyl peptidaseIII inhibitor with an IC₅₀ of 0.44 μg/mL. Fluostatin A can be extracted from Streptomyces sp. TA-3391 .

HY-163292

Antibacterial agent 180	Bacterial Parasite	Infection
Antibacterial agent 180 (15g), an appropriate substrate for the type I nitro reductases (TcNTR I), is a promising antitrypanosomatid agent. Antibacterial agent 180 (15g) shows nonmutagenic potential against Salmonella typhimurium strains (TA98, TA100, and TA102) .

HY-109592

Imidaprilate 6366A; Imidaprilat	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Imidaprilate is an active metabolite of TA-6366, acts as a potent angiotensin converting enzyme (ACE) inhibitor, with an IC₅₀ of 2.6 nM, and is used in the research of hypertensive disease.

HY-174673

Human GATA4 mRNA	mRNA	Cancer
Human GATA4 mRNA encodes the human GATA binding protein 4 (GATA4) protein, a member of the GATA family of zinc-finger transcription factors. GATA4 is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function. It is also necessary for normal testicular development.

HY-B0691

Ecabet	Reactive Oxygen Species (ROS) Bacterial	Infection
Ecabet sodium (TA-2711) is currently applied to some clinical gastrointestinal disease by inhibiting the ROS production and improving Helicobacter pylori eradication . Ecabet sodium reduces apoptosis

HY-109592S

Imidaprilate-d5 6366A-d₅; Imidaprilat-d₅	Isotope-Labeled Compounds Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Imidaprilate-d₅ is deuterium labeled Imidaprilate. Imidaprilate is an active metabolite of TA-6366, acts as a potent angiotensin converting enzyme (ACE) inhibitor, with an IC50 of 2.6 nM, and is used in the research of hypertensive disease.

HY-W739949

Imidaprilat-d3 6366Ad₃	Isotope-Labeled Compounds Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Imidaprilat-d₃ (6366A-d₃) is deuterium labeled Imidaprilate. Imidaprilate is an active metabolite of TA-6366, acts as a potent angiotensin converting enzyme (ACE) inhibitor, with an IC₅₀ of 2.6 nM, and is used in the research of hypertensive disease .

HY-N5054

(R)-5,7-Dimethoxyflavanone	TNF Receptor	Inflammation/Immunology
(R)-5,7-Dimethoxyflavanone shows potent antimutagenic activity against MeIQ mutagenesis in Ames test using the S. typhimurium TA100 and TA98 strains . And (R)-5,7-Dimethoxyflavanone significantly and dose-dependently inhibits the inflammatory mediato .

HY-120002

Proclonol Kilacar; R 8284	Parasite	Infection
Proclonol (Kilacar) is an insecticide-acaricide. Proclonol is a weak mutagen in the TA97 strain of S. typhimurium .

HY-177442

DS-3939a DS-3939	Antibody-Drug Conjugates (ADCs) Mucin Topoisomerase Apoptosis	Cancer
DS-3939a (DS-3939) is an anti-TA-MUC1 (tumor-associated mucin-1) antibody-drug conjugate (ADC). DS-3939a consists of a humanized anti-TA-MUC1 IgG1 monoclonal antibody Gatipotuzumab ( HY-P99634), a stable and cleavable tetrapeptide-based linker (Gly-Gly-Phe-Gly), and a DNA topoisomerase I inhibitor payload (DXd) (HY-13631D), and the drug-linker conjugate for ADC is Deruxtecan (HY-13631E). DS-3939a inhibits the growth of TA-MUC1-positive cancer cells (CFPAC-1, NCI-H2110) by inducing DNA damage and apoptosis. DS-3939a exhibits significant antitumor activity in a variety of TA-MUC1-expressing advanced solid tumors. DS-3939a can be used for the study of TA-MUC1-expressing advanced cancers .

Cat. No.	Product Name	Type

HY-112486G

TA-316 (GMP) Megakaryocytes/platelets inducing agent (GMP)	Fluorescent Dye
TA-316 (GMP) is TA-316 (HY-112486) produced by using GMP guidelines. GMP grade small molecules can be used as auxiliary agents in cell therapy. TA-316 is a c-MPL agonist and a thrombopoietin (TPO) receptor agonist .

HY-177442

DS-3939a

DS-3939

Chromogenic Assays

DS-3939a (DS-3939) is an anti-TA-MUC1 (tumor-associated mucin-1) antibody-drug conjugate (ADC). DS-3939a consists of a humanized anti-TA-MUC1 IgG1 monoclonal antibody Gatipotuzumab ( HY-P99634), a stable and cleavable tetrapeptide-based linker (Gly-Gly-Phe-Gly), and a DNA topoisomerase I inhibitor payload (DXd) (HY-13631D), and the drug-linker conjugate for ADC is Deruxtecan (HY-13631E). DS-3939a inhibits the growth of TA-MUC1-positive cancer cells (CFPAC-1, NCI-H2110) by inducing DNA damage and apoptosis. DS-3939a exhibits significant antitumor activity in a variety of TA-MUC1-expressing advanced solid tumors. DS-3939a can be used for the study of TA-MUC1-expressing advanced cancers .

Cat. No.	Product Name	Type

HY-112486G

TA-316 (GMP) Megakaryocytes/platelets inducing agent (GMP)	Biochemical Assay Reagents
TA-316 (GMP) is TA-316 (HY-112486) produced by using GMP guidelines. GMP grade small molecules can be used as auxiliary agents in cell therapy. TA-316 is a c-MPL agonist and a thrombopoietin (TPO) receptor agonist .

Cat. No.	Product Name	Target	Research Area

HY-P99823

Recifercept TA-46; sFGFR3	FGFR	Others
Recifercept (TA-46) is a soluble, recombinant fibroblast growth factor receptor 3 (FGFR3) molecule. Recifercept can be used as a decoy/ligand trap to decrease the amount of fibroblast growth factors that can bind to mutant FGFR3 receptors. Recifercept can be used for the research of achondroplasia .

HY-P9970

Infliximab 20+ Cited Publications Avakine; CT-P13; SB2; TA-650	TNF Receptor	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Infliximab (Avakine) is a chimeric monoclonal IgG1 antibody that specifically binds to TNF-α. Infliximab prevents the interaction of TNF-α with TNF-α receptor (TNFR1 and TNFR2). Infliximab has the potential for autoimmune, chronic inflammatory diseases and diabetic neuropathy research . The component ratio of this product is Active ingredient : Excipients = 9 : 47.

HY-P99634

Gatipotuzumab PankoMab; DS-3939a antibody	Mucin	Cancer
Gatipotuzumab (PankoMab) is a humanized monoclonal antibody which recognizes the tumor-specific epitope of mucin-1 (TA-MUC1). Gatipotuzumab reveals a potent tumor-specific antibody-dependent cell cytotoxicity (ADCC) .

HY-P990469

Anti-MPL/TPOR/CD110 Antibody (TA136) TA136	Inhibitory Antibodies	Inflammation/Immunology
The Anti-MPL/TPOR/CD110 Antibody (TA136) is a CHO-expressed humanized antibody that targets MPL/TPOR/CD110. The Anti-MPL/TPOR/CD110 Antibody (TA136) features a huIgG1 heavy chain and a huλ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for the Anti-MPL/TPOR/CD110 Antibody (TA136) can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990149

Anti-Mouse/Human TYRP1 Antibody (TA99)	Tyrosinase	Cancer
Anti-Mouse/Human TYRP1 Antibody (TA99) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse/human TYRP1. Anti-Mouse/Human TYRP1 Antibody (TA99) binds to Tyrp1 (tyrosinase related protein-1) on tumor. Anti-Mouse/Human TYRP1 Antibody (TA99) enhances infiltration of the tumor by CD8+ T cells. Anti-Mouse/Human TYRP1 Antibody (TA99) can be used for the research of melanoma .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-18252

Avanafil 1 Publications Verification TA1790	Cardiovascular Disease Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Endocrinology	Phosphodiesterase (PDE) NO Synthase Endogenous Metabolite
Avanafil (TA-1790) is a potent and selective phosphodiesterase-5 (PDE-5) inhibitor with IC₅₀ values of 5.2 nM, 630 nM, 5700 nM, 6200 nM, 12000 nM, 27000 nM, 51000 nM and 53000 nM for PDE-5, PDE-6, PDE-4, PDE-10, PDE-8, PDE-7, PDE-2 and PDE-1, respectively. Avanafil activates NO/cGMP/PKG signaling-pathway to decrease loss in BMD, bone atrophy, and oxidative stress. Avanafil inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels. Avanafil can be used for the research of erectile dysfunction and osteoporosis .

HY-N5054

(R)-5,7-Dimethoxyflavanone	Flavonoids other families Classification of Application Fields Flavonones Source classification Plants Inflammation/Immunology Disease Research Fields	TNF Receptor
(R)-5,7-Dimethoxyflavanone shows potent antimutagenic activity against MeIQ mutagenesis in Ames test using the S. typhimurium TA100 and TA98 strains . And (R)-5,7-Dimethoxyflavanone significantly and dose-dependently inhibits the inflammatory mediato .

HY-W001189

1,3-Dithiane	Infection Natural Products Animals Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	Bacterial
1,3-Dithiane is a protected formaldehyde anion equivalent and a sulfur-containing Maillard reaction product. 1,3-Dithiane is found in cooked beef extracts. 1,3-Dithiane is a potent mutagenic agent against *S. typhimurium* TA98 and TA100. 1,3-Dithiane can be used as a useful marker synthon .

HY-W275553

4-Decanol	Natural Products Capillipedium parviflorum (R. Br.) Stapf Gramineae Source classification Plants	DNA Alkylator/Crosslinker
4-Decanol is an antimutagenic compound, that can be isolated from mustard leaves. 4-Decanol inhibits mutagenic activities of Aflatoxin B1 (HY-N6615) and MNNG (HY-128612) in Salmonella typhimurium TA100 .

HY-18252R

Avanafil (Standard) TA1790 (STAndard)	Natural Products Source classification Endogenous metabolite	Reference Standards Phosphodiesterase (PDE) NO Synthase Endogenous Metabolite
Avanafil (Standard) is the analytical standard of Avanafil. This product is intended for research and analytical applications. Avanafil (TA-1790) is a potent and selective phosphodiesterase-5 (PDE-5) inhibitor with IC50 values of 5.2 nM, 630 nM, 5700 nM, 6200 nM, 12000 nM, 27000 nM, 51000 nM and 53000 nM for PDE-5, PDE-6, PDE-4, PDE-10, PDE-8, PDE-7, PDE-2 and PDE-1, respectively. Avanafil activates NO/cGMP/PKG signaling-pathway to decrease loss in BMD, bone atrophy, and oxidative stress. Avanafil inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels. Avanafil can be used for the research of erectile dysfunction and osteoporosis .

HY-18252A

Avanafil dibenzenesulfonate TA1790 dibenzenesulfonate	Cardiovascular Disease Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Endocrinology	Phosphodiesterase (PDE) NO Synthase Endogenous Metabolite
Avanafil (TA-1790) dibenzenesulfonate is a potent and selective phosphodiesterase-5 (PDE-5) inhibitor with IC₅₀ values of 5.2 nM, 630 nM, 5700 nM, 6200 nM, 12000 nM, 27000 nM, 51000 nM and 53000 nM for PDE-5, PDE-6, PDE-4, PDE-10, PDE-8, PDE-7, PDE-2 and PDE-1, respectively. Avanafil dibenzenesulfonate activates NO/cGMP/PKG signaling-pathway to decrease loss in BMD, bone atrophy, and oxidative stress. Avanafil dibenzenesulfonate inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels. Avanafil dibenzenesulfonate can be used for the research of erectile dysfunction and osteoporosis .

HY-N12695

Altertoxin III	Natural Products Microorganisms Ketones, Aldehydes, Acids Source classification	Bacterial
Altertoxin III is a mutagen that is mutagenic to Salmonella typhimurium TA98, TA100, and TA1537. Altertoxin III can be obtained from the extract of the A. alternata isolate that shows a mutagenic response in the Ames Salmonella typhimurium assay .

HY-N3549

Catalpin	Iridoids Terpenoids Source classification Sorbus pohuashanensis (Hance) Hedl. Rosaceae Plants	Bacterial
Catalpin is an iridoid that can be isoalted from Catalpae Fructus.Catalpin shows mutagenic activity towards Salmonella typhimurium strain TA100 .

HY-W001189R

1,3-Dithiane (Standard)	Natural Products Animals Source classification Endogenous metabolite	Reference Standards Bacterial
1,3-Dithiane (Standard) is an analytical standard of 1,3-Dithiane (HY-W001189). This product is intended for research and analytical applications. 1,3-Dithiane is a protected formaldehyde anion equivalent and a sulfur-containing Maillard reaction product. 1,3-Dithiane is found in cooked beef extracts. 1,3-Dithiane is a potent mutagenic agent against *S. typhimurium* TA98 and TA100. 1,3-Dithiane can be used as a useful marker synthon .

HY-N10322

2-Hydroxyemodin	Quinones other families Classification of Application Fields Anthraquinones Source classification Other Diseases Phenols Polyphenols Plants Disease Research Fields	Drug Metabolite
2-Hydroxyemodin is an active metabolite of emodin in the hepatic microsomes. Emodin is an anthraquinone present in fungal metabolites and constituent of rhubarb. 2-Hydroxyemodin proves to be mutagenic to Salmonella typhimurium TA1537 in the absence of activation system .

HY-113972R

Methyl mycophenolate (Standard)	Monophenols Microorganisms Marine natural products Phenols Marine microorganism	Reference Standards Others
Avanafil (Standard) is the analytical standard of Avanafil. This product is intended for research and analytical applications. Avanafil (TA-1790) is a potent and selective phosphodiesterase-5 (PDE-5) inhibitor with IC50 values of 5.2 nM, 630 nM, 5700 nM, 6200 nM, 12000 nM, 27000 nM, 51000 nM and 53000 nM for PDE-5, PDE-6, PDE-4, PDE-10, PDE-8, PDE-7, PDE-2 and PDE-1, respectively. Avanafil activates NO/cGMP/PKG signaling-pathway to decrease loss in BMD, bone atrophy, and oxidative stress. Avanafil inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels. Avanafil can be used for the research of erectile dysfunction and osteoporosis .

HY-N5092

7-Methylcoumarin	Microorganisms Source classification Coumarins Metabolic Disease Phenylpropanoids Disease Research Fields	Reactive Oxygen Species (ROS) Cytochrome P450
7-Methylcoumarin is a coumarin derivative with potent hepatoprotective and antioxidant properties. 7-Methylcoumarin is a mechanism-based inhibitor for CYP2A6. 7-Methylcoumarin significantly decreases alanine aminotransferase (ALT), aspartate aminotransferase (AST), and serum bilirubin (TB) in rats with CCl₄-induced liver damage, whilst restoring total protein (TP) and albumin (TA) levels in serum as well as preventing oxidative stress. 7-Methylcoumarin can decline mitotic activity of A. sativum promeristem .

HY-N5092R

7-Methylcoumarin (Standard)	Microorganisms Source classification Coumarins Phenylpropanoids	Reference Standards Reactive Oxygen Species (ROS) Cytochrome P450
7-Methylcoumarin (Standard) is the analytical standard of 7-Methylcoumarin. This product is intended for research and analytical applications. 7-Methylcoumarin is a coumarin derivative with potent hepatoprotective and antioxidant properties. 7-Methylcoumarin is a mechanism-based inhibitor for CYP2A6. 7-Methylcoumarin significantly decreases alanine aminotransferase (ALT), aspartate aminotransferase (AST), and serum bilirubin (TB) in rats with CCl₄-induced liver damage, whilst restoring total protein (TP) and albumin (TA) levels in serum as well as preventing oxidative stress. 7-Methylcoumarin can decline mitotic activity of A. sativum promeristem .

Species:	Human (2)
Tag:	His (1) Tag Free (1) Strep (1)
Source:	Sf9 insect cells (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P701579

	KBTBD8 Protein, Human (sf9) KBTBD8; Kelch repeat and BTB domain-conTAining protein 8; T-cell activation kelch repeat protein; TA-KRP	Human	Sf9 insect cells
	KBTBD8 in the BCR E3 ubiquitin ligase complex plays a critical regulatory role in neural crest specification. The BCR(KBTBD8) complex coordinates this action by monoubiquitinating NOLC1 and TCOF1. KBTBD8 Protein, Human (sf9) is the recombinant human-derived KBTBD8 protein, expressed by sf9 insect cells , with tag free.

HY-P701580

	KBTBD8 Protein, Human (sf9, His, StrepⅡ) KBTBD8; Kelch repeat and BTB domain-conTAining protein 8; T-cell activation kelch repeat protein; TA-KRP	Human	Sf9 insect cells
	KBTBD8 in the BCR E3 ubiquitin ligase complex plays a critical regulatory role in neural crest specification. The BCR(KBTBD8) complex coordinates this action by monoubiquitinating NOLC1 and TCOF1. KBTBD8 Protein, Human (sf9, His, Strep) is the recombinant human-derived KBTBD8 protein, expressed by sf9 insect cells , with N-Strep, N-8*His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-18252S2

Avanafil-d4
Avanafil-d₄ (TA1790-d₄) is deuterium-labeled Avanafil (HY-18252) .

HY-B0596S

Taltirelin-13C,d3
Taltirelin- ¹³C,d₃ (TA-0910- ¹³C,d₃) is ¹³C and deuterated labeled Taltirelin (HY-B0596). Taltirelin (TA0910) is a superagonist at thyrotropin-releasing hormone receptor (TRH-R) with an IC₅₀ of 910 nM and EC₅₀ of 36 nM for stimulating an increase in cytosolic Ca ²⁺ concentration (Ca ²⁺ release).

HY-18252S3

Avanafil-13C5

Avanafil- ¹³C₅ (TA1790- ¹³C₅) is ¹³C labeled Avanafil. Avanafil (TA-1790) is a potent and selective phosphodiesterase-5 (PDE-5) inhibitor with IC₅₀ values of 5.2 nM, 630 nM, 5700 nM, 6200 nM, 12000 nM, 27000 nM, 51000 nM and 53000 nM for PDE-5, PDE-6, PDE-4, PDE-10, PDE-8, PDE-7, PDE-2 and PDE-1, respectively. Avanafil activates NO/cGMP/PKG signaling-pathway to decrease loss in BMD, bone atrophy, and oxidative stress. Avanafil inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels. Avanafil can be used for the research of erectile dysfunction and osteoporosis .

HY-18252S

Avanafil-13C,d3
Avanafil- ¹³C,d₃ is the ¹³C- and deuterium labeled Avanafil.

HY-B1451S

Imidapril-d3 hydrochloride
Imidapril-d₃ hydrochloride (TA-6366-d₃) is the deuterium labeled Imidapril hydrochloride. Imidapril hydrochloride (TA-6366) is the hydrochloride salt of Imidapril, an angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity .

HY-109592S

Imidaprilate-d5
Imidaprilate-d₅ is deuterium labeled Imidaprilate. Imidaprilate is an active metabolite of TA-6366, acts as a potent angiotensin converting enzyme (ACE) inhibitor, with an IC50 of 2.6 nM, and is used in the research of hypertensive disease.

HY-W739949

Imidaprilat-d3
Imidaprilat-d₃ (6366A-d₃) is deuterium labeled Imidaprilate. Imidaprilate is an active metabolite of TA-6366, acts as a potent angiotensin converting enzyme (ACE) inhibitor, with an IC₅₀ of 2.6 nM, and is used in the research of hypertensive disease .

HY-W001189S

1,3-Dithiane-d2
1,3-Dithiane-d2 is the deuterium labeled 1,3-Dithiane (HY-W001189). 1,3-Dithiane is a protected formaldehyde anion equivalent and a sulfur-containing Maillard reaction product. 1,3-Dithiane is found in cooked beef extracts. 1,3-Dithiane is a potent mutagenic agent against *S. typhimurium* TA98 and TA100. 1,3-Dithiane can be used as a useful marker synthon .

HY-18252S1

Avanafil-13C5,15N,d2

Avanafil- ¹³C₅, ¹⁵N,d₂ is ¹⁵N and deuterated labeled Avanafil (HY-18252). Avanafil (TA-1790) is a potent and selective phosphodiesterase-5 (PDE-5) inhibitor with IC₅₀ values of 5.2 nM, 630 nM, 5700 nM, 6200 nM, 12000 nM, 27000 nM, 51000 nM and 53000 nM for PDE-5, PDE-6, PDE-4, PDE-10, PDE-8, PDE-7, PDE-2 and PDE-1, respectively. Avanafil activates NO/cGMP/PKG signaling-pathway to decrease loss in BMD, bone atrophy, and oxidative stress. Avanafil inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels. Avanafil can be used for the research of erectile dysfunction and osteoporosis .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P84678

	KBTBD8 Antibody (YA4375) TA-KRP	WB, FC, ELISA	Human
	KBTBD8 Antibody (YA4375) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to KBTBD8.

HY-P81885

	Napsin A Antibody (YA1630) ASP4; KAP; Kdap; NAP1; NAPA; Napsa; Napsin-1; Napsin-A; Pronapsin A; SNAPA; TA01/TA02	WB, IHC-P, IP	Human
	Napsin A Antibody (YA1630) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Napsin A.

HY-P85849

	Napsin A Antibody (YA5541) Napsin-A; Aspartyl protease 4; ASP4; Asp 4; Napsin-1; TA01/TA02;	IHC-P, WB, ICC/IF, ELISA	Human
	Napsin A Antibody (YA5541) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to Napsin A.

HY-P84156

	Hexokinase I Antibody (YA3853) HKI; HXK1; HK1-TA; HK1-tb; HK1-tc; HK1	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat
	Hexokinase I Antibody (YA3853) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Hexokinase I.

HY-P81786

	p63 Antibody (YA1531) EEC3; KET; LMS; SHFM4; TA p63 alpha; TP63; p51; p73H; p73L; tumor protein p63	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	p63 Antibody (YA1531) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to p63.

HY-P86021

	Napsin A Antibody (YA5713) Napsin-A; Aspartyl protease 4; ASP4; Asp 4; Napsin-1; TA01/TA02;	IHC-P, ICC/IF, ELISA	Human
	Napsin A Antibody (YA5713) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Napsin A.

HY-P85528

	Hexokinase I Antibody (YA5220) BB404130; Brain form hexokinase; dea; Glycolytic enzyme; HEXOKIN; Hexokinase PI; Hexokinase type I; Hexokinase, tumor isozyme; Hexokinase-1; Hexokinase-A; HK I; HK1; HK1 tb; Hk1-s; HK1-TA; HK1-tb; HK1-tc; HKD; HKI; HMSNR; HXK1; HXK1_HUMAN; mHk1-s.	WB	Human, Mouse, Rat
	Hexokinase I Antibody (YA5220) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Hexokinase I.

HY-P87107

	TIMP3 Antibody (YA6800) HSMRK222 antibody; K222 antibody; K222TA2 antibody; MeTAlloproteinase inhibitor 3 antibody; MIG 5 protein antibody; MIG5 protein antibody; Protein MIG 5 antibody; Protein MIG-5 antibody; SFD antibody; Sorsby fundus dystrophy pseudoinflammatory antibody; HSMRK222 antibody; K222 antibody; K222TA2 antibody; MeTAlloproteinase inhibitor 3 antibody; MIG 5 protein antibody; MIG5 protein antibody; Protein MIG 5 antibody; Protein MIG-5 antibody; SFD antibody; Sorsby fundus dystrophy pseudoinflammatory antibody; TIMP 3 antibody; TIMP meTAllopeptidase inhibitor 3 antibody; TIMP-3 antibody; TIMP3 antibody; TIMP3_HUMAN antibody; Tissue Inhibitor of MeTAlloproteinase 3 antibody; Tissue inhibitor of meTAlloproteinases 3 antibody; Tissue inhibitor of meTAlloproteinases3 antibody;	WB, ICC/IF	Human, Rat
	TIMP3 Antibody (YA6800) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TIMP3.

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Cat. No.	Product Name		Classification

HY-174673

Human GATA4 mRNA		mRNA
Human GATA4 mRNA encodes the human GATA binding protein 4 (GATA4) protein, a member of the GATA family of zinc-finger transcription factors. GATA4 is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function. It is also necessary for normal testicular development.

HY-RS17841

Prss2 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Prss2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Prss2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS16949

Eda Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Eda Mouse Pre-designed siRNA Set A contains three designed siRNAs for Eda gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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