KBTBD8 Antibody (YA4375)

KBTBD8 Antibody (YA4375) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to KBTBD8.

KBTBD8 serves as a substrate-specific adapter within the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex, functioning as a crucial regulator of neural crest specification. The BCR(KBTBD8) complex orchestrates this regulatory role by mediating the monoubiquitination of NOLC1 and TCOF1. Monoubiquitination facilitates the formation of a NOLC1-TCOF1 complex, serving as a platform that connects RNA polymerase I with enzymes responsible for ribosomal processing and modification. This orchestrated interaction leads to the remodeling of the translational program in differentiating cells, favoring neural crest specification. As a component of the BCR(KBTBD8) E3 ubiquitin ligase complex, alongside CUL3 and RBX1, KBTBD8 plays a pivotal role in modulating cellular processes involved in neural crest development.

Q8NFY9

Predicted band size: 69 kDa; Observed band size: 69 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Mouse

Human

WB: 1:500-1:2000; FC: 1:200-1:400; ELISA: 1:10000

WB, FC, ELISA

Liquid

Supplied in PBS with 0.05% sodium azide

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG1

Purified recombinant fragment of human KBTBD8 (AA: 264-464) expressed in E. Coli.