Smad1

By Targets:	Anaplastic lymphoma kinase (ALK) (2) Bacterial (1) Glycosidase (1) MMP (1) RAR/RXR (1) Reactive Oxygen Species (ROS) (1) Small Interfering RNA (siRNA) (3) TGF-beta/Smad (3) TGF-β Receptor (6) β-catenin (1)
By Research Areas:	Cancer (6) Cardiovascular Disease (2) Endocrinology (1) Infection (1) Metabolic Disease (3)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-145608

Zilurgisertib INCB-000928; NBU-928	TGF-β Receptor	Cardiovascular Disease Cancer
Zilurgisertib (INCB-000928; NBU-928) is a selective ALK2 inhibitor with an IC₅₀ value of 15 nM. Zilurgisertib inhibits *SMAD1/5* phosphorylation with an IC₅₀ value of 63 nM. Zilurgisertib inhibits hepcidin production and improve anemia. Zilurgisertib can be used in melanoma research ^[1] .

HY-12274

ML347 Maximum Cited Publications 7 Publications Verification LDN 193719	TGF-β Receptor	Cancer
ML347 (LDN193719) is a highly selective *ALK1/ALK2* inhibitor. ML347 has IC₅₀ values of 46 and 32 nM against ALK1 and ALK2, respectively, >300-fold selective over ALK3. ML347 block the phosphorylation of Smad1/5 by TGF-β1 ^[1] .

HY-164145

CDD-1653	TGF-β Receptor	Others Cancer
CDD-1653 is a potent and selective BMPR2 inhibitor (IC₅₀=2.8 nM). CDD-1653 reduces the ability of ATP to bind to the kinase domain of BMPR2, thereby affecting the phosphorylation of SMAD1/5/8 transcription factors, which play a key role in the BMP signaling pathway. CDD-1653 can be used to study diseases related to the BMP signaling pathway ^[1].

HY-P99359

Elezanumab ABT-555; AE12-1Y-QL; Anti-RGMA Reference Antibody (elezanumab)	TGF-beta/Smad	Metabolic Disease
Elezanumab (ABT-555; AE12-1Y-QL) is a human monoclonal antibody that selectively targets repulsive guidance molecule A (RGMa). Elezanumab potently inhibited RGMa mediated BMP signalling via the SMAD1/5/8 pathway, with an IC₅₀ around 97 pM. Elezanumab promotes neuroregeneration and neuroprotection in neuronal injury and demyelination models binds N-terminal RGMa, blocks BMP signaling and lacks RGMc cross-reactivity. elezanumab has neuroregenerative and neuroprotective activities without impact on iron metabolism ^[1] .

HY-108527

CD1530 1 Publications Verification	RAR/RXR Bacterial TGF-beta/Smad β-catenin MMP Reactive Oxygen Species (ROS)	Infection Metabolic Disease Endocrinology
CD1530 is an orally active, selective RARγ agonist and antibacterial agent. CD1530 reduces *Smad1/5/8* phosphorylation and overall Smad levels. CD1530 reduces β-catenin, MMP9 protein, and ROS levels. CD1530 exhibits activities such as inhibiting heterotopic ossification, promoting Achilles tendon healing, and inhibiting muscle fatty infiltration. CD1530 can be used in the research of orthopedic diseases (such as heterotopic ossification, Achilles tendon injury), muscle diseases (such as muscle fatty infiltration-related diseases) ^[1] .

HY-N0946

(-)-Pinoresinol 4-O-glucoside (-)-Pinoresinol 4-O-β-D-glucopyranoside	Glycosidase	Metabolic Disease
(-)-Pinoresinol 4-O-glucoside ((-)-Pinoresinol 4-O-β-D-glucopyranoside) is a potent and orally active α-glucosidase inhibitor with an IC₅₀ value of 48.13 µM. (-)-Pinoresinol 4-O-glucoside increases cell migration and early differentiation of pre-osteoblasts. (-)-Pinoresinol 4-O-glucoside increases protein level of BMP2, p-Smad1/5/8, RUNX2. (-)-Pinoresinol 4-O-glucoside attenuates oxidative stress, hyperglycemia and hepatic toxicity. (-)-Pinoresinol 4-O-glucoside has the potential for the research of osteoporosis and periodontal disease ^[1] .

HY-RS13392

SMAD1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SMAD1 Human Pre-designed siRNA Set A contains three designed siRNAs for SMAD1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SMAD1 Human Pre-designed siRNA Set A SMAD1 Human Pre-designed siRNA Set A

HY-RS24664

Smad1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Smad1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Smad1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Smad1 Rat Pre-designed siRNA Set A Smad1 Rat Pre-designed siRNA Set A

HY-RS18190

Smad1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Smad1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Smad1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Smad1 Mouse Pre-designed siRNA Set A Smad1 Mouse Pre-designed siRNA Set A

HY-173149

CDD-2789	Anaplastic lymphoma kinase (ALK) TGF-beta/Smad TGF-β Receptor	Cancer
CDD-2789 is a highly selective small-molecule inhibitor targeting Activin receptor type 1 (ALK2, also known as *ACVR1). It blocks the SMAD1/5* signaling pathway mediated by *ALK2/ALK1, thereby effectively suppressing downstream phosphorylation events induced by BMP* and activin A. In the NanoBRET cellular model, CDD-2789 exhibits an inhibitory IC₅₀ of 0.54 µM against ALK2. CDD-2789 holds promise for research on ALK2-related diseases, including diffuse intrinsic pontine glioma (DIPG), ependymoma, endometrial cancer, melanoma, non–small cell lung cancer, colorectal cancer, and pancreatic cancer ^[1].

HY-P99353

Ascrinvacumab 2 Publications Verification Anti-ACVRL1 / ALK-1 Reference Antibody (ascrinvacumab); PF-03446962	Anaplastic lymphoma kinase (ALK)	Cancer
Ascrinvacumab (PF-03446962) is a human IgG2 monoclonal antibody targets *ALK-1. Ascrinvacumab shows binding efficiency with human ALK1 with a K_d* value of 7 nM. Ascrinvacumab can be used for the research of hepatocellular carcinoma (HCC) ^[1].

HY-123900

AZ12799734	TGF-β Receptor	Cardiovascular Disease
AZ12799734 is a selective, orally active *TGFBR1* kinase inhibitor with an IC₅₀ of 47 nM. AZ12799734 is also a pan BMP and TGFβ inhibitor ^[1].

HY-124697

BMP signaling agonist sb4 5 Publications Verification	TGF-β Receptor	Cancer
BMP signaling agonist sb4 is a potent benzoxazole bone morphogenetic protein 4 (BMP4) signaling agonist with a EC₅₀ value of 74 nM, activates BMP signaling by stabilizing intracellular p-SMAD-1/5/9. BMP signaling agonist sb4 activates BMP4 target genes (inhibitors of DNA binding,?Id1?and?Id3) canonical BMP signaling ^[1].

Cat. No.	Product Name	Target	Research Area

HY-P99359

Elezanumab ABT-555; AE12-1Y-QL; Anti-RGMA Reference Antibody (elezanumab)	TGF-beta/Smad	Metabolic Disease
Elezanumab (ABT-555; AE12-1Y-QL) is a human monoclonal antibody that selectively targets repulsive guidance molecule A (RGMa). Elezanumab potently inhibited RGMa mediated BMP signalling via the SMAD1/5/8 pathway, with an IC₅₀ around 97 pM. Elezanumab promotes neuroregeneration and neuroprotection in neuronal injury and demyelination models binds N-terminal RGMa, blocks BMP signaling and lacks RGMc cross-reactivity. elezanumab has neuroregenerative and neuroprotective activities without impact on iron metabolism ^[1] .

HY-P99353

Ascrinvacumab 2 Publications Verification Anti-ACVRL1 / ALK-1 Reference Antibody (ascrinvacumab); PF-03446962	Anaplastic lymphoma kinase (ALK)	Cancer
Ascrinvacumab (PF-03446962) is a human IgG2 monoclonal antibody targets *ALK-1. Ascrinvacumab shows binding efficiency with human ALK1 with a K_d* value of 7 nM. Ascrinvacumab can be used for the research of hepatocellular carcinoma (HCC) ^[1].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0946

(-)-Pinoresinol 4-O-glucoside (-)-Pinoresinol 4-O-β-D-glucopyranoside	Structural Classification Artemisia selengensis Turcz. ex Bess. Source classification Plants Compositae Saccharides Monosaccharides	Glycosidase
(-)-Pinoresinol 4-O-glucoside ((-)-Pinoresinol 4-O-β-D-glucopyranoside) is a potent and orally active α-glucosidase inhibitor with an IC₅₀ value of 48.13 µM. (-)-Pinoresinol 4-O-glucoside increases cell migration and early differentiation of pre-osteoblasts. (-)-Pinoresinol 4-O-glucoside increases protein level of BMP2, p-Smad1/5/8, RUNX2. (-)-Pinoresinol 4-O-glucoside attenuates oxidative stress, hyperglycemia and hepatic toxicity. (-)-Pinoresinol 4-O-glucoside has the potential for the research of osteoporosis and periodontal disease ^[1] .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80323

	Smad1 Antibody (YA077)	WB, ICC/IF, IHC-P	Human, Mouse
	Smad1 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 52 kDa, targeting to Smad1. It can be used for WB,ICC/IF,IHC-P assays with tag free, in the background of Human, Mouse.

HY-P80852

	*Phospho-Smad1* (Ser463/Ser465) Antibody (YA153)** Smad1; BSP1; MADH1; MADR1; Mothers against decapentaplegic homolog 1; MAD homolog 1; Mothers against DPP homolog 1; JV4-1; Mad-related protein 1; Smad family member 1; Smad 1; Smad1; hSmad1; Transforming growth factor-beta-signaling protein	WB, IP	Human, Rat
	Phospho-Smad1 (Ser463/Ser465) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 52 kDa, targeting to Phospho-Smad1 (Ser463/Ser465). It can be used for WB,IP assays with tag free, in the background of Human, Rat.

HY-P84600

	SMAD1 Antibody (YA4297) BSP1; JV41; BSP-1; JV4-1; MADH1; MADR1	WB, ELISA	Human, Mouse, Monkey

HY-P84601

	SMAD1 Antibody (YA4298) BSP1; JV41; BSP-1; JV4-1; MADH1; MADR1	WB, ELISA	Human, Mouse, Rat

HY-P83309

	GARS Antibody (YA3054) HMN5; CMT2D; DSMAV; GlyRS; Smad1	WB, IHC-P	Human, Mouse, Rat
	GARS Antibody (YA3054) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3054), targeting GARS, with a predicted molecular weight of 83 kDa (observed band size: 75 kDa). GARS Antibody (YA3054) can be used for WB, IHC-P experiment in human, mouse, rat background.

HY-P83771

	*Phospho-Smad1/5/9 (S463/S465/S467)Antibody(YA3567)* BSP-1 antibody; BSP1 antibody; HSmad1 antibody; JV4-1 antibody; JV41 antibody; MAD homolog 1 antibody; MAD mothers against decapentaplegic homolog 1 antibody; Mad related protein 1 antibody; Mad-related protein 1 antibody; MADH1 antibody; MADR1 antibody; Mothers against decapentaplegic homolog 1 antibody; Mothers against DPP homolog 1 antibody; SMA- AND MAD-RELATED PROTEIN 1 antibody; Smad 1 antibody	WB, IHC, ICC/IF	Human, Mouse, Rat

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Cat. No.	Product Name		Classification

HY-RS13392

SMAD1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
SMAD1 Human Pre-designed siRNA Set A contains three designed siRNAs for SMAD1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS24664

Smad1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Smad1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Smad1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS18190

Smad1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Smad1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Smad1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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