Smad1 Antibody (YA4297)

Smad1 Antibody (YA4297) is a mouse-derived and non-conjugated IgG1 antibody, targeting to SMAD1. It can be applicated for WB, ELISA assays, in the background of human, mouse, monkey.

SMAD1, a versatile transcriptional modulator, plays pivotal roles in various cellular processes, including embryonic development, cell differentiation, and tissue homeostasis. Upon binding of BMP ligands to their receptors, SMAD1 undergoes phosphorylation by activated type I BMP receptors, forming a heteromeric complex with SMAD4 that translocates into the nucleus, functioning as a transcription factor. This hetero-trimeric complex recognizes cis-regulatory elements containing Smad Binding Elements (SBEs), thus modulating the signaling network's outcome. Notably, the SMAD1/OAZ1/PSMB4 complex participates in the degradation of the CREBBP/EP300 repressor SNIP1 and positively regulates BMP4-induced expression of the odontogenic development regulator MSX1. Interactions with various partners such as SMAD4, YY1, HGS, NANOG, ZCCHC12, PEBP2-alpha subunit, CREB-binding protein (CBP), p300, SMURF1, SMURF2, USP15, HOXC8, ZNF423, ZNF521, SKOR1, LEMD3, PSMB4, OAZ1, FAM83G, ZC3H3, TMEM119, ZNF8, RANBP3L, EGR1, SMAD6, and YAP1 highlight the complex and dynamic nature of SMAD1's regulatory network, emphasizing its central role in cellular processes.

Q15797

Predicted band size: 52 kDa; Observed band size: 52 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Mouse

Human, Mouse, Monkey

WB: 1/500-1/2000; ELISA: 1/10000

WB, ELISA

Liquid

Supplied in PBS with 0.05% sodium azide

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG1

Purified recombinant fragment of human SMAD1 (AA: 1-110) expressed in E. Coli.