From 11:00 pm to 12:00 pm EST ( 8:00 pm to 9:00 pm PST ) on January 6th, the website will be under maintenance. We are sorry for the inconvenience. Please arrange your schedule properly.
SULT1A2 Human Pre-designed siRNA Set A contains three designed siRNAs for SULT1A2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
SULT2A1 Human Pre-designed siRNA Set A contains three designed siRNAs for SULT2A1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
SULT1A3 Human Pre-designed siRNA Set A contains three designed siRNAs for SULT1A3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Sult1a1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sult1a1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Sult4a1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sult4a1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Sult2a1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sult2a1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Sult2a1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sult2a1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
SULT1A1 Human Pre-designed siRNA Set A contains three designed siRNAs for SULT1A1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Sult4a1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sult4a1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Sult1a1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sult1a1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
SULT4A1 Human Pre-designed siRNA Set A contains three designed siRNAs for SULT4A1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
SULT1B1 Human Pre-designed siRNA Set A contains three designed siRNAs for SULT1B1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
SULT1E1 Human Pre-designed siRNA Set A contains three designed siRNAs for SULT1E1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Sult2b1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sult2b1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Sult1c2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sult1c2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Sult1c2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sult1c2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Sult1b1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sult1b1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
SULT1C4 Human Pre-designed siRNA Set A contains three designed siRNAs for SULT1C4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Sult1e1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sult1e1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
SULT1C2 Human Pre-designed siRNA Set A contains three designed siRNAs for SULT1C2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Sult2b1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sult2b1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Sult1b1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sult1b1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
SULT2B1 Human Pre-designed siRNA Set A contains three designed siRNAs for SULT2B1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Sult1e1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sult1e1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
12-Hydroxynevirapine (12-hydroxy-NVP; 12-OH-NVP) is a major oxidative metabolite of Nevirapine (HY-10570). Nevirapine is a non-nucleoside reverse transcriptase inhibitor indicated for the HIV-1 infections. Nevirapine causes idiosyncratic hepatotoxicity and mild-to-severe skin rashes. 12-Hydroxynevirapine, a non-reactive metabolite, can be bioactivated by sulphotransferases (SULTs) in the liver and skin, yielding the reactive species 12-Sulphoxy-nevirapine .
Dopamine 4-sulfate (DA-4S) is an inactive metabolite of the catecholamine dopamine. It is formed from dopamine by the sulfotransferase (SULT) isoform SULT1A3. Dopamine 4-O-sulfate is found at lower levels in the brain and circulation than dopamine 3-O-sulfate.
1-Methylpyrene is a ubiquitous environmental pollutant and rodent carcinogen. Its mutagenic activity depends on sequential activation by various CYP and sulfotransferase (SULT) enzymes. 1-Methylpyrene induces chromosome loss and mitotic disturbance, proba
4-Hydroxyphenylacetic acid (Standard) is the analytical standard of 4-Hydroxyphenylacetic acid. This product is intended for research and analytical applications. 4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of Nrf2 .
IC50 & Target:Nrf2
In Vivo: 4-Hydroxyphenylacetic acid (6, 12, or 25 mg/kg) increases Nrf2 translocation to the nucleus and enhances the activity of phase II and antioxidant enzymes. The protein levels of nuclear Nrf2 are increased by 170% and 230% in pre-treated 12 and 25 mg/kg 4-Hydroxyphenylacetic acid groups, respectively, compared with the control group.The 4-Hydroxyphenylacetic acid pretreatment at a final dose of 25 mg/kg markedly and selectively up-regulated the target genes of phase II enzymes and resulted in higher up-regulation than that of the control group by 270%, 400%, and 500% or UGT1A1, UGT1A9, and SULT2A1, respectively. 4-Hydroxyphenylacetic acid also suppresses the expression of CYP2E1 .
1-Methylpyrene is a ubiquitous environmental pollutant and rodent carcinogen. Its mutagenic activity depends on sequential activation by various CYP and sulfotransferase (SULT) enzymes. 1-Methylpyrene induces chromosome loss and mitotic disturbance, proba
4-Hydroxyphenylacetic acid (Standard) is the analytical standard of 4-Hydroxyphenylacetic acid. This product is intended for research and analytical applications. 4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of Nrf2 .
IC50 & Target:Nrf2
In Vivo: 4-Hydroxyphenylacetic acid (6, 12, or 25 mg/kg) increases Nrf2 translocation to the nucleus and enhances the activity of phase II and antioxidant enzymes. The protein levels of nuclear Nrf2 are increased by 170% and 230% in pre-treated 12 and 25 mg/kg 4-Hydroxyphenylacetic acid groups, respectively, compared with the control group.The 4-Hydroxyphenylacetic acid pretreatment at a final dose of 25 mg/kg markedly and selectively up-regulated the target genes of phase II enzymes and resulted in higher up-regulation than that of the control group by 270%, 400%, and 500% or UGT1A1, UGT1A9, and SULT2A1, respectively. 4-Hydroxyphenylacetic acid also suppresses the expression of CYP2E1 .
The SULT1C4 protein is an important member of the sulfotransferase 1 family and plays a crucial role in phase II drug metabolism and binding of endogenous compounds.Its research enhances the understanding of xenobiotic metabolism and has potential applications in pharmacology.SULT1C4 Protein, Human (His) is the recombinant human-derived SULT1C4 protein, expressed by E.coli , with N-6*His labeled tag.
The SULT1C2 protein utilizes PAPS to catalyze sulfate conjugation and has specific affinity for sulfonated p-nitrophenol. It selectively avoids sulfonated steroids, dopamine, acetaminophen or alpha-naphthol. SULT1C2 Protein, Human (His) is the recombinant human-derived SULT1C2 protein, expressed by E. coli , with N-6*His labeled tag.
Sulfotransferase 1B1 (SULT1B1) is a sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of dopamine, small phenols such as 1-naphthol and p-nitrophenol, thyroid hormones and many xenobiotic compounds.SULT1B1 may play a role in gut microbiota-host metabolic interaction.SULT1B1 Protein, Human (His) is the recombinant human-derived SULT1B1 protein, expressed by E.coli , with N-6*His labeled tag.
SULT4A1 Protein, an atypical sulfotransferase, shows low PAPS affinity and minimal catalytic activity toward substrates like L-triiodothyronine and estrone.Despite limited efficiency, SULT4A1 may impact drug and neurotransmitter metabolism in the central nervous system (CNS).SULT4A1 Protein, Human is the recombinant human-derived SULT4A1 protein, expressed by E.coli , with tag free.
The SULT2A1 protein utilizes PAPS for critical sulfonation of steroids and bile acids in the liver and adrenal glands. Its multifunctional activity extends to a variety of compounds, enhancing its water solubility to facilitate renal excretion. SULT2A1 Protein, Human (His) is the recombinant human-derived SULT2A1 protein, expressed by E. coli , with N-6*His labeled tag.
The SULT2B1 protein uses PAPS to catalyze sulfate conjugation, mainly sulfating cholesterol, and shows significant activity on steroids such as pregnenolone and DHEA.It plays a crucial role in epidermal cholesterol metabolism, regulating epidermal proliferation and differentiation.SULT2B1 Protein, Human (C-His) is the recombinant human-derived SULT2B1 protein, expressed by E.coli , with C-6*His labeled tag.
The SULT1E1 protein is a sulfotransferase that critically regulates estrogen homeostasis by sulfating estradiol and estrone, resulting in hormone inactivation. Its versatility extends to sulfated DHEA, pregnenolone, and xenobiotics such as ethinyl estradiol. SULT1E1 Protein, Human (His) is the recombinant human-derived SULT1E1 protein, expressed by E. coli , with N-His labeled tag.
The SULT1E1 protein is a sulfotransferase that critically regulates estrogen homeostasis by sulfating estradiol and estrone, resulting in hormone inactivation. Its versatility extends to sulfated DHEA, pregnenolone, and xenobiotics such as ethinyl estradiol. SULT1E1 Protein, Human (N-His) is the recombinant human-derived SULT1E1 protein, expressed by E. coli , with N-His labeled tag.
The SULT2B1 protein uses PAPS to catalyze sulfate conjugation, mainly sulfating cholesterol, and shows significant activity on steroids such as pregnenolone and DHEA. It plays a crucial role in epidermal cholesterol metabolism, regulating epidermal proliferation and differentiation. SULT2B1 Protein, Human (364a.a, His) is the recombinant human-derived SULT2B1 protein, expressed by E. coli , with N-His labeled tag.
Sulfotransferase 1A2 (SULT1A2) is a phenol sulfotransferase with thermostable enzyme activity. SULT1A2 utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. SULT1A2 is also responsible for the sulfonation and activation of minoxidil. SULT1A2 induces the mutagenicity and carcinogenicity of certain substrates by influencing DNA adduct formation. SULT1A2 Protein, Human (His) is the recombinant human-derived SULT1A2 protein, expressed by E. coli , with N-6*His labeled tag.
SULT1A3 protein, a sulfotransferase utilizing PAPS, catalyzes the sulfate conjugation of phenolic monoamines, including neurotransmitters (dopamine, norepinephrine, serotonin) and drugs. This activity contributes significantly to inactivation and elimination, emphasizing SULT1A3's crucial role in regulating neurotransmitter and drug levels, maintaining homeostasis, and ensuring proper biological system functioning. SULT1A3 Protein, Human (His) is the recombinant human-derived SULT1A3 protein, expressed by E. coli , with N-6*His labeled tag.
SULT1A3 protein, a sulfotransferase utilizing PAPS, catalyzes the sulfate conjugation of phenolic monoamines, including neurotransmitters (dopamine, norepinephrine, serotonin) and drugs. This activity contributes significantly to inactivation and elimination, emphasizing SULT1A3's crucial role in regulating neurotransmitter and drug levels, maintaining homeostasis, and ensuring proper biological system functioning. SULT1A3 Protein, Human (N-His) is the recombinant human-derived SULT1A3, expressed by E. coli , with N-6*His labeled tag. ,
SULT1A2 Human Pre-designed siRNA Set A contains three designed siRNAs for SULT1A2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
SULT2A1 Human Pre-designed siRNA Set A contains three designed siRNAs for SULT2A1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
SULT1A3 Human Pre-designed siRNA Set A contains three designed siRNAs for SULT1A3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Sult1a1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sult1a1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Sult4a1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sult4a1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Sult2a1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sult2a1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Sult2a1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sult2a1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
SULT1A1 Human Pre-designed siRNA Set A contains three designed siRNAs for SULT1A1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Sult4a1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sult4a1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Sult1a1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sult1a1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
SULT4A1 Human Pre-designed siRNA Set A contains three designed siRNAs for SULT4A1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
SULT1B1 Human Pre-designed siRNA Set A contains three designed siRNAs for SULT1B1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
SULT1E1 Human Pre-designed siRNA Set A contains three designed siRNAs for SULT1E1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Sult2b1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sult2b1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Sult1c2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sult1c2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Sult1c2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sult1c2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Sult1b1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sult1b1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
SULT1C4 Human Pre-designed siRNA Set A contains three designed siRNAs for SULT1C4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Sult1e1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sult1e1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
SULT1C2 Human Pre-designed siRNA Set A contains three designed siRNAs for SULT1C2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Sult2b1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sult2b1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Sult1b1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sult1b1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
SULT2B1 Human Pre-designed siRNA Set A contains three designed siRNAs for SULT2B1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Sult1e1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sult1e1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Inquiry Online
Your information is safe with us. * Required Fields.
