Search Result
Results for "
SPPS
" in MedChemExpress (MCE) Product Catalog:
7
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
-
- HY-16246
-
|
Fungal
|
Infection
|
Haloprogin is a potent antifungal agent. Haloprogin has activity against dermatophytes, Candida spp and a limited number of Gram-positive bacteria .
|
-
-
- HY-105282
-
MM 45289; A 82846A
|
Antibiotic
Bacterial
|
Infection
|
Eremomycin (MM 45289) is a potent glycopeptide antibiotic closely related to Vancomycin (HY-B0671). Eremomycin shows antibacterial activity in Staphylococcus spp. and Bacillus subtilis ATCC6633, with the MIC values of 0.03-1.6 μg/mL .
|
-
-
- HY-Y1636
-
-
-
- HY-163548
-
|
Sialyltransferase
|
Cancer
|
SPP-002 is a sulfate analogue that acts as a potential Sialyltransferase (ST) inhibitor. SPP-002 selectively inhibits n-glycosialylation with inhibition at least an order of magnitude greater than that of unmodified parental cholic acid (LCA). SPP-002 reduces tumor cell migration and invasion by inhibiting the integrin /FAK/Paxillin signaling pathway. SPP-002 can be used in the study of tumor metastasis .
|
-
-
- HY-116479
-
|
Bacterial
|
Others
|
Citromycetin is an aromatic polyketide compound from Australian marine-derived and terrestrial Penicillium spp .
|
-
-
- HY-164207
-
|
Biochemical Assay Reagents
|
Infection
|
VLPA-GlcNAc is a chromogenic glucosaminide substrate. VLPA-GlcNAc can be used to prepare agar media for the identification of Candida spp .
|
-
-
- HY-N12178
-
A 83094A; Omomycin
|
Antibiotic
Bacterial
Parasite
|
Infection
|
16-Deethylindanomycin (A 83094A) is an antibiotic, which can be produced by Streptomyces setonii. 16-Deethylindanomycin exhibits antimicrobial activities against gram-positive bacteria Staphylococcus spp. and Streptococcus with MIC of 2-4 µg/mL. 16-Deethylindanomycin exhibits anticoccidial activity against Eimeria tenella .
|
-
-
- HY-151671
-
|
ADC Linker
|
Others
|
Fmoc-L-MeLys(N3)-OH is a click chemistry reagent containing an azide. Fmoc-L-MeLys(N3)-OH is a SPPS building-block for the introduction of N-Me-Lys that can be modified at the N3-group using Click-chemistry . Fmoc-L-MeLys(N3)-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
-
- HY-172888
-
|
Endogenous Metabolite
FAK
|
Cancer
|
SPP-037 is an orally active and selective inhibitor of ST6GAL1 (IC50: 3.59 μM). SPP-037 exhibits anti-MDA-MB-231 cell migration activity by inhibiting integrin α2,6-sialylation and integrin-FAK-paxillin pathway. SPP-037 has anti-tumor activity in MDA-MB-231 xenograft mouse model. SPP-037 can be used in breast cancer research .
|
-
-
- HY-120729
-
Curamil
|
Fungal
|
Infection
|
Pyrazophos (Curamil) is a slightly systemic fungicide against the powdery mildew on crops and cereals. Pyrazophos is widely used in Greece to control diseases caused by Erysiphe spp., Sphaerotheca spp., Leveillula spp. and Oidium spp. .
|
-
-
- HY-125388
-
|
Antibiotic
Bacterial
|
Infection
|
Martinomycin is an antibiotic, which inhibits Staphylococcus spp., Streptococcus spp. and Enterococcus spp., with MICs ranging from 0.06 to 0.5 μg/mL .
|
-
-
- HY-W020785
-
|
Cholinesterase (ChE)
|
Others
|
Fosthiazate is a broad-spectrum nematicide against various plant parasitic nematodes, including Meloidogyne spp., Globodera spp., and Pratylenchus spp., through inhibiting the synthesis of acetylcholinesterase .
|
-
-
- HY-151786
-
|
ADC Linker
|
Others
|
Fmoc-L-Lys(Pentynoyl-DIM)-OH is a click chemistry reagent containing an azide. Fmoc-L-Lys(Pentynoyl-DIM)-OH can be used as a SPPS building block for the “helping hand” strategy for purification of highly insoluble peptides. Solubilizing residues are attached to the Lys side-chains using Click-chemistry. The solubilizing tag can be removed with 1M hydrazine or hydroxylamine solution . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
|
-
-
- HY-108009
-
Biafungin; CD101; SP-3025
|
Fungal
|
Infection
|
Rezafungin (Biafungin) is a next-generation, broad-spectrum, and long-lasting echinocandin. Rezafungin shows potent antifungal activity against Candida spp., Aspergillus spp., and Pneumocystis spp. .
|
-
-
- HY-108009A
-
Biafungin acetate; CD101 acetate; SP-3025 acetate
|
Fungal
|
Infection
|
Rezafungin acetate (Biafungin acetate) is a next-generation, broad-spectrum, and long-lasting echinocandin. Rezafungin acetate shows potent antifungal activity against Candida spp., Aspergillus spp., and Pneumocystis spp. .
|
-
-
- HY-120729R
-
|
Fungal
|
Infection
|
Pyrazophos (Standard) is the analytical standard of Pyrazophos. This product is intended for research and analytical applications. Pyrazophos (Curamil) is a slightly systemic fungicide against the powdery mildew on crops and cereals. Pyrazophos is widely used in Greece to control diseases caused by Erysiphe spp., Sphaerotheca spp., Leveillula spp. and Oidium spp. .
|
-
-
- HY-129367
-
|
ADC Linker
|
Cancer
|
NO2-SPP is a cleavable linker that is used for making antibody-drug conjugate (ADC).
|
-
-
- HY-110193
-
SPP-86
2 Publications Verification
|
RET
|
Cancer
|
SPP-86 is a potent and selective cell permeable inhibitor of RET tyrosine kinase, with an IC50 of 8 nM. SPP-86 inhibits RET-induced phosphatidylinositide 3-kinases (PI3K)/Akt and MAPK signaling, also inhibits RET-induced estrogen receptorα (ERα) phosphorylation in MCF7 cells . SPP-86 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
-
- HY-15195
-
-
-
- HY-W286805
-
Phenalenone
|
Fungal
|
Infection
|
Perinaphthenone has antifungal activity, with IC50s of 36.2 μM (at day 3), 13.3 μM (at day 3), and 39.0 μM (at 60 h) for Botrytis spp., Fusarium spp. and Botryodiplodia spp., respectively .
|
-
-
- HY-W020785R
-
|
Cholinesterase (ChE)
|
Others
|
Fosthiazate (Standard) is the analytical standard of Fosthiazate. This product is intended for research and analytical applications. Fosthiazate is a broad-spectrum nematicide against various plant parasitic nematodes, including Meloidogyne spp., Globodera spp., and Pratylenchus spp., through inhibiting the synthesis of acetylcholinesterase .
|
-
-
- HY-111360
-
SPL-707
1 Publications Verification
|
γ-secretase
|
Inflammation/Immunology
|
SPL-707 is an orally active, selective signal peptide peptidase-like 2a (SPPL2a) inhibitor with an IC50 of 77 nM for hSPPL2a. SPL-707 inhibits γ-secretase (IC50=6.1 μM) and SPP (IC50=3.7 μM). SPL-707 has the potential for autoimmune diseases research by targeting B cells and dendritic cells .
|
-
-
- HY-RS16219
-
|
Small Interfering RNA (siRNA)
|
Others
|
SPP1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for SPP1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
SPP1 Mouse Pre-designed siRNA Set A
SPP1 Mouse Pre-designed siRNA Set A
-
- HY-RS25876
-
|
Small Interfering RNA (siRNA)
|
Others
|
Spp2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Spp2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
Spp2 Rat Pre-designed siRNA Set A
Spp2 Rat Pre-designed siRNA Set A
-
- HY-RS13703
-
|
Small Interfering RNA (siRNA)
|
Others
|
SPP2 Human Pre-designed siRNA Set A contains three designed siRNAs for SPP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
SPP2 Human Pre-designed siRNA Set A
SPP2 Human Pre-designed siRNA Set A
-
- HY-RS13702
-
|
Small Interfering RNA (siRNA)
|
Others
|
SPP1 Human Pre-designed siRNA Set A contains three designed siRNAs for SPP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
SPP1 Human Pre-designed siRNA Set A
SPP1 Human Pre-designed siRNA Set A
-
- HY-126491
-
|
Drug-Linker Conjugates for ADC
|
Cancer
|
SPP-DM1 is a agent-linker conjugate for ADC with potent antitumor activity by using DM1 (a potent microtubule-disrupting agent), linked via the ADC linker SPP .
|
-
-
- HY-RS22980
-
|
Small Interfering RNA (siRNA)
|
Others
|
Spp1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Spp1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
Spp1 Rat Pre-designed siRNA Set A
Spp1 Rat Pre-designed siRNA Set A
-
- HY-RS19384
-
|
Small Interfering RNA (siRNA)
|
Others
|
Spp2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Spp2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
Spp2 Mouse Pre-designed siRNA Set A
Spp2 Mouse Pre-designed siRNA Set A
-
- HY-P990116
-
|
Integrin
|
Others
|
Anti-Mouse osteopontin/SPP1 Antibody (103D6) is a mouse-derived IgG2c, κ type antibody inhibitor, targeting to mouse osteopontin/SPP1.
|
-
-
- HY-P2148
-
|
Bacterial
Antibiotic
|
Infection
Inflammation/Immunology
|
P-113 is an antimicrobial peptide (AMP) derived from the human salivary protein histatin 5. P-113 is active against clinically important microorganisms such as Pseudomonas spp., Staphylococcus spp., and C. albicans .
|
-
-
- HY-151679
-
|
ADC Linker
|
Others
|
Fmoc-L-Lys(4-N3-Z)-OH is a click chemistry reagent containing an azide group. Fmoc-L-Lys(4-N3-Z)-OH acts as Lysine building-block for SPPS containing an Azide moiety as a bioorthogonal ligation handle, an infrared probe and a photo-affinity reagent. It can be decaged by trans-cyclooctenols via a strain-promoted 1,3-dipolar cycloaddition . Fmoc-L-Lys(4-N3-Z)-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
-
- HY-129377
-
|
ADC Linker
|
Cancer
|
Sulfo-SPP is a heterobifunctional, thiol-cleavable and membrane impermeable crosslinker.
|
-
-
- HY-129377A
-
|
ADC Linker
|
Cancer
|
Sulfo-SPP sodium a heterobifunctional, thiol-cleavable and membrane impermeable crosslinker.
|
-
-
- HY-N11995
-
|
Others
|
Others
|
allo-Aloeresin D is a chromone glycoside isolated from Aloe spp. .
|
-
-
- HY-N15183
-
|
Fungal
|
Infection
|
Aselacin C is a cyclic peptide that can be isolated from the fungus Acremonium spp. .
|
-
-
- HY-N9142
-
Ergosterol 3-O-β-D-glucopyranoside
|
Others
|
Others
|
Ergosterol glucoside is a phenolic compound that can be isolated from Tuber spp. truffles .
|
-
-
- HY-W250315
-
pectate sodium
|
Glycosidase
Bacterial
Endogenous Metabolite
|
Others
|
Polypectate sodium is a major component of cell wall polysaccharides (pectins) and is used as a carbon source and inducer of polygalacturonase. Polypectate sodium can also be used to evaluate alkaline active and alkaline stable pectate lyases from Streptomyces spp. and to study the optimization of polygalacturonase production from Xanthophyllum spp. and reaction conditions .
|
-
-
- HY-130111
-
|
ADC Linker
|
Cancer
|
DMAC-SPP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .
|
-
-
- HY-N1136
-
|
Bacterial
|
Infection
|
(+)-Totarol is a diterpenoid compound isolated from Podocarpus spp.. (+)-Totarol is a potent antioxidant and antibacterial agent .
|
-
-
- HY-N2340
-
(+)-Melezitose; D-Melezitose
|
Bacterial
|
Infection
|
D-(+)-Melezitose can be used to identify clinical isolates of indole-positive and indole-negative Klebsiella spp.
|
-
-
- HY-130110
-
|
ADC Linker
|
Cancer
|
Sulfo-DMAC-SPP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .
|
-
-
- HY-N2728
-
|
Others
|
Others
|
6-O-Syringoylajugol (compound 65) is a natural product that can be found in Verbacum spp .
|
-
-
- HY-N2340A
-
(+)-Melezitose hydrate; D-Melezitose hydrate
|
Bacterial
|
Infection
|
D-(+)-Melezitose hydrate ((+)-Melezitose hydrate) can be used to identify clinical isolates of indole-positive and indole-negative Klebsiella spp .
|
-
-
- HY-129378
-
|
ADC Linker
|
Cancer
|
NO2-SPP-sulfo-Me is a cleavable linker that is used for making antibody-drug conjugate (ADC) .
|
-
-
- HY-N15015
-
|
Phosphatase
|
Metabolic Disease
|
Dephostatin is a competitive protein tyrosine phosphatase (PTP) inhibitor that can be isolated from Streptomyces spp., with activity in the micromolar range .
|
-
-
- HY-133547
-
|
ADC Linker
|
Cancer
|
NO2-SPP-sulfo is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .
|
-
-
- HY-129034
-
|
Bacterial
Antibiotic
|
Infection
|
Ramoplanin is a broad-spectrum lipoglycodepsipeptide antibiotic derived from the Actinoplanes spp with with activity against gram-positive bacteria .
|
-
-
- HY-P0068
-
HMR 3270; IP960; NXL201
|
Fungal
|
Infection
|
Aminocandin (HMR 3270) is water-soluble antifungal agent of the echinocandin class with excellent activity against Aspergillus and Candida spp. .
|
-
-
- HY-N12414
-
|
Bacterial
|
Cancer
|
Apicularen A is a macrolide isolated from the mucoid bacterium Chondrosporium spp. Apicularen A is also a highly selective inhibitor of vesicular ATPase .
|
-
- HY-12613
-
NSC 45109
|
Drug Derivative
Fungal
|
Others
|
2-C-methylene-myo-inositol oxide (NSC 45109), an inositol derivative, induces pseudohyphae formation in Saccharomyces spp .
|
-
- HY-126409
-
|
Others
|
Others
|
Petunidin-3-O-arabinoside chloride is an anthocyanin with antioxidant activity that can be isolated from blueberry (Vaccinium Spp.) puree .
|
-
- HY-N6695
-
Aflatoxin R0
|
Drug Metabolite
|
Cancer
|
Aflatoxin (Aflatoxin R0) is a metabolite of aflatoxin B1 produced from Rhizopus spp , and is mutagenic and carcinogenic mycotoxin .
|
-
- HY-136384
-
|
Fungal
|
Infection
|
Diethofencarb is a fungicide with strong activity against Botrytis cinerea and Benzimidazole-resistant strains of Botryis spp. Diethofencarb has a role as an antifungal agrochemical .
|
-
- HY-N1117
-
|
Others
|
Others
|
Tristin is a bibenzyl derivatives. Tristin is a nature product isolated from Dendrobii Herba (stems of Dendrobium spp.). Tristin has antioxidative activity .
|
-
- HY-N1923
-
|
Others
|
Cardiovascular Disease
|
Hypaconine is a C19-diterpenoid alkaloid isolated from Aconitum and Delphinium spp. Hypaconine exhibits strong cardiac activity .
|
-
- HY-125306
-
|
Others
|
Others
|
Rotihibin A is a novel plant growth regulator isolated from Streptomyces spp., which has the activity of inhibiting the growth of various plants without lethal activity.
|
-
- HY-126157
-
|
Apoptosis
|
Inflammation/Immunology
|
Linearol, a diterpene extracted from Sideritis L. spp. (Lamiaceae), exhibits a diverse array of properties, including potent antioxidant, anti-inflammatory, and anti-apoptotic effects.
|
-
- HY-128926
-
N-succinimidyl 4-(2-pyridyldithio) pentanoate
|
ADC Linker
|
Cancer
|
SPP (N-succinimidyl 4-(2-pyridyldithio) pentanoate) is a cleavable disulfide linker, can be used to form cytotoxic compound- linker conjugate .
|
-
- HY-126987
-
|
Acetolactate Synthase (ALS)
|
Others
|
Mesosulfuron-methyl is a sulfonylurea herbicide that inhibits acetolactate synthase (ALS) and is used in research for post-emergence control of ryegrass and Avena spp. (wild oat) in wheat fields .
|
-
- HY-W099729
-
|
Bacterial
|
Inflammation/Immunology
|
Ethylhexylglycerin has antimicrobial activity, inhibiting the growth of Acinetobacter spp., Pseudomonas aeruginosa complex, and Stenotrophomonas maltophilia. Ethylhexylglycerin can cause pigmentary contact dermatitis .
|
-
- HY-N7709
-
|
Others
|
Cardiovascular Disease
|
Cinchonain IIb is a proanthocyanidin. Cinchonain IIb has the effect of rational utilization of decreased cardiac function. Cinchonain IIb is isolated from natural hawthorn (Crataegus spp. ) .
|
-
- HY-W009168
-
|
Bacterial
Antibiotic
|
Infection
Cancer
|
Tazobactam sodium is an antibiotic of the beta-lactamase inhibitor class. Ceftolozane combines with Tazobactam, extends the activity of ceftolozane against many ESBL-producing Enterobacteriaceae and some Bacteroides spp..
|
-
- HY-B2060
-
Thiamutilin
|
Bacterial
Antibiotic
|
Infection
|
Tiamulin (Thiamutilin) is a diterpenic antibiotic that is widely used in pigs and poultry for the control of infectious diseases. Tiamulin is effectively used in the study of airsacculitis, which is primarily caused by Mycoplasma spp .
|
-
- HY-B2060A
-
Thiamutilin fumarate
|
Bacterial
Antibiotic
|
Infection
Cancer
|
Tiamulin (Thiamutilin) fumarate is a diterpenic antibiotic that is widely used in pigs and poultry for the control of infectious diseases. Tiamulin fumarate is effectively used in the study of airsacculitis, which is primarily caused by Mycoplasma spp .
|
-
- HY-139746
-
|
Beta-lactamase
Bacterial
|
Infection
|
FPI-1602 is a β-lactamase inhibitor. FPI-1602 displays marked antimicrobial activity against P. aeruginosa, E. coli, and Enterobacter spp. .
|
-
- HY-16911
-
API-1252; Debio 1452
|
Bacterial
Antibiotic
|
Infection
|
AFN-1252 is an orally active and selective inhibitor of FabI, an essential enzyme in fatty acid biosynthesis in Staphylococcus spp. AFN-1252 exhibits exquisite and highly selective activity against Staphylococcus spp. AFN-1252 exhibits typical MIC90 values of ⩽0.015 μg/ml against diverse clinical isolates of S. aureus. AFN-1252 is efficacious in a mouse model of septicemia providing 100% protection from an otherwise lethal peritoneal infection of S. aureus Smith .
|
-
- HY-W013781
-
|
Biochemical Assay Reagents
|
Others
|
Boc-Glu(OBzl)-OH (Compound 9) is a glutamic acid derivative commonly used in Boc SPPS. Glutamic acid residues increase the hydrophilicity of the polypeptide and play an important structural and receptor binding role .
|
-
- HY-139698
-
LCB10-0200
|
Antibiotic
Bacterial
|
Infection
|
GT-1 (LCB10-0200), a siderophore-linked cephalosporin, is effective against clinical isolates of P. aeruginosa, Klebsiella oxytoca, Proteus spp., Serratia marcescens, and Enterobacter aerogenes.
|
-
- HY-N12882
-
|
Others
|
Others
|
(Z)-10-Hexadecen-1-ol is a insect sex pheromones, which can be secreted by some female nocturnal moths, or by the heads of male bumblebees (Bombus spp.) .
|
-
- HY-136425
-
Fosetyl-Al
|
Fungal
|
Infection
|
Fosetyl-aluminum (Fosetyl-Al) is an active ingredient in many fungicides against downy mildew. Fosetyl-aluminum is used to control many diseases caused by Phytophthora spp. on agricultural and horticultural crops .
|
-
- HY-114622
-
API-1252 tosylate; Debio 1452 tosylate
|
Bacterial
Antibiotic
|
Infection
|
AFN-1252 (API-1252) tosylate is an orally active and selective inhibitor of FabI, an essential enzyme in fatty acid biosynthesis in Staphylococcus spp. AFN-1252 tosylate exhibits exquisite and highly selective activity against Staphylococcus spp. AFN-1252 tosylate exhibits typical MIC90 values of 0.015 μg/ml against diverse clinical isolates of S. aureus. AFN-1252 tosylate is efficacious in a mouse model of septicemia providing 100% protection from an otherwise lethal peritoneal infection of S. aureus Smith .
|
-
- HY-B0643
-
LY237216
|
Bacterial
Antibiotic
|
Infection
|
Dirithromycin (LY237216), a derivative of Erythromycin, is a potent and orally active semi-synthetic macrolide antibiotic. Dirithromycin is active against gram-positive bacteria, Legionella spp., Helicobacter pylori, and Chlamydia trachomatis .
|
-
- HY-104029
-
F901318
|
Fungal
Dihydroorotate Dehydrogenase
|
Infection
|
Olorofim (F901318) selectively inhibits fungal dihydroorotate dehydrogenase (DHODH), a key enzyme in the pyrimidine biosynthesis pathway. Olorofim (F901318). Olorofim exhibits excellent activity against A. fumigatus and other Aspergillus spp. .
|
-
- HY-B0293A
-
|
Fungal
|
Infection
|
Butoconazole, an imidazole antifungal agent, is active against Candida spp. and effective against vaginal infections due to Candida albicans. Butoconazole is presumed to function as other imidazole derivatives via inhibition of steroid synthesis .
|
-
- HY-N6740
-
|
Apoptosis
|
Metabolic Disease
|
Beta-Zearalenol is an mycotoxin produced by Fusarium spp, which causes apoptosis and oxidative stress in mammalian reproductive cells . Beta-Zearalenol is the derivative of zearalenone (ZEA) which can conjugate with glucuronic acid .
|
-
- HY-12176A
-
CGP 60536 hydrochloride; CGP60536B hydrochloride; SPP 100 hydrochloride
|
Renin
Autophagy
|
Cardiovascular Disease
Cancer
|
Aliskiren (CGP 60536; CGP60536B; SPP 100) hydrochloride is an orally active and selective renin inhibitor, with IC50 of 1.5 nM. Aliskiren hydrochloride can be used for the research of hypertension, cardiovascular diseases and cancer cachexia - .
|
-
- HY-B1036
-
|
Parasite
|
Infection
|
Decoquinate is an orally active, selective inhibitor of the mitochondrial bc1 complex, targeting Eimeria spp. sporozoites and first generation schizonts, and Plasmodium spp. Decoquinate inhibits electron transfer by competitively binding to the mitochondrial cytochrome b system, blocking the parasite's energy metabolism, thereby inhibiting its development and reproduction. Decoquinate has significant anticoccidial activity, preventing intestinal damage and improving host growth performance, and also has inhibitory effects on the liver and blood stages of Plasmodium. Decoquinate is mainly used in veterinary research to prevent and treat coccidiosis in ruminants and poultry .
|
-
- HY-12136
-
-
- HY-136384R
-
|
Fungal
|
Infection
|
Diethofencarb (Standard) is the analytical standard of Diethofencarb. This product is intended for research and analytical applications. Diethofencarb is a fungicide with strong activity against Botrytis cinerea and Benzimidazole-resistant strains of Botryis spp. Diethofencarb has a role as an antifungal agrochemical .
|
-
- HY-N4108
-
|
P-glycoprotein
|
Inflammation/Immunology
Cancer
|
Hypophyllanthin is a major lignan in Phyllanthus spp, with strong anti-inflammatory activity. Hypophyllanthin directly inhibits P-glycoprotein (P-gp) activity and did not interfere with multidrug resistance protein 2 (MRP2) activity .
|
-
- HY-105048
-
|
Bacterial
Antibiotic
|
Infection
|
Omiganan is a cationic antimicrobial peptide. Omiganan as an analogue of indolicidin shows activity against gram-positive and gram-negative bacteria but also Candida spp. isolates. Omiganan can be used for the research of alcohol nose and acne .
|
-
- HY-12177
-
CGP 60536 hemifumarate; CGP60536B hemifumarate; SPP 100 hemifumarate
|
Renin
Autophagy
|
Cardiovascular Disease
Cancer
|
Aliskiren (CGP 60536; CGP60536B; SPP 100) hemifumarate is an orally active and selective renin inhibitor, with IC50 of 1.5 nM. Aliskiren hemifumarate can be used for the research of hypertension, cardiovascular diseases and cancer cachexia .
|
-
- HY-N6688
-
|
Potassium Channel
Bacterial
Antibiotic
|
Infection
|
Verruculogen is a toxin produced mainly by Penicillium and Aspergillus spp. and causes severe tremors in affected animals. Verruculogen inhibits Ca 2+-activated K + channels. Verruculogen is an M phase inhibitor of the mammalian cell cycle .
|
-
- HY-103249
-
Reutericycline
|
Bacterial
Antibiotic
|
Infection
|
Reutericyclin (Reutericycline), a unique tetramic acid, is an antibiotic produced by some strains of Lactobacillus reuteri. Reutericyclin (Reutericycline) exhibits a broad inhibitory spectrum including Lactobacillus spp., Bacillus subtilis, B. cereus, Enterococcus faecalis, Staphylococcus aureus, and Listeria innocua .
|
-
- HY-B0293
-
RS 35887
|
Fungal
|
Infection
|
Butoconazole nitrate (RS 35887), an imidazole antifungal agent, is active against Candida spp. and effective against vaginal infections due to Candida albicans. Butoconazole nitrate is presumed to function as other imidazole derivatives via inhibition of steroid synthesis .
|
-
- HY-B2060S1
-
|
Isotope-Labeled Compounds
Bacterial
Antibiotic
|
Infection
|
Tiamulin-d10-1 (hydrochloride) is deuterium labeled Tiamulin. Tiamulin (Thiamutilin) is a diterpenic antibiotic that is widely used in pigs and poultry for the control of infectious diseases. Tiamulin is effectively used in the study of airsacculitis, which is primarily caused by Mycoplasma spp .
|
-
- HY-19688B
-
WR 6026 tosylate
|
Parasite
Mitochondrial Metabolism
|
Infection
|
Sitamaquine (WR6026) tosylate, an orally active 8-aminoquinoline analog, is an antileishmanial agent. Sitamaquine tosylate inhibits mitochondrial complex II (succinate dehydrogenase). Sitamaquine tosylate is a lipophilic weak base that rapidly accumulates in acidic compartments of Leishmania spp., mainly in acidocalcisomes .
|
-
- HY-B2060AR
-
|
Bacterial
Antibiotic
|
Infection
Cancer
|
Tiamulin (fumarate) (Standard) is the analytical standard of Tiamulin (fumarate). This product is intended for research and analytical applications. Tiamulin (Thiamutilin) fumarate is a diterpenic antibiotic that is widely used in pigs and poultry for the control of infectious diseases. Tiamulin fumarate is effectively used in the study of airsacculitis, which is primarily caused by Mycoplasma spp .
|
-
- HY-B2060R
-
|
Bacterial
Antibiotic
|
Infection
|
Tiamulin (Standard) is the analytical standard of Tiamulin. This product is intended for research and analytical applications. Tiamulin (Thiamutilin) is a diterpenic antibiotic that is widely used in pigs and poultry for the control of infectious diseases. Tiamulin is effectively used in the study of airsacculitis, which is primarily caused by Mycoplasma spp .
|
-
- HY-125152
-
CndD
|
Antibiotic
Fungal
|
Infection
|
Candicidin D (CndD) is an antibiotic, which exhibits antifungal activity through interaction with steroids in cell membranes. Candicidin D inhibits S. cerevisiae, Candida albicans and other Candida spp. with MIC of 0.25-1 μg/mL in RPMI-1640 medium.
|
-
- HY-19688A
-
WR 6026 hydrochloride
|
Parasite
Mitochondrial Metabolism
|
Infection
|
Sitamaquine (WR6026) hydrochloride, an orally active 8-aminoquinoline analog, is an antileishmanial agent. Sitamaquine hydrochloride inhibits mitochondrial complex II (succinate dehydrogenase). Sitamaquine hydrochloride is a lipophilic weak base that rapidly accumulates in acidic compartments of Leishmania spp., mainly in acidocalcisomes .
|
-
- HY-N7071
-
Maduramycin
|
Antibiotic
Apoptosis
|
Infection
|
Maduramicin (Maduramycin) is isolated from the actinomycete Actinomadura rubra. Maduramicin is an anticoccidial agent for the the treatment of Eimeria spp., E. adenoeides, E. gallopavonis, and E. dispersa infection . Maduramicin induces cell apoptosis in chicken myocardial cells via intrinsic and extrinsic pathways .
|
-
- HY-126987R
-
|
Acetolactate Synthase (ALS)
|
Others
|
Mesosulfuron-methyl (Standard) is the analytical standard of Mesosulfuron-methyl. This product is intended for research and analytical applications. Mesosulfuron-methyl is a sulfonylurea herbicide that inhibits acetolactate synthase (ALS) and is used in research for post-emergence control of ryegrass and Avena spp. (wild oat) in wheat fields .
|
-
- HY-N7101
-
U-76,252; CS-807
|
Bacterial
Antibiotic
Penicillin-binding protein (PBP)
|
Infection
|
Cefpodoxime Proxetil is an orally active broad spectrum third-generation cephalosporin with potent antibacterial activity against both Gram-positive and Gram-negative bacteria including staphylococci, streptococci, Haemophilus influenzae, Neisseria gonorrhoeae, Escherichia coli, Klebsiella pnuemoniae, Citrobacter spp., and Proteus spp. Cefpodoxime Proxetil binds to penicillin binding proteins (PBPs), which inhibits peptidoglycan synthesis, finally results in interfering bacterial cell wall biosynthesis. Cefpodoxime Proxetil can be used against skin structure infections, acute otitis media, pharyngitis, tonsillitis, upper respiratory tract infection, urinary tract infections and sexually transmitted diseases .
|
-
- HY-W012349
-
|
NF-κB
Fungal
Apoptosis
Autophagy
|
Infection
Cancer
|
2′-Hydroxychalcone is a hydroxyl derivative of chalcones with anticancer activities. 2'-Hydroxychalcone inhibits NF-κB pathway and induces autophagy and apoptosis in breast cancer cells . 2′-Hydroxychalcone shows a better antifungal activity against the complex Paracoccidioides spp .
|
-
- HY-N9075
-
|
Glycosidase
|
Cancer
|
9-(4′-Hydroxyphenyl)-2-methoxyphenalen-1-one is a phytoalexin and mixed competitive α-glucosidase inhibitor of Bacillus stearothermophilus (IC50: 3.86 mg/L) .
|
-
- HY-19882
-
|
Bacterial
|
Infection
|
BAL-30072, a siderophore sulfactam, is a monocyclic beta-lactam antibiotic, with activity against multiresistant gram-negative bacilli. BAL30072 shows MIC90 values of 4 μg/mL for MDR Acinetobacter spp. and 8 μg/mL for MDR P. aeruginosa, respectively .
|
-
- HY-B0643R
-
|
Bacterial
Antibiotic
|
Infection
|
Dirithromycin (Standard) is the analytical standard of Dirithromycin. This product is intended for research and analytical applications. Dirithromycin (LY237216), a derivative of Erythromycin, is a potent and orally active semi-synthetic macrolide antibiotic. Dirithromycin is active against gram-positive bacteria, Legionella spp., Helicobacter pylori, and Chlamydia trachomatis .
|
-
- HY-136425R
-
|
Fungal
|
Infection
|
Fosetyl-aluminum (Standard) is the analytical standard of Fosetyl-aluminum. This product is intended for research and analytical applications. Fosetyl-aluminum (Fosetyl-Al) is an active ingredient in many fungicides against downy mildew. Fosetyl-aluminum is used to control many diseases caused by Phytophthora spp. on agricultural and horticultural crops .
|
-
- HY-N7101R
-
U-76,252 (Standard); CS-807 (Standard)
|
Reference Standards
Bacterial
Antibiotic
Penicillin-binding protein (PBP)
|
Infection
|
Cefpodoxime Proxetil (Standard) is the analytical standard of Cefpodoxime Proxetil. This product is intended for research and analytical applications. Cefpodoxime Proxetil is an orally active broad spectrum third-generation cephalosporin with potent antibacterial activity against both Gram-positive and Gram-negative bacteria including staphylococci, streptococci, Haemophilus influenzae, Neisseria gonorrhoeae, Escherichia coli, Klebsiella pnuemoniae, Citrobacter spp., and Proteus spp. Cefpodoxime Proxetil binds to penicillin binding proteins (PBPs), which inhibits peptidoglycan synthesis, finally results in interfering bacterial cell wall biosynthesis. Cefpodoxime Proxetil can be used against skin structure infections, acute otitis media, pharyngitis, tonsillitis, upper respiratory tract infection, urinary tract infections and sexually transmitted diseases .
|
-
- HY-N4108R
-
|
P-glycoprotein
|
Inflammation/Immunology
Cancer
|
Hypophyllanthin (Standard) is the analytical standard of Hypophyllanthin. This product is intended for research and analytical applications. Hypophyllanthin is a major lignan in Phyllanthus spp, with strong anti-inflammatory activity. Hypophyllanthin directly inhibits P-glycoprotein (P-gp) activity and did not interfere with multidrug resistance protein 2 (MRP2) activity .
|
-
- HY-B2033
-
|
Fungal
|
Infection
|
Pyrimethanil is an anilinopyrimidine and broad-spectrum contact fungicide for the control of Botrytis spp. on a wide variety of crops . Pyrimethanil inhibits the biosynthesis of methionine and other amino acids in Botrytis cinerea. Pyrimethanil can be used for the research of fungal diseases prevention on fruit, vegetable and ornamental plants with mold infection .
|
-
- HY-131134S
-
Fosetyl-Al-d15
|
Fungal
Isotope-Labeled Compounds
|
Infection
|
Fosetyl-aluminum-d15 (Fosetyl-Al-d15) is the deuterium labeled Fosetyl-aluminum. Fosetyl-aluminum (Fosetyl-Al) is an active ingredient in many fungicides against downy mildew. Fosetyl-aluminum is used to control many diseases caused by Phytophthora spp. on agricultural and horticultural crops .
|
-
- HY-146079
-
|
Fungal
|
Infection
|
Antifungal agent 31 (compound 12) is a potent and orally active triazole antifungal agents with a pyrrolotriazinone scaffold. Antifungal agent 31 shows antifungal activity against Candida spp. and filamentous fungi. Antifungal agent 31 significantly reduced mortality rates and kidney fungal burden in two murine models of lethal systemic infections .
|
-
- HY-N7071A
-
Maduramycin ammonium
|
Bacterial
Apoptosis
Antibiotic
Autophagy
AMPK
Eukaryotic Initiation Factor (eIF)
|
Infection
Cardiovascular Disease
|
Maduramicin ammonium (Maduramycin ammonium) is isolated from the actinomycete Actinomadura rubra. Maduramicin ammonium (Maduramycin ammonium) is an anticoccidial agent for the the treatment of Eimeria spp., E. adenoeides, E. gallopavonis, and E. dispersa infection . Maduramicin ammonium (Maduramycin ammonium) induces cell apoptosis in chicken myocardial cells via intrinsic and extrinsic pathways .
|
-
- HY-136380
-
|
Herbicide
|
Others
|
Clodinafop-propargyl, a main member of aryloxyphenoxy-propionate herbicides, is used for postemergence control of annual grasses in cereals, including Avena, Lolium, Setaria, Phalaris and Alopecurus spp . Clodinafop-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-Y1636S1
-
|
Isotope-Labeled Compounds
|
Others
|
Fmoc-Arg(Pbf)-OH- 13C6 is the 13C labeled Fmoc-Arg(Pbf)-OH[1]. Fmoc-Arg(Pbf)-OH is an arginine derivative containing amine protecting group Fmoc. Fmoc-Arg(Pbf)-OH is a building block for the introduction of Arg into SPPS (Solid-Phase Peptide Synthesis)[2].
|
-
- HY-N6740S
-
|
Isotope-Labeled Compounds
Apoptosis
|
Metabolic Disease
|
β-Zearalanol-d4 is a deuterium labeled Beta-Zearalanol (HY-N6740) . Beta-Zearalenol is an mycotoxin produced by Fusarium spp, which causes apoptosis and oxidative stress in mammalian reproductive cells . Beta-Zearalenol is the derivative of zearalenone (ZEA) which can conjugate with glucuronic acid .
|
-
- HY-B0293R
-
|
Fungal
|
Infection
|
Butoconazole (nitrate) (Standard) is the analytical standard of Butoconazole (nitrate). This product is intended for research and analytical applications. Butoconazole nitrate (RS 35887), an imidazole antifungal agent, is active against Candida spp. and effective against vaginal infections due to Candida albicans. Butoconazole nitrate is presumed to function as other imidazole derivatives via inhibition of steroid synthesis .
|
-
- HY-N8461
-
3-Hydroxypropionaldehyde; 3-Hydroxypropanal
|
Bacterial
|
Infection
|
Reuterin is a broad-spectrum antimicrobial agent active against Gram positive and Gram negative bacteria, as well as yeasts, moulds and protozoa. Reuterin is produced by specific strains of Lactobacillus reuteri during anaerobic metabolism of glycerol. Reuterin also demonstrates potent antimicrobial activity against a broad panel of human and poultry meat campylobacter spp. Isolates .
|
-
- HY-125042
-
|
Bacterial
|
Infection
|
Sarothralin G is an antibacterial compound isolated from Hypericum japonicum Thunb. (Japanese spurfle). The structure of Sarothralin G contains phenolic and aromatic acid moieties and shows excellent antibacterial activity against Gram-positive bacteria such as Staphylococcus aureus, Bacillus subtilis and Nocardia spp., which is stronger than Sarothralen A, B and Saroaspidin A, B, C. Sarothralin G exhibits significant antibacterial potential.
|
-
- HY-B2033S1
-
|
Fungal
Isotope-Labeled Compounds
|
Others
|
Pyrimethanil-d5 is the deuterium labeled Pyrimethanil (HY-B2033). Pyrimethanil is an anilinopyrimidine and broad-spectrum contact fungicide for the control of Botrytis spp. on a wide variety of crops . Pyrimethanil inhibits the biosynthesis of methionine and other amino acids in Botrytis cinerea. Pyrimethanil can be used for the research of fungal diseases prevention on fruit, vegetable and ornamental plants with mold infection .
|
-
- HY-B2033R
-
|
Fungal
|
Infection
|
Pyrimethanil (Standard) is the analytical standard of Pyrimethanil. This product is intended for research and analytical applications. Pyrimethanil is an anilinopyrimidine and broad-spectrum contact fungicide for the control of Botrytis spp. on a wide variety of crops . Pyrimethanil inhibits the biosynthesis of methionine and other amino acids in Botrytis cinerea. Pyrimethanil can be used for the research of fungal diseases prevention on fruit, vegetable and ornamental plants with mold infection .
|
-
- HY-163632
-
|
EGFR
|
Cancer
|
EGFR-IN-112 (SPP10) is an EGFR kinase inhibitor which exhibits IC50s of 2.31 ± 0.3, 3.16 ± 0.8, and 4.2 ± 0.2 μM, against MCF-7, H69AR, and PC-3 cancer cells, respectively. EGFR-IN-112 also demonstrates selective cytotoxicity against cancer cells .
|
-
- HY-146023
-
|
Bacterial
Fungal
|
Infection
|
Antifungal agent 27 (compound 7) is a antifungal agent. Antifungal agent 27 shows moderate antibacterial and weak antifungal activities against MRSA and C. albicans SS5314, with MIC values of 8 and 32 μg/mL, respectively .
|
-
- HY-146024
-
|
Fungal
|
Infection
|
Antifungal agent 28 (compound 18) is a potent and selective antifungal agent. Antifungal agent 28 inhibits pathogenic strains of C. albicans and non-albicans species including fluconazole-resistant strains. Antifungal agent 28 inhibits Cryptococcus and Aspergillus strains. Antifungal agent 28 disrupts mature Candida biofilm .
|
-
- HY-N7071AR
-
|
Bacterial
Apoptosis
Antibiotic
|
Infection
|
Maduramicin (ammonium) (Standard) is the analytical standard of Maduramicin (ammonium). This product is intended for research and analytical applications. Maduramicin ammonium (Maduramycin ammonium) is isolated from the actinomycete Actinomadura rubra. Maduramicin ammonium (Maduramycin ammonium) is an anticoccidial agent for the the treatment of Eimeria spp., E. adenoeides, E. gallopavonis, and E. dispersa infection . Maduramicin ammonium (Maduramycin ammonium) induces cell apoptosis in chicken myocardial cells via intrinsic and extrinsic pathways .
|
-
- HY-B2033S
-
|
Isotope-Labeled Compounds
Fungal
|
Infection
|
Pyrimethanil- 13C, 15N2 is the 13C-labeled and 15N-labeled Pyrimethanil. Pyrimethanil is an?anilinopyrimidine?and broad-spectrum?contact fungicide for the control of Botrytis spp. on a wide variety of crops . Pyrimethanil inhibits the biosynthesis of methionine and other amino acids in?Botrytis cinerea. Pyrimethanil can be used for the research of fungal diseases prevention on fruit, vegetable and ornamental plants with mold infection .
|
-
- HY-136380R
-
|
Herbicide
|
Others
|
Clodinafop-propargyl (Standard) is the analytical standard of Clodinafop-propargyl. This product is intended for research and analytical applications. Clodinafop-propargyl, a main member of aryloxyphenoxy-propionate herbicides, is used for postemergence control of annual grasses in cereals, including Avena, Lolium, Setaria, Phalaris and Alopecurus spp . Clodinafop-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-151659
-
|
ADC Linker
|
Others
|
Fmoc-L-Lys(N3-Gly)-OH is a click chemistry reagent containing a lysine-containing azidoacetyl group building-block for SPPS and can be used for various biochemical studies . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
|
-
- HY-135813
-
|
Bacterial
|
Infection
|
LtaS-IN-1 (compound 1771) is a potent small-molecule inhibitor of Lipoteichoic acid (LTA) synthesis in multidrug-resistant (MDR) E. faecium and by altering the cell wall morphology. LtaS-IN-1 alone inhibits Enterococcus.spp 28 strains with varying MIC values ranging from 0.5 μg/mL to 64 μg/mL. LtaS-IN-1 combination with antibiotics abolishs multidrug-resistant E. faecium growth almost completely .
|
-
- HY-155131
-
|
Fungal
|
Infection
|
Y18501 is a oxysterol-binding protein (OSBPI) inhibitor with a similar structure to Oxathiapiprolin. Y18501 shows strong inhibitory activities against Phytophthora spp. and Pseudoperonospora cubensis, with EC50 ranging from 0.0005 to 0.0046 μg/mL. Y18501 shows excellent protective and curative activities against P. cubensis. Y18501 in combination with Chlorothalonil (HY-N6625) can significantly promote the inhibition of P. cubensis .
|
-
- HY-162521
-
|
Bacterial
Fungal
|
Infection
|
Antibacterial agent 215 (Compound 3b) is an inhibitor for carbonic anhydrase (CA), with Ki of 17.61, 5.14 and 43.74 nM, for hCA I, hCA II and AChE, respectively. Antibacterial agent 215 exhibits anti-tuberculosis, with MIC of 62.5 µg/ml against M. tuberculosis. Antibacterial agent 215 exhibits antifungal activities against Candida spp. strains ATCC 14053, ATCC 1369, and ATCC 15126, with MICs of 125 µg/ml .
|
-
- HY-15275
-
|
CDK
Angiotensin-converting Enzyme (ACE)
|
Infection
Cardiovascular Disease
Cancer
|
BMS-265246 is a potent and selective cyclin-dependent kinase CDK1 and CDK2 inhibitor, with IC50 values of 6 and 9 nM, respectively. BMS-265246 inhibits CHI3L1 (chitinase 3-like-1) stimulation of ACE2 (angiotensin converting enzyme 2) and SPP (viral spike protein priming proteases). BMS-265246 can be used for ovarian cancer and COVID-19 research .
|
-
- HY-136380S
-
|
Isotope-Labeled Compounds
|
Others
|
Clodinafop-propargyl- 13C6 is the 13C-labeled Clodinafop-propargyl. Clodinafop-propargyl, a main member of aryloxyphenoxy-propionate herbicides, is used for postemergence control of annual grasses in cereals, including Avena, Lolium, Setaria, Phalaris and Alopecurus spp . Clodinafop-propargyl-13C6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-120462
-
|
Dihydroorotate Dehydrogenase
Parasite
|
Infection
|
Genz-669178 is an inhibitor for dihydroorotate dehydrogenase (DHODH) with IC50 of 0.015-0.05 μM in Plasmodium spp.. Genz-669178 inhibits P. berghei, P. falciparum strains 3D7 and Dd2 with IC50 of 0.068, 0.008 and 0.01 μM, respectively. Genz-669178 exhibits anti-malarial efficacy in P. berghei-infected mice with ED50 of 13-21 mg/kg/day. Genz-669178 exhibits good pharmacokinetic characteristics in mice .
|
-
- HY-155808
-
|
STAT
JAK
Apoptosis
COX
|
Cancer
|
STAT3-IN-18 (compound SPP) is a platinum (IV) complex with an axial ligand derived from sandalwood. STAT3-IN-18 inhibits the JAK2-STAT3 pathway in breast cancer (BC) cells, with anti-proliferative activity. STAT3-IN-18 activates caspase-3 and increases cleaved polyADP-ribose polymerase to induce apoptosis. STAT3-IN-18 promotes maturation and antigen presentation of dendritic cells and demonstrates safety in vivo.
|
-
- HY-151787
-
|
ADC Linker
|
Others
|
Fmoc-L-Lys(N3-Aca-DIM)-OH is a click chemistry reagent containing an azide group. Used as a SPPS building-block for the “helping hand” strategy for purification of highly insoluble peptides. Solubilizing residues are attached to the Lys side-chains using Click-chemistry. The solubilizing tag can be removed with 1M hydrazine or hydroxylamine solution . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
|
-
- HY-B0398
-
|
Bacterial
Antibiotic
Topoisomerase
|
Infection
|
Nalidixic acid, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria .
|
-
- HY-B0398A
-
|
Bacterial
Antibiotic
Topoisomerase
|
Infection
|
Nalidixic acid sodium salt, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria .
|
-
- HY-B0398AR
-
|
Bacterial
Antibiotic
Topoisomerase
|
Infection
|
Liquiritin (Standard) is the analytical standard of Liquiritin. This product is intended for research and analytical applications. Liquiritin, a flavonoid isolated from Glycyrrhiza uralensis, is a potent and competitive AKR1C1 inhibitor with IC50s of 0.62 μM, 0.61 μM, and 3.72μM for AKR1C1, AKR1C2 and AKR1C3, respectively. Liquiritin efficiently inhibits progesterone metabolism mediated by AKR1C1 in vivo . Liquiritin acts as an antioxidant and has neuroprotective, anti-cancer and anti-inflammatory activity .
|
-
- HY-B0398R
-
|
Bacterial
Antibiotic
Topoisomerase
|
Infection
|
Nalidixic acid (Standard) is the analytical standard of Nalidixic acid. This product is intended for research and analytical applications. Nalidixic acid, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria .
|
-
- HY-135125
-
|
ADC Cytotoxin
|
Cancer
|
DC4, an ADC cytotoxin, can be used in the synthesis of antibody-drug conjugate (ADC). DC4 can be used for the targeted treatment of cancer .
|
-
Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P0123
-
|
Peptides
|
Others
|
SPACE peptide is a skin penetrating peptide (SPPs). SPACE peptide can enhance topical delivery of a macromolecule, hyaluronic acid .
|
-
- HY-Y1636
-
-
- HY-P2148
-
|
Bacterial
Antibiotic
|
Infection
Inflammation/Immunology
|
P-113 is an antimicrobial peptide (AMP) derived from the human salivary protein histatin 5. P-113 is active against clinically important microorganisms such as Pseudomonas spp., Staphylococcus spp., and C. albicans .
|
-
- HY-129034
-
|
Bacterial
Antibiotic
|
Infection
|
Ramoplanin is a broad-spectrum lipoglycodepsipeptide antibiotic derived from the Actinoplanes spp with with activity against gram-positive bacteria .
|
-
- HY-W013781
-
|
Biochemical Assay Reagents
|
Others
|
Boc-Glu(OBzl)-OH (Compound 9) is a glutamic acid derivative commonly used in Boc SPPS. Glutamic acid residues increase the hydrophilicity of the polypeptide and play an important structural and receptor binding role .
|
-
- HY-105048
-
|
Bacterial
Antibiotic
|
Infection
|
Omiganan is a cationic antimicrobial peptide. Omiganan as an analogue of indolicidin shows activity against gram-positive and gram-negative bacteria but also Candida spp. isolates. Omiganan can be used for the research of alcohol nose and acne .
|
-
- HY-P0068
-
HMR 3270; IP960; NXL201
|
Fungal
|
Infection
|
Aminocandin (HMR 3270) is water-soluble antifungal agent of the echinocandin class with excellent activity against Aspergillus and Candida spp. .
|
-
- HY-W344602
-
|
Peptides
|
Others
|
Substance P, [Met-OMet11] is a selective SP-P agonist. Substance P, [Met-OMet11] also is an active peptide. Substance P, [Met-OMet11] can be used for various biochemical studies .
|
Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P990116
-
|
Integrin
|
Others
|
Anti-Mouse osteopontin/SPP1 Antibody (103D6) is a mouse-derived IgG2c, κ type antibody inhibitor, targeting to mouse osteopontin/SPP1.
|
-
- HY-P990117
-
|
Inhibitory Antibodies
|
Others
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Anti-Mouse/Rat/Human Osteopontin/SPP1 Antibody (MPIIIB10) is a mouse-derived IgG1, κ type antibody inhibitor, targeting to mouse/rat/human Osteopontin/SPP1.
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- HY-P990795
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Inhibitory Antibodies
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Others
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Anti-Mouse osteopontin/SPP1 Antibody (100D3) is a kind of mouse IgG2c kappa in vivo mouse antibody, targeting to osteopontin/SPP1. The recommend isotype control of Anti-Mouse osteopontin/SPP1 Antibody (100D3): Mouse IgG2c kappa, Isotype Control (HY-P99981).
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Chemical Structure |
Cat. No. |
Product Name |
Chemical Structure |
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- HY-N6740S
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β-Zearalanol-d4 is a deuterium labeled Beta-Zearalanol (HY-N6740) . Beta-Zearalenol is an mycotoxin produced by Fusarium spp, which causes apoptosis and oxidative stress in mammalian reproductive cells . Beta-Zearalenol is the derivative of zearalenone (ZEA) which can conjugate with glucuronic acid .
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- HY-B2033S1
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Pyrimethanil-d5 is the deuterium labeled Pyrimethanil (HY-B2033). Pyrimethanil is an anilinopyrimidine and broad-spectrum contact fungicide for the control of Botrytis spp. on a wide variety of crops . Pyrimethanil inhibits the biosynthesis of methionine and other amino acids in Botrytis cinerea. Pyrimethanil can be used for the research of fungal diseases prevention on fruit, vegetable and ornamental plants with mold infection .
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- HY-B2060S1
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Tiamulin-d10-1 (hydrochloride) is deuterium labeled Tiamulin. Tiamulin (Thiamutilin) is a diterpenic antibiotic that is widely used in pigs and poultry for the control of infectious diseases. Tiamulin is effectively used in the study of airsacculitis, which is primarily caused by Mycoplasma spp .
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- HY-131134S
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Fosetyl-aluminum-d15 (Fosetyl-Al-d15) is the deuterium labeled Fosetyl-aluminum. Fosetyl-aluminum (Fosetyl-Al) is an active ingredient in many fungicides against downy mildew. Fosetyl-aluminum is used to control many diseases caused by Phytophthora spp. on agricultural and horticultural crops .
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- HY-Y1636S1
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Fmoc-Arg(Pbf)-OH- 13C6 is the 13C labeled Fmoc-Arg(Pbf)-OH[1]. Fmoc-Arg(Pbf)-OH is an arginine derivative containing amine protecting group Fmoc. Fmoc-Arg(Pbf)-OH is a building block for the introduction of Arg into SPPS (Solid-Phase Peptide Synthesis)[2].
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- HY-B2033S
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Pyrimethanil- 13C, 15N2 is the 13C-labeled and 15N-labeled Pyrimethanil. Pyrimethanil is an?anilinopyrimidine?and broad-spectrum?contact fungicide for the control of Botrytis spp. on a wide variety of crops . Pyrimethanil inhibits the biosynthesis of methionine and other amino acids in?Botrytis cinerea. Pyrimethanil can be used for the research of fungal diseases prevention on fruit, vegetable and ornamental plants with mold infection .
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- HY-136380S
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Clodinafop-propargyl- 13C6 is the 13C-labeled Clodinafop-propargyl. Clodinafop-propargyl, a main member of aryloxyphenoxy-propionate herbicides, is used for postemergence control of annual grasses in cereals, including Avena, Lolium, Setaria, Phalaris and Alopecurus spp . Clodinafop-propargyl-13C6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-136380
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Alkynes
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Clodinafop-propargyl, a main member of aryloxyphenoxy-propionate herbicides, is used for postemergence control of annual grasses in cereals, including Avena, Lolium, Setaria, Phalaris and Alopecurus spp . Clodinafop-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-151671
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Azide
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Fmoc-L-MeLys(N3)-OH is a click chemistry reagent containing an azide. Fmoc-L-MeLys(N3)-OH is a SPPS building-block for the introduction of N-Me-Lys that can be modified at the N3-group using Click-chemistry . Fmoc-L-MeLys(N3)-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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- HY-151786
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Azide
Alkynes
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Fmoc-L-Lys(Pentynoyl-DIM)-OH is a click chemistry reagent containing an azide. Fmoc-L-Lys(Pentynoyl-DIM)-OH can be used as a SPPS building block for the “helping hand” strategy for purification of highly insoluble peptides. Solubilizing residues are attached to the Lys side-chains using Click-chemistry. The solubilizing tag can be removed with 1M hydrazine or hydroxylamine solution . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
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- HY-151679
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Azide
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Fmoc-L-Lys(4-N3-Z)-OH is a click chemistry reagent containing an azide group. Fmoc-L-Lys(4-N3-Z)-OH acts as Lysine building-block for SPPS containing an Azide moiety as a bioorthogonal ligation handle, an infrared probe and a photo-affinity reagent. It can be decaged by trans-cyclooctenols via a strain-promoted 1,3-dipolar cycloaddition . Fmoc-L-Lys(4-N3-Z)-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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- HY-151659
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Azide
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Fmoc-L-Lys(N3-Gly)-OH is a click chemistry reagent containing a lysine-containing azidoacetyl group building-block for SPPS and can be used for various biochemical studies . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
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- HY-136380S
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Alkynes
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Clodinafop-propargyl- 13C6 is the 13C-labeled Clodinafop-propargyl. Clodinafop-propargyl, a main member of aryloxyphenoxy-propionate herbicides, is used for postemergence control of annual grasses in cereals, including Avena, Lolium, Setaria, Phalaris and Alopecurus spp . Clodinafop-propargyl-13C6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-151787
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Azide
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Fmoc-L-Lys(N3-Aca-DIM)-OH is a click chemistry reagent containing an azide group. Used as a SPPS building-block for the “helping hand” strategy for purification of highly insoluble peptides. Solubilizing residues are attached to the Lys side-chains using Click-chemistry. The solubilizing tag can be removed with 1M hydrazine or hydroxylamine solution . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
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Product Name |
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Classification |
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- HY-RS16219
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siRNAs
Mouse Pre-designed siRNA Sets
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SPP1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for SPP1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
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- HY-RS13702
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siRNAs
Human Pre-designed siRNA Sets
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SPP1 Human Pre-designed siRNA Set A contains three designed siRNAs for SPP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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- HY-RS25876
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siRNAs
Rat Pre-designed siRNA Sets
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Spp2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Spp2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
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- HY-RS13703
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siRNAs
Human Pre-designed siRNA Sets
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SPP2 Human Pre-designed siRNA Set A contains three designed siRNAs for SPP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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- HY-RS22980
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siRNAs
Rat Pre-designed siRNA Sets
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Spp1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Spp1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
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- HY-RS19384
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siRNAs
Mouse Pre-designed siRNA Sets
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Spp2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Spp2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
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