2. Antibody-drug Conjugate/ADC Related
  3. Drug-Linker Conjugates for ADC
  4. SPP-DM1

SPP-DM1 is a agent-linker conjugate for ADC with potent antitumor activity by using DM1 (a potent microtubule-disrupting agent), linked via the ADC linker SPP.

For research use only. We do not sell to patients.

SPP-DM1

SPP-DM1 Chemical Structure

CAS No. : 452072-20-7

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Customer Review

Based on 1 publication(s) in Google Scholar

SPP-DM1 Related Antibodies

Top Publications Citing Use of Products

View All Drug-Linker Conjugates for ADC Isoform Specific Products:

View All Isoforms
Auristatin Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents Dual payloads

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  • Customer Review

Description

SPP-DM1 is a agent-linker conjugate for ADC with potent antitumor activity by using DM1 (a potent microtubule-disrupting agent), linked via the ADC linker SPP[1].

IC50 & Target[1]

Maytansinoids

 

Molecular Weight

967.54

Formula

C44H59ClN4O14S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@]12[C@H]([C@@H]([C@](O3)([H])C[C@]([C@](/C=C/C=C(C)/CC4=CC(N(C)C(C[C@]2([H])OC([C@H](C)N(C)C(CCSSC(C)CCC(ON5C(CCC5=O)=O)=O)=O)=O)=O)=C(C(OC)=C4)Cl)([H])OC)(NC3=O)O)C)O1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (103.35 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0335 mL 5.1677 mL 10.3355 mL
5 mM 0.2067 mL 1.0335 mL 2.0671 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.0335 mL 5.1677 mL 10.3355 mL 25.8387 mL
5 mM 0.2067 mL 1.0335 mL 2.0671 mL 5.1677 mL
10 mM 0.1034 mL 0.5168 mL 1.0335 mL 2.5839 mL
15 mM 0.0689 mL 0.3445 mL 0.6890 mL 1.7226 mL
20 mM 0.0517 mL 0.2584 mL 0.5168 mL 1.2919 mL
25 mM 0.0413 mL 0.2067 mL 0.4134 mL 1.0335 mL
30 mM 0.0345 mL 0.1723 mL 0.3445 mL 0.8613 mL
40 mM 0.0258 mL 0.1292 mL 0.2584 mL 0.6460 mL
50 mM 0.0207 mL 0.1034 mL 0.2067 mL 0.5168 mL
60 mM 0.0172 mL 0.0861 mL 0.1723 mL 0.4306 mL
80 mM 0.0129 mL 0.0646 mL 0.1292 mL 0.3230 mL
100 mM 0.0103 mL 0.0517 mL 0.1034 mL 0.2584 mL
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SPP-DM1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SPP-DM1452072-20-7Drug-Linker Conjugates for ADCInhibitorinhibitorinhibit

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