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Results for "

SDH

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Aldehyde Dehydrogenase (ALDH) (2) Aldose Reductase (1) Antibiotic (6) Apoptosis (5) Bacterial (4) Biochemical Assay Reagents (1) Cannabinoid Receptor (1) Drug Intermediate (1) Fluorescent Dye (1) Fungal (48) Insecticide (2) Keap1-Nrf2 (2) Mitochondrial Metabolism (3) MMP (2) NOD-like Receptor (NLR) (2) Parasite (2) Reactive Oxygen Species (ROS) (5) Reference Standards (3) Small Interfering RNA (siRNA) (8) Succinate Dehydrogenase (19)
By Research Areas:	Cancer (1) Cardiovascular Disease (2) Infection (55) Inflammation/Immunology (4) Metabolic Disease (8) Neurological Disease (3)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (2) Mouse Pre-designed siRNA Sets (2) Human Pre-designed siRNA Sets (4) siRNAs (8)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Natural
Products

Antibodies

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-148921

SDH-IN-2	Fungal	Infection
SDH-IN-2 is a potent succinate dehydrogenase (SDH) inhibitor with an IC₅₀ of 0.55 μg/mL. SDH-IN-2 is also an antifungal agent. SDH-IN-2 inhibits phytopathogenic fungia with average EC₅₀ values of 3.82-9.81 μg/mL for all the fungi . SDH-IN-2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-E70398

Sorbitol dehydrogenase L-Iditol dehydrogenase; Polyol dehydrogenase; SDH	Biochemical Assay Reagents	Others
Sorbitol dehydrogenase is an oxidoreductase. Sorbitol dehydrogenase can be used as a marker for drug-induced liver injury .

HY-178469

SDH-IN-35	Fungal	Infection
SDH-IN-35 (Compound A17) is a potent succinate dehydrogenase (SDH) inhibitor with antifungal activity (EC₅₀=11.9 μM). SDH-IN-35 is promising for research of agricultural fungicide .

HY-178177

SDH-IN-31	Fungal	Infection
SDH-IN-31 is a succinate dehydrogenase (SDH) inhibitor with an IC₅₀ of 1.11 μM. SDH-IN-31 exhibits anti-fungal activity. SDH-IN-31 can be used for the research of infection, such as infection, such as rice sheath blight .

HY-172804

SDH-IN-26	Succinate Dehydrogenase Fungal Apoptosis	Infection
SDH-IN-26 (Compound C3) is a succinate dehydrogenase (SDH) inhibitor. SDH-IN-26 exhibits significant inhibitory activity against multiple phytopathogenic fungi, such as Rhizoctonia solani and Botrytis cinerea, with an EC₅₀ value of 0.270 μg/mL against Rhizoctonia solani. SDH-IN-26 damages the integrity of the fungal cell membrane, increases membrane permeability, disrupts cell structure, and reduces the number of mitochondria, thus affecting the normal growth of mycelia. SDH-IN-26 leads to a decrease in mitochondrial membrane potential, and induces cell apoptosis. SDH-IN-26 is promising for research of plant diseases caused by fungi .

HY-159481

SDH-IN-17	Succinate Dehydrogenase Fungal	Infection Inflammation/Immunology
SDH-IN-17 (compound C32), a hydrazide-containing flavonol derivative, is a potent succinate dehydrogenase (SDH) inhibitor with an IC₅₀ of 8.42 μM. SDH-IN-17 can occupy the active site and form strong interactions with the key residues of SDH. SDH-IN-17 exhibits antifungal activity against Rhizoctonia solani (EC₅₀=0.170 μg/mL). SDH-IN-17 disrupts the normal growth of hyphae by affecting the structural integrity of the cell membrane and cellular respiration. SDH-IN-17 has the potential for plant disease control research .

HY-155004

SDH-IN-3	Antibiotic Fungal	Infection
SDH-IN-3 is a succinate dehydrogenase (SDH) inhibitor with an IC₅₀ of 7.2 μg/mL. SDH-IN-3 exhibits excellent antifungal activities against Nigrospora oryzae with an EC₅₀ of 1.9 μg/mL. SDH-IN-3 can be used for anti-infection research .

HY-172777

SDH-IN-25	Succinate Dehydrogenase Fungal Reactive Oxygen Species (ROS) MMP	Infection
SDH-IN-25 is a succinate dehydrogenase (SDH) inhibitor (IC₅₀ = 4.82 mg/L). SDH-IN-25 exhibited broad-spectrum and potent antifungal activity. SDH-IN-25 mimics the interaction pattern of commercial fungicide Fluxapyroxad (HY-135549) through binding to *SDH* amino acid residues (TRP173, TYR58, and ARG43). SDH-IN-25 can induce hyphal morphology, interfere with respiratory metabolism by binding to complex II, generate reactive oxygen species (ROS), and affect mitochondrial membrane potential (MMP) in mycelia. SDH-IN-25 can be studied in research for agricultural disease control .

HY-178050

SDH-IN-30	Fungal Succinate Dehydrogenase	Infection
SDH-IN-30 (Compound 7m) is a Succinate dehydrogenase (SDH) inhibitor with an IC₅₀ of 0.34 μM. SDH-IN-30 has potent antifungal activities against Rhizoctonia solani and Sclerotinia sclerotiorum with EC₅₀s of 0.004 and 0.028 μg/mL. SDH-IN-30 also has remarkable protective and curative efficacies against R. solani and significantly inhibits S. sclerotiorum growth on oilseed rape leaves by damaging the fungal cell structure. SDH-IN-30 can be used for fungal infections like rice sheath blight (RSB) and sclerotinia stem rot (SSR) research .

HY-178196

SDH-IN-32	Fungal MMP Apoptosis	Infection
SDH-IN-32 is a succinate dehydrogenase (SDH) inhibitor with an IC₅₀ of 2.74 μM. SDH-IN-32 exhibits excellent antifungal activity. SDH-IN-32 can destroy the cell membrane structure and increase the permeability of the cell membrane. SDH-IN-32 can decrease the mitochondrial membrane potential (MMP), thereby inducing cell apoptosis and inhibiting the normal growth of mycelia. SDH-IN-32 can be used for the research of infection .

HY-149601

SDH-IN-8	Fungal	Infection
SDH-IN-8 (compound G40) is a potent succinate dehydrogenase (SDH) inhibitor with an IC₅₀ of 27 nM for porcine SDH. SDH-IN-8 has fungicidal properties .

HY-149600

SDH-IN-7	Fungal	Infection
SDH-IN-7 (compound G28) is a potent succinate dehydrogenase (SDH) inhibitor with an IC₅₀ of 26 nM for porcine SDH. SDH-IN-7 has fungicidal properties .

HY-172212

SDH-IN-23	Insecticide Reactive Oxygen Species (ROS)	Infection
SDH-IN-23 (Compound B21) is an *SDH* inhibitor. SDH-IN-23 exhibits excellent nematicidal activity. SDH-IN-23 can inhibit the feeding, reproduction, and embryonic development of nematodes. Meanwhile, SDH-IN-23 exerts a lethal effect on nematodes by triggering oxidative stress, causing intestinal damage, and inhibiting *SDH*, among other mechanisms .

HY-158321

SDH-IN-15	Fungal Succinate Dehydrogenase	Infection
SDH-IN-15 (Compound 5e) is an inhibitor of succinate dehydrogenase (SDH) (IC₅₀=2.04 μM). SDH-IN-15 has significant antifungal activity. SDH-IN-15 blocks the mitochondrial respiratory chain of the fungus through inhibition of SDH, resulting in fungal death .

HY-157459

SDH-IN-11	Fungal	Infection
SDH-IN-11 (compound A7) is a *SDH* inhibitor, and shows inhibitory effect on nematode feeding, reproductive ability, and egg hatching. SDH-IN-11 promotes the oxidative stress of nematodes and causes intestinal damage to nematodes. SDH-IN-11 inhibits the activity of succinate dehydrogenase (SDH) in nematodes .

HY-139983

SDH-IN-1 1 Publications Verification	Fungal	Infection
SDH-IN-1 (compound 4i) is a succinate dehydrogenase (SDH) inhibitor with an IC₅₀ of 4.53 μM. SDH-IN-1 has potent antifungal activities. SDH-IN-1 displays potent activity against *S. sclerotiorum* (EC₅₀ of 0.14 mg/L) .

HY-161504

SDH-IN-14	Fungal Succinate Dehydrogenase	Infection
SDH-IN-14 (Compound Z2) is an inhibitor of succinate dehydrogenase (SDH). SDH-IN-14 has antifungal activity (EC₅₀=2.7 μg/mL) against B.cinerea. SDH-IN-14 acts by disrupting the integrity of the cell wall and cell membrane .

HY-155700

SDH-IN-6	Fungal	Infection
SDH-IN-6 (compound 6i) is a potent succinate dehydrogenase (SDH) inhibitor. SDH-IN-6 has antifungal activity against Valsa mali with an EC₅₀ value of 1.77 mg/L .

HY-178801

SDH-IN-39	Succinate Dehydrogenase Fungal	Infection
SDH-IN-39 (Compound A16) is a *SDH* inhibitor, with an IC₅₀ value of 6.83 μg/mL. SDH-IN-39 is also an antifungal agent. SDH-IN-39 shows antifungal activity against Rhizoctonia solani (EC₅₀ of 1.49 μg/mL), G. zeae, C. gloeosporioides, S. sclerotiorum and M. oryzae .

HY-173264

SDH-IN-24	Parasite Insecticide	Infection
SDH-IN-24 (Compound 51) is an inhibitor of succinate dehydrogenase (SDH). The LC50 against the second-stage juveniles of Bursaphelenchus xylophilus (B. xylophilus) is 6.9 mg/L, and the IC₅₀ for *SDH* is 15.0 μM. SDH-IN-24 exerts its nematicidal activity by inhibiting the activity of *SDH* to interfere with the energy metabolism of nematodes. Meanwhile, it inhibits the motility, feeding, and reproduction of nematodes, induces oxidative stress, reduces the protein content of nematodes, and impairs their antioxidant capacity. SDH-IN-24 can be used in the research related to anti-nematode fields .

HY-172362

SDH-IN-22	Succinate Dehydrogenase Fungal	Infection
SDH-IN-22 (Compound SEZC7) is the inhibitor for succinate dehydrogenase (SDH) with an IC₅₀ of 16.6 μM. SDH-IN-22 exhibits antifungal activity that inhibits Magnaporthe grisea with an EC₅₀ of 0.5 mg/L .

HY-178346

SDH-IN-33	Fungal	Infection
SDH-IN-33 (Compound I-9) is a succinate dehydrogenase inhibitor. SDH-IN-33 exhibits excellent fungicidal activity with an EC₅₀ of 0.07 μg/mL. SDH-IN-33 inhibits R. solani succinate dehydrogenase (RsSDH) with an IC₅₀ 0.35 μg/mL. SDH-IN-33 can be used for the study of fungal infection .

HY-178778

SDH-IN-38	Fungal	Infection
SDH-IN-38 (Compound IIIe) is a Succinate dehydrogenase inhibitor. SDH-IN-38 is an antifungal agent, with an EC₅₀ value of 0.009 μg/mL against R. solani mycelia. SDH-IN-38 inhibits mycelial growth by affecting mycelial respiration. SDH-IN-38 induces cellular senescenc and reduces mitochondrial membrane potential in mycelia .

HY-170974

SDH-IN-20	Fungal	Infection
SDH-IN-20 (compound A19) is an antifungal agent. SDH-IN-20 against Verticillium dahlia, R. solani with EC₅₀s of less than 3.0 μg/mL, 2.87 μg/mL. SDH-IN-20 exerts its highly antifungal effects by acting as an effective succinate dehydrogenase (SDH) inhibitor with an IC₅₀ of 29.33 μM. SDH-IN-20 adversely impacts the integrity of cell membranes and mycelial morphologies of R. solani .

HY-161375

SDH-IN-13	Fungal	Infection
SDH-IN-13 (Compound 5IIIh) is a *SDH* inhibitor (IC₅₀: 13.7 μg/mL) and an antifungal agent .

HY-149876

SDH-IN-5	Fungal	Infection
SDH-IN-5 (compound 7d) is a potent succinate dehydrogenase (SDH) inhibitor, with an IC₅₀ of 3.293 μM. SDH-IN-5 is also exhibits antifungal activity, with an EC₅₀ of 0.046 μg/mL against R. solani. SDH-IN-5 could significantly inhibit the growth of R. solani in rice leaves with excellent protective and curative efficacies .

HY-178799

SDH-IN-37	Succinate Dehydrogenase Fungal	Infection
SDH-IN-37 (Compound A37) is a potent *SDH* inhibitor, with an IC₅₀ value of 0.0263 μM. SDH-IN-37 is also an antifungal agent. SDH-IN-37 demonstrates antifungal activities against Rhizoctonia solani, S. sclerotiorum and F. graminearum, with EC₅₀ values of 0.0144, 0.882 and 1.99 μg/mL, respectively .

HY-178457

SDH-IN-34	Succinate Dehydrogenase Fungal	Infection
SDH-IN-34 is a Succinate Dehydrogenase inhibitor with antifungal activity. SDH-IN-34 can be used for the research of infection .

HY-159486

SDH-IN-18	Succinate Dehydrogenase Fungal	Infection
SDH-IN-18 (Compound 3a) is an inhibitor for succinate dehydrogenase (SDH) with an IC₅₀ of 8.70 mg/L. SDH-IN-18 destroys fungal morphology and reproduction, exhibits antifungal activity against Rhizoctonia solani and Sclerotinia sclerotiorum with EC₅₀ of 0.48 and 1.4 mg/L .

HY-178495

SDH-IN-36	Mitochondrial Metabolism Reactive Oxygen Species (ROS) Apoptosis	Cancer
SDH-IN-36 (Compound 17) is a derivative of alpha-D-tocopherol. SDH-IN-36 increases ROS and induces apoptosis by inhibiting SDHC and blocking electron transfer. SDH-IN-36 can inhibit the proliferation of various tumor cells, such as SSK4 (GI₅₀ = 0.156 µM), SSNU638 (GI₅₀ = 0.659 µM), and SKATOIII (GI₅₀ = 0.490 µM) cells. SDH-IN-36 can significantly inhibit tumor growth. SDH-IN-36 can be used for research on cancers such as gastric cancer .

HY-149323

SDH-IN-4	Fungal	Infection
SDH-IN-4 (compound B6) is a selective inhibitor against succinate dehydrogenase (SDH) with an IC₅₀ value of 0.28 μg/mL. SDH-IN-4 has highly efficient and broad-spectrum antifungal activity, against R. solani with an EC₅₀ value of 0.23 μg/mL .

HY-174390

SDH-IN-29	Fungal Succinate Dehydrogenase	Infection
SDH-IN-29 (Compound A33) is a *SDH* inhibitor with an IC₅₀ of 0.0709 μM. SDH-IN-29 has a broad spectrum of antifungal activities (EC₅₀s of 0.356, 0.798 and 0.146 μg/mL for Fusarium graminearum, Sclerotinia sclerotiorum, and Rhizoctonia solani, respectively). SDH-IN-29 has moderate to significant protective effects against rice blast, wheat scab and cucumber powdery mildew .

HY-163911

SDH-IN-19	Fungal Antibiotic	Infection
SDH-IN-19 (compound A13) is a fungicide, with an EC₅₀ value of 0.83 μg/mL against Rhizoctonia solani. SDH-IN-19 can be used in antifungal research of crops .

HY-156270

SDH-IN-9	Bacterial	Infection
SDH-IN-9 (compound Ip) is a potent inhibitor of Succinate Dehydrogenase. SDH-IN-9 shows fungicidal activity against Fusarium graminearum Schw with the EC₅₀ of 0.93 μg/mL .

HY-174831

SDH-IN-28	Fungal Succinate Dehydrogenase	Infection
SDH-IN-28 is a succinate dehydrogenase inhibitor with an IC₅₀ value of 2.65 mg/L. SDH-IN-28 demonstrates broad-spectrum fungicidal efficacy, with EC₅₀ values of 0.21 (Valsa mali), 0.95 (Botrytis cinerea), 0.64 (Rhizoctonia solani), 1.33 (Fusarium graminearum), and 0.66 mg/L (Gaeumannomyces graminis). SDH-IN-28 effectively prevents V. mali infection in apples .

HY-176413

SDH-IN-27	Fungal	Infection
SDH-IN-27 (Compound Q18) is a succinate dehydrogenase inhibitor (SDHI) (IC₅₀: 9.7 mg/L). SDH-IN-27 induces mycelial morphology changes and lipid peroxidation, and exhibits antifungal activity against C. camelliae (EC₅₀: 6.0 mg/L). SDH-IN-27 is an ergosterol biosynthesis inhibitor (EBI) that binds to the active site of CYP51, ultimately leading to cell death of pathogenic fungi .

HY-149653

SDH-IN-10	Fungal	Infection
SDH-IN-10 is a potent succinate dehydrogenase inhibitor (SDHI) with antifungal effects .

HY-163284

SDH-IN-12	Succinate Dehydrogenase Fungal	Infection
SDH-IN-12 (compound 9b) is a succinate dehydrogenase inhibitor, which exhibits activity against S. sclerotiorum and C. arachidicola, with EC₅₀s of 0.97 and 2.07 μM, respectively. SDH-IN-12 reveals no significant herbicidal activity against monocotyledonous and dicotyledonous plants .

HY-162559

SDH-IN-16	Fungal	Infection
SDH-IN-16 (compound 5aa) is a potent inhibitor of Succinate Dehydrogenase, with the IC₅₀ of 1.62 μM. SDH-IN-16 displays a broad spectrum of antifungal activity against F. graminearum, B. cinerea, S. sclerotiorum, and R. solani, with the corresponding EC₅₀ values of 0.12, 4.48, 0.33, and 0.15 μg/mL, respectively .

HY-RS12593

SDHB Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SDHB Human Pre-designed siRNA Set A contains three designed siRNAs for SDHB gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SDHB Human Pre-designed siRNA Set A SDHB Human Pre-designed siRNA Set A

HY-119976

Boscalid 1 Publications Verification	Fungal	Infection
Boscalid is an anti-fungal agent. Boscalid is a succinate dehydrogenase (SDH) inhibitor .

HY-162500

Antifungal agent 99	Fungal	Infection
Antifungal agent 99 (Compound E1) is a fungal succinate dehydrogenase (SDH) inhibitor. Antifungal agent 99 reduces mycelial density and significantly increase the mitochondrial number in mycelia cytoplasm .

HY-162776

Succinate dehydrogenase-IN-3	Succinate Dehydrogenase Fungal	Infection
Succinate dehydrogenase-IN-3 (Ig) is an inhibitor of Succinate dehydrogenase (SDH). Succinate dehydrogenase-IN-3 has antifungal activity .

HY-119976R

Boscalid (Standard)	Fungal Reference Standards	Infection
Boscalid (Standard) is the analytical standard of Boscalid. This product is intended for research and analytical applications. Boscalid is an anti-fungal agent. Boscalid is a succinate dehydrogenase (SDH) inhibitor .

HY-D0064

6,7-Dihydroxy-4-coumarinylacetic acid	Aldose Reductase	Metabolic Disease
6,7-Dihydroxy-4-coumarinylacetic acid is a potent and selective inhibitor of ALR2. 6,7-Dihydroxy-4-coumarinylacetic acid inhibits ALR2, *SDH* andALR1 with IC₅₀s of 9.6, 288 and 66.3 μM, respectively. 6,7-Dihydroxy-4-coumarinylacetic acid clearly suppresses galactitol accumulation .

HY-175722

JSZ16	Fungal	Infection
JSZ16 is a Succinate dehydrogenase (SDH) inhibitor with an IC₅₀ of 30.3  μM. JSZ16 has potent broad-spectrum fungicidal activity, such as Sclerotinia sclerotiorum, Botrytis cinerea and Colletotrichum fragariae, with an EC₅₀ of 4.4 mg/L for Sclerotinia sclerotiorum. JSZ16 influences the cell membrane permeability of pathogenic fungi. JSZ16 can be used for the development of fungicide .

HY-W272811

Camphorsulfonate sodium	Drug Intermediate Fungal	Infection
Camphorsulfonate sodium is an organic synthesis intermediate. Camphorsulfonate sodium can be used for synthesis of derivatives with SDH inhibitory activity through scaffold hopping. Camphorsulfonate sodium is also an organocatalyst that can be used as a pore-forming additive for modulating the porosity of the graphene film. Camphorsulfonate sodium can be used for binder-free porous graphene film and fungicide research .

HY-178051

Antifungal agent 135	Succinate Dehydrogenase Fungal	Infection
Antifungal agent 135 (Compound C2), an antifungal agent, is a Succinate dehydrogenase (SDH) inhibitor with an IC₅₀ of 1.99 μM. Antifungal agent 135 has potent antifungal activities against Valsa mali, Sclerotinia sclerotiorum and Phytophthora capsici with EC₅₀s of 0.280, 1.11 and 0.130 mg/L, respectively. Antifungal agent 135 shows protective and curative activities against P. capsici and V. mali by effectively disrupting hyphal structural integrity and inhibiting mycelial growth .

HY-RS25462

Sord Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Sord Rat Pre-designed siRNA Set A contains three designed siRNAs for Sord gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sord Rat Pre-designed siRNA Set A Sord Rat Pre-designed siRNA Set A

HY-RS16499

Sds Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Sds Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sds gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sds Mouse Pre-designed siRNA Set A Sds Mouse Pre-designed siRNA Set A

Cat. No.	Product Name	Type

HY-D0064

6,7-Dihydroxy-4-coumarinylacetic acid	Dyes
6,7-Dihydroxy-4-coumarinylacetic acid is a potent and selective inhibitor of ALR2. 6,7-Dihydroxy-4-coumarinylacetic acid inhibits ALR2, *SDH* andALR1 with IC₅₀s of 9.6, 288 and 66.3 μM, respectively. 6,7-Dihydroxy-4-coumarinylacetic acid clearly suppresses galactitol accumulation .

Cat. No.	Product Name	Type

HY-119976

Boscalid 1 Publications Verification	Microbial Culture
Boscalid is an anti-fungal agent. Boscalid is a succinate dehydrogenase (SDH) inhibitor .

HY-D0007

Blue Tetrazolium

Tetrazolium blue

Indicators

Blue Tetrazolium (Tetrazolium blue), as a blue dye for microbial research, can be reduced into blue tetrazolium formazan (BTF). Blue Tetrazolium can be used to determine the activity of succinate dehydrogenase (SDH) in yeast strains, which has been reduced as a substrate. Use DMSO to extract BTF from cells, and test absorption spectrum of BTF. The BTF shows a wide wavelength range of 480-600 nm with maximal absorbance seen at 540 nm. Blue Tetrazolium, combines with succinate dehydrogenase (SDH) .

HY-119976R

Boscalid (Standard)	Microbial Culture
Boscalid (Standard) is the analytical standard of Boscalid. This product is intended for research and analytical applications. Boscalid is an anti-fungal agent. Boscalid is a succinate dehydrogenase (SDH) inhibitor .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-Y1787

Dimethyl malonate Maximum Cited Publications 6 Publications Verification	Natural Products Source classification Melia azedarach L. Plants Meliaceae	Apoptosis
Dimethyl malonate is a competitive inhibitor of succinate dehydrogenase (SDH). Dimethyl malonate is able to cross the blood-brain barrier and hydrolyse to malonate. Dimethyl malonate reduces neuronal apoptosis .

HY-N7114A

Chloramphenicol succinate sodium 3 Publications Verification	Infection Microorganisms Classification of Application Fields Antibiotics Source classification Metabolic Disease Antibacterial Disease Research Disease Research Fields Other Antibiotics	Bacterial Antibiotic
Chloramphenicol succinate sodium is a proagent of Chloramphenicol, with haemotoxicity. Chloramphenicol succinate is a competitive substrate and inhibitor of succinate dehydrogenase (SDH) that is the possible reason for its toxicity. Chloramphenicol succinate acts as a prodrug, being converted to active chloramphenicol by esterases while it is circulating in the body .

HY-113298

Citraconic acid 3 Publications Verification Methylmaleic acid	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	NOD-like Receptor (NLR) Keap1-Nrf2 Reactive Oxygen Species (ROS)
Citraconic acid (Methylmaleic acid) is an orally active inhibitor targeting the NLRP3 inflammasome and Keap1-Nrf2 pathway. Citraconic acid reduces reactive oxygen species (ROS) generation by inhibiting succinate dehydrogenase (SDH) activity. Citraconic acid also modifies the conformation of Keap1 protein, relieves its inhibition of Nrf2, promotes antioxidant gene expression, and inhibits NLRP3 activation and the release of pro-inflammatory factors such as IL-1β and IL-18. Citraconic acid has anti-inflammatory and antioxidant activities, can reduce oxidative stress and cell pyroptosis, improve tissue damage, and can be used for the research of inflammation-related diseases such as acute renal ischemia-reperfusion injury. Citraconic acid is an isomer of Itaconic acid (HY-Y052) .

HY-120183

Harzianopyridone	Natural Products Microorganisms Source classification	Fungal
Harzianopyridone is a compound that can be isolated from Trichoderma harzianum. Harzianopyridone is a succinate dehydrogenase (SDH) inhibitor with an IC₅₀ of 80 nM. Harzianopyridone has antifungal, antibacterial, and herbicidal activities .

HY-Y1787R

Dimethyl malonate (Standard)	Natural Products Source classification Melia azedarach L. Plants Meliaceae	Apoptosis
Dimethyl malonate is a competitive inhibitor of succinate dehydrogenase (SDH). Dimethyl malonate is able to cross the blood-brain barrier and hydrolyse to malonate. Dimethyl malonate reduces neuronal apoptosis .

HY-N7114

Chloramphenicol succinate	Microorganisms Antibiotics Source classification Disease Research Other Antibiotics	Antibiotic Bacterial
Chloramphenicol succinate is a proagent of Chloramphenicol, with Haemotoxicity. Chloramphenicol succinate also is an antibiotic. Chloramphenicol succinate is a competitive substrate and inhibitor of succinate dehydrogenase (SDH) that is the possible reason for its toxicity .

HY-N7114AR

Chloramphenicol succinate sodium (Standard)	Microorganisms Antibiotics Source classification Antibacterial Disease Research Other Antibiotics	Reference Standards Bacterial Antibiotic
Chloramphenicol succinate (sodium) (Standard) is the analytical standard of Chloramphenicol succinate (sodium). This product is intended for research and analytical applications. Chloramphenicol succinate sodium is a proagent of Chloramphenicol, with Haemotoxicity. Chloramphenicol succinate sodium is a proagent of Chloramphenicol, with haemotoxicity. Chloramphenicol succinate is a competitive substrate and inhibitor of succinate dehydrogenase (SDH) that is the possible reason for its toxicity. Chloramphenicol succinate acts as a prodrug, being converted to active chloramphenicol by esterases while it is circulating in the body .

HY-113298R

Citraconic acid (Standard) Methylmaleic acid (Standard)	Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Reference Standards NOD-like Receptor (NLR) Keap1-Nrf2 Reactive Oxygen Species (ROS)
Citraconic acid (Methylmaleic acid) (Standard) is the analytical standard of Citraconic acid (HY-113298). This product is intended for research and analytical applications. Citraconic acid is an orally active inhibitor targeting the NLRP3 inflammasome and Keap1-Nrf2 pathway. Citraconic acid reduces reactive oxygen species (ROS) generation by inhibiting succinate dehydrogenase (SDH) activity. Citraconic acid also modifies the conformation of Keap1 protein, relieves its inhibition of Nrf2, promotes antioxidant gene expression, and inhibits NLRP3 activation and the release of pro-inflammatory factors such as IL-1β and IL-18. Citraconic acid has anti-inflammatory and antioxidant activities, can reduce oxidative stress and cell pyroptosis, improve tissue damage, and can be used for the research of inflammation-related diseases such as acute renal ischemia-reperfusion injury. Citraconic acid is an isomer of Itaconic acid (HY-Y052) .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81835

	SDHB Antibody (YA1580) SDHB; SDH; SDH1; Succinate dehydrogenase [ubiquinone] iron-sulfur subunit; mitochondrial; Iron-sulfur subunit of complex II; Ip	WB, IHC-P, IP, FC	Human, Mouse, Rat
	SDHB Antibody (YA1580) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SDHB.

HY-P87067

	SDHC Antibody(YA6760) CYB560 antibody; C560_HUMAN antibody; CYBL antibody; Cytochrome B large subunit of complex II antibody; Integral membrane protein CII-3 antibody; mitochondrial antibody; PGL3 antibody; QPs-1 antibody; QPs1 antibody; SDH3 antibody; CYB560 antibody; C560_HUMAN antibody; CYBL antibody; Cytochrome B large subunit of complex II antibody; Integral membrane protein CII-3 antibody; mitochondrial antibody; PGL3 antibody; QPs-1 antibody; QPs1 antibody; SDH3 antibody; SDHC antibody; succinate dehydrgenase cytochrome b antibody; succinate dehydrogenase 3, integral membrane subunit antibody; Succinate dehydrogenase complex subunit C antibody; Succinate dehydrogenase complex subunit C integral membrane protein 15kDa antibody; Succinate dehydrogenase cytochrome b560 subunit antibody; Succinate dehydrogenase cytochrome b560 subunit mitochondrial antibody; Succinate dehydrogenase cytochrome b560 subunit, mitochondrial precursor antibody; Succinate-ubiquinone oxidoreductase cytochrome B large subunit antibody;	WB, IHC-P	Human, Mouse, Rat
	SDHC Antibody(YA6760) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SDHC.

HY-P84184

	SDHB Antibody (YA3881) IP; SDH; CWS2; PGL4; SDH1; SDH2; SDHIP	IHC-P, FC, ELISA	Human
	SDHB Antibody (YA3881) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SDHB.

HY-P84251

	SDHA Antibody (YA3948) FP; PGL5; SDH1; SDH2; SDHF; CMD1GG; MC2DN1; NDAXOA	WB, ICC/IF, FC, ELISA	Human, Mouse
	SDHA Antibody (YA3948) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to SDHA.

HY-P86391

	SDHB Antibody (YA6083) SDHB; SDH; SDH1; Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur subunit of complex II; Ip	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	SDHB Antibody (YA6083) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SDHB.

HY-P86640

	SDHA Antibody (YA6332) SDHA; SDH2; SDHF; Succinate dehydrogenase [ubiquinone] flavoprotein subunit; mitochondrial; Flavoprotein subunit of complex II; Fp	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	SDHA Antibody (YA6332) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SDHA.

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