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Pathways Recommended:	Metabolic Enzyme/Protease

Results for "

SARS-CoV papain-like protease

" in MedChemExpress (MCE) Product Catalog:

By Targets:	SARS-CoV (26) Virus Protease (8) Bacterial (2) Deubiquitinase (1) Fluorescent Dye (3) Fungal (2) HIF/HIF Prolyl-Hydroxylase (2) Isotope-Labeled Compounds (1) Monocarboxylate Transporter (2)
By Research Areas:	Cancer (3) Infection (25) Inflammation/Immunology (1)

Inhibitors & Agonists

Fluorescent Dye

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Targets Recommended:

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-150784

XR8-89	SARS-CoV	Infection
XR8-89 is a potent papain-like protease (PL ^pro) inhibitor with an IC₅₀ value of 0.1 μM. XR8-89 induces conformational changes in SARS-COV-2 papain-like protease, inhibiting SARS-CoV-2 replication. XR8-89 can be used for SARS-CoV-2 research .

HY-168584

SARS-CoV-2-IN-102	SARS-CoV	Infection
SARS-CoV-2-IN-102 (example 58) is a SARS-CoV papain-like protease (PLpro) inhibitor with an IC₅₀ <100 nM .

HY-161729

PLpro-IN-3	SARS-CoV	Infection
PLpro-IN-3 (compound 26R) is a potent Papain-like protease (PLpro) inhibitor with a IC₅₀ of 1.0μM. PLpro-IN-3 exhibits antiviral activity against *SARS-CoV-2* with a EC₅₀ of 4.3 μM .

HY-150783

SARS-CoV-2-IN-24	SARS-CoV	Infection
SARS-CoV-2-IN-24 (compound 7) is a potent papain-like protease (PL ^pro) inhibitor. SARS-CoV-2-IN-24 induces conformational changes in SARS-COV-2 papain-like protease, inhibiting SARS-CoV-2 replication. SARS-CoV-2-IN-24 can be used for SARS-CoV-2 research .

HY-P2296

Abz-FRLKGGAPIKGV-EDDNP TFA	Fluorescent Dye	Others
Abz-FRLKGGAPIKGV-EDDNP TFA is a fluorogenic substrate used to measure the enzymatic activities of protease forms, such as papain-like protease 2 (PLP2) from severe acute respiratory syndrome coronavirus (SARS-CoV). Abz-FRLKGGAPIKGV-EDDNP TFA has the potential for study 2019-nCoV (COVID-19) infection .

HY-150786

PLP_Snyder530	SARS-CoV	Infection
PLP_Snyder530 is a potent papain-like protease (PL ^pro) inhibitor with an IC₅₀ value of 6.4 μM. PLP_Snyder530 induces conformational changes in SARS-COV-2 papain-like protease, inhibiting SARS-CoV-2 replication. PLP_Snyder530 can be used for SARS-CoV-2 research .

HY-150789

SARS-CoV-2-IN-23	SARS-CoV	Infection
SARS-CoV-2-IN-23 (compound GRL-0617) is a *SARS-COV-2* papain-like protease (PLpro) inhibitor with an IC₅₀ value of 2.3 μM .

HY-157439

SARS-CoV-2-IN-72	SARS-CoV	Infection
SARS-CoV-2-IN-72 (compound 12) is a potent allosteric inhibitor of the *SARS-COV-2 papain-like* protease domain that can trigger the degradation of NSP3 .

HY-173305

Mpro/PLPro-IN-2	SARS-CoV Virus Protease	Infection
Mpro/PLPro-IN-2 (Compound 22l) is a non-covalent competitive dual inhibitor of the papain-like protease and main protease of *SARS-CoV-2, with a K_i* of 0.2 μM for the papain-like protease and a K_i of 1.1 μM for the main protease . Mpro/PLPro-IN-2 can be used in the research field of anti-SARS-CoV-2 .

HY-159985

Jun13728	SARS-CoV	Infection
Jun13728 is a potent and covalent **SARS-CoV-2 papain-like protease inhibitor, with an IC₅₀** of 0.1 μM. Jun13728 can be used for SARS-CoV-2 antiviral research .

HY-161365

PLpro-IN-2	SARS-CoV	Infection
PLpro-IN-2 (Compound 16) is an inhibitor for SARS-CoV-2 papain-like protease (PLpro), with an IC₅₀ of 0.25 μM .

HY-169419

SARS-CoV-2-IN-108	SARS-CoV Virus Protease	Infection
SARS-CoV-2-IN-108 (Compound 29) is an inhibitor for **SARSCoV-2 papain-like protease with an IC₅₀** of 0.14 µM. SARS-CoV-2-IN-108 inhibits the virus replication with an EC₅₀ of 0.21 µM .

HY-164868

SARS-CoV-2-IN-106	SARS-CoV	Infection
SARS-CoV-2-IN-106 (compound 19) is a **SARS-CoV-2 papain-like protease inhibitor with the IC₅₀** values of 0.44 μM and 0.18 μM for PLpro enzymatic and viral replication ,respectively .

HY-168259

PLpro-IN-8	SARS-CoV	Infection
PLpro-IN-8 (compound 1) is a SARS-CoV papain-like protease (PLpro) inhibitor with IC₅₀ values of 5.9 μM and 0.46 μM for SARS-CoV-2 PLpro and SARS -CoV-1 PLpro, respectively. PLpro-IN-8 inhibits Wuhan strain WK-521 of SARS-CoV-2 with an EC₅₀ of 2.7 μM .

HY-168917

9-AMN	SARS-CoV Virus Protease	Infection
9-AMN is the inhibitor for **SARS-CoV-2 papain-like protease (SARS-CoV-2 PLpro*), inhibits its deubiquitination (DUB) activity and protease* activity with IC₅₀ of 4.55 µM and 4.15 µM. 9-AMN inhibits the SARS-CoV variants Delta and Omicron replication in Calu-3 cell with IC₅₀ of 1.04 µM and 2.35 µM .

HY-N1910

4'-O-Methylbavachalcone 2 Publications Verification	SARS-CoV	Infection
4'-O-Methylbavachalcone is a chalcone isolated from Psoralea corylifolia, inhibits severe acute respiratory syndrome coronavirus (SARS-CoV) papain-like protease (PLpro) activity, with an IC₅₀ of 10.1 μM .

HY-17542

PLpro inhibitor 5+ Cited Publications	SARS-CoV	Infection
PLpro inhibitor is a potent inhibitor of papain-like protease (PLpro) with an IC₅₀ of 2.6 µM . PLpro inhibitor inhibits SARS-CoV-2 PLpro with an IC₅₀ of 5.0 µM and an EC₅₀ of 21.0 µM .

HY-117043

GRL0617 Maximum Cited Publications 11 Publications Verification	Deubiquitinase SARS-CoV	Infection
GRL0617 is a selective and competitive noncovalent inhibitor of *severe acute respiratory syndrome (SARS-CoV) papain-like* protease (PLpro), with an IC₅₀** of 0.6 μM and a Ki value of 0.49 μM. GRL0617 also inhibits SARS-CoV with an EC₅₀ of 14.5 μM. GRL0617 can be used for the research of severe acute respiratory syndrome .

HY-170504

ZHAWOC25153	SARS-CoV Virus Protease	Infection
ZHAWOC25153 (Compound 17o) is a SARS-CoV-2 papain-like cysteine protease (PLpro) inhibitor, with an IC₅₀ of 7 μM. ZHAWOC25153 exhibits antiviral activity and can be used in research within the field of anti-infection .

HY-168916

Jun13296	SARS-CoV Virus Protease
Jun13296 is an orally active quinoline **SARS-CoV-2 papain-like protease inhibitor (IC₅₀ = 0.13 µM, K_i** = 8.8 nM). Jun13296 exhibits potent inhibition against SARS-CoV-2 variants and Nirmatrelvir (HY-138687)-resistant mutants. Jun13296 improves lung viral titers, and prevents lung tissue damage in a SARS-CoV-2 infection model .

HY-159655

PLpro-IN-6	SARS-CoV	Infection Inflammation/Immunology
PLpro-IN-6 (compound 6) is a papain-like protease (PLpro) inhibitor, with an IC₅₀ of 0.019 μM for SARS CoV2 PLpro enzyme .

HY-169092

PF-07957472	SARS-CoV Virus Protease	Infection
PF-07957472 (Compound 4) is an orally active SARS-CoV-2 papain-like protease (PLpro) inhibitor. PF-07957472 shows cytopathic effect in SARS-CoV-2 infected NHBE cells (EC₅₀ = 13.9 nM). PF-07957472 shows antiviral effect in a mouse-adapted model of COVID-19 infection model .

HY-172350

WEHI-P8	SARS-CoV	Infection
WEHI-P8 is an orally active inhibitor targeting the papain-like protease (PLpro) of coronaviruses. WEHI-P8 againsts SARS-CoV-2 PLpro with an IC₅₀ value of 12 nM. WEHI-P8 has good cellular activity with a EC₅₀ of 298 nM. WEHI-P8 protects mice from SARS-CoV-2 induced long-term symptoms in lung and brain. WEHI-P8 can be used for post-acute sequelae of COVID-19 study .

HY-162484

GZNL-P36	SARS-CoV Virus Protease	Infection
GZNL-P36 is an orally active inhibitor for SARS-CoV-2 papain-like protease (PL ^pro), with an IC₅₀ of 6.45 nM. GZNL-P36 inhibits SARS-CoV and its variants with EC₅₀ range from 58.2 nM to 2.66 μM. GZNL-P36 exhibits a peak plasma concentration C_max of 549 ng/mL, a half-life T_1/2 of 1.45 h and a bioavailability of 74.7% in CD-1 mouse. GZNL-P36 exhibits antiviral activity in SARS-CoV-2 XXB.1 infection in mouse .

HY-157403

Jun12682	Virus Protease SARS-CoV	Infection
Jun12682 is an orally active *SARS-CoV-2* papain-like protease (PL ^pro) inhibitor, with a K_i value of 37.7 nM and an EC₅₀ value of 1.1 μM in the FlipGFP PL ^pro assay. Jun12682 has efficacy in hindering PL ^pro both deubiquitination and deISGylation, with K_i values of 63.5 and 38.5 nM, respectively. Jun12682 exhibits resistance in multiple PL ^pro mutant strains, and its enzymatic activity is comparable to that of the wild-type. Jun12682 can be used for the study of the SARS-CoV-2 .

HY-100575

Acriflavine 5+ Cited Publications Acriflavinium chloride 3,6-Acridinediamine mix	Fluorescent Dye HIF/HIF Prolyl-Hydroxylase Bacterial SARS-CoV Monocarboxylate Transporter Fungal	Infection Cancer
Acriflavine (Acriflavinium chloride) is a fluorescent acridine dye that can be used to label nucleic acid. Acriflavine is an antiseptic agent. Acriflavine is a potent HIF-1 inhibitor that prevents the dimerization of HIF-1α and HIF-1β subunits. Acriflavine inhibits the interaction between monocarboxylate transporter 4 (MCT4) and Basigin. Acriflavine is used in cancer research, such as breast cancer, brain tumor and chronic myeloid leukemia. Acriflavine is a potent papain-like protease (PLpro) inhibitor, which inhibits *SARS-CoV-2* .

HY-W088075

Acriflavine hydrochloride 5+ Cited Publications Acriflavinium chloride hydrochloride	Fluorescent Dye HIF/HIF Prolyl-Hydroxylase Bacterial SARS-CoV Monocarboxylate Transporter Fungal	Infection Cancer
Acriflavine (Acriflavinium chloride) hydrochloride is a fluorescent acridine dye that can be used to label nucleic acid. Acriflavine hydrochloride is an antiseptic agent. Acriflavine hydrochloride is a potent HIF-1 inhibitor that prevents the dimerization of HIF-1α and HIF-1β subunits. Acriflavine hydrochloride inhibits the interaction between monocarboxylate transporter 4 (MCT4) and Basigin. Acriflavine hydrochloride is used in cancer research, such as breast cancer, brain tumor and chronic myeloid leukemia. Acriflavine hydrochloride is a potent papain-like protease (PLpro) inhibitor, which inhibits *SARS-CoV-2* .

HY-176347S

Alpha Feto Protein, Arg-13C6,15N4, Lys-13C6,15N2	Isotope-Labeled Compounds	Cancer
Alpha Feto Protein, Arg- ¹³C₃₆, ¹⁵N₄, Lys- ¹³C₆, ¹⁵N₂ is the ¹³C- and ¹⁵N-labeled Alpha Feto Protein.

Cat. No.	Product Name	Type

HY-100575

Acriflavine 5+ Cited Publications Acriflavinium chloride 3,6-Acridinediamine mix	Fluorescent Dyes/Probes
Acriflavine (Acriflavinium chloride) is a fluorescent acridine dye that can be used to label nucleic acid. Acriflavine is an antiseptic agent. Acriflavine is a potent HIF-1 inhibitor that prevents the dimerization of HIF-1α and HIF-1β subunits. Acriflavine inhibits the interaction between monocarboxylate transporter 4 (MCT4) and Basigin. Acriflavine is used in cancer research, such as breast cancer, brain tumor and chronic myeloid leukemia. Acriflavine is a potent papain-like protease (PLpro) inhibitor, which inhibits *SARS-CoV-2* .

Acriflavine

5+ Cited Publications

Acriflavinium chloride 3,6-Acridinediamine mix

Fluorescent Dyes/Probes

Acriflavine (Acriflavinium chloride) is a fluorescent acridine dye that can be used to label nucleic acid. Acriflavine is an antiseptic agent. Acriflavine is a potent HIF-1 inhibitor that prevents the dimerization of HIF-1α and HIF-1β subunits. Acriflavine inhibits the interaction between monocarboxylate transporter 4 (MCT4) and Basigin. Acriflavine is used in cancer research, such as breast cancer, brain tumor and chronic myeloid leukemia. Acriflavine is a potent papain-like protease (PLpro) inhibitor, which inhibits SARS-CoV-2 .

Cat. No.	Product Name	Target	Research Area

HY-P2296

Abz-FRLKGGAPIKGV-EDDNP TFA	Fluorescent Dye	Others
Abz-FRLKGGAPIKGV-EDDNP TFA is a fluorogenic substrate used to measure the enzymatic activities of protease forms, such as papain-like protease 2 (PLP2) from severe acute respiratory syndrome coronavirus (SARS-CoV). Abz-FRLKGGAPIKGV-EDDNP TFA has the potential for study 2019-nCoV (COVID-19) infection .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N1910

4'-O-Methylbavachalcone 2 Publications Verification	Infection Structural Classification Chalcones Flavonoids Classification of Application Fields Leguminosae Source classification Phenols Polyphenols Psoralea corylifolia L. Plants Disease Research Fields	SARS-CoV
4'-O-Methylbavachalcone is a chalcone isolated from Psoralea corylifolia, inhibits severe acute respiratory syndrome coronavirus (SARS-CoV) papain-like protease (PLpro) activity, with an IC₅₀ of 10.1 μM .

Species:	Virus (3)
Tag:	His (2) Tag Free (1)
Source:	E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P74581

	SARS-CoV Plpro/papain-like protease Protein (His) SARS-CoV (strain WH20) Plpro / papain-like protease	Virus	E. coli
	SARS CoV ORF1ab polyprotein (PP1ab) is a 7073 residues long polyprotein which further produces 5 non-structural proteins (NSPs) after processing through virally encoded proteases (NSP12-NSP16).All these 5 proteins are mainly involved in viral replication, assembly, and immune response modulation.SARS-CoV Plpro/papain-like protease Protein (His) is the recombinant Virus-derived SARS-CoV Plpro/papain-like protease protein, expressed by E.coli , with C-His labeled tag.

HY-P70122

	SARS-CoV-2 PLpro Protein 1 Publications Verification rReplicase polyprotein 1ab/2019-nCoV papain-like protease; papain-like protease; PLpro; PL-PRO; pp1a; Replicase polyprotein 1a	Virus	E. coli
	The multifunctional SARS-CoV-2 PP1ab protein is essential for viral RNA transcription and replication, utilizing proteases for multi-protein cleavage. It inhibits host translation by binding to the 40S subunit and blocks ribosomal mRNA entry channels, thereby hindering the antiviral response. SARS-CoV-2 PLpro Protein is the recombinant Virus-derived SARS-CoV-2 PLpro protein, expressed by E. coli , with tag free.

HY-P76021

	SARS-CoV-2 Plpro/Papain-like protease Protein (His) SARS-CoV-2 (2019-nCoV) Plpro/papain-like protease-His Protein	Virus	E. coli
	SARS-CoV-2 NSP3 (NSP3) is one of non-structure protein that binds to viral RNA, nucleocapsid protein, as well as other viral proteins, and contributes in polyprotein processing. NSP3 has also an important role in innate immune response antagonism and is responsible for release of NSP1, NSP2, and NSP3 from the N-terminal region of pp1a and pp1ab. SARS-CoV-2 Plpro/Papain-like protease Protein (His) is the recombinant Virus-derived SARS-CoV-2 Plpro/Papain-like protease protein, expressed by E. coli , with N-His labeled tag.

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