2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. HRASLS

HRASLS

H-RAS-like suppressor

HRASLS is a family of proteins that are involved in the metabolism of phospholipids, particularly lysophospholipids. HRASLS proteins can act as phospholipases, catalyzing the hydrolysis of lysophospholipids like LPA and LPC. This hydrolysis plays a crucial role in regulating the levels of these bioactive lipids in the cell. For example, HRASLS3 has phospholipase D activity and can influence the production of signaling molecules derived from lysophospholipids. HRASLS6, on the other hand, has LPCAT activity and can modify the acyl composition of LPC. Dysregulation of HRASLS functions has been associated with various physiological and pathological processes, including inflammation, cancer, and lipid metabolism disorders[1][2].

HRASLS Related Products (1):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-125254
    LEI110
    		Inhibitor 99.72%
    LEI110 is a potent, selective and cell-permeable pan-inhibitor of the HRASLS family of thiol hydrolases. LEI110 inhibits PLA2G16, HRASLS2, RARRES3 and iNAT, with pIC50 values of 7.0, 6.8, 6.8, and 7.6, respectively. LEI110 reduces cellular arachidonic acid levels and oleic acid-induced lipolysis in HepG2 cells.
    LEI110