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PC-3/TxR

" in MedChemExpress (MCE) Product Catalog:

By Targets:	11β-HSD (1) ADC Payload (1) Adrenergic Receptor (1) Akt (9) Aldose Reductase (2) AMPK (3) Androgen Receptor (9) Antibiotic (2) Apoptosis (66) ATM/ATR (1) Aurora Kinase (2) Autophagy (4) Bacterial (10) Bcl-2 Family (5) Biochemical Assay Reagents (5) Bombesin Receptor (2) c-Met/HGFR (2) Calcium Channel (1) Carbonic Anhydrase (1) Caspase (13) Cathepsin (1) CD3 (1) CDK (5) Chloride Channel (1) Complement System (1) COX (2) Cytochrome P450 (1) Dihydrofolate reductase (DHFR) (1) DNA Stain (1) DNA/RNA Synthesis (4) Drug Derivative (3) E1/E2/E3 Enzyme (1) EGFR (10) Endogenous Metabolite (2) Epigenetic Reader Domain (13) ERK (1) Estrogen Receptor/ERR (1) FAK (1) Farnesyl Transferase (1) Fatty Acid Synthase (FASN) (4) Fungal (8) Glucocorticoid Receptor (1) Glutaminase (1) Glutathione Peroxidase (1) Glutathione S-transferase (1) Glycosidase (1) GSK-3 (1) HDAC (6) Hedgehog (1) HIF/HIF Prolyl-Hydroxylase (1) Histone Acetyltransferase (1) Histone Demethylase (4) Histone Methyltransferase (4) HSP (4) IAP (1) ICMT (3) IGF-1R (1) Insecticide (1) Interleukin Related (4) Isotope-Labeled Compounds (2) JAK (3) Keap1-Nrf2 (1) mAChR (6) MAGL (1) MDM-2/p53 (4) MEK (1) MetAP (2) Microtubule/Tubulin (10) Mitochondrial Metabolism (1) MMP (2) mTOR (7) NADPH Oxidase (1) Necroptosis (2) NF-κB (6) NO Synthase (1) Opioid Receptor (2) P-glycoprotein (4) p38 MAPK (1) Paraptosis (2) Parasite (3) PARP (1) PERK (1) Phosphatase (1) PI3K (9) Pim (4) PKC (3) Polo-like Kinase (PLK) (1) Prostaglandin Receptor (2) PROTACs (15) Proteasome (1) Proton Pump (1) PSMA (3) Radionuclide-Drug Conjugates (RDCs) (2) Raf (3) Ras (5) Reactive Oxygen Species (ROS) (14) Reference Standards (5) ROCK (1) ROS Kinase (1) SARS-CoV (5) SGK (1) Small Interfering RNA (siRNA) (3) Smo (1) SOS1 (1) Src (1) STAT (4) Survivin (2) TGF-beta/Smad (1) TGF-β Receptor (1) Toll-like Receptor (TLR) (1) Topoisomerase (4) VEGFR (5) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (216) Cardiovascular Disease (4) Endocrinology (2) Infection (17) Inflammation/Immunology (24) Metabolic Disease (11) Neurological Disease (7)
Click Chemistry:	Azide (1) Alkynes (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Phospholipids (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

230

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Phytochelatin 3 PC 3	Biochemical Assay Reagents	Others
Phytochelatin 3 (PC 3) is the small metal chelating peptide that can be used for chelating heavy metals. Phytochelatin 3 is a short metal detoxification peptide made from the sulfur-rich molecule glutathione. Phytochelatin 3 can be found in different sources including plant, fungal, algal, and bacterial species, as a detoxification mechanism in response to heavy metal exposure. Phytochelatin 3 plays an important metabolic role in plants ^[3].

Cathepsin X-IN-1 1 Publications Verification	Cathepsin	Neurological Disease Cancer
Cathepsin X-IN-1 (compound 25) is a potent Cathepsin X inhibitor with an IC₅₀ of 7.13 µM. Cathepsin X-IN-1 decreases PC-3 cell migration with low cytotoxic .

AGPS-IN-1	Others	Cancer
AGPS-IN-1 (Compound 2i) is an effective AGPS binder. AGPS-IN-1 reduces ether lipids levels and cell migration rate. AGPS-IN-1 inhibits epithelial-mesenchymal transition (EMT) in prostate PC-3 and breast MDA-MB-231 cancer cells .

Incadronic acid	Bacterial	Infection Metabolic Disease Cancer
Incadronic acid inhibits growth of Dictyostelium discoideum with an IC₅₀ of 1.6 μM. Incadronic acid binds the farnesyl diphosphate synthase (FPPS) in Leishmania major with the K_i of 23 nM. Incadronic acid inhibits the bone resorption and reduces bone loss, that can be used in osteoporosis research. Incadronic acid inhibits the proliferation of cells RAW264.7, PC-3 and MCF-7 with IC₅₀ of 48 to 228.6 µM .

Pim-1 kinase inhibitor 4	Pim	Cancer
Pim-1 kinase inhibitor 4 (Compound 10f) is a Pim-1 kinase inhibitor (IC₅₀: 17.01 nM). Pim-1 kinase inhibitor 4 also has antioxidant activity and inhibits DPPH. Pim-1 kinase inhibitor 4 induces apoptosis in PC-3 cell, and inhibits PC-3 cell growth with an IC₅₀ of 16 nM. Pim-1 kinase inhibitor 4 can be used for research of prostate cancer .

Humulene oxide II	Others	Cancer
Humulene oxide II is an essential oil component from Zingiber striolatum Diels flowers, leaves and stems. Humulene oxide II has cytotoxicity against A549, PC-3 and K562 cell lines .

Monascuspiloin Monascinol	Akt mTOR AMPK Androgen Receptor Apoptosis Autophagy	Cancer
Monascuspiloin (Monascinol) exhibits anti-androgenic activity with an IC₅₀ of 7 μM. Monascuspiloin inhibits viability of PC-3 and LNCaP with IC₅₀ of 45 and 47 μM. Monascuspiloin induces apoptosis in LNCaP through inhibition of Akt/mTOR signaling pathway, induces autophagy through activation AMPK signaling pathway and arrest cell cycle at G2/M phase in PC-3. Monascuspiloin exhibits antitumor efficacy in mice .

VEGFR-2-IN-32	VEGFR	Cancer
VEGFR-2-IN-32 (Comp 3a) is an inhibitor of VEGFR-2 with an IC₅₀ of 8.93 nM. VEGFR-2-IN-32 has cytotoxic activity against PC-3 cells with an IC₅₀ of 1.22 μM. VEGFR-2-IN-32 can be used for anti-prostate cancer research .

visamminol-3'-O-glucoside	Others	Cancer
Visamminol-3'-O-glucoside (Compound 4) is a chromone glycoside, which is initially isolated from Saposhnikovia divaricata. Visamminol-3'-O-glucoside exhibits weak cytotoxicity against cancer cells PC-3, SK-OV-3 and H460, with IC₅₀s of 93.91, >100 and >100 μM, respectively .

DCEM1	HSP β-catenin	Cancer
DCEM1 binds to heat shock protein 60 (HSP60) and inhibits the interaction of HSP60 with ClpP, thereby blocking the mitochondrial unfolded protein response. DCEM1 inhibits β-catenin expression and ATP production in PC-3 and TKO cells. DCEM1 can be used in prostate cancer research .

ML356	Fatty Acid Synthase (FASN)	Cancer
ML356 (Compound 16) is an inhibitor for fatty acid synthase (FAS), that inhibits the thioesterase domain of FAS (FAS TE) with an IC₅₀ of 0.334 μM, and blocks the de novo palmitate synthesis in PC-3 cell with an IC₅₀ of 20 μM. ML356 exhibits good membrane permeability, and good stability in human and mouse plasma .

CCG-203971 1 Publications Verification	Ras	Inflammation/Immunology Cancer
CCG-203971 is a second-generation Rho/MRTF/SRF pathway inhibitor. CCG-203971 potently targets RhoA/C-activated SRE-luciferase (IC₅₀ =6.4 μM). CCG-203971 inhibits PC-3 cell migration with an IC₅₀ of 4.2 μM. Potential anti-metastasis Agent .

Topoisomerase II inhibitor 18	Topoisomerase	Cancer
Topoisomerase II inhibitor 18 (Compound IV) is a Quinoxaline derivative, which inhibits topoisomerase II with IC₅₀ of 7.5 μM. Topoisomerase II inhibitor 18 inhibits proliferation, cell cycle at S phase and induces apoptosis in PC-3 cells. Topoisomerase II inhibitor 18 reveals antitumor activity against cancer .

Spisulosine 1 Publications Verification ES-285	PKC Apoptosis	Cancer
Spisulosine (ES-285) is an antiproliferative (antitumoral) compound of marine origin. Spisulosine inhibits the growth of the prostate PC-3 and LNCaP cells through intracellular ceramide accumulation and PKCζ activation. Spisulosine induces apoptosis in PC-3 and LNCaP cells .

Antitumor agent-182	Reactive Oxygen Species (ROS) Apoptosis	Cancer
Antitumor agent-182 (Compound 12a) decreases mitochondrial membrane potential (MMP) and enhances ROS levels. Antitumor agent-182 arrests the cell cycle at G0/G1 phase, induces apoptosis in HeLa. Antitumor agent-182 inhibits the proliferation of HeLa, PC-3 and HCT-15 with IC₅₀s of 8.83, 10.07 and 7.84 μM, respectively .

10-Deacetyl-13-oxobaccatin III	Others	Cancer
10-Deacetyl-13-oxobaccatin III is an taxane that can be isolated from Taxus sumatrana. 10-Deacetyl-13-oxobaccatin III (30 μg/mL) shows cytotoxicity against A498, NCI-H226, A549, PC-3 cells, with inhibition a rate of 29.7%, 49.2%, 43.9%, 65.3% .

EGFR-IN-112	EGFR	Cancer
EGFR-IN-112 (SPP10) is an EGFR kinase inhibitor which exhibits IC₅₀s of 2.31 ± 0.3, 3.16 ± 0.8, and 4.2 ± 0.2 μM, against MCF-7, H69AR, and PC-3 cancer cells, respectively. EGFR-IN-112 also demonstrates selective cytotoxicity against cancer cells .

WAY-170523	MMP	Cancer
WAY-170523 is a potent and selective MMP-13 (matrix metalloproteinase-13) inhibitor, with an IC₅₀ of 17 nM. WAY-170523 can directly attenuate ERK1/2 phosphorylation. WAY-170523 inhibits the invasion of PC-3 cells, can be used for prostate cancer research .

19-Hydroxy-10-deacetylbaccatin III	Others	Cancer
19-Hydroxy-10-deacetylbaccatin III (compound 13) is a taxane with potential antitumor activity. 19-Hydroxy-10-deacetylbaccatin III has weak cytotoxicity against A498 and NCI-H226 cell lines. The study found that the inhibition rates of 30 μg/mL 19-Hydroxy-10-deacetylbaccatin III on A498, NCI-H226 and PC-3 were 16.6% and 32% respectively .

Survivin-IN-2	Survivin	Cancer
Survivin-IN-2 is a survivin inhibitor. Survivin-IN-2 shows cytotoxicity in cells with IC₅₀s of 0.53 μM (C4-2 cells) and 1.06 μM (PC-3 cells). Survivin-IN-2 effectively suppresses xenograft tumor growth without apparent toxicity and eliminates survivin in the tumors. Survivin-IN-2 can be used for the study of prostate cancer .

Anticancer agent 40	Microtubule/Tubulin	Cancer
Anticancer agent 40 (compound 3e) is a potent anticancer agent. Anticancer agent 40 shows anticancer activities with IC₅₀s of 0.94, 0.98, 0.96, 0.95, 2.13 nM for SKBR-3, SKOV-3, PC-3, U-87, HDF cells, respectively .

LQZ-7F	Survivin Apoptosis	Cancer
LQZ-7F, a survivin dimerization inhibitor, induces spontaneous apoptosis and synergizes with Docetaxel in prostate cancer cells. LQZ-7F dose-dependently inhibits survival of both PC-3 and C4-2 cells with IC₅₀s of 2.99 and 2.47 µM, respectively .

Antiangiogenic agent 7	Reactive Oxygen Species (ROS) Apoptosis	Inflammation/Immunology Cancer
Antiangiogenic agent 7 (Compound 1) can induce cell apoptosis, increase Reactive Oxygen Species, and inhibit the intracellular enzyme thioredoxin reductase. Antiangiogenic agent 7 has anti-cancer activity, with an IC₅₀ of 0.08-3.5 μM against cervical cancer cells HeLa, prostate cancer cells PC-3, and non-small cell lung cancer A549. Antiangiogenic agent 7 inhibits tumor growth in mouse xenograft models .

3289-8625	Wnt	Cancer
3289-8625 is an inhibitor of the PDZ domain of Dishevelled (Dvl) protein (K_d=10.6 μM) and has an inhibitory effect on Wnt signaling. In addition, 3289-8625 can slow the growth of prostate cancer PC-3 cells (IC₅₀=12.5 μM). 3289-8625 can be used in the study of embryonic development and cancer .

NF-κB-IN-2	NF-κB	Neurological Disease
NF-κB-IN-2 inhibits TNF-α-induced canonical NF-κB signaling in PC-3 cells.

CDK2-IN-45	CDK Apoptosis	Cancer
CDK2-IN-45 (Compound 8f) is a CDK2 inhibitor (IC₅₀: 0.64 μM). CDK2-IN-45 inhibits the proliferation of DU-145 and PC-3 cell lines with IC₅₀ of 2.20 μM and 4.17 μM, respectively. CDK2-IN-45 induces G0/G1 cell cycle arrest and apoptosis. CDK2-IN-45 can be used in prostate cancer research .

Antitumor agent-55	Apoptosis ROS Kinase MDM-2/p53 Bcl-2 Family	Cancer
Antitumor agent-55 (compound 5q) is a potent antitumor agent. Antitumor agent-55 effectively inhibits PC3, with an IC₅₀ of 0.91 μM. Antitumor agent-55 effectively inhibits the colony formation, suppresses the cell migration in PC3. Antitumor agent-55 induces G1/S phase arrest and apoptosis in PC3 .

α-Tubulin polymerization-IN-1	Microtubule/Tubulin Keap1-Nrf2 Reactive Oxygen Species (ROS) Apoptosis	Cancer
α-Tubulin polymerization-IN-1 (Compound 8l) is an inhibitor for α-Tubulin polymerization. α-Tubulin polymerization-IN-1 modulates the NRF2/KEAP-1 signaling pathway, induces ROS generation in PC-3 cell, thereby inducing apoptosis in PC-3. α-Tubulin polymerization-IN-1 inhibits the proliferation of PC-3 cell with a GI₅₀ of 0.17 µM, arrests the cell cycle at G2/M phase. α-Tubulin polymerization-IN-1 exhibits antitumor efficacy in mouse model .

B-Raf IN 9	Raf Apoptosis	Cancer
B-Raf IN 9 (compound 8b) is a potent B-Raf inhibitor, with an IC₅₀ of 24.79 nM. B-Raf IN 9 induces apoptosis and shows cell cycle arrest at G2/M phase. B-Raf IN 9 exhibits potent antitumor activity against human prostate cancer PC-3 cell line, with an IC₅₀ of 7.83 µM .

Jacaric acid	Apoptosis	Inflammation/Immunology Cancer
Jacaric acid is a conjugated linolenic acid, which inhibits viability in cells PC-3 (IC₅₀ is 11.8 μM), LNCaP (IC₅₀ is 2.2 μM) and DLD-1, induces apoptosis and necrosis . Jacaric acid exhibits anticaner activity against prostate cancer and adenocarcinoma . Jacaric acid exhibits immunomodulating activity in murine peritoneal macrophages as an immunopotentiator ^[3]. Jacaric acid is orally active.

GLS1 Inhibitor-1	Glutaminase	Cancer
GLS1 Inhibitor-1 (Compound 27) is an orally active inhibitor for glutaminase 1 (GLS1) with an IC₅₀ of 0.021 μM. GLS1 Inhibitor-1 inhibits the proliferation of PC-3 with an IC₅₀ of 0.3 nM. GLS1 Inhibitor-1 exhibits antitumor efficacy against NCI-H1703 with GI₅₀ of 0.011 μM. GLS1 Inhibitor-1 exhibits moderate pharmacokinetic characteristics .

B-Raf IN 8	Raf	Cancer
B-Raf IN 8 (compound 7g) is a potent B-Raf inhibitor, with an IC₅₀ of 70.65 nM. B-Raf IN 8 exhibits antitumor activity against hepatocellular carcinoma (HEPG-2), colon carcinoma (HCT-116), mammary gland (MCF-7) and human prostate cancer (PC-3) cells, with IC₅₀ values of 9.78, 13.78, 18.52 and 29.85 µM .

KDM5B-IN-4	Histone Demethylase	Cancer
KDM5B-IN-4 (compound 11ad) is a lysine demethylase 5B (KDM5B) inhibitor with an IC₅₀ of 0.025 μM KDM5B-IN-4 increases substrate H3K4me1/2/3 level by inhibiting KDM5B in PC-3 cells. KDM5B-IN-4 downregulates PI3K/AKT. KDM5B-IN-4 reduces tumor volume in mice and shows less toxic to organs .

B-Raf IN 7	Raf	Cancer
B-Raf IN 7 (compound 6a) is a potent B-Raf inhibitor, with an IC₅₀ of 110.23 nM. B-Raf IN 7 exhibits antitumor activity against colon carcinoma (HCT-116), mammary gland (MCF-7), hepatocellular carcinoma (HEPG-2), human cervical carcinoma (Hela) and human prostate cancer (PC-3) cells, with IC₅₀ values of 7.50, 9.87, 10.57, 11.63 and 12.83 µM .

STX140	Estrogen Receptor/ERR Microtubule/Tubulin Apoptosis	Cancer
STX140 is an orally active microtubule disruptor. STX140 induces apoptosis in the hormone-independent PC-3 prostate cell lines. STX140 has anti-angiogenic and anti-tumour activities .

19-Hydroxybufalin	Others	Cancer
19-Hydroxybufalin is a bufadienolide, inhibits epithelial-mesenchymal transition and attenuates the migration and invasion of PC3 cells .

Saprorthoquinone NSC 648341	Others	Cancer
Saprorthoquinone (NSC 648341) is a diterpenoid that can be found in salvia atropatana. Saprorthoquinone shows cytotoxicity for PC3 cells .

Anticancer agent 25	Others	Cancer
Anticancer agent 25 exhibits the strongest cytotoxicity against PC3 cells with an IC₅₀ value of 0.19 μM.

PROTAC CDK2/9 Degrader-1	PROTACs CDK	Cancer
PROTAC CDK2/9 Degrader-1 (Compound F3) is a potent dual degrader for CDK2 (DC₅₀=62 nM) and CDK9 (DC₅₀=33 nM). PROTAC CDK2/9 Degrader-1 suppresses prostate cancer PC-3 cell proliferation (IC₅₀=0.12 µM) by effectively blocking the cell cycle in S and G2/M phases. PROTAC CDK2/9 Degrader-1 is a PROTAC by tethering CDK inhibitor with Cereblon ligand .

MS5033	PROTACs Akt	Cancer
MS5033 is a potent PROTAC-based AKT (protein kinase B) degrader, with a DC₅₀ of 430 nM in PC3 cells .

19-Oxocinobufotalin	Others	Cancer
19-Oxocinobufotalin is capable of suppressing EMT (Epithelial-mesenchymal transition) and weakening the migratory and invasive potential of PC3 cells .

Lepidozin G	Apoptosis	Cancer
Lepidozin G inhibits the growth of a panel of cancer cell lines with IC₅₀ values ranging from 4.2 ± 0.2 to 5.7 ± 0.5 μM. Lepidozin G induces PC-3 cell death via mitochondrial-related apoptosis.

HTS07944 HTS07944SC	Caspase Interleukin Related	Inflammation/Immunology Cancer
HTS07944 (HTS07944SC, C3) is a potent modulator of laminin receptor (37 LR). HTS07944 (HTS07944SC, C3) possesses anti-cancer activity in PC-3 cells and activates Caspase 3/7 .

Kopsoffinol	Others	Cancer
Kopsoffinol, a bisindole alkaloid, shows in vitro growth inhibitory activity against human PC-3, HCT-116, MCF-7, and A549 cells and moderate effects in reversing multidrug-resistance in vincristine-resistant human KB cells .

SOS1/EGFR-IN-1	SOS1 EGFR Ras	Cancer
SOS1/EGFR-IN-1 (compound SE-9) is a dual-target inhibitor for the prostate cancer. SOS1/EGFR-IN-1 inhibits effectively SOS1(IC₅₀=42.13±1.55 nM) and EGFR(IC₅₀=1.01±0.04 nM) by inhibiting their downstream effector molecules. SOS1/EGFR-IN-1 induces apoptosis and G1 phase cell cycle arrest, reducing angiogenesis and migration. SOS1/EGFR-IN-1 shows significant antitumor effects in prostate cancer cells PC-3 (IC₅₀=0.45±0.03 μM) .

Cat. No.	Product Name	Type

HY-W782083

p-SCN-Bn-NOTA trihydrochloride

Chelators

p-SCN-Bn-NOTA trihydrochloride is a macrocyclic chelator. p-SCN-Bn-NOTA trihydrochloride can be covalently coupled to molecules such as peptides through the thiocyanate group to form hexacoordinate copper (such as ⁶⁴Cu) complexes. p-SCN-Bn-NOTA trihydrochloride specifically binds to GRPR or EGFR highly expressed on the surface of tumor cells, mediating tumor enrichment of radioactive probes. p-SCN-Bn-NOTA trihydrochloride can be used to study malignant tumors expressing GRPR or EGFR, such as prostate cancer and colorectal cancer .

Cat. No.	Product Name	Target	Research Area

HY-P3320

Phytochelatin 3 PC 3	Biochemical Assay Reagents	Others
Phytochelatin 3 (PC 3) is the small metal chelating peptide that can be used for chelating heavy metals. Phytochelatin 3 is a short metal detoxification peptide made from the sulfur-rich molecule glutathione. Phytochelatin 3 can be found in different sources including plant, fungal, algal, and bacterial species, as a detoxification mechanism in response to heavy metal exposure. Phytochelatin 3 plays an important metabolic role in plants ^[3].

HY-P1793A

α-Casein (90-95) TFA	Opioid Receptor Biochemical Assay Reagents	Neurological Disease Inflammation/Immunology Cancer
α-Casein (90-95) TFA is a partial agonist of opioid receptors and a copper ion ligand, with opioid activity. α-Casein (90-95) TFA inhibits the secretion of β-hexosaminidase by rat peritoneal mast cells (PMC) with IC₅₀= 0.1 μM. α-Casein (90-95) TFA inhibits the proliferation of prostate cancer cells LNCaP, DU145, and PC3 with IC₅₀ of 0.94 nM, 137 nM, and 6.92 nM, respectively. α-Casein (90-95) TFA activates G_i-like proteins through a membrane-assisted, receptor-independent pathway, or reversibly binds to opioid receptors, inducing intracellular calcium release and conformational changes, and exerts the activity of promoting mast cell secretion and inhibiting tumor cell proliferation. α-Casein (90-95) TFA can be used in the study of the mechanisms of allergic diseases and prostate cancer ^[3].

HY-P1793

α-Casein (90-95)	Opioid Receptor Biochemical Assay Reagents	Neurological Disease Inflammation/Immunology Cancer
α-Casein (90-95) is a partial agonist of opioid receptors and a copper ion ligand, with opioid activity. α-Casein (90-95) inhibits the secretion of β-hexosaminidase by rat peritoneal mast cells (PMC) with IC₅₀= 0.1 μM. α-Casein (90-95) inhibits the proliferation of prostate cancer cells LNCaP, DU145, and PC3 with IC₅₀ of 0.94 nM, 137 nM, and 6.92 nM, respectively. α-Casein (90-95) activates G_i-like proteins through a membrane-assisted, receptor-independent pathway, or reversibly binds to opioid receptors, inducing intracellular calcium release and conformational changes, and exerts the activity of promoting mast cell secretion and inhibiting tumor cell proliferation. α-Casein (90-95) can be used in the study of the mechanisms of allergic diseases and prostate cancer ^[3].

HY-125747

Actinomycin X2 1 Publications Verification Actinomycin V	Bacterial Antibiotic Apoptosis	Infection Cancer
Actinomycin X2 (Actinomycin V)，produced by many Streptomyces sp.，shows strong inhibition of MRSA with a minimum inhibitory concentration (MIC) value of 0.25 μg/mL. Actinomycin X2 can be used for cancer and bacterial infection .

HY-P5831

Biotin-H10	Peptides MDM-2/p53	Cancer
Biotin-H10 is a specific anterior gradient homolog 2 (AGR2) inhibitor with a K_D of 6.4 nM. Biotin-H10 inhibits cancer cells viability .

HY-P3320A

Phytochelatin 3 TFA PC 3 TFA	Peptides	Others
Phytochelatin 3 (PC 3) TFA is the small metal chelating peptide that can be used for chelating heavy metals .

HY-P5580

Dermaseptin-B3	Bacterial	Infection Cancer
Dermaseptin-B3 inhibits the growth of Gram-positive and Gram-negative bacteria (MIC: 1.3, 2.3, 5.0, 2.6, 2.3 μM for S. aureus, P. aeruginosa, P. aeruginosa, E. (ATCC 25922), E. (54127) respectively). Dermaseptin-B3 also inhibits tumor cell proliferation .

Cat. No.	Product Name	Target	Research Area

HY-P99802

Pasotuxizumab BAY 2010112; AMG 212; MT112	CD3	Cancer
Pasotuxizumab (BAY 2010112) is a PSMA and *CD3* bispecific T-cell engager (BiTE). Pasotuxizumab binds to CD3 and PSMA with K_Ds of 9.4 nM and 47.0 nM for human CD3 and PSMA. Pasotuxizumab can be used for research of metastatic castration-resistant prostate cancer (mCRPC) .

HY-P991316

KD014 DX-2400; DX-2410	MMP TGF-β Receptor TGF-beta/Smad NO Synthase	Cancer
KD014 (DX-2400) is a human monoclonal antibody (mAb) targeting MMP14 (K_i: 0.9 nM). KD014 inhibits TGFβ and *SMAD2/3* activity, increases macrophage numbers and iNOS expression, and shifts macrophage phenotype toward anti-tumor M1-like. KD014 has anti-tumor activity in three different tumor models (MDA-MB-231, MDA-MB-435, and PC3). KD014 can be used in breast cancer research .

Cat. No.	Product Name	Chemical Structure

HY-W782079

Geraniol-d6 (Major)
Geraniol-d6 (Major) is the deuterated labeled Geraniol (Major). Geraniol is an olefin terpene with oral activity. Geraniol inhibits cell proliferation and promotes apoptosis. Geraniol has antibacterial, antifungal, antioxidant, anti-inflammatory and antitumor activities. Geraniol can be used to study diabetes ^[3] .

HY-17037S1

Pirenzepine-d8 dihydrochloride

Pirenzepine-d₈ (LS 519-d₈; Pirenzepin-d₈) dihydrochloride is a deuterium labeled Pirenzepine (dihydrochloride) (HY-17037). Pirenzepine (LS 519) dihydrochloride is a selective M1 mAChR (muscarinic acetylcholine receptor) antagonist. Pirenzepine dihydrochloride reduces gastric acid secretion and reduces muscle spasm, can be used in peptic ulcers research. Pirenzepine dihydrochloride shows anti-proliferative activity to cancer cells ^[3].

HY-13626S

Spisulosine-d3
Spisulosine-d₃ (ES-285-d₃) is deuterium labeled Spisulosine (HY-13626). Spisulosine is an antiproliferative (antitumoral) compound of marine origin. Spisulosine inhibits the growth of the prostate PC-3 and LNCaP cells through intracellular ceramide accumulation and PKCζ activation. Spisulosine induces apoptosis in PC-3 and LNCaP cells .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80556

	ATG3 Antibody (YA602) APG3; APG3L; PC3-96; APG3-LIKE	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
	ATG3 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 36 kDa, targeting to ATG3. It can be used for WB,IHC-F,IHC-P,ICC/IF assays with tag free, in the background of Human, Mouse, Rat.

HY-P84807

	CBX8 Antibody (YA4504) PC3; RC1	WB, FC, ELISA	Human
	CBX8 Antibody (YA4504) is a mouse-derived and non-conjugated IgG1 antibody, targeting to CBX8. It can be applicated for WB, FC, ELISA assays, in the background of human.

HY-P82941

	ACTR1B Antibody (YA2686) PC3; ARP1B; CTRN2	WB, IHC-F, IHC-P, ICC/IF, IP	Human
	ACTR1B Antibody (YA2686) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2686), targeting ACTR1B, with a predicted molecular weight of 42 kDa (observed band size: 42 kDa). ACTR1B Antibody (YA2686) can be used for WB, IHC-F, IHC-P, ICC/IF, IP experiment in human background.

HY-P83921

	KRT6A Antibody (YA3618) KRT6A; K6A; K6C; K6D; PC3; CK6C; CK6D; CK-6C; CK-6E; KRT6C; KRT6D	WB, ICC/IF, FC, ELISA	Human
	KRT6A Antibody (YA3618) is a mouse-derived and non-conjugated IgG2b antibody, targeting to KRT6A. It can be applicated for WB, ICC/IF, FC, ELISA assays, in the background of human.

HY-P84825

	ATG3 Antibody (YA4522) APG3; APG3L; PC3-96; APG3-LIKE	WB, IHC-P, ICC/IF, ELISA	Human, Monkey
	ATG3 Antibody (YA4522) is a mouse-derived and non-conjugated IgG1 antibody, targeting to ATG3. It can be applicated for WB, IHC-P, ICC/IF, ELISA assays, in the background of human, monkey.

HY-P84826

	ATG3 Antibody (YA4523) APG3; APG3L; PC3-96; APG3-LIKE	WB, IHC-P, ICC/IF, FC, ELISA	Human
	ATG3 Antibody (YA4523) is a mouse-derived and non-conjugated IgG1 antibody, targeting to ATG3. It can be applicated for WB, IHC-P, ICC/IF, FC, ELISA assays, in the background of human.

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Cat. No.	Product Name		Classification

HY-169098

HSP90/LSD1-IN-1		Alkynes
HSP90/LSD1-IN-1 (compound 6) is a HSP90/LSD1 dual inhibitor. HSP90/LSD1-IN-1 inhibits the proliferation of prostate cancer cell lines PC-3 and DU145, with GI₅₀ values of 0.24 and 0.30 μM, respectively .

HY-157880

N3-PC Azido-PC		Azide
N3-PC (Azido-PC) is a photoactivatable phosphatidylcholine that can be used in the synthesis of cell membrane structures. N3-PC (Azido-PC) is a click chemistry reagent containing an azide group .

Cat. No.	Product Name		Classification

HY-RS27449

G6pc3 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
G6pc3 Rat Pre-designed siRNA Set A contains three designed siRNAs for G6pc3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS20932

G6pc3 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
G6pc3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for G6pc3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS05193

G6PC3 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
G6PC3 Human Pre-designed siRNA Set A contains three designed siRNAs for G6PC3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-W725327

1,2-Dipropionyl-sn-glycero-3-phosphocholine 1,2-Dipropionyl-sn-glycero-3-Phosphatidylcholine; 1,2-Dipropionyl-sn-glycero-3-Phosphocholine; PC(3:0/3:0)		Phospholipids
1,2-Dipropionyl-sn-glycero-3-PC is a phospholipid containing propionic acid at the sn-1 and sn-2 positions. It has been used to study the interaction between water and the phosphocholine headgroup in aqueous solutions.

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