2. Apoptosis Vitamin D Related/Nuclear Receptor
  3. Apoptosis Androgen Receptor
  4. Torulene

Torulene (Torulin) is an orally active carotenoid with anti-cancer activity. Torulene inhibits proliferation and induces apoptosis of tumor cells via a mitochondrial signal pathway and the down-regulation of androgen receptor (AR) expression. Torulene can be used for the study of prostate cancer.

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Torulene Chemical Structure

Torulene Chemical Structure

CAS No. : 547-23-9

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Torulene Related Antibodies

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Description

Torulene (Torulin) is an orally active carotenoid with anti-cancer activity. Torulene inhibits proliferation and induces apoptosis of tumor cells via a mitochondrial signal pathway and the down-regulation of androgen receptor (AR) expression. Torulene can be used for the study of prostate cancer[1][2].

In Vitro

Torulene (40 μM, 24 h) exhibits dose-dependent inhibition of the proliferation of two types of LNCaP cells and PC-3 cells[2].
Torulene (30 μM, 12-48 h) leads to cell apoptosis time-dependently in LNCaP cells and PC-3 cells, and it is more significant in the androgen-sensitive LNCaP cells[2].
Torulene (10-40 μM, 24 h) reduces mitochondrial membrane potential (MMP) and Bax expression and leads to an increase in intracellular calcium ion concentration and Bcl-2 expression in LNCaP cells and PC-3 cells[2].
Torulene (10-30 μM, 24 h) significantly decreased AR and PSA protein and mRNA expression in a dose-dependent manner in LNCaP cells.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Torulene Related Antibodies

Cell Viability Assay[2]

Cell Line: LNCaP and PC-3 cells
Concentration: 0, 10, 20, 30, 40, 50 μM
Incubation Time: 24 h
Result: Decreased cell viability approx. 50% on androgen-insensitive PC-3 cells.
Decreased cell viability approx. 15% on androgen-sensitive LNCaP cells.

RT-PCR[2]

Cell Line: LNCaP and PC-3 cells
Concentration: 10, 20 and 30 μM
Incubation Time: 24 h
Result: Decreased mRNA expression of Bcl-2 was from 1.00 to 0.94 (LNCap) and 0.59 (PC-3)-fold.
Increased expression of Bax from 1.00 to 2.29 (LNCap)- and 3.08 (PC-3)-fold.
In Vivo

Torulene (9 and 18 mg/kg, p.o., for 2 weeks) markedly inhibits the growth of prostate cancer in nude mice injected with hormone-independent prostatic carcinoma PC-3 cells and likely associated with the apoptosis of the tumor[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: PC-3 xenograft prostate tumors model established in six-week-old BALB/c male nude mice[1]
Dosage: 9 and 18 mg/kg
Administration: Oral administration (p.o.), for 2 weeks
Result: Lowered the mean number of tumors from 248.13 to 50.83.
Showed tumor degeneration, apoptosis and necrosis presented.
Decreased the expression of Bcl-2 and Increased the expression of Bax.
Increased the mRNA expressions of caspase-3, 8 and 9 in tumor tissues.
Molecular Weight

534.86

Formula

C40H54
CAS No.
SMILES

C/C(C)=C/C=C/C(C)=C/C=C/C(C)=C/C=C/C(C)=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C
Structure Classification
Initial Source

Ramalina usnea thalli
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Torulene Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Torulene547-23-9TorulinApoptosisAndrogen ReceptorTorularhodinChemopreventionPC-3 xenograft prostate tumorsInhibitorinhibitorinhibit

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