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  5. Geraniol

Geraniol is an olefin terpene with oral activity. Geraniol inhibits cell proliferation and promotes apoptosis. Geraniol has antibacterial, antifungal, antioxidant, anti-inflammatory and antitumor activities. Geraniol can be used to study diabetes.

For research use only. We do not sell to patients.

Geraniol

Geraniol Chemical Structure

CAS No. : 106-24-1

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Solution
10 mM * 1 mL in DMSO In-stock
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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Geraniol:

Geraniol Related Antibodies

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  • Purity & Documentation

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Description

Geraniol is an olefin terpene with oral activity. Geraniol inhibits cell proliferation and promotes apoptosis. Geraniol has antibacterial, antifungal, antioxidant, anti-inflammatory and antitumor activities. Geraniol can be used to study diabetes[1][2][3][4][5].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Geraniol (0.25-1 mM, 24, 48, 72 h) blocks the cell cycle and induces apoptosis in PC-3 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Geraniol Related Antibodies

Cell Viability Assay [2]

Cell Line: PC-3
Concentration: 0.068, 0.125, 0.25, 0.5, 1 mM
Incubation Time: 72 h
Result: Decreased cell growth in a concentration-dependment manner.

Cell Cycle Analysis [2]

Cell Line: PC-3
Concentration: 0.25, 0.5, 1 mM
Incubation Time: 24 h
Result: Increased the percentage of G1 and/or sub-G1 phase cells.

Western Blot Analysis [2]

Cell Line: PC-3
Concentration: 0.25, 0.5, 1 mM
Incubation Time: 24 h
Result: Increased the activity of caspase-3.
Reduced the expressions of four cyclin isotypes (cyclin A, B, D, and E), two of CDK family (CDK1 and CDK4), and two anti-apoptotic Bcl-2 family members (Bcl-2 and Bcl-w).
Elevated the expressions of two CDK inhibitory proteins (p21 and p27) and two pro-apoptotic Bcl-2 family members (Bax and BNIP3).
In Vivo

Geraniol (60, 300 mg/kg, subcutaneously injected into tumor cells daily for 38 consecutive days) inhibits tumor growth in PC-3 nude mouse tumor models[2].
Geraniol (200 mg/kg, orally, for 45 consecutive days) improves hyperglycemia by reducing a key enzyme in carbohydrate metabolism induced by streptomycin (HY-13753) in diabetic rats[3].
Geraniol (100 mg/kg/day, orally, for 4 weeks) alleviates oxidative stress, bioaccumulation, serological and histopathological changes during aluminum chloride hepatopancreas poisoning in male Wistar rats[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: PC-3 cell xenograft in nude mice[2]
Dosage: 60, 300 mg/kg
Administration: s.c.
Result: Reduced the tumor volume and weight.
Increased the percentage of apoptotic cells and reduced the expression level of Ki-67.
Animal Model: Streptozotocin-induced diabetic rats [3]
Dosage: 200 mg/kg
Administration: p.o.
Result: Decreased the body weight in diabetes rats and decreased blood glucose and increased plasma insulin to near normal.
Reverted the levels of Hb and HbA1C towards near normal and reversed the activities of these enzymes to near normal.
Animal Model: Aluminum chloride-hepatopancreatic toxicity rats[4]
Dosage: 100 mg/kg
Administration: p.o.
Result: Reduced AST, ALT, ALP, LDH, pancreatic enzymes and FBS levels.
Reduced the MDA and Increased the TAC levels.
Molecular Weight

154.25

Formula

C10H18O
CAS No.
Appearance

Liquid (Density: 0.879 g/cm3)

Color

Colorless to light yellow

SMILES

C/C(C)=C\CC/C(C)=C/CO
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

H2O : 1 mg/mL (6.48 mM; ultrasonic and warming and heat to 80°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.4830 mL 32.4149 mL 64.8298 mL
5 mM 1.2966 mL 6.4830 mL 12.9660 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (648.30 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.79%

SDS (393 KB)

COA (240 KB) HNMR (242 KB) LCMS (93 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 6.4830 mL 32.4149 mL 64.8298 mL 162.0746 mL
5 mM 1.2966 mL 6.4830 mL 12.9660 mL 32.4149 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Geraniol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Geraniol106-24-1FungalEndogenous MetaboliteApoptosisBacterialAntitumorAnti-inflammationPC-3Prostate cancerDiabetes ratsInhibitorinhibitorinhibit

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